CN104800881A - Biological fiber film and its preparing method - Google Patents
Biological fiber film and its preparing method Download PDFInfo
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- CN104800881A CN104800881A CN201510046087.0A CN201510046087A CN104800881A CN 104800881 A CN104800881 A CN 104800881A CN 201510046087 A CN201510046087 A CN 201510046087A CN 104800881 A CN104800881 A CN 104800881A
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- membrane
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- fibers
- biological fibers
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- 239000000835 fiber Substances 0.000 title claims abstract description 116
- 238000000034 method Methods 0.000 title claims description 7
- 239000012528 membrane Substances 0.000 claims abstract description 82
- 239000010410 layer Substances 0.000 claims abstract description 32
- 241000894006 Bacteria Species 0.000 claims abstract description 7
- 239000012531 culture fluid Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 12
- 239000011229 interlayer Substances 0.000 claims description 10
- 241000589232 Gluconobacter oxydans Species 0.000 claims description 8
- 239000001888 Peptone Substances 0.000 claims description 7
- 108010080698 Peptones Proteins 0.000 claims description 7
- 229940041514 candida albicans extract Drugs 0.000 claims description 7
- 235000019319 peptone Nutrition 0.000 claims description 7
- 239000012138 yeast extract Substances 0.000 claims description 7
- 108090000790 Enzymes Proteins 0.000 claims description 5
- 102000004190 Enzymes Human genes 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- 102000013275 Somatomedins Human genes 0.000 claims description 3
- 238000004299 exfoliation Methods 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 239000000080 wetting agent Substances 0.000 claims description 3
- 230000002087 whitening effect Effects 0.000 claims description 3
- 229920001817 Agar Polymers 0.000 claims description 2
- 239000008272 agar Substances 0.000 claims description 2
- 241000933941 bacterium 24 Species 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 230000014759 maintenance of location Effects 0.000 abstract description 2
- 239000002344 surface layer Substances 0.000 abstract 2
- 241000032681 Gluconacetobacter Species 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 230000001815 facial effect Effects 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000004744 fabric Substances 0.000 description 5
- 238000012423 maintenance Methods 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000005266 casting Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 1
- 241001428166 Eucheuma Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010070716 Intercellular Signaling Peptides and Proteins Proteins 0.000 description 1
- 102000005755 Intercellular Signaling Peptides and Proteins Human genes 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a biological fiber membrane and a preparation method thereof. Wherein the biofabric membrane is formed by a bacterium of the genus gluconacetobacter and has: first and second opposing skin layers; and a three-dimensional net structure combined between the first surface layer and the second surface layer, so as to improve the moisture retention of the dressing and carry more active ingredients. The invention also provides a preparation method of the biological fiber membrane.
Description
Technical field
The present invention has about a kind of membrane of biological fibers, in more detail, has about a kind of membrane of biological fibers sticked on skin.
Background technology
In current medical field, cotton pad or gauze are selected in the dressing of looking after in wound mostly, but this type of casting product antibiotic property is not good, and wound infection probability is high, easily produce the phenomenon sticking wound, and when the dressing is changed, have the shortcoming not easily removed.
Thereafter have and replace gauze and cotton pad with adhesive-bonded fabric dressing, dressing nothing more than non-woven fabrics kenel has preferably imbibition ability and moist environment can be provided to help the characteristic of wound repair, but the liquid drawn when non-woven fabrics or after moisture content loses gradually, also easily produces the problem that wound sticks.
On the other hand, modern, except basic living demand, more payes attention to cosmetology, and the demand emphasis of industry of especially improving looks especially to the maintenance of face, therefore develops multiple mask product.The facial film of prior art is of a great variety, such as mud cream profile film, tear stripping profile film and demihull shape facial film etc.
