CN101502607B - Cordyceps sinensis and mushroom composition, Cordyceps sinensis and mushroom polysaccharide oral liquid, and preparation method thereof - Google Patents
Cordyceps sinensis and mushroom composition, Cordyceps sinensis and mushroom polysaccharide oral liquid, and preparation method thereof Download PDFInfo
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- CN101502607B CN101502607B CN2009100802533A CN200910080253A CN101502607B CN 101502607 B CN101502607 B CN 101502607B CN 2009100802533 A CN2009100802533 A CN 2009100802533A CN 200910080253 A CN200910080253 A CN 200910080253A CN 101502607 B CN101502607 B CN 101502607B
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- cordyceps
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- mushroom
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- 235000001674 Agaricus brunnescens Nutrition 0.000 title claims abstract description 25
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 239000007788 liquid Substances 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims description 7
- 241001248610 Ophiocordyceps sinensis Species 0.000 title 2
- 150000004676 glycans Chemical class 0.000 title 1
- 229920001282 polysaccharide Polymers 0.000 title 1
- 239000005017 polysaccharide Substances 0.000 title 1
- 241000190633 Cordyceps Species 0.000 claims abstract description 28
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000012141 concentrate Substances 0.000 claims description 4
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims description 3
- 235000011293 Brassica napus Nutrition 0.000 claims description 3
- 240000008100 Brassica rapa Species 0.000 claims description 3
- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 claims description 3
- 240000000599 Lentinula edodes Species 0.000 claims description 3
- 235000001715 Lentinula edodes Nutrition 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 2
- 239000002893 slag Substances 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 238000011017 operating method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 206010028980 Neoplasm Diseases 0.000 abstract description 5
- 230000036039 immunity Effects 0.000 abstract description 4
- 239000004615 ingredient Substances 0.000 abstract description 2
- 244000088415 Raphanus sativus Species 0.000 abstract 2
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 abstract 2
- 240000005528 Arctium lappa Species 0.000 abstract 1
- 235000003130 Arctium lappa Nutrition 0.000 abstract 1
- 235000008078 Arctium minus Nutrition 0.000 abstract 1
- 244000000626 Daucus carota Species 0.000 abstract 1
- 235000002767 Daucus carota Nutrition 0.000 abstract 1
- 241001236817 Paecilomyces <Clavicipitaceae> Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 10
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 206010061534 Oesophageal squamous cell carcinoma Diseases 0.000 description 4
- 208000036765 Squamous cell carcinoma of the esophagus Diseases 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 208000007276 esophageal squamous cell carcinoma Diseases 0.000 description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 241000282414 Homo sapiens Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 201000005296 lung carcinoma Diseases 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000556 factor analysis Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention provides a cordyceps mushroom composition, comprising the following ingredients by weight portions: 130 portions to 170 portions of white radish, 130 portions to 170 portions of radish leaf, 90 portions to 110 portions of carrot, 55 portions to 65 portions of mushroom, 27 portions to 33 portions of burdock root, 13 portions to 17 portions of yam and 13 portions to 17 portions of paecilomyces bepiali chen. The invention also provides a polyose oral liquid of cordyceps mushroom, which contains water extract of the cordyceps mushroom composition. The polyose oral liquid can utilize the cordyceps mushroom composition and obtain juice by adding water and extracting. The cordyceps mushroom composition and the polyose oral liquid have very obvious effect for improving immunity of living body and even can achieve the purpose of effectively treating cancers.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, contain the oral liquid of extract of said composition and the preparation method of this oral liquid.
Background technology
Though modern doctor trained in Western medicine is quite flourishing, and numerous disease is not also had good medicine or method, these diseases comprise cancer, subhealth state and chronic disease etc.This mainly is because doctor trained in Western medicine mainly is to carry out specific aim treatment at diseased region, and above-mentioned disease or be that pathological tissues is difficult to cure, cancer for example, or be to can not find clear and definite pathological tissues, for example some subhealth state diseases.So doctor trained in Western medicine just has great limitation aspect the above-mentioned disease of treatment, and the traditional Chinese medical science just has bigger advantage comparatively speaking, because what the traditional Chinese medical science was implemented mainly is comprehensive dialectical treatment, assign life entity as highly on the whole treating of cooperation, consider so a lot of middle medical drugs all are based on the allomeric function that improves life entity, just improve the immunocompetence of viable organism.In development courses in several thousand of Chinese medicine, found much physical function to be improved and recover effectively Chinese herbal medicine, Cordyceps mycelium is exactly wherein a kind of, it has the effect of tonifying the lung, kidney tonifying, strong liver, QI invigorating, benefit essence, have no side effect, can improve the immunity of human body, improve the life entity function.Yet single effect with Cordyceps mycelium is still quite limited, cooperates mutually if can cooperate other Chinese herbal medicine or food to reach various effective ingredient, and the effect of effect multiplication will be highly profitable to the human beings'health level.
