CN104784756A - 一种粘附血小板的三维微支架复合多孔金属支架 - Google Patents
一种粘附血小板的三维微支架复合多孔金属支架 Download PDFInfo
- Publication number
- CN104784756A CN104784756A CN201510208294.1A CN201510208294A CN104784756A CN 104784756 A CN104784756 A CN 104784756A CN 201510208294 A CN201510208294 A CN 201510208294A CN 104784756 A CN104784756 A CN 104784756A
- Authority
- CN
- China
- Prior art keywords
- dimensional micro
- rack
- porous metal
- prepared
- compound porous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052751 metal Inorganic materials 0.000 title claims abstract description 59
- 239000002184 metal Substances 0.000 title claims abstract description 59
- 210000001772 blood platelet Anatomy 0.000 title abstract 6
- 239000002131 composite material Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 claims abstract description 36
- 239000000463 material Substances 0.000 claims abstract description 14
- 238000004132 cross linking Methods 0.000 claims abstract description 12
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 11
- 238000004108 freeze drying Methods 0.000 claims abstract description 11
- 238000010146 3D printing Methods 0.000 claims abstract description 7
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 48
- 150000001875 compounds Chemical class 0.000 claims description 46
- 229920000159 gelatin Polymers 0.000 claims description 35
- 235000019322 gelatine Nutrition 0.000 claims description 35
- 108010010803 Gelatin Proteins 0.000 claims description 32
- 239000008273 gelatin Substances 0.000 claims description 32
- 235000011852 gelatine desserts Nutrition 0.000 claims description 32
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 28
- 238000002360 preparation method Methods 0.000 claims description 27
- 230000001464 adherent effect Effects 0.000 claims description 24
- 210000004623 platelet-rich plasma Anatomy 0.000 claims description 24
- 150000002739 metals Chemical class 0.000 claims description 22
- 239000011780 sodium chloride Substances 0.000 claims description 14
- 230000001954 sterilising effect Effects 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000003462 bioceramic Substances 0.000 claims description 7
- 239000008367 deionised water Substances 0.000 claims description 7
- 229910021641 deionized water Inorganic materials 0.000 claims description 7
- 238000004821 distillation Methods 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 7
- 210000002381 plasma Anatomy 0.000 claims description 6
- 238000009736 wetting Methods 0.000 claims description 6
- 239000001828 Gelatine Substances 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 abstract description 8
- 210000004027 cell Anatomy 0.000 abstract description 7
- 230000012010 growth Effects 0.000 abstract description 7
- 210000001519 tissue Anatomy 0.000 abstract description 7
- 230000004071 biological effect Effects 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000002449 bone cell Anatomy 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 238000011049 filling Methods 0.000 description 6
- 229910000883 Ti6Al4V Inorganic materials 0.000 description 5
- 239000003146 anticoagulant agent Substances 0.000 description 5
- 229940127219 anticoagulant drug Drugs 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000003760 magnetic stirring Methods 0.000 description 5
- 239000007769 metal material Substances 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 4
- 239000001506 calcium phosphate Substances 0.000 description 4
- 230000007547 defect Effects 0.000 description 4
- 238000007639 printing Methods 0.000 description 4
- 239000010936 titanium Substances 0.000 description 4
- 229910052719 titanium Inorganic materials 0.000 description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- -1 dextran sulfate Polymers 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 2
- 229920001287 Chondroitin sulfate Polymers 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 108010022355 Fibroins Proteins 0.000 description 2
- 229920000288 Keratan sulfate Polymers 0.000 description 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
