CN104781668B - 免疫特征分析：通向早期诊断和健康监测的途径 - Google Patents

免疫特征分析：通向早期诊断和健康监测的途径 Download PDF

Info

Publication number
CN104781668B
CN104781668B CN201380056857.9A CN201380056857A CN104781668B CN 104781668 B CN104781668 B CN 104781668B CN 201380056857 A CN201380056857 A CN 201380056857A CN 104781668 B CN104781668 B CN 104781668B
Authority
CN
China
Prior art keywords
peptides
array
peptide
monomer
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380056857.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN104781668A (zh
Inventor
斯蒂芬·阿尔伯特·约翰斯顿
菲利普·斯塔福德
尼尔·伍德伯里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arizona State University
Original Assignee
Arizona State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arizona State University filed Critical Arizona State University
Priority to CN201810764110.3A priority Critical patent/CN108957005A/zh
Publication of CN104781668A publication Critical patent/CN104781668A/zh
Application granted granted Critical
Publication of CN104781668B publication Critical patent/CN104781668B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00729—Peptide nucleic acids [PNA]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2410/00—Assays, e.g. immunoassays or enzyme assays, involving peptides of less than 20 animo acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380056857.9A 2012-08-29 2013-08-29 免疫特征分析：通向早期诊断和健康监测的途径 Expired - Fee Related CN104781668B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810764110.3A CN108957005A (zh) 2012-08-29 2013-08-29 免疫特征分析：通向早期诊断和健康监测的途径

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261694598P 2012-08-29 2012-08-29
US61/694,598 2012-08-29
PCT/US2013/057373 WO2014036312A2 (en) 2012-08-29 2013-08-29 Immunosignaturing: a path to early diagnosis and health monitoring

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810764110.3A Division CN108957005A (zh) 2012-08-29 2013-08-29 免疫特征分析：通向早期诊断和健康监测的途径

Publications (2)

Publication Number Publication Date
CN104781668A CN104781668A (zh) 2015-07-15
CN104781668B true CN104781668B (zh) 2018-07-24

Family

ID=50184639

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380056857.9A Expired - Fee Related CN104781668B (zh) 2012-08-29 2013-08-29 免疫特征分析：通向早期诊断和健康监测的途径
CN201810764110.3A Pending CN108957005A (zh) 2012-08-29 2013-08-29 免疫特征分析：通向早期诊断和健康监测的途径

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201810764110.3A Pending CN108957005A (zh) 2012-08-29 2013-08-29 免疫特征分析：通向早期诊断和健康监测的途径

Country Status (8)

