CN104782622A - Hydrogen sulfide slow-release inhibitor as well as preparation method and application thereof - Google Patents
Hydrogen sulfide slow-release inhibitor as well as preparation method and application thereof Download PDFInfo
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- CN104782622A CN104782622A CN201510217662.9A CN201510217662A CN104782622A CN 104782622 A CN104782622 A CN 104782622A CN 201510217662 A CN201510217662 A CN 201510217662A CN 104782622 A CN104782622 A CN 104782622A
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- paraffin
- sustained release
- release agent
- nahs
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- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 229910000037 hydrogen sulfide Inorganic materials 0.000 title abstract 5
- 239000003112 inhibitor Substances 0.000 title abstract 5
- 239000012188 paraffin wax Substances 0.000 claims abstract description 26
- HYHCSLBZRBJJCH-UHFFFAOYSA-M sodium hydrosulfide Chemical compound [Na+].[SH-] HYHCSLBZRBJJCH-UHFFFAOYSA-M 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 9
- 230000008635 plant growth Effects 0.000 claims abstract description 6
- 238000001816 cooling Methods 0.000 claims abstract description 5
- 238000001035 drying Methods 0.000 claims abstract description 5
- 230000001737 promoting effect Effects 0.000 claims abstract description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 40
- 238000013268 sustained release Methods 0.000 claims description 32
- 239000012730 sustained-release form Substances 0.000 claims description 32
- 239000007788 liquid Substances 0.000 claims description 10
- 239000011324 bead Substances 0.000 claims description 9
- 235000013399 edible fruits Nutrition 0.000 claims description 8
- 238000002844 melting Methods 0.000 claims description 5
- 230000008018 melting Effects 0.000 claims description 5
- 238000007605 air drying Methods 0.000 claims description 4
- 235000019441 ethanol Nutrition 0.000 claims description 3
- 229920002521 macromolecule Polymers 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Natural products C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- 125000003158 alcohol group Chemical group 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- -1 morpholine fatty acid salt Chemical class 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 8
- 239000000243 solution Substances 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 239000011248 coating agent Substances 0.000 abstract 3
- 239000011259 mixed solution Substances 0.000 abstract 2
- 238000009792 diffusion process Methods 0.000 abstract 1
- 238000007598 dipping method Methods 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- IHYNKGRWCDKNEG-UHFFFAOYSA-N n-(4-bromophenyl)-2,6-dihydroxybenzamide Chemical compound OC1=CC=CC(O)=C1C(=O)NC1=CC=C(Br)C=C1 IHYNKGRWCDKNEG-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000008569 process Effects 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 235000010149 Brassica rapa subsp chinensis Nutrition 0.000 description 3
- 235000000536 Brassica rapa subsp pekinensis Nutrition 0.000 description 3
- 241000499436 Brassica rapa subsp. pekinensis Species 0.000 description 3
- 239000012452 mother liquor Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 239000002361 compost Substances 0.000 description 2
- 230000009514 concussion Effects 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000008236 heating water Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 2
- 241000219194 Arabidopsis Species 0.000 description 1
- 241000219195 Arabidopsis thaliana Species 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 description 1
- YZCKVEUIGOORGS-IGMARMGPSA-N Protium Chemical compound [1H] YZCKVEUIGOORGS-IGMARMGPSA-N 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 230000005961 cardioprotection Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 210000004925 microvascular endothelial cell Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000007226 seed germination Effects 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 230000026799 smooth muscle cell apoptotic process Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a hydrogen sulfide slow-release inhibitor as well as a preparation method and an application thereof. The method comprises the following steps: respectively dissolving a hydrogen sulfide donor such as sodium bisulfide (NaHS) and a coating agent into absolute ethyl alcohol, mixing and swirly mixing to obtain a mixed solution; adding the mixed solution into fused paraffin, ultrasonically mixing to obtain a paraffin solution containing the NaHS and the coating agent; dipping the paraffin solution into cold water to obtain a paraffin globule, cooling and drying to obtain the hydrogen sulfide slow-release inhibitor, wherein the mass ratio of the NaHS, the coating agent, the absolute ethyl alcohol to the paraffin is (0.5-5%): (1.5-15%): (5-20%): (60-93%). By adopting an ultrasonic-assisted dispersion technology, the mutual diffusion efficiency and effect of two solvents are improved. The concentration and the speed for releasing the H2S by the prepared slow-release inhibitor are stable and controllable and the slow-release inhibitor has an obvious promoting effect for the plant growth.