- 229920002494 Zein Polymers 0.000 description 2
- 229940072056 alginate Drugs 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 229940045110 chitosan Drugs 0.000 description 2
- 229940059329 chondroitin sulfate Drugs 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 229960000633 dextran sulfate Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 229960001008 heparin sodium Drugs 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 238000000110 selective laser sintering Methods 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
- 229940078499 tricalcium phosphate Drugs 0.000 description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 description 2
- 229940093612 zein Drugs 0.000 description 2
- 239000005019 zein Substances 0.000 description 2
- 229910000531 Co alloy Inorganic materials 0.000 description 1
- 241000248503 Euplotes woodruffi Species 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 208000002607 Pseudarthrosis Diseases 0.000 description 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 102000009618 Transforming Growth Factors Human genes 0.000 description 1
- 108010009583 Transforming Growth Factors Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000005859 cell recognition Effects 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 231100000045 chemical toxicity Toxicity 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 238000010041 electrostatic spinning Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 238000007539 photo-oxidation reaction Methods 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000003361 porogen Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000034655 secondary growth Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000004808 supercritical fluid chromatography Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 239000003634 thrombocyte concentrate Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P10/00—Technologies related to metal processing
- Y02P10/25—Process efficiency
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510208294.1A CN104784756B (zh) | 2015-04-28 | 2015-04-28 | 一种粘附血小板的三维微支架复合多孔金属支架 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510208294.1A CN104784756B (zh) | 2015-04-28 | 2015-04-28 | 一种粘附血小板的三维微支架复合多孔金属支架 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104784756A true CN104784756A (zh) | 2015-07-22 |
CN104784756B CN104784756B (zh) | 2017-04-19 |
Family
ID=53550233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510208294.1A Active CN104784756B (zh) | 2015-04-28 | 2015-04-28 | 一种粘附血小板的三维微支架复合多孔金属支架 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104784756B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107185039A (zh) * | 2017-07-14 | 2017-09-22 | 中国人民解放军第四军医大学 | 一种多孔金属骨植入材料及其制备方法和应用 |
CN107233619A (zh) * | 2017-07-14 | 2017-10-10 | 中国人民解放军第四军医大学 | 一种功能化的多孔钛金属骨植入材料及其制备方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE29822563U1 (de) * | 1998-12-18 | 1999-02-18 | Aesculap AG & Co. KG, 78532 Tuttlingen | Implantat |
US20100028404A1 (en) * | 2007-03-08 | 2010-02-04 | Arne Briest | Compound and device for treating bone and/or cartilage defects |
CN102512267A (zh) * | 2011-12-07 | 2012-06-27 | 上海交通大学 | 一种复合多孔结构骨修复体及其制备方法 |
CN102665775A (zh) * | 2009-10-20 | 2012-09-12 | 日东电工株式会社 | 诱导硬组织再生的材料 |
CN104353122A (zh) * | 2014-11-24 | 2015-02-18 | 吴志宏 | 一种具有仿生三维微支架的3d打印多孔金属及其制备方法 |
CN104368040A (zh) * | 2014-11-24 | 2015-02-25 | 吴志宏 | 一种复合脱钙骨基质的3d打印多孔金属支架及其制备方法 |
-
2015
- 2015-04-28 CN CN201510208294.1A patent/CN104784756B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE29822563U1 (de) * | 1998-12-18 | 1999-02-18 | Aesculap AG & Co. KG, 78532 Tuttlingen | Implantat |
US20100028404A1 (en) * | 2007-03-08 | 2010-02-04 | Arne Briest | Compound and device for treating bone and/or cartilage defects |
CN102665775A (zh) * | 2009-10-20 | 2012-09-12 | 日东电工株式会社 | 诱导硬组织再生的材料 |
CN102512267A (zh) * | 2011-12-07 | 2012-06-27 | 上海交通大学 | 一种复合多孔结构骨修复体及其制备方法 |
CN104353122A (zh) * | 2014-11-24 | 2015-02-18 | 吴志宏 | 一种具有仿生三维微支架的3d打印多孔金属及其制备方法 |