Country Link
US (2) US20140087963A1 (enExample)
EP (1) EP2890984B1 (enExample)
JP (2) JP6463678B2 (enExample)
CN (2) CN104781668B (enExample)
AU (2) AU2013308682A1 (enExample)
CA (1) CA2882801C (enExample)
GB (1) GB2525743A (enExample)
WO (1) WO2014036312A2 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9732131B2 (en) 2006-02-27 2017-08-15 Calviri, Inc. Identification and use of novopeptides for the treatment of cancer
EP2430574A1 (en) 2009-04-30 2012-03-21 Patientslikeme, Inc. Systems and methods for encouragement of data submission in online communities
WO2014062981A1 (en) * 2012-10-17 2014-04-24 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University In situ chemical patterning
JP6503966B2 (ja) * 2015-08-05 2019-04-24 株式会社島津製作所 多変量解析結果表示装置
US10758886B2 (en) 2015-09-14 2020-09-01 Arizona Board Of Regents On Behalf Of Arizona State University Conditioned surfaces for in situ molecular array synthesis
US20180284114A1 (en) * 2015-10-02 2018-10-04 Arizona Board Of Regents On Behalf Of Arizona State University Methods for processing biopolymeric arrays
CA3005070A1 (en) 2015-11-11 2017-05-18 Serimmune Inc. Methods and compositions for assessing antibody specificities
WO2017223116A2 (en) * 2016-06-20 2017-12-28 Healthtell Inc. Methods for differential diagnosis of autoimmune diseases
WO2017223117A1 (en) * 2016-06-20 2017-12-28 Healthtell Inc. Methods for diagnosis and treatment of autoimmune diseases
JP2019536860A (ja) 2016-11-09 2019-12-19 ヘルステル・インコーポレイテッドＨｅａｌｔｈｔｅｌｌ Ｉｎｃ． 調整可能なアミン比重を有するコーティング
CN116514861A (zh) 2016-11-09 2023-08-01 库博科学公司 预组装的、受保护的、化学稳定的化学选择性接头
CN110168370A (zh) 2016-11-11 2019-08-23 健康之语公司 用于鉴定候选生物标志物的方法
CN110740813B (zh) 2016-11-28 2022-06-03 亚利桑那州立大学董事会 涉及连续流动液滴反应的系统和方法
WO2018144571A2 (en) 2017-01-31 2018-08-09 Arizona Board Of Regents On Behalf Of Arizona State University Diagnostic to distinguish bacterial infections
EP3630131B1 (en) 2017-06-02 2022-08-31 Arizona Board of Regents on behalf of Arizona State University A method to create personalized canine cancer vaccines
US12025615B2 (en) * 2017-09-15 2024-07-02 Arizona Board Of Regents On Behalf Of Arizona State University Methods of classifying response to immunotherapy for cancer
US12417825B2 (en) 2017-09-15 2025-09-16 Alden Scientific, Inc. Systems and methods for collecting and analyzing comprehensive medical information
WO2020033271A1 (en) * 2018-08-06 2020-02-13 Arizona Board Of Regents On Behalf Of Arizon State University Computational analysis to comprehensively predict and design molecular recognition between peptides and proteins
US11894139B1 (en) 2018-12-03 2024-02-06 Patientslikeme Llc Disease spectrum classification
AU2020266136B2 (en) * 2019-04-29 2026-04-02 Nautilus Subsidiary, Inc. Methods and systems for integrated on-chip single-molecule detection
EP4038222A4 (en) 2019-10-02 2023-10-18 Arizona Board of Regents on behalf of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer
WO2021236790A1 (en) * 2020-05-19 2021-11-25 Laboratory Corporation Of America Holdings Methods and systems for quantitative detection of antibodies
US20240379192A1 (en) * 2021-10-01 2024-11-14 Arizona Board Of Regents On Behalf Of Arizona State University Machine learning approaches to enhance disease diagnostics
CN114512244B (zh) * 2021-12-09 2025-05-06 广东省人民医院 一种基于深度学习的感染类疾病无创诊断方法
US12091715B2 (en) 2022-04-21 2024-09-17 Paragon Genomics, Inc. Methods and compositions for reducing base errors of massive parallel sequencing using triseq sequencing
US11680293B1 (en) 2022-04-21 2023-06-20 Paragon Genomics, Inc. Methods and compositions for amplifying DNA and generating DNA sequencing results from target-enriched DNA molecules
US20240266008A1 (en) * 2023-02-01 2024-08-08 Unlearn.AI, Inc. Systems and Methods for Designing Augmented Randomized Trials

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001056691A2 (de) * 2000-02-03 2001-08-09 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verfahren und vorrichtung zur synthese und analyse von trägergebundenen arrays von oligomeren, insbesondere von primerpaaren für die pcr, sowie träger mit oligomeren
CN1438324A (zh) * 2003-03-10 2003-08-27 东南大学 一种寡聚核苷酸微阵列芯片及其制备方法
WO2007068240A2 (de) * 2005-12-18 2007-06-21 Charite-Universitätsmedizin Berlin Peptide für die wechselwirkung mit alpha-helikalen coiled-coil-strukturen und/oder coiled-coil-sequenzen, davon abgeleitete mittel und ihre verwendung
US20080188618A1 (en) * 2007-01-23 2008-08-07 Greving Matthew P Porous Acrylate Copolymer Films and Uses Therefor
CN102099372A (zh) * 2008-07-15 2011-06-15 奇斯药制品公司 抗淀粉样蛋白免疫原性组合物、方法和应用
WO2012055069A1 (en) * 2010-10-27 2012-05-03 Capitalbio Corporation Luminophore-labeled molecules coupled with particles for microarray-based assays
US20120190574A1 (en) * 2009-06-19 2012-07-26 The Arizona Board of Regents, A body Corporate of the State of Arizona for and on behalf of Arizona Compound Arrays for Sample Profiling

