CN104800299B - A kind of concocting method of giant knotweed - Google Patents
A kind of concocting method of giant knotweed Download PDFInfo
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Abstract
A kind of concocting method of giant knotweed, step are：Rhizoma Polygoni Cuspidati is immersed in after being soaked in the pretreatment mixed solution of cellulase, β glucuroides, puts in micro-wave oven and processed under different capacity, produce giant knotweed microwave processing product.It is described pretreatment mixed solution preparation method be：Cellulase is weighed respectively, β glucuroides add distilled water to dissolve to produce；The cellulase, the weight proportion of β glucuroides are 1:5‑5:1.Giant knotweed concocting method provided by the invention, the content of two kinds of active ingredient of resveratrol and rheum emodin can be dramatically increased simultaneously, and the content of polydatin reduces, having effectively facilitated must convert between Resveratrol in Rhizoma Polygoni Cuspidati glycosides and resveratrol；Compared with giant knotweed tradition processing procedure, the concocting method does not have particular/special requirement to temperature, environment etc., and working condition is easily manipulated, and product quality controllability is good, the effective way of an adaptation industrialized production is provided for the application of giant knotweed, there is important actual application value.
Description
Technical field
The present invention relates to Chinese medicine preparation field, more particularly to a kind of concocting method of giant knotweed.
Background technology
Polygonum cuspidatum Sieb. et Zucc is polygonaceae plant giant knotweed（Polygonum cuspidatum Sieb. et Zucc.）Dry root and
Rhizome, the ground such as Jiangxi, Sichuan, Jiangsu, Shandong are mainly originated in, its cold nature, mildly bitter flavor, Return liver, courage, lung channel, there is heat-clearing solution
The effect of poison, preventing phlegm from forming and stopping coughing, removing dampness through diuresis and removing jaundice, blood stasis removing analgesic.It is a variety of that anthraquinone, diphenylethylene compounds etc. are mainly contained in giant knotweed
Composition, wherein anthraquinone derivatives, based on sequestered, there is the compositions such as rheum emodin, Physcion, Chrysophanol, have antibacterial,
Liver protection, under rushing down, the function such as anticancer；And diphenylethylene compounds mainly include resveratrol and polygonin（Resveratrol
Glycosides）, there is antitumor, reducing blood lipid, suppress a variety of medicines such as platelet aggregation, regulation lipoprotein metabolism, liver protection, anti-oxidant, antibacterial
Reason acts on.Giant knotweed has extensive pharmacological activity because its medicine source is enriched, and has therapeutic action to the multiple systemic diseases of human body, and
Receive much concern.It is presently used for treating the giant knotweed glycoside injection liquid of angiocardiopathy, its main component polygonin is to be carried from giant knotweed
The monomer active ingredient taken.But the technique that lifts to giant knotweed is all using resveratrol or polygonin as single finger mostly at present
Mark, if finding a kind of processing procedure can simultaneously improve and extract two kinds of even two or more active ingredients, it will to giant knotweed
It must utilize and bring bigger economic benefit and social benefit.
The purpose of Chinese medicine preparation is by the process of processing to reach the purpose of attenuation or synergy.Chinese medicine is by adding
Work process after there occurs the chemical change of complexity, so as to cause the change of nature and flavor, function and activity before and after Chinese medicine preparation.On
The concocting method of giant knotweed writes first recorded in Tang's SUN Si miao《Qianjin Yi Fang》Say：" remove brains, wash away soil, be hot-tempered to cut ".The Northern and Southern Dynasties
Liu Song's epoch thunder Xiao writes《Lei Gong Pao Zhi Lun》Say：" after Fan Cai get, thin Shaved, but wrapping up in a night with japanese fleeceflower leaf, go out to dry use ".Song
, in addition to continuing to use " Xi Shaved " concocting method, still there are the methods such as " for end ", " burning " in generation.As Song Wang Huai is hidden etc. compile《It is peaceful holy
Hui Fang》In mention " Xi Shaved ", " Shaved ".《Rebuilding is had stable political situation demonstrate,proves the standby book on Chinese herbal medicine of class through history》Say：" take root to wash away chapped Pi , Shaved roastings and smash sieve ",
" for end ".《General Records of Holy Universal Relief》Say：" burning ".Song《Peaceful holy benevolent prescriptions》：" unsmooth menorrhea.Three liang of giant knotweed, myrrh one or two is end, hot
Wine often takes a money ".The Ming Dynasty still continues to use the volume such as the experience of forefathers, Ming Zhu Su《Prescriptions for Universal Relief》Record " burning ".《Herbal guiding principle
Mesh》Say：" adopting to obtain , Xi Shaved, but with the night of leaf bag one, dry use "." control postpartum blood stasis blood pain, and pendant flutter dusk it is vexed：Polygoni cuspidati,radix, grind
Wine takes ".《Big gun processs pandect》Also record：" polygoni cuspidati,radix, going epithelium use ".The clear concocting method that giant knotweed is not documented.To now
Generation, giant knotweed record kind as Chinese Pharmacopoeia, have clearly been advised in 5 editions pharmacopeia in the case where giant knotweed processes item since the version in 1985
It is fixed.Version in 2010《Pharmacopeia》、《National Chinese medicine preparation specification》Record：" remove impurity, clean, run through, cut sheet, dry ".
