CN104812888A - 一次性瓶式反应罐 - Google Patents

一次性瓶式反应罐 Download PDF

Info

Publication number
CN104812888A
CN104812888A CN201380059829.2A CN201380059829A CN104812888A CN 104812888 A CN104812888 A CN 104812888A CN 201380059829 A CN201380059829 A CN 201380059829A CN 104812888 A CN104812888 A CN 104812888A
Authority
CN
China
Prior art keywords
retort
reaction tank
reactor
reaction vessel
bottle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380059829.2A
Other languages
English (en)
Chinese (zh)
Inventor
J·考灵
A·瓦尔德海姆
H·布罗德
V·赫尔曼
S·雅各布
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Technology Services GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Technology Services GmbH filed Critical Bayer Technology Services GmbH
Publication of CN104812888A publication Critical patent/CN104812888A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/08—Flask, bottle or test tube
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/38—Caps; Covers; Plugs; Pouring means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/48—Holding appliances; Racks; Supports
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/10—Rotating vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/14—Rotation or movement of the cells support, e.g. rotated hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/20—Degassing; Venting; Bubble traps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201380059829.2A 2012-09-18 2013-09-13 一次性瓶式反应罐 Pending CN104812888A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12006536 2012-09-18
EP12006536.2 2012-09-18
PCT/EP2013/069024 WO2014044612A1 (de) 2012-09-18 2013-09-13 Einweg-flaschenreaktortank

Publications (1)

Publication Number Publication Date
CN104812888A true CN104812888A (zh) 2015-07-29

Family

ID=46940197

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380059829.2A Pending CN104812888A (zh) 2012-09-18 2013-09-13 一次性瓶式反应罐

Country Status (11)

Country Link
US (1) US20150218501A1 (enExample)
EP (1) EP2898059A1 (enExample)
JP (1) JP2015531602A (enExample)
KR (1) KR20150056548A (enExample)
CN (1) CN104812888A (enExample)
AU (1) AU2013320374A1 (enExample)
BR (1) BR112015005781A2 (enExample)
CA (1) CA2884865A1 (enExample)
IN (1) IN2015DN02120A (enExample)
SG (1) SG11201501572TA (enExample)
WO (1) WO2014044612A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107974408A (zh) * 2017-12-26 2018-05-01 广州汉腾生物科技有限公司 细胞培养玻璃瓶
CN109563461A (zh) * 2016-07-29 2019-04-02 拜耳股份公司 用于细胞培养容器的适配器
CN112143629A (zh) * 2019-06-27 2020-12-29 肖特股份有限公司 培养系统及用于培养容器的容器附件
CN114945659A (zh) * 2020-01-02 2022-08-26 豪夫迈·罗氏有限公司 具有一个或多个原位在线传感器的一次性细胞培养容器
CN115353962A (zh) * 2022-09-13 2022-11-18 深圳市同信生物科技有限公司 一种一次性生物反应器及其制造方法

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102014214077A1 (de) 2014-07-18 2016-01-21 Hamilton Bonaduz Ag Laborbehälter, insbesondere Zellkulturbehälter, mit einer in das Behältervolumen hinein verlaufenden Gas-Ausgleichsleitung
WO2016137231A1 (ko) * 2015-02-28 2016-09-01 김두현 바이오리액터의 일회용 컨테이너
US11274274B2 (en) * 2015-04-20 2022-03-15 Global Life Sciences Solutions Usa Llc Inactivation of viruses
US11052165B2 (en) 2015-04-20 2021-07-06 Global Life Sciences Solutions Usa Llc Method for virus clearance
US10047596B2 (en) 2015-07-23 2018-08-14 General Electric Company System and method for disposal of water produced from a plurality of wells of a well-pad
US10323494B2 (en) 2015-07-23 2019-06-18 General Electric Company Hydrocarbon production system and an associated method thereof
US10077646B2 (en) 2015-07-23 2018-09-18 General Electric Company Closed loop hydrocarbon extraction system and a method for operating the same
WO2017062874A1 (en) * 2015-10-09 2017-04-13 Deka Products Limited Partnership Fluid pumping and bioreactor system
DK3199616T3 (da) * 2016-01-29 2024-11-25 Eppendorf Se Engangsforbindelsesindretning
WO2018209133A1 (en) * 2017-05-12 2018-11-15 Jerry Shevitz Bioreactors
JP6512493B2 (ja) * 2017-06-05 2019-05-15 大日本印刷株式会社 培養装置および培養方法
CN110244027A (zh) * 2018-03-07 2019-09-17 中国石油化工股份有限公司 重油加工反应评价装置
DE102018003676B4 (de) * 2018-05-04 2025-08-21 Sartorius Stedim Biotech Gmbh Überdrucksicherung
DE102018131184A1 (de) * 2018-12-06 2020-06-10 Adolf Kühner Ag Begasungsvorrichtung
DE102019107622B4 (de) * 2019-03-25 2021-02-25 Sartorius Stedim Biotech Gmbh Sensorpositioniersystem für eine bioprozesstechnische Anlage
WO2020226149A1 (ja) * 2019-05-08 2020-11-12 株式会社島津製作所 細胞評価用デバイス
US20210002598A1 (en) * 2019-07-02 2021-01-07 Pbs Biotech, Inc. Methods of mixing and dispensing cells
CN111534420A (zh) * 2020-04-07 2020-08-14 天津大学 一种生物反应器
EP4636068A1 (en) * 2024-04-19 2025-10-22 Sartorius Stedim Biotech GmbH Single-use closed bioreactor for culturing, fermenting or processing a biomass