Summary of the invention
The purpose of this invention is to provide a kind of medicine that contains Cordyceps mycelium, the effect that makes this medicine improve life entity immunity increases greatly, even can reach the effect of effective treatment cancer.
Based on above purpose, the invention provides a kind of cordyceps mushroom composition, comprise following component:
White turnip 130-170 weight portion; Folium Raphani 130-170 weight portion;
Radix Dauci Sativae 90-110 weight portion; Lentinus Edodes 55-65 weight portion;
Radix Arctii 27-33 weight portion; Rhizoma Dioscoreae 13-17 weight portion;
Cordyceps mycelium 13-17 weight portion.
The present invention also provides a kind of cordyceps mushroom polyoses oral liquid, and it contains the water extract of above-described cordyceps mushroom composition.
Above-mentioned cordyceps mushroom polyoses oral liquid can utilize above-mentioned cordyceps mushroom composition, adds flooding and obtains juice.
Preferably, use the slow fire lixiviate, lixiviate is carried out several times, and each amount of water is 2-10 with the weight ratio of described cordyceps mushroom composition: 1, and extracting juice stays slag after lixiviate 0.5-2 hour at every turn, merges juice after finishing extracted many times.
Juice after the lixiviate can be purified and concentrate again.Can also add antiseptic after concentrating, then packing and sterilization.Antiseptic can be selected from sorbic acid, benzoic acid and propanoic acid etc.Sterilizing methods can be selected from boiling method, steaming process and pressure sintering etc.
Cordyceps mushroom composition provided by the invention, cordyceps mushroom polyoses oral liquid have very significant effect to improving life entity immunity, even can reach the degree of effective treatment cancer.
The specific embodiment
Below by the specific embodiment the present invention is further specified.
Take by weighing following each component respectively:
White turnip 150 grams; Folium Raphani 150 grams;
Radix Dauci Sativae 100 grams; Lentinus Edodes 60 grams;
Radix Arctii 30 grams; Rhizoma Dioscoreae 15 grams;
Cordyceps mycelium 15 grams.
Add water 2000 grams then, slow fire boiling was carried out lixiviate in 0.5 hour, poured out lixiviating solution, repeat to add water 5000 grams again, continue slow fire boiling and carried out lixiviate in 1.5 hours, merge the gained lixiviating solution, carry out vacuum distilling behind the filtration, purification and concentrate, obtain about 500 grams of concentrated solution at last.
Zhengzhou University has carried out the evaluation of pesticide effectiveness to above-mentioned concentrated solution in the new drug research development centre.Be that example describes only below with esophageal squamous cell carcinoma cell line EC9706 and lung carcinoma cell.
The esophageal squamous cell carcinoma cell line EC9706 of logarithmic (log) phase growth inoculates 96 orifice plates, 5000 cells in every hole, 37 ℃, 5%CO2 cultivated 48 hours, add above-mentioned gained medicine concentrated solution (long-pending 0,1,3,5,6,7,8,9, the 10 μ l that are respectively of institute's dosing object, each volume is established 3 multiple holes), cultivated again 24 hours, add MTT, cultivated again 4 hours, the sucking-off culture fluid, dissolve with 150 μ lDMSO in every hole, jolting is 10 minutes on shaking table, measures cell absorbance (OD value) with microplate reader.
According to the aforesaid operations step, esophageal squamous cell carcinoma cell line EC9706 is replaced with lung cancer cell line operate fully.
Gained The data row one factor analysis of variance (one-way ANOVA), P＜0.05 tool significance, statistical procedures is finished on SPSS13.0.The data that obtain after the analysis are listed in the table below.
Annotate:
*Do not compare P＜0.05 with adding the medicine group, in the table suppression ratio by formula [suppression ratio=(control wells cell OD value-processing porocyte OD value)/control wells cell OD value] calculate.
