CN104777137A - Spectral position adjustment device for biomarker detection - Google Patents
Spectral position adjustment device for biomarker detection Download PDFInfo
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- CN104777137A CN104777137A CN201510131585.5A CN201510131585A CN104777137A CN 104777137 A CN104777137 A CN 104777137A CN 201510131585 A CN201510131585 A CN 201510131585A CN 104777137 A CN104777137 A CN 104777137A
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- 239000000090 biomarker Substances 0.000 title claims abstract description 55
- 238000001514 detection method Methods 0.000 title claims abstract description 36
- 230000003595 spectral effect Effects 0.000 title claims abstract description 34
- 230000003287 optical effect Effects 0.000 claims abstract description 47
- 230000001105 regulatory effect Effects 0.000 claims description 30
- 230000000694 effects Effects 0.000 claims description 16
- 238000005452 bending Methods 0.000 claims description 14
- 230000008859 change Effects 0.000 abstract description 29
- 238000005516 engineering process Methods 0.000 abstract description 10
- 230000005540 biological transmission Effects 0.000 abstract description 6
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 abstract description 5
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 abstract description 4
- 230000009471 action Effects 0.000 abstract description 2
- 238000007689 inspection Methods 0.000 abstract 1
- 230000033001 locomotion Effects 0.000 description 8
- 238000010586 diagram Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000001228 spectrum Methods 0.000 description 6
- 239000002184 metal Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000005674 electromagnetic induction Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000002331 protein detection Methods 0.000 description 1
- 210000004895 subcellular structure Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D3/00—Control of position or direction
- G05D3/12—Control of position or direction using feedback
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention relates to the biomarker detection field, more specifically to a spectral position adjustment device for biomarker detection. The spectral position adjustment device includes an optical receiving module (3), a transmission mechanism, a coil (9), a magnet (10) and a pedestal (11). One part of the transmission mechanism is fixed on the optical receiving module (3), and another part is fixed on the pedestal (11). The coil (9) is fixed on the transmission mechanism, and the magnet (10) is close to the coil (9), so that after energization, the coil (9) can drive the optical receiving module (3) to move through the transmission mechanism under the action of the magnet (10). The device provided by the invention can conveniently and rapidly change the infrared irradiation reflection ray's spectral position of the biomarker in a test object during biomarker surface plasmon resonance technology inspection, thereby obtaining the effective information of the biomarker in the test object.
Description
Technical field
The present invention relates to biomarker detection field, relate to biomarker detection spectral position regulating device in particular.
Background technology
Biomarker (Biomarker) refers to can Mk system, organ, tissue, cell and subcellular structure or the change of function or the biochemical indicator of contingent change, has purposes widely.Biomarker can be used for medical diagnosis on disease, judges staging or be used for evaluating new drug or the safety and efficacy of new treatment in target group.When detecting biomarker, commonly use surface plasma resonance technology SPR (Surface Plasmon Resonance), namely utilize the total reflection of metal film/liquid level interface light to connect a kind of physical optics phenomenon caused and carry out analysing biomolecules interaction, and measure biomarker concentration by infrared light in conjunction with SPR technique, specifically can refer to paper " application of surface plasma resonance technology in biomedicine "-Peking University's biomedical engineering 2004 grades of Zhang Rui Bin (10403048), and paper " application of surface plasma body resonant vibration immunosensor in protein detection and progress thereof "-" analytical chemistry " the 7th phase 1052-1059 in 2010, but, in measuring process, how can obtain the characteristic spectrum positional information of the infrared light detecting biomarker more accurately, thus the relevant information of biomarker in acquisition determinand, the a difficult problem of pendulum in face of numerous biomedical sector scholar.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of reflection ray that can obtain biomarker, and adjust a kind of biomarker detection spectral position regulating device of biomarker reflected light spectral position.
The present invention for solving the problems of the technologies described above adopted technical scheme is: a kind of biomarker detection spectral position regulating device, comprise Optical Receivers, gear train, coil, magnet and base, described gear train one place is fixed on described Optical Receivers, another place is fixed on described base, described coil is fixed on described gear train, described magnet near described coil, after making in described coil energising its can be driven by described gear train under the effect of described magnet described in batten motion.
For a kind of biomarker detection spectral position regulating device in the present invention, as further setting, it also comprises spring, and described Optical Receivers is by described spring supporting.
For a kind of biomarker detection spectral position regulating device above-mentioned in the present invention, as a kind of optional embodiment for gear train, described gear train comprises intermeshing rack and pinion, described tooth bar is fixed on described Optical Receivers, being fixed on described base of described gear being rotatable.
In the first embodiment for the gear train of a kind of biomarker detection spectral position regulating device above-mentioned in the present invention, as further setting, also comprise axle, described geared sleeve is on described axle, and described axle is rotating to be fixed on base.
For a kind of biomarker detection spectral position regulating device above-mentioned in the present invention, as a kind of optional embodiment for gear train, described gear train comprises intermeshing worm gear and worm screw, described worm screw is fixed on described Optical Receivers, and described worm gear is rotating to be fixed on described base.
For a kind of biomarker detection spectral position regulating device above-mentioned in the present invention, as further setting, described gear train is also provided with balance device, described balance device and described coil are distributed in the both sides of described gear train.
For a kind of biomarker detection spectral position regulating device above-mentioned in the present invention, as further setting, be also provided with batten, described Optical Receivers is arranged on batten.
For a kind of biomarker detection spectral position regulating device above-mentioned in the present invention, as the further improvement for batten, described batten comprises straight-line segment and bending segment, described Optical Receivers is fixed on described straight-line segment, described bending segment comprises horizontal segment and vertical section, and described rack structure is arranged in the vertical section of described bending segment.