As can be seen here, the concocting method of giant knotweed, successive dynasties medical literature, which is recorded, only has wine system, vinegar system, salt etc., and China is for tiger at present
It is also weaker that cane processes research, is also not known the effect of existing concocting method, is especially the absence of processing front and rear material base change
Change and the comparative study of pharmacological effect activity, the concocting method that only can improve giant knotweed drug effect just have actual application value.Cause
This, needs a kind of efficient, cheap, environmental protection of exploitation badly, while improves the giant knotweed concocting method of two or more active ingredient, with
Meet the needs of people.
The content of the invention
Contain in view of the above-mentioned problems, the present invention provides one kind while dramatically increases two kinds of active ingredients of resveratrol and rheum emodin
The giant knotweed concocting method of amount, for this method using cellulase, beta-glucosidase as auxiliary material, concocting process is easy, easily standardization
And popularization.
To realize the above-mentioned purpose of the present invention, the present invention provides a kind of concocting method of giant knotweed, and step is：By Rhizoma Polygoni Cuspidati
It is immersed in after being soaked in the pretreatment mixed solution of cellulase, beta-glucosidase, puts the interior big gun under different capacity of micro-wave oven
System, produces giant knotweed microwave processing product.
The cellulase, the weight proportion of beta-glucosidase are 1:5-5:1.
It is described pretreatment mixed solution preparation method be：Cellulase is weighed respectively, beta-glucosidase adds distilled water
Dissolve and produce.
The dosage summation of the cellulase and beta-glucosidase be Rhizoma Polygoni Cuspidati dosage 0.1-10 ‰, soak time
For 2-12h.
Power used in being processed in the micro-wave oven is 40%-100% power, and the time used is 10min-30min.
The Rhizoma Polygoni Cuspidati may be from different sources.
Beneficial effects of the present invention compared with prior art.
Giant knotweed concocting method provided by the invention, it is microwaved to be using cellulase, beta-glucosidase as auxiliary material
；The concocting method can dramatically increase the content of two kinds of active ingredient of resveratrol and rheum emodin simultaneously, and polydatin
Content reduce, having effectively facilitated must convert between Resveratrol in Rhizoma Polygoni Cuspidati glycosides and resveratrol；With giant knotweed tradition processing procedure phase
Than, the concocting method does not have particular/special requirement to temperature, environment etc., and medicinal material absorbs microwave energy in microwave heating process,
Within the scope of certain temperature, main component is activated or concluded state decrease inside medicinal material, so as to the generation of medicinal material interior molecules
Change in structure so that the content of main component changes.This method can make full use of resource, and concocting process is easy, is produced into
This is low, and whole concocting process is sent without organic pollution, and environmental pollution very little, working condition is easily manipulated, product matter
Amount controllability is good, provides the effective way of an adaptation industrialized production for the application of giant knotweed, has important practical application valency
Value.
Brief description of the drawings
Fig. 1 is the content that polygonin, resveratrol and rheum emodin in giant knotweed processed product are measured under different processing factors of influence
（mg•g-1）.
Embodiment
The present invention is further described with reference to specific embodiment.
Embodiment 1.