Though mud cream profile film is containing maintenance composition or mineral, need to rinse after having applied facial film, maintenance composition is difficult really to be absorbed by skin, and due to containing more mineral, and must add more antiseptic and grow in moistening mud cream to prevent antibacterial.Tearing stripping profile film main component is macromolecule glue, water and ethanol, and by raising skin temperature, promote cutaneous circulation, but need wait until that facial film drying just can remove owing to tearing stripping profile film, the process that removes probably damages sensitivity skin, and it is not this tears for asking drying not add moisturizing ingredient in stripping profile film, for dry skin, also very applicable.Mainly be adsorbed with the monolayer lamellar body of the essence with effect as demihull shape facial film, and by adjusting component for the various skin quality of maintenance, do not need flushing although applied, do not have a cleaning effect.Above-mentioned demihull shape facial film many uses single-layer nonwoven is made.When user uses the non-woven fabrics of the liquid that deflowers, what often volatilize fast because of moisture in non-woven fabrics considers, and the essence that working concentration is higher, not only produce waste, still cannot solve the problem of moisture evaporation simultaneously.
Therefore, still have the casting product needing to develop a kind of novelty.
Summary of the invention
Because the disappearance of above-mentioned known techniques, the invention provides a kind of membrane of biological fibers, the bacterium belonged to by Acetobacter gluconicum is formed, and this membrane of biological fibers has: the first relative top layer and the second top layer and the space network be incorporated between this first top layer and second top layer, and the density of this space network is less than the density on this first top layer and the second top layer.
In a specific embodiment, this space network is made up of this plural biological fiber.
Moreover this space network has plural number key fiber parallel to each other and is interwoven in the interlayer fiber of adjacent wantonly two these key fibers.This key fiber and interlayer fiber are all biological fiber, and the diameter of this key fiber is more than or equal to the diameter of this interlayer fiber.
In another specific embodiment, described membrane of biological fibers also comprises active component or medicine.This active component can be wetting agent, whitening composition, crease-resistant composition, exfoliation composition, somatomedin (growth factors) or enzyme (enzymes).
The present invention also provides a kind of method for making of membrane of biological fibers, comprising: provide the container that is equipped with culture fluid, wherein, this culture fluid has carbon source, peptone and the yeast extract that weight fraction ratio is 5:1:1 to 4:1:1; And in this culture fluid, cultivate the bacterium 24 to 96 hours that Acetobacter gluconicum belongs to.
The bacterium that membrane of biological fibers of the present invention is belonged to by Acetobacter gluconicum is formed, and has space network between the first top layer of this membrane of biological fibers and the second top layer, promotes the moisture retention of this dressing by this, and the more active component of portability.
Accompanying drawing explanation
Fig. 1 is the structural representation of membrane of biological fibers of the present invention;
Fig. 2 A is sweep electron microscope (SEM) photo of the space network showing membrane of biological fibers of the present invention, and Fig. 2 B is the side-looking photo showing membrane of biological fibers of the present invention;
Fig. 3 A and 3B is respectively 500 times of SEM photos amplified of display membrane of biological fibers of the present invention and 500 times of SEM photos amplified of traditional biological fibrous membrane; And
Fig. 4 is the testing permeability result of display membrane of biological fibers of the present invention and commercially available traditional biological fibrous membrane, and wherein, Fig. 4 (a) is the test result of membrane of biological fibers of the present invention, and Fig. 4 (b) is the test result of commercially available traditional biological fibrous membrane.
Symbol description
1 membrane of biological fibers
10a first top layer
10b second top layer
101 space networks
The key fiber of 101a
101b interlayer fiber
12 fibers.
Detailed description of the invention
Below by way of particular specific embodiment, embodiments of the present invention are described, these those skilled in the art can understand other advantages of the present invention and effect easily by content disclosed in the present specification.
Notice, structure, ratio, size etc. that this description institute accompanying drawings illustrates, content all only in order to coordinate description to disclose, understand for these those skilled in the art and read, and be not used to limit the enforceable qualifications of the present invention, therefore the not technical essential meaning of tool, the adjustment of the modification of any structure, the change of proportionate relationship or size, do not affecting under effect that the present invention can produce and the object that can reach, all should still drop in scope that disclosed technology contents can contain.Simultaneously, quote in this description as " first ", " second ", " on " and term such as " ", also only for ease of understanding of describing, and be not used to limit the enforceable scope of the present invention, the change of its relativeness or adjustment, under changing technology contents without essence, when being also considered as the enforceable category of the present invention.