Description
Technical field:
The present invention relates to sustained release agent, specifically relate to a kind of hydrogen sulphide sustained release agent and its preparation method and application.
Background technology:
Hydrogen sulphide (H
2s) as the third gaseous signal molecule, there is comparatively deep research in animal body, proved the H of physiological concentration
2s almost participates in all vital movement processes: cardioprotection, vasodilator; suppress vascular smooth muscle cell proliferation, induction of vascular Vascular Smooth Muscle Cell Apoptosis, promote proliferation of microvascular endothelial cells, improve the multiple regulatory functions such as heart failure, diabetes, cirrhosis, septicemia, asthma.In recent years, H
2the research of S in plant corpus also achieves certain progress, finds that it can promote seed germination, root morphology builds up, and strengthen photosynthesis, adjustment is bloomed, and delays senility, increase yield etc.
At present about H
2the research of S physiological function in vivo, mainly carries out based on some pharmacology experiments.By with H
2the medicine donor process experiment material of S, observes and measures corresponding situation of change in material bodies.The most frequently used H
2s donor is NaHS (NaHS), can produce H after water-soluble
2s gas.The i.e. sulphur hydrogen radical ion (HS of NaHS
-) with water in hydrogen ion (H
+) combine and release H
2s, concrete reaction equation is: HS
-+ H
+=H
2s, and this course of reaction is very fast.
Based on H
2the characteristic that S low concentration is useful, high concentration is poisonous, is utilizing H
2during S gas treatment biomaterial often a micro-dosage continue process.Therefore, in actual mechanical process, be all generally the NaHS mother liquor preparing higher concentration in first closed container, and then dilute in proportion.Due to H
2the volatility of S, above operation not only cannot accurately control its concentration, and the repeatability of experiment reduces greatly; Also there is waste greatly, each actual NaHS used is only the some thousandths of of preparation mother liquor simultaneously.Therefore a kind of H of research and development is badly in need of
2s sustained release agent, meets the application demand of scientific experiment and agricultural production.
Summary of the invention:
The object of the invention is to overcome the H existed in prior art
2s concentration is wayward, the defect that availability is not high, provides a kind of stable performance, quality controllable H
2s sustained release agent and preparation method thereof.
A kind of H provided by the invention
2s sustained release agent, its raw material components by mass percentage: H
2the donor NaHS 0.5-5% of S, fruit glaze agent 1.5-15%, absolute ethyl alcohol 5-20%, paraffin 60-93%.
Its preparation method comprises the following steps:
1) NaHS and fruit glaze agent are dissolved in absolute ethyl alcohol respectively, after merging, whirlpool mixing, is prepared into mixed liquor;
2) mixed liquor is added in the paraffin of melting, ultrasonic mixing, makes the paraffin liquid containing NaHS and fruit glaze agent;
3) obtain paraffin bead by described paraffin liquid instillation cold water, through cooling, drying, obtain H
2s sustained release agent.
Wherein, described fruit glaze agent is alcohol insoluble macromolecular substance, as polyethylene glycol, lac, morpholine fatty acid salt, stearic acid etc.
Described ultrasonic power 100-500W, the time is 10-30 minute, will ensure that the temperature of mixed liquor is greater than paraffin melting point temperature in ultrasonic procedure;
Described drying mode is air drying.