The present invention provides a kind of concocting method of giant knotweed, and step is：By 15g Rhizoma Polygoni Cuspidatis be immersed in 20ml cellulases,
In the pretreatment mixed solution of beta-glucosidase, after soaking 10h, put in micro-wave oven and process 25min under 40% power, produce
Giant knotweed microwave processing product.
The cellulase, the weight proportion of beta-glucosidase are 1:2.
It is described pretreatment mixed solution preparation method be：Cellulase 5mg is weighed respectively, beta-glucosidase 10mg adds
30ml distilled water, which dissolves, to be produced, and takes the Pretreatment Mixed Liauid 20ml prepared to be processed for above-mentioned giant knotweed.
Further to verify the beneficial effect of giant knotweed concocting method of the present invention, following experiments have been carried out.
1st, the different investigations for processing factor of influence.
1.1st, method：（1）Cellulose enzyme process：Rhizoma Polygoni Cuspidati 15g is taken, is immersed in 20ml cellulase solutions, soaks 10h
Afterwards, put in micro-wave oven and process 25min under 40% power；The cellulase solution is to add 30mL distilled water by 5mg cellulases
Dissolving is made；（2）Beta-glucosidase enzyme process：Rhizoma Polygoni Cuspidati 15g is taken, is immersed in 20ml beta-glucosidase enzyme solutions, soaks 10h
Afterwards, put in micro-wave oven and process 25min under 40% power；The beta-glucosidase enzyme solutions are added by 10mg beta-glucosidases
The dissolving of 30mL distilled water is made；（3）Double enzyme oven drying methods：Rhizoma Polygoni Cuspidati 15g is taken, is immersed in 20ml cellulases, beta-glucosidase
In enzyme mixed solution, after soaking 10h, after solution is sucked, it is put into 40 DEG C of baking ovens, is dried to constant mass；The mixing
Solution is to add the dissolving of 30mL distilled water to be made by 5mg cellulases, 10mg beta-glucosidases；（4）The processing side of the present embodiment 1
Method（Referred to as double enzyme microwave methods）.
1.2nd, result, refers to Fig. 1, and Fig. 1 measures polygonin in giant knotweed processed product, white lamb's-quarters for different process under factors of influence
The content of reed alcohol and rheum emodin（mg•g-1）.
As shown in Figure 1, Rhizoma Polygoni Cuspidati uses cellulose enzyme process, beta-glucosidase enzyme process, double enzyme oven drying methods and double enzyme microwaves
Method is processed, and compared with the Rhizoma Polygoni Cuspidati without any processing, its resveratrol and emodin content have gained processed product
Improved, and the content of polygonin decreases.But resveratrol and rheum emodin contain in the giant knotweed processed product of double enzyme microwave methods
Amount improves most notable, and the content of polygonin reduces also most notable, it can be seen that, giant knotweed concocting method provided by the invention can be with
The content of two kinds of active ingredient of resveratrol and rheum emodin is dramatically increased simultaneously, and the content of polygonin reduces, and effectively facilitates
It must be converted between Resveratrol in Rhizoma Polygoni Cuspidati glycosides and resveratrol；This absorbs in microwave heating process micro- mainly due to Rhizoma Polygoni Cuspidati
Wave energy, within the scope of certain temperature, main component is activated or concluded state decrease inside medicinal material, so that inside medicinal material
Change on molecule recurring structure so that the content of main component changes.
2nd, the investigation of different sources giant knotweed difference concocting method.
2.1st, the different concocting methods of different sources giant knotweed.（1）Wine system：Take Rhizoma Polygoni Cuspidati（Hubei, Sichuan, Anhui）Each 5
G, add the mL of yellow rice wine 4 to mix thoroughly, vexed profit, after wine is sucked, be put into 40 DEG C of baking ovens, dry（To constant mass）；（2）Vinegar system：
Take Rhizoma Polygoni Cuspidati（Hubei, Sichuan, Anhui）Each 5 g, add the mL of rice vinegar 4 to mix thoroughly, vexed profit, after rice vinegar is sucked, be put into 40 DEG C
In baking oven, drying；（3）Salt system：Take Rhizoma Polygoni Cuspidati（Hubei, Sichuan, Anhui）Each 5 g, add the mL of salt solution 4 to mix thoroughly, vexed profit, treat salt
Water is sucked, and is put into 40 DEG C of baking ovens, drying（Note：2g salt is added per 100g Chinese medicines）；(4) concocting method of the present embodiment 1（Letter
Claim double enzyme microwave methods）.