Term " parallel " herein refers to that plural key fiber is in same direction, the form that such as membrane of biological fibers length direction or width extend.
The invention provides a kind of membrane of biological fibers, the bacterium belonged to by Acetobacter gluconicum is formed, and this membrane of biological fibers has: the first relative top layer and the second top layer and space network, be incorporated between this first top layer and second top layer, and the density of this space network is less than the density on this first top layer and the second top layer.
Membrane of biological fibers of the present invention refers to the winner by the cultivation of microorganism.The present invention finds that the bacterium belonged to by this Acetobacter gluconicum forms this membrane of biological fibers side and has the biological fiber that plural stereoscopic three-dimensional is wound around combination in the culture fluid with mannitol, peptone (peptone), yeast extract (yeast extract) and agar.
In the specific embodiment producing membrane of biological fibers, started by the fermentation culture of strain, first, there is provided culture fluid, this culture fluid is placed in container, and the composition of culture fluid comprise be selected from animal glue, arabic gum, Eucheuma gelatinosum glue, etc. known component, but this culture fluid also needs to have carbon source, such as mannitol, glucose or its combination etc., other compositions are as peptone and yeast extract, and the weight fraction ratio of carbon source, peptone and yeast extract can be between 5:1:1 to 4:1:1.Then the pH-value of culture fluid is controlled in acidity, such as between pH value 0.5 to 6, and original microorganism concentration range can be controlled in 102 to 105/ml, 25 to 28 DEG C of quiescent culture 24 to 96 hours, owing to can use the container of flat, therefore described space network is flat membranaceous, afterwards, treat that 24 is little of taking-up in 72 hours, obtain membrane of biological fibers of the present invention.
After testing, the thickness of this membrane of biological fibers is at least 20 μm, such as 20 to 30 μm or such as 20 to 26 μm or 24 to 26 μm, and the diameter of the biological fiber of membrane of biological fibers of the present invention about 20 to 100nm.Again, the per unit area biological fiber amount of this membrane of biological fibers is 0.005 to 0.008g/cm
2.
As shown in Figure 1, membrane of biological fibers 1 of the present invention comprises the first relative top layer 10a and the second top layer 10b; And space network 101, be incorporated between this first top layer 10a and the second top layer 10b.
In addition, refer to Fig. 2 A, it shows the second top layer 10b and is extended with space network 101, is combined on the fiber 12 of a cloth film.
As shown in the figure, this space network 101, extend to the fiber 12 of this cloth film, and this space network 101 is made up of from this second top layer 10b plural biological fiber.Specifically, this space network 101 has plural number key fiber 101a parallel to each other and is interwoven in the interlayer fiber 101b of adjacent wantonly two these key fiber 101a, so, in the horizontal direction and vertical direction connects adjacent wantonly two these key fiber 101a, to form 3 D stereo network structure 101.And this key fiber 101a and interlayer fiber 101b is all this biological fiber, and as shown in the figure, the diameter of this key fiber 101a is more than or equal to the diameter of this interlayer fiber 101b.
Refer to Fig. 2 B, the side-looking photo of its display membrane of biological fibers 1, wherein, this membrane of biological fibers 1 also has the parallel to each other or key fiber 101a that extends in this membrane of biological fibers 1 length direction or width and the interlayer fiber 101b interweaved with this key fiber 101a of plural number, in this embodiment, the thickness of this membrane of biological fibers 1 is 20 to 30 μm.Moreover as shown in the figure, the density of this space network is less than the density on this membrane of biological fibers 1 two top layer, active component or medicine adsorbable between this two top layer, the effect of Evening Primerose Oil.
In addition, the preparation of this membrane of biological fibers can utilize base material film body temporarily or is for good and all combined, in any case but, this kind of preparation method can omit the step of the space network of the aforementioned shape of overturning flat in a reservoir.For example, in the embodiment of Fig. 2 A, use cloth film as base material.
Refer to Fig. 3 A and 3B, be respectively 500 times of SEM photos amplified of display membrane of biological fibers of the present invention and 500 times of SEM photos amplified of traditional biological fibrous membrane.