H of the present invention
2s sustained release agent can in the developmental application of Promoting plant growth.Select various dose as required during use, put in the soil of planting plants, and water.
H of the present invention
2s sustained release agent has the following advantages:
1, various H is overcome
2the shortcoming that S donor rate of release is too fast;
2, product cost is low, and preparation technology is simply easy to implement;
3, H
2each composition of S sustained release agent is safe, nontoxic, meets environmental requirement;
4, slow releasing, significantly improves H
2the lasting period of S effect, reduce spraying times, reduce labour intensity.
Accompanying drawing illustrates:
Fig. 1 is the H that embodiment 1 and embodiment 2 obtain
2s sustained release agent;
Fig. 2 is the H that embodiment 1 and embodiment 2 obtain
2s sustained release agent discharges H in time in water
2the assay of S;
Fig. 3 is the growth Arabidopsis thaliana Seedlings of 2 weeks, keeps moistening after burying sustained release agent in compost, after 10 days with compare plant growth situation;
Fig. 4 is the growth Chinese cabbage seedling of 2 weeks, keeps moistening after burying sustained release agent in compost, after 10 days with compare plant growth situation.
Embodiment
Below in conjunction with embodiment, the present invention is described in further detail.
The paraffin wax (fusing point 68 DEG C) that embodiment 1. takes 10g is placed in small beaker, and heating water bath, to 70-80 DEG C, makes it fully melt; Accurately take the PEG-8000 of NaHS and 0.1g of 0.03g respectively in the centrifuge tube of two 2ml, add 1ml absolute ethyl alcohol respectively, metal bath is heated to 70-80 DEG C, makes it fully dissolve; Merged by two kinds of solution, whirlpool concussion is to fully mixing; Joined by mixed liquor in the paraffin of melting, select power 300W to make it dispersed in paraffin liquid in ultrasonic 10 minutes, this process ensures that mixeding liquid temperature is greater than 68 DEG C; Draw paraffin liquid with liquid-transfering gun, be injected into rapidly in cold water and obtain paraffin bead, cooling, pulls rear air drying out, obtains H
2s sustained release agent (see accompanying drawing 1).
The paraffin wax (fusing point 68 DEG C) that embodiment 2. takes 10g is placed in small beaker, and heating water bath, to 70-80 DEG C, makes it fully melt; Accurately take the PEG-8000 of NaHS and 0.2g of 0.05g respectively in the centrifuge tube of two 2ml, add 1ml absolute ethyl alcohol respectively, metal bath is heated to 70-80 DEG C, makes it fully dissolve; Merged by two kinds of solution, whirlpool concussion is to fully mixing; Joined by mixed liquor in the paraffin of melting, select power 300W to make it dispersed in paraffin liquid in ultrasonic 15 minutes, this process ensures that mixeding liquid temperature is greater than 68 DEG C; Draw paraffin liquid with liquid-transfering gun, be injected into rapidly in cold water and obtain paraffin bead, cooling, pulls rear air drying out, obtains H
2s sustained release agent (see accompanying drawing 1).
Bead sustained release agent prepared by Example 1 and 2 carries out release rate assay:
The preparation of working curve: accurately take 0.14gNaHS and be dissolved in 2.5ml H
2in O, obtain the NaHS mother liquor of 0.1M.Then stepwise dilution obtains NaHS final concentration is 0,1.25,2.5,5,10,20, and 40,100 μMs, get 2ml and be placed in little triangular flask with cover; Put into the Ep pipe of the 1%ZnAc being added with 500 μ L in triangular flask, room temperature places 30min; Take out the Ep pipe in little triangular flask, add DPD and FeCl of 200 μ L respectively
3, dark reaction 15min; Measure absorbance at 667nm place, obtain H
2s content standard curve: y=0.0059x-0.0005 (R
2=1).