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5759774A (en) * 1988-05-18 1998-06-02 Cobe Laboratories, Inc. Method of detecting circulating antibody types using dried or lyophilized cells
US5449754A (en) * 1991-08-07 1995-09-12 H & N Instruments, Inc. Generation of combinatorial libraries
US6346423B1 (en) * 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
CA2504443A1 (en) * 2002-10-30 2004-05-13 Pointilliste, Inc. Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides
WO2005050224A2 (en) * 2003-11-13 2005-06-02 Epitome Biosystems Inc. Small molecule and peptide arrays and uses thereof
WO2006124644A2 (en) * 2005-05-12 2006-11-23 Board Of Regents, The University Of Texas System Protein and antibody profiling using small molecule microarrays
WO2008003100A2 (en) * 2006-06-29 2008-01-03 Xiaolian Gao Make and use of surface molecules of varied densities
JP2008063285A (ja) * 2006-09-08 2008-03-21 Univ Nagoya 高親和性ペプチドの設計法及び調製法、並びに高親和性ペプチド
US20090176664A1 (en) * 2007-06-01 2009-07-09 Keting Chu High density peptide arrays containing kinase or phosphatase substrates
WO2010043668A1 (en) * 2008-10-17 2010-04-22 Zentech S.A. Dried blood spots for blood analysis
AU2011223789A1 (en) * 2010-03-01 2012-09-20 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
WO2011150168A1 (en) * 2010-05-28 2011-12-01 Gen9, Inc. Methods and devices for in situ nucleic acid synthesis

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001056691A2 (de) * 2000-02-03 2001-08-09 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verfahren und vorrichtung zur synthese und analyse von trägergebundenen arrays von oligomeren, insbesondere von primerpaaren für die pcr, sowie träger mit oligomeren
CN1438324A (zh) * 2003-03-10 2003-08-27 东南大学 一种寡聚核苷酸微阵列芯片及其制备方法
WO2007068240A2 (de) * 2005-12-18 2007-06-21 Charite-Universitätsmedizin Berlin Peptide für die wechselwirkung mit alpha-helikalen coiled-coil-strukturen und/oder coiled-coil-sequenzen, davon abgeleitete mittel und ihre verwendung
US20080188618A1 (en) * 2007-01-23 2008-08-07 Greving Matthew P Porous Acrylate Copolymer Films and Uses Therefor
CN102099372A (zh) * 2008-07-15 2011-06-15 奇斯药制品公司 抗淀粉样蛋白免疫原性组合物、方法和应用
US20120190574A1 (en) * 2009-06-19 2012-07-26 The Arizona Board of Regents, A body Corporate of the State of Arizona for and on behalf of Arizona Compound Arrays for Sample Profiling
WO2012055069A1 (en) * 2010-10-27 2012-05-03 Capitalbio Corporation Luminophore-labeled molecules coupled with particles for microarray-based assays

Also Published As

Publication number Publication date
CA2882801C (en) 2022-01-18
JP6463678B2 (ja) 2019-02-06
CN108957005A (zh) 2018-12-07
EP2890984B1 (en) 2018-10-03
AU2019204047C1 (en) 2021-11-18
JP2015535336A (ja) 2015-12-10
WO2014036312A3 (en) 2015-05-14
AU2013308682A1 (en) 2015-03-12
JP2019012072A (ja) 2019-01-24
EP2890984A2 (en) 2015-07-08
US20140087963A1 (en) 2014-03-27
AU2019204047B2 (en) 2021-08-05
AU2019204047A1 (en) 2019-06-27
US20200256861A1 (en) 2020-08-13
CN104781668A (zh) 2015-07-15
CA2882801A1 (en) 2014-03-06
JP6873950B2 (ja) 2021-05-19
WO2014036312A2 (en) 2014-03-06
WO2014036312A8 (en) 2015-04-09
EP2890984A4 (en) 2016-05-25
GB2525743A (en) 2015-11-04
GB201504970D0 (en) 2015-05-06

Similar Documents

Publication Publication Date Title
JP6873950B2 (ja) 免疫署名：早期診断および健康モニタリングの方法
CN104769168A (zh) 发现治疗靶标的方法
US11067582B2 (en) Peptide array quality control
JP2012530906A (ja) 試料のプロファイリングのための化合物アレイ
CN110168370A (zh) 用于鉴定候选生物标志物的方法
CN109791151A (zh) 用于自身免疫疾病的鉴别诊断的方法
EP2300826A1 (en) Biomarkers for lupus
JP2020524275A (ja) 鑑別診断のための免疫シグネチャー
CN104903727A (zh) 诊断、预后、治疗和筛选方案
Stafford et al. General assessment of humoral activity in healthy humans
AU2022387692A1 (en) Systems and methods for evaluating immunological peptide sequences
HK40001559A (en) Immunosignaturing: a path to early diagnosis and health monitoring
HK40006694A (en) Methods for discovering therapeutic targets
US20110269246A1 (en) Measuring levels of frataxin
Venkatraman Commercialization of Molecular Impression Polymers as a Diagnostic Kit at Point of Care

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
EXSB Decision made by sipo to initiate substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180724