2.2nd, result refers to table 1, and table 1 is that different concocting methods measure polygonin in different sources giant knotweed processed product, white
The content of veratryl alcohol and rheum emodin（mg•g-1）（n=3）.
Table 1：Different concocting methods measure constituent content in different sources giant knotweed processed product.
| The place of production | Concocting method | Polygonin | Resveratrol | Rheum emodin |
| Hubei | Wine system | 15.514 | 5.808 | 6.774 |
| Hubei | Vinegar system | 16.708 | 5.251 | 6.629 |
| Hubei | Salt system | 17.402 | 4.720 | 6.194 |
| Hubei | Double enzyme microwave methods | 13.337 | 7.784 | 8.267 |
| Sichuan | Wine system | 10.719 | 5.753 | 6.550 |
| Sichuan | Vinegar system | 11.304 | 3.753 | 3.679 |
| Sichuan | Salt system | 12.632 | 2.293 | 2.658 |
| Sichuan | Double enzyme microwave methods | 9.240 | 6.687 | 8.861 |
| Anhui | Wine system | 12.802 | 5.289 | 5.296 |
| Anhui | Vinegar system | 13.937 | 5.031 | 4.849 |
| Anhui | Salt system | 14.802 | 4.214 | 4.085 |
| Anhui | Double enzyme microwave methods | 11.074 | 6.552 | 6.963 |
As shown in Table 1, to the Rhizoma Polygoni Cuspidati of different sources, resveratrol and emodin content improve most in double enzyme microwave methods
Significantly, the content of polygonin reduces also most significantly, shows that the concocting method of giant knotweed of the present invention is not limited by the medicinal material place of production.In addition,
The giant knotweed of different sources, its effect is after processing：Double enzyme microwave methods>Wine system>Vinegar system>Salt system.This is mainly due to giant knotweed
For medicinal material in double enzyme microwave methods, enzymolysis promotes conversion of the polygonin to resveratrol, and microwave is absorbed in microwave heating process
Energy, within the scope of certain temperature, main component is activated or concluded state decrease inside medicinal material, so that medicinal material inside points
Change on sub- recurring structure so that the content of main component changes；Though wine vinegar system can promote turning for glycosides to a certain extent
Change, but its effect does not have that enzyme process is effective, and conversion of the salt system then to glycosides is weaker.
Embodiment 2.
The present invention provides a kind of concocting method of giant knotweed, and step is：By 6g Rhizoma Polygoni Cuspidatis be immersed in 10ml cellulases, β-
In the pretreatment mixed solution of glucuroide, after soaking 2h, put in micro-wave oven and process 10min under 80% power, produce giant knotweed
Microwave processing product.
The cellulase, the weight proportion of beta-glucosidase are 3:1.
It is described pretreatment mixed solution preparation method be：Cellulase 3mg is weighed respectively, beta-glucosidase 1mg adds
10ml distilled water, which dissolves, to be produced, and takes the Pretreatment Mixed Liauid 10ml prepared to be processed for above-mentioned giant knotweed.
Embodiment 3.
The present invention provides a kind of concocting method of giant knotweed, and step is：By 3.5g Rhizoma Polygoni Cuspidatis be immersed in 10ml cellulases,
In the pretreatment mixed solution of beta-glucosidase, after soaking 10h, put in micro-wave oven and process 20min under 60% power, produce
Giant knotweed microwave processing product.
The cellulase, the weight proportion of beta-glucosidase are 5:2.
It is described pretreatment mixed solution preparation method be：Cellulase 0.5mg, beta-glucosidase are weighed respectively
0.2mg adds 10ml distilled water to dissolve to produce, and takes the Pretreatment Mixed Liauid 10ml prepared to be processed for above-mentioned giant knotweed.
Embodiment 4.
The present invention provides a kind of concocting method of giant knotweed, and step is：By 15g Rhizoma Polygoni Cuspidatis be immersed in 30ml cellulases,
In the pretreatment mixed solution of beta-glucosidase, after soaking 8h, put in micro-wave oven and process 30min under 40% power, produce tiger
Cane microwave processing product.