Sustained release agent rate of release of the present invention measures: choose uniform sustained release agent bead and be placed in little triangular flask with cover respectively, add 2ml distilled water; Put into the Ep pipe of the 1%ZnAc being added with 500 μ L in triangular flask, room temperature places 30min; Take out the Ep pipe in little triangular flask, add DPD and FeCl of 200 μ L respectively
3, dark reaction 15min; Absorbance is measured at 667nm place.H is calculated according to above-mentioned calibration curve
2s content.Getting the time that sustained release agent bead stops in the with cover little triangular flask added water respectively is 1,3,5,7,10,15,20,30 days, calculate its release H
2the speed (see accompanying drawing 2) of S.
Adopt the application of above-mentioned obtained sustained release agent in different growing process:
Due to sustained release agent provided by the invention, to have in damp soil evenly, continue, stable, controllably discharge H
2the drug release feature of S, makes H
2s concentration maintains a metastable numerical value, avoids high concentration H
2the toxicity that S causes, this continual and steady administering mode adds the operability of dispenser simultaneously, more facilitates growing of plant corpus.
Sustained release agent bead 2 obtained in embodiment 3. Example 1, is placed in the growth arabidopsis culturing pot of 2 weeks, keeps the ground moistening that it covers, and after 10 days compared with the control, plant individual is obviously comparatively large, and situation of growing better (see accompanying drawing 3).
Sustained release agent bead 2 obtained in embodiment 4. Example 2, is placed in the growth Chinese cabbage culturing pot of 2 weeks, keeps the ground moistening that it covers, after 10 days compared with the control, plant individual is obviously comparatively large, and makes Chinese cabbage bloom in advance, and situation of growing better (see accompanying drawing 4).
From above result, sustained release agent provided by the invention can discharge low concentration H sustainedly and stably
2s, obvious Promoting plant growth developmental process, reaches the objects such as high yield early blossoming.
Claims (6)
1. a hydrogen sulphide sustained release agent, its raw material components by mass percentage: NaHS 0.5-5%, fruit glaze agent 1.5-15%, absolute ethyl alcohol 5-20%, paraffin 60-93%.
2. the preparation method of a kind of hydrogen sulphide sustained release agent as claimed in claim 1, is characterized in that, comprise the steps:
1) by raw material components proportioning according to claim 1, NaHS and fruit glaze agent are dissolved in absolute ethyl alcohol respectively, after merging, whirlpool mixing, is prepared into mixed liquor;
2) mixed liquor is added in the paraffin of melting, ultrasonic mixing, makes the paraffin liquid containing NaHS and fruit glaze agent;
3) obtain paraffin bead by described paraffin liquid instillation cold water, through cooling, drying, obtain hydrogen sulphide sustained release agent.
3. the preparation method of a kind of hydrogen sulphide sustained release agent as claimed in claim 2, is characterized in that, described fruit glaze agent is alcohol insoluble macromolecular substance.
4. the preparation method of a kind of hydrogen sulphide sustained release agent as claimed in claim 3, is characterized in that, described alcohol insoluble macromolecular substance is polyethylene glycol, lac, morpholine fatty acid salt or stearic acid.
5. the preparation method of a kind of hydrogen sulphide sustained release agent as claimed in claim 2, is characterized in that, described drying mode is air drying.