As shown in Figure 3A, membrane of biological fibers surface of the present invention is smooth, and the bar shown in figure is the fiber of the cloth film base material below film body, therefore membrane of biological fibers surface of the present invention is very smooth.But the traditional biological fibrous membrane surface shown in Fig. 3 B then has much fold.Therefore, the attaching of this membrane of biological fibers and skin is not good, so that affect sense of touch, causes medicine or active ingredient to absorb not good problem.
The biological fiber amount of the per unit area of membrane of biological fibers of the present invention and water content test
Get membrane of biological fibers of the present invention, and the size cutting into 5cm x 5cm is after totally 16 samples, dries 10 minutes, weigh dry kind of the sample of drying in 60 DEG C.So that respectively this sample dry weight is divided by this sample area, the per unit area biological fiber amount recording this membrane of biological fibers is 0.005 to 0.008g/cm
2.
Again those samples to be soaked in water 5 minutes, to weigh the weight in wet base of sample, when measuring the water content of per unit area, to calculate according to following formula:
Water content=(weight in wet base-dry kind)/sample area of per unit area
After testing, the per unit area water content of membrane of biological fibers of the present invention is 0.06 to 0.14g/cm
2.
In comparison, the biological fiber amount of the per unit area of commercially available traditional biological fibrous membrane only reaches 0.001g/cm usually
2, and water content only reaches 0.04g/cm
2.Therefore the more moisture of membrane of biological fibers portability of the present invention or active component, there is more moistening effect.
The testing permeability of membrane of biological fibers of the present invention
Membrane of biological fibers of the present invention and commercially available traditional biological fibrous membrane are lain against on a ground respectively, then the dyed essence of equivalent is dripped in membrane of biological fibers of the present invention and commercially available traditional biological fibrous membrane, waited for for 10 seconds, the infiltration situation of this ground of visualization.
As shown in Figure 4, Fig. 4 (a) is the test result of membrane of biological fibers of the present invention, Fig. 4 (b) is the test result of commercially available traditional biological fibrous membrane, wherein, commercially available traditional biological fibrous membrane is when firm dropping essence, its essence diffusion effect is not good, and after waiting for for 10 seconds, essence cannot be infiltrated into ground by nature effectively, but membrane of biological fibers of the present invention then has preferably essence diffusibility and significant permeability.
In sum, membrane of biological fibers of the present invention, for sticking on skin, especially can be used as facial film and use, therefore this membrane of biological fibers also can comprise active component or medicine.Before the fermentation culture of strain ends, this active component or medicine are dropped on this space network, the preparation of membrane of biological fibers to be done, namely this active component or medicine can be included in film body, and the example of this active component comprises wetting agent, whitening composition, crease-resistant composition, exfoliation composition, somatomedin (growthfactors) or enzyme (enzymes).Medicine can be massage and drug, it can be paste or liquid, such as massage or pressure quintessence oil etc. of relaxing, because membrane of biological fibers of the present invention has space network, therefore, active component or medicine can not expose easily, but membrane of biological fibers of the present invention is attached at after on body surface or skin, applies pressure to membrane of biological fibers through manual massage or other contact devices, namely contribute to the release of active component or medicine, moreover, also can pass through the release that the mode of heating helps active component or medicine.
Above-described embodiment in order to illustrative principle of the present invention and effect thereof, but not for limiting the present invention.These those skilled in the art any all without prejudice under spirit of the present invention and category, can modify to above-described embodiment.Therefore the scope of the present invention, should listed by claims.
Claims (14)
1. a membrane of biological fibers, the bacterium belonged to by Acetobacter gluconicum is formed, and this membrane of biological fibers has:
The first relative top layer and the second top layer; And
Space network, is incorporated between this first top layer and second top layer, and the density of this space network is less than the density on this first top layer and the second top layer.
2. membrane of biological fibers as claimed in claim 1, it is characterized in that, this space network is made up of plural biological fiber.
3. membrane of biological fibers as claimed in claim 1, is characterized in that, this space network has plural number key fiber parallel to each other and is interwoven in fiber between the plural layer of adjacent wantonly two these key fibers.