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN201933090U (zh) * 2010-11-22 2011-08-17 朱学仁 细胞微载体灌注培养截留装置
CN102648044A (zh) * 2009-05-05 2012-08-22 拜尔技术服务有限责任公司 用于培养细胞和/或微生物的装置

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952510A (en) * 1987-01-02 1990-08-28 Bio-North, Inc. Apparatus for detecting and culturing microorganisms using a biphasic culture vessel
US5573951A (en) * 1995-06-07 1996-11-12 Accumed, Inc. Dual chamber blood culture bottle with rotating inlet valve assembly
DE60238863D1 (de) 2001-08-31 2011-02-17 Bayer Schering Pharma Ag Vorrichtung und verfahren zur fermentation in hohen zelldichten
DE10301421A1 (de) 2003-01-16 2004-07-29 Bayer Ag Prozessanalysensysteme mit automatischer Flüssigprobenvorbereitung und Anbindung zu Prozessleitsystemen
EP1591517A1 (en) * 2004-04-30 2005-11-02 Ismatec SA, Laboratoriumstechnik Lid for bioreactor bottles and/or centrifugation tubes
DE102006019242A1 (de) 2006-04-21 2007-10-25 Bayer Technology Services Gmbh Prozessanalysensystem mit steriler Probenahme von mechanisch empfindlichem Material aus einem Bioreaktor
DE102006018824A1 (de) 2006-04-22 2007-10-25 Bayer Technology Services Gmbh Einweg-Bioreaktor
WO2007142664A1 (en) * 2006-06-08 2007-12-13 Amprotein Corporation A method to increase dissolved oxygen in a culture vessel
US8197650B2 (en) 2007-06-07 2012-06-12 Sensor Innovations, Inc. Silicon electrochemical sensors
TWI325401B (en) * 2007-12-17 2010-06-01 Duen Gang Mou Vessel structure
DE102008033286A1 (de) 2008-07-11 2010-01-14 Sann, Heiner, Dr. Vorrichtung und Verfahren zur Abtrennung, Portionierung und Ausgabe von Medien, steril
US9783769B2 (en) * 2008-07-16 2017-10-10 Emd Millipore Corporation Layered flask cell culture system
EP2251407B1 (en) * 2009-05-12 2016-06-29 Eppendorf AG Disposable bioreactor and method for its production
DE102010001779A1 (de) * 2010-02-10 2011-08-11 Hamilton Bonaduz Ag Kalibrierbare Sensoreinheit für Reaktionsbehälter
US20130115588A1 (en) * 2010-04-15 2013-05-09 G & G Technologies, Inc. Integrated bioreactor and separation system and methods of use therof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102648044A (zh) * 2009-05-05 2012-08-22 拜尔技术服务有限责任公司 用于培养细胞和/或微生物的装置
CN201933090U (zh) * 2010-11-22 2011-08-17 朱学仁 细胞微载体灌注培养截留装置

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109563461A (zh) * 2016-07-29 2019-04-02 拜耳股份公司 用于细胞培养容器的适配器
CN107974408A (zh) * 2017-12-26 2018-05-01 广州汉腾生物科技有限公司 细胞培养玻璃瓶
CN112143629A (zh) * 2019-06-27 2020-12-29 肖特股份有限公司 培养系统及用于培养容器的容器附件
CN112143629B (zh) * 2019-06-27 2024-08-02 肖特股份有限公司 培养系统及用于培养容器的容器附件
CN114945659A (zh) * 2020-01-02 2022-08-26 豪夫迈·罗氏有限公司 具有一个或多个原位在线传感器的一次性细胞培养容器
CN115353962A (zh) * 2022-09-13 2022-11-18 深圳市同信生物科技有限公司 一种一次性生物反应器及其制造方法

Also Published As

Publication number Publication date
BR112015005781A2 (pt) 2017-07-04
US20150218501A1 (en) 2015-08-06
KR20150056548A (ko) 2015-05-26
IN2015DN02120A (enExample) 2015-08-14
SG11201501572TA (en) 2015-05-28
AU2013320374A1 (en) 2015-03-26
WO2014044612A1 (de) 2014-03-27
EP2898059A1 (de) 2015-07-29
JP2015531602A (ja) 2015-11-05
CA2884865A1 (en) 2014-03-27

Similar Documents

Publication Publication Date Title
CN104812888A (zh) 一次性瓶式反应罐
US8602636B2 (en) Eccentrically-rotating reactor
US10821409B2 (en) Disposable bioreactor system
EP2020433B2 (en) Continuous perfusion bioreactor system
AU2010238548B2 (en) Cell culture system
TWI696698B (zh) 振動型培養裝置及使用其之培養方法
CN102648044B (zh) 用于培养细胞和/或微生物的装置
JP2015506715A (ja) 細胞を保持し再循環させるための一方向分離器
WO1998031782A1 (en) Gas permeable pouches for growing cultures
US20110117639A1 (en) Taylor Vortex Flow Bioreactor for Cell Culture
JP2009505672A (ja) 半連続的発酵方法
JP2016202089A (ja) 培養装置及びこれを用いた培養方法
CN217677586U (zh) 细胞培养器和细胞培养装置
RU2841776C1 (ru) Биореактор для культивации клеток и получения вирусной суспензии и способ его работы
HK1099336A (en) Stirred-tank reactor system
HK1127367B (en) Continuous perfusion bioreactor system

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150729