By above experimental result as can be seen, the concentrated solution that obtains with said method can reach 67.5% to esophageal squamous cell carcinoma cell inhibiting and kill ratio, can reach 53.3% to the inhibition and the kill ratio of lung carcinoma cell.Effect with highly significant.
Claims (5)
1. cordyceps mushroom composition is characterized in that, and is composed of the following components:
White turnip 130-170 weight portion; Folium Raphani 130-170 weight portion;
Radix Dauci Sativae 90-110 weight portion; Lentinus Edodes 55-65 weight portion;
Radix Arctii 27-33 weight portion; Rhizoma Dioscoreae 13-17 weight portion;
Cordyceps mycelium 13-17 weight portion.
2. a cordyceps mushroom polyoses oral liquid and preparation method thereof is characterized in that, comprises following operating procedure: the described cordyceps mushroom composition of weighing claim 1 adds flooding and obtains juice.
3. cordyceps mushroom polyoses oral liquid and preparation method thereof according to claim 2, it is characterized in that, use the slow fire lixiviate, lixiviate is carried out several times, the weight ratio of each amount of water and described cordyceps mushroom composition is 2-10: 1, each after lixiviate 0.5-2 hour extracting juice stay slag, merge juice after finishing extracted many times.
4. cordyceps mushroom polyoses oral liquid and preparation method thereof according to claim 3 is characterized in that, the juice after the lixiviate is purified and concentrates.
5. cordyceps mushroom polyoses oral liquid and preparation method thereof according to claim 4 is characterized in that, concentrates the back and adds antiseptic, then packing and sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100802533A CN101502607B (en) | 2009-03-17 | 2009-03-17 | Cordyceps sinensis and mushroom composition, Cordyceps sinensis and mushroom polysaccharide oral liquid, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100802533A CN101502607B (en) | 2009-03-17 | 2009-03-17 | Cordyceps sinensis and mushroom composition, Cordyceps sinensis and mushroom polysaccharide oral liquid, and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101502607A CN101502607A (en) | 2009-08-12 |
| CN101502607B true CN101502607B (en) | 2011-07-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100802533A Expired - Fee Related CN101502607B (en) | 2009-03-17 | 2009-03-17 | Cordyceps sinensis and mushroom composition, Cordyceps sinensis and mushroom polysaccharide oral liquid, and preparation method thereof |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027574A (en) * | 2014-06-18 | 2014-09-10 | 李献国 | Traditional Chinese medicine composition for treating cancer and preparation method thereof |
| CN105105236A (en) * | 2015-07-09 | 2015-12-02 | 淮阴师范学院 | Burdock fermented composite polysaccharide beverage |
| CN106070857A (en) * | 2016-06-20 | 2016-11-09 | 王国泰 | A kind of multi-function health-care burdock tea slurry and preparation method thereof |
| CN109123642A (en) * | 2018-09-27 | 2019-01-04 | 蔡勤 | With the integration of drinking and medicinal herbs food of zero injury repair gene therapy cancer |
-
2009
- 2009-03-17 CN CN2009100802533A patent/CN101502607B/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 栾兰等.冬虫夏草菌丝体化学成分的研究.《中草药》.2007,第38卷(第6期),825-826. * |
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| CN101502607A (en) | 2009-08-12 |
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| ASS | Succession or assignment of patent right |
Owner name: ZHENG SHUIQUAN Effective date: 20121112 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20121112 Address after: 450047, Zhengzhou East Economic Development Zone, Henan, Zhengzhou Province, East Road and Seventh Avenue intersection, 300 meters south Patentee after: Li Xianguo Patentee after: Zheng Shuiquan Address before: 450047, Zhengzhou East Economic Development Zone, Henan, Zhengzhou Province, East Road and Seventh Avenue intersection, 300 meters south Patentee before: Li Xianguo |
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Effective date of registration: 20151103 Address after: 336399 Yifeng County Industrial Park, Jiangxi, Yichun Patentee after: Polytron Technologies Inc in Yichun, odd creatures Address before: 450047, Zhengzhou East Economic Development Zone, Henan, Zhengzhou Province, East Road and Seventh Avenue intersection, 300 meters south Patentee before: Li Xianguo Patentee before: Zheng Shuiquan |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110720 Termination date: 20210317 |
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| CF01 | Termination of patent right due to non-payment of annual fee |