4. membrane of biological fibers as claimed in claim 3, it is characterized in that, this key fiber and interlayer fiber are all biological fiber, and the diameter of this key fiber is more than or equal to the diameter of this interlayer fiber.
5. membrane of biological fibers as claimed in claim 3, is characterized in that, this key fiber extends in this membrane of biological fibers length direction or width.
6. membrane of biological fibers as claimed in claim 1, also comprises active component or medicine.
7. membrane of biological fibers as claimed in claim 6, it is characterized in that, this active component is wetting agent, whitening composition, crease-resistant composition, exfoliation composition, somatomedin or enzyme.
8. membrane of biological fibers as claimed in claim 1, the bacterium belonged to by Acetobacter gluconicum formed in the culture fluid with mannitol, peptone, yeast extract and agar.
9. membrane of biological fibers as claimed in claim 2, it is characterized in that, the per unit area biological fiber amount of this membrane of biological fibers is 0.005 to 0.008g/cm
2.
10. membrane of biological fibers as claimed in claim 1, its thickness is at least 20 μm.
11. membrane of biological fiberss as claimed in claim 10, its thickness is 20 to 30 μm.
12. membrane of biological fiberss as claimed in claim 2, it is characterized in that, the diameter of this biological fiber is 20 to 100nm.
The method for making of 13. 1 kinds of membrane of biological fiberss, comprising:
There is provided the container that is equipped with culture fluid, wherein, this culture fluid has carbon source, peptone and the yeast extract that weight fraction ratio is 5:1:1 to 4:1:1; And
The bacterium 24 to 96 hours that Acetobacter gluconicum belongs to is cultivated in this culture fluid.
14. method for makings as claimed in claim 13, is characterized in that, the pH value of this culture fluid is 0.5 to 6.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017113262A1 (en) * | 2015-12-31 | 2017-07-06 | 奈菲儿生医股份有限公司 | Antioxidative biocellulose and manufacturing method thereof |
CN106974837A (en) * | 2016-05-17 | 2017-07-25 | 百岳特化妆品(上海)有限公司 | The preparation method and functional living being fiber facial mask of functional living being tunica fibrosa |
CN107854453A (en) * | 2017-12-18 | 2018-03-30 | 济南格莱威医疗科技有限公司 | A kind of medical aquogel eyeshield dressing |
CN111374023A (en) * | 2018-12-28 | 2020-07-07 | 娇朋生技股份有限公司 | Cultivation material composition |
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WO2012003640A1 (en) * | 2010-07-09 | 2012-01-12 | 奈菲儿国际股份有限公司 | Membrane of biological fibers, and use thereof |
CN103233050A (en) * | 2013-04-22 | 2013-08-07 | 东华大学 | Bacterial cellulose membrane with gradient structure and preparation method thereof |
Family Cites Families (1)
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CN101591626B (en) | 2009-06-30 | 2011-04-27 | 南开大学 | Strain of gluconacetobacter and application thereof |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2012003640A1 (en) * | 2010-07-09 | 2012-01-12 | 奈菲儿国际股份有限公司 | Membrane of biological fibers, and use thereof |
CN103233050A (en) * | 2013-04-22 | 2013-08-07 | 东华大学 | Bacterial cellulose membrane with gradient structure and preparation method thereof |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017113262A1 (en) * | 2015-12-31 | 2017-07-06 | 奈菲儿生医股份有限公司 | Antioxidative biocellulose and manufacturing method thereof |
CN106974837A (en) * | 2016-05-17 | 2017-07-25 | 百岳特化妆品(上海)有限公司 | The preparation method and functional living being fiber facial mask of functional living being tunica fibrosa |
CN107854453A (en) * | 2017-12-18 | 2018-03-30 | 济南格莱威医疗科技有限公司 | A kind of medical aquogel eyeshield dressing |
CN111374023A (en) * | 2018-12-28 | 2020-07-07 | 娇朋生技股份有限公司 | Cultivation material composition |
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Publication number | Publication date |
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TWI653060B (en) | 2019-03-11 |
TW201529101A (en) | 2015-08-01 |
CN104800881B (en) | 2017-11-03 |
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