CN104812748B - 二氢吡唑gpr40调节剂 - Google Patents

二氢吡唑gpr40调节剂 Download PDF

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Publication number
CN104812748B
CN104812748B CN201380059799.5A CN201380059799A CN104812748B CN 104812748 B CN104812748 B CN 104812748B CN 201380059799 A CN201380059799 A CN 201380059799A CN 104812748 B CN104812748 B CN 104812748B
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agent
compound
methyl
mmol
dihydro
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CN104812748A (zh
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B·A·埃尔斯沃斯
史俊
W·R·尤因
E·A·朱里卡
A·S·埃尔南德斯
吴锡茂
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Bristol Myers Squibb Co
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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CN201380059799.5A 2012-11-16 2013-11-15 二氢吡唑gpr40调节剂 Expired - Fee Related CN104812748B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261727262P 2012-11-16 2012-11-16
US61/727,262 2012-11-16
US201361777294P 2013-03-12 2013-03-12
US61/777,294 2013-03-12
PCT/US2013/070215 WO2014078610A1 (en) 2012-11-16 2013-11-15 Dihydropyrazole gpr40 modulators

Publications (2)

Publication Number Publication Date
CN104812748A CN104812748A (zh) 2015-07-29
CN104812748B true CN104812748B (zh) 2017-10-24

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US (1) US9133163B2 (enExample)
EP (1) EP2920165B1 (enExample)
JP (1) JP6322203B2 (enExample)
KR (1) KR102204804B1 (enExample)
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KR102635333B1 (ko) 2018-10-24 2024-02-15 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
CN115490638A (zh) * 2022-09-22 2022-12-20 哈尔滨理工大学 5-官能团化吡唑啉及其制备方法
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