CN104368040A (zh) * | 2014-11-24 | 2015-02-25 | 吴志宏 | 一种复合脱钙骨基质的3d打印多孔金属支架及其制备方法 |
Non-Patent Citations (1)
Title |
---|
邝辉等: ""壳聚糖多孔支架制备新方法初探"", 《北京生物医学工程》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107185039A (zh) * | 2017-07-14 | 2017-09-22 | 中国人民解放军第四军医大学 | 一种多孔金属骨植入材料及其制备方法和应用 |
CN107233619A (zh) * | 2017-07-14 | 2017-10-10 | 中国人民解放军第四军医大学 | 一种功能化的多孔钛金属骨植入材料及其制备方法 |
CN107185039B (zh) * | 2017-07-14 | 2020-09-15 | 中国人民解放军第四军医大学 | 一种多孔金属骨植入材料及其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
CN104784756B (zh) | 2017-04-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Feng et al. | Application of 3D printing technology in bone tissue engineering: a review | |
Veeman et al. | Additive manufacturing of biopolymers for tissue engineering and regenerative medicine: an overview, potential applications, advancements, and trends | |
Khandan et al. | Hydrogels: Types, structure, properties, and applications | |
Deb et al. | Scaffold development using biomaterials: a review | |
Prasad et al. | State of art on solvent casting particulate leaching method for orthopedic scaffoldsfabrication | |
CN105796214B (zh) | 一种定向缓释rhBMP‑2的多孔金属颈椎间融合器 | |
Chinta et al. | Assessment of properties, applications and limitations of scaffolds based on cellulose and its derivatives for cartilage tissue engineering: A review | |
CN105641753B (zh) | 一种复合rhBMP-2的可实现血管转移的3D打印可降解支架 | |
CN104353124B (zh) | 一种复合磁性纳米材料的3d打印多孔金属支架及其制备方法 | |
CN104368040B (zh) | 一种复合脱钙骨基质的3d打印多孔金属支架及其制备方法 | |
CN105457101A (zh) | 一种三层结构小口径血管支架的制备方法 | |
CN104490491A (zh) | 一种生物相容的人工耳及其体外快速构建方法 | |
Gupta et al. | Multiscale porosity in a 3D printed gellan–gelatin composite for bone tissue engineering | |
Wang et al. | Implantable and biodegradable macroporous iron oxide frameworks for efficient regeneration and repair of infracted heart | |
CN114558170B (zh) | 一种含生长因子颅骨修复聚醚醚酮材料及其制备方法 | |
CN104784756A (zh) | 一种粘附血小板的三维微支架复合多孔金属支架 | |
CN108578780B (zh) | 一种载银离子具有力学梯度的人工骨支架的制备方法 | |
Xu et al. | In Vitro and In Vivo Analysis of the Effects of 3D‐Printed Porous Titanium Alloy Scaffold Structure on Osteogenic Activity | |
CN115414526B (zh) | 一种仿生学结构的生物降解锌合金承重骨支架及加工方法 | |
CN204766705U (zh) | 一种具有仿生三维微支架的3d打印医用多孔金属支架 | |
Wu et al. | Chitosan/alginate multilayer scaffold encapsulating bone marrow stromal cells in situ on titanium | |
Dalavi et al. | Biological macromolecules in tissue engineering | |
Suhail et al. | Fabrication of bioactive nano assimilated polymeric scaffold for the metamorphosis of organs or tissues: triumph, confrontation and prospective | |
CN205569387U (zh) | 一种负载rhBMP-2缓释系统的可实现血管转移的可降解支架 | |
CN205391219U (zh) | 载有rhBMP-2缓释系统的颈椎间融合器 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
EXSB | Decision made by sipo to initiate substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhu Wei Inventor after: Wu Zhihong Inventor after: Weng Xisheng Inventor after: Liu Jian Inventor after: Xu Haiyan Inventor after: Yin Bo Inventor after: Wu Gui Inventor before: Zhu Wei Inventor before: Liu Jian Inventor before: Xu Haiyan Inventor before: Yin Bo Inventor before: Wu Zhihong Inventor before: Wu Gui |
|
COR | Change of bibliographic data | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20150923 Address after: 100730 Beijing city Shuaifuyuan Dongcheng District No. 1 Peking Union Medical College Hospital Applicant after: Wu Zhihong Applicant after: Zhu Wei Applicant after: Weng Xisheng Address before: 100730 Beijing city Shuaifuyuan Dongcheng District No. 1 Peking Union Medical College Hospital Applicant before: Wu Zhihong |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20180803 Address after: 100730 Wangfujing, Dongcheng District, Dongcheng District, Beijing Patentee after: Beijing Xiehe Hospital, Chinese Academy of Medical Sciences Address before: 100730 Peking Union Medical College Hospital, 1 Shuai Fu Garden, Dongcheng District, Beijing. Co-patentee before: Zhu Wei Patentee before: Wu Zhihong Co-patentee before: Weng Xisheng |
|
TR01 | Transfer of patent right |