The cellulase, the weight proportion of beta-glucosidase are 1:1.
It is described pretreatment mixed solution preparation method be：Cellulase 3mg is weighed respectively, beta-glucosidase 3mg adds
30ml distilled water, which dissolves, to be produced, and takes the Pretreatment Mixed Liauid 30ml prepared to be processed for above-mentioned giant knotweed.
Embodiment 5.
The present invention provides a kind of concocting method of giant knotweed, and step is：By 2g Rhizoma Polygoni Cuspidatis be immersed in 10ml cellulases, β-
In the pretreatment mixed solution of glucuroide, after soaking 5h, put in micro-wave oven and process 10min under 80% power, produce giant knotweed
Microwave processing product.
The cellulase, the weight proportion of beta-glucosidase are 1:2.5.
It is described pretreatment mixed solution preparation method be：Cellulase 1mg, beta-glucosidase 2.5mg are weighed respectively
Add 30ml distilled water to dissolve to produce, take the Pretreatment Mixed Liauid 10ml prepared to be processed for above-mentioned giant knotweed.
Embodiment 6.
The present invention provides a kind of concocting method of giant knotweed, and step is：By 0.5g Rhizoma Polygoni Cuspidatis be immersed in 5ml cellulases,
In the pretreatment mixed solution of beta-glucosidase, after soaking 6h, put in micro-wave oven and process 20min under 40% power, produce tiger
Cane microwave processing product.
The cellulase, the weight proportion of beta-glucosidase are 1:4.
It is described pretreatment mixed solution preparation method be：Cellulase 1mg is weighed respectively, beta-glucosidase 4mg adds
5ml distilled water, which dissolves, to be produced, and takes the Pretreatment Mixed Liauid 5ml prepared to be processed for above-mentioned giant knotweed.
Embodiment 7.
The present invention provides a kind of concocting method of giant knotweed, and step is：By 5g Rhizoma Polygoni Cuspidatis be immersed in 20ml cellulases, β-
In the pretreatment mixed solution of glucuroide, after soaking 3h, put in micro-wave oven and process 15min under 60% power, produce giant knotweed
Microwave processing product.
The cellulase, the weight proportion of beta-glucosidase are 3.5:1.
It is described pretreatment mixed solution preparation method be：Cellulase 35mg, beta-glucosidase 10mg are weighed respectively
Add 20ml distilled water to dissolve to produce, take the Pretreatment Mixed Liauid 20ml prepared to be processed for above-mentioned giant knotweed.
Embodiment 8.
The present invention provides a kind of concocting method of giant knotweed, and step is：By 5g Rhizoma Polygoni Cuspidatis be immersed in 5ml cellulases, β-
In the pretreatment mixed solution of glucuroide, after soaking 12h, put in micro-wave oven and process 25min under 40% power, produce tiger
Cane microwave processing product.
The cellulase, the weight proportion of beta-glucosidase are 3:4.
It is described pretreatment mixed solution preparation method be：Cellulase 1.2mg, beta-glucosidase are weighed respectively
1.6mg adds 5ml distilled water to dissolve to produce, and takes the Pretreatment Mixed Liauid 5ml prepared to be processed for above-mentioned giant knotweed.
Concocting method of the present invention, it is also applied for the processing of the Chinese medicines such as burdock, the root of kudzu vine.
Claims (1)
- A kind of 1. concocting method of giant knotweed, it is characterised in that by Rhizoma Polygoni Cuspidati be immersed in cellulase, beta-glucosidase it is pre- Handle after being soaked in mixed solution, put in micro-wave oven and process, produce giant knotweed microwave processing product；The system of the pretreatment mixed solution Preparation Method is：Cellulase is weighed respectively, beta-glucosidase adds distilled water to dissolve to produce；The cellulase and β-glucose Total dosage of glycosides enzyme is the 0.1-10 ‰, soak time 2-12h of Rhizoma Polygoni Cuspidati dosage；Power used in being processed in the micro-wave oven For 40%-100% power, concocted time used is 10min-30min；The weight of the cellulase and β-glucuroide is matched somebody with somebody Than for 1:5-5:1.
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| CN107536928A (en) * | 2017-09-07 | 2018-01-05 | 陇南远大生物科技有限公司 | A kind of habitat processing method of the fresh tuber of pinellia |
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