6. hydrogen sulphide sustained release agent as claimed in claim 1 is in the developmental application of Promoting plant growth.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510217662.9A CN104782622B (en) | 2015-04-30 | 2015-04-30 | A kind of hydrogen sulfide slow releasing agent and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510217662.9A CN104782622B (en) | 2015-04-30 | 2015-04-30 | A kind of hydrogen sulfide slow releasing agent and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104782622A true CN104782622A (en) | 2015-07-22 |
| CN104782622B CN104782622B (en) | 2016-06-22 |
Family
ID=53548180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510217662.9A Active CN104782622B (en) | 2015-04-30 | 2015-04-30 | A kind of hydrogen sulfide slow releasing agent and its preparation method and application |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106879627A (en) * | 2017-01-24 | 2017-06-23 | 山西大学 | NaHS as Plant Pollen Germination accelerator application |
| TWI638666B (en) | 2017-03-22 | 2018-10-21 | 國立清華大學 | Sustained-release composition, method for fabricating, and use thereof |
| CN108849978A (en) * | 2018-09-07 | 2018-11-23 | 山西大学 | The application as plant drought-resisting agent is used in combination in a kind of NaHS and epiphysin |
| CN109970162A (en) * | 2019-03-28 | 2019-07-05 | 浙江大学 | A kind of novel dephosphorization sustained release agent and preparation method thereof |
| CN113702376A (en) * | 2021-08-03 | 2021-11-26 | 温州大学 | Evaluation of environmental pollutants H by using zebra fish2Method of S developmental toxicity |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB568673A (en) * | 1943-02-25 | 1945-04-16 | Associated Fumigators Ltd | Improvements in and relating to preparations for combating animal and insect pests |
| US20030235571A1 (en) * | 2002-06-19 | 2003-12-25 | Gabriel Gojon-Romanillos | Systemic treatment of pathological conditions resulting from oxidative stress and/or redox imbalance |
| WO2013045951A1 (en) * | 2011-09-30 | 2013-04-04 | The University Of Exeter | Hydrogen sulfide releasing compounds and their use |
| US8541396B2 (en) * | 2009-04-24 | 2013-09-24 | National University Of Singapore | Morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) as a novel vasodilator agent |
| CN103734131A (en) * | 2013-12-12 | 2014-04-23 | 江苏艾津农化有限责任公司 | Oncomelania-hupensis killing medicament niclosamide-ethanolamine-salt sustained-release granules and preparation method thereof |
| WO2014132083A2 (en) * | 2013-03-01 | 2014-09-04 | Aston University | Hydrogen sulphide compounds |
-
2015
- 2015-04-30 CN CN201510217662.9A patent/CN104782622B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB568673A (en) * | 1943-02-25 | 1945-04-16 | Associated Fumigators Ltd | Improvements in and relating to preparations for combating animal and insect pests |
| US20030235571A1 (en) * | 2002-06-19 | 2003-12-25 | Gabriel Gojon-Romanillos | Systemic treatment of pathological conditions resulting from oxidative stress and/or redox imbalance |
| US8541396B2 (en) * | 2009-04-24 | 2013-09-24 | National University Of Singapore | Morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) as a novel vasodilator agent |
| WO2013045951A1 (en) * | 2011-09-30 | 2013-04-04 | The University Of Exeter | Hydrogen sulfide releasing compounds and their use |
| WO2014132083A2 (en) * | 2013-03-01 | 2014-09-04 | Aston University | Hydrogen sulphide compounds |
| CN103734131A (en) * | 2013-12-12 | 2014-04-23 | 江苏艾津农化有限责任公司 | Oncomelania-hupensis killing medicament niclosamide-ethanolamine-salt sustained-release granules and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106879627A (en) * | 2017-01-24 | 2017-06-23 | 山西大学 | NaHS as Plant Pollen Germination accelerator application |
| CN106879627B (en) * | 2017-01-24 | 2019-09-24 | 山西大学 | Application of the NaHS as Plant Pollen Germination promotor |
| TWI638666B (en) | 2017-03-22 | 2018-10-21 | 國立清華大學 | Sustained-release composition, method for fabricating, and use thereof |
| CN108849978A (en) * | 2018-09-07 | 2018-11-23 | 山西大学 | The application as plant drought-resisting agent is used in combination in a kind of NaHS and epiphysin |
| CN109970162A (en) * | 2019-03-28 | 2019-07-05 | 浙江大学 | A kind of novel dephosphorization sustained release agent and preparation method thereof |
| CN113702376A (en) * | 2021-08-03 | 2021-11-26 | 温州大学 | Evaluation of environmental pollutants H by using zebra fish2Method of S developmental toxicity |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104782622B (en) | 2016-06-22 |
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