For a kind of biomarker detection spectral position regulating device above-mentioned in the present invention, as the further setting of spring fixing mode, described spring one end is fixed, and the other end is connected with the horizontal segment of the bending segment of described batten.
For a kind of biomarker detection spectral position regulating device above-mentioned in the present invention, described magnet is neodium magnet.
In the present invention, that gear can be fixed is enclosed within the outer ring of bearing, is then fixed on axle by bearing, makes gear can enclose pivoting movement under lower resistance; But, also directly can select Bearing gear when application choice gear, directly be fixed on axle.Meanwhile, for this problem, also can adopt existing alternate manner, will not enumerate at this.
In the present invention, for the engagement system of gear and tooth bar, similar engagement system can also be selected to replace, such as: gear is changed to worm gear, coil is fixed on worm gear, rack structure on batten is replaced with worm screw or worm structure, relies on the engagement transmission of worm and gear, complete the adjustment to batten and Optical Receivers above thereof; Also gear can be replaced with nut, accordingly coil is fixed on nut, change the rack structure on batten into threaded rod or similar structures, make coil under the effect of magnet by driving nut to rotate, and then drive threaded rod, batten to move, thus the position of adjustment batten and Optical Receivers above thereof is or/and angle.
A kind of biomarker of the present invention detects and adopts technique scheme by spectral position regulating device, the technique effect brought is: owing to being combined with coil by gear train by Optical Receivers in the present invention, and a magnet is set on the side of coil, make when passing into electric current in coil, coil produces magnetic field, under the magnetic fields of magnet, coil drives Optical Receivers motion by gear train, when measuring biomarker concentration based on surface plasma resonance technology, use this device, Optical Receivers can be made to receive the light beam of sensing chip injection and form spectrum, first null position is set, by regulating the electric current passed in coil, the position of spectrum when controlling there is determinand on Optical Receivers moves it to null position, corresponding relation between the electric signal sent by electric current and Optical Receivers in calculating coil, the Detection Information of the biomarker in determinand can be obtained easily and fast.
Accompanying drawing explanation
Fig. 1 is the fundamental diagram of the surface plasma resonance technology that the present invention relates to;
Fig. 2 is the one-piece construction schematic diagram of a kind of biomarker detection of the present invention spectral position regulating device;
Fig. 3 is the using state schematic diagram of a kind of biomarker detection of the present invention spectral position regulating device.
Embodiment
For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly described, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Fig. 1 is the fundamental diagram of the surface plasma resonance technology that the present invention relates to, it is prior art, as shown in the figure, surface plasma resonance technology is utilized to detect the process of biomarker concentration, first, a flow channel 300 and sensing chip 400 are set, sensing chip 400 arranges one deck gold film, and the face portion making sensing chip 400 be provided with golden film is arranged in flow channel 300, make the thing to be detected flowed in flow channel 300 can touch sensing chip 400 with golden film, during measurement, thing to be detected with biomarker is passed into flow channel 300, thing to be detected is contacted with sensing chip, one deck antibody molecule is modified in advance in reaction interface, when after target antigen and antibody recognition, the refractive index of gold film surface dielectric changes, SPR resonance angle can change along with the change of refractive index, the change of refractive index again be combined in metal surface biomacromolecule quality be changing into direct ratio, large young pathbreaker's reflection of resonance peak displacement is fixed on the change of metal surface biotinylated molecular weight, and then realize immunoassay.In FIG, light beam is sent by light source 600, be irradiated on sensing chip 400, by optical detection unit 700 (in the present invention will with Optical Receivers as optical detection unit) reception after its reflection, the change of the beam information received by it is responded to by optical detection unit 700, draw the corresponding relation of this change information and thing biomarker concentration to be detected, finally from this change information, draw biomarker concentration value in thing to be detected.For light source 600, can adopt monochromatic source, such as infrared beams light source, effect is better.
Fig. 2 is one-piece construction schematic diagram of the present invention, as shown in the figure, a kind of biomarker detects uses spectral position regulating device, comprise batten 2, Optical Receivers 3, spring 4, gear 7, coil 9 and magnet 10, one end of batten 2 is fixed in hinged mode, the other end is fixedly connected with tooth bar 6, a gear 7 is provided with on the side of tooth bar 6, gear 7 and tooth bar 6 are in engagement, gear 7 is rotating to be fixed on axle 8, axle 8 is fixing on the pedestal 11, conveniently stationary rack 6 on batten 2, batten 2 can be set to the two parts be fixedly connected with, a part is straight-line segment 21, another part is bending segment 22, one end of straight-line segment 21 adopts hinged mode to fix, its other end is fixedly connected with bending segment 22, and make straight-line segment 21 and horizontal direction be certain angle (generally in the majority with acute angle), straight-line segment 21 is fixed with Optical Receivers 3, for reflecting Infrared when detecting biomarker, bending segment 22 is in 90 degree of bending-likes, its horizontal component is fixedly connected with straight-line segment, its vertical portion stationary rack 6, certainly, also rack structure can be set in this vertical section, tooth bar and bending segment 22 are arranged to integrative-structure, comparatively speaking, the vertical portion of bending segment 22 arranges rack structure, namely the structure of formula is made of one in making, can be convenient when installing and use.
Rack structure on batten 2 or the tooth bar 6 be fixed wtih are in engagement with gear 7, and when rotating under the effect of gear 7 in external force, the rack structure on batten 2 or tooth bar 6 rotate along with the rotation of gear 7, thus drive batten 2 to move.In order to control/rotation of adjusting gear 7, gear 7 is fixed a closed coil 9, this coil 9 will extend the body of gear 7, and the segment distance that stretches out, the magnet be fixed wtih 10 is being set with coil 9 side, a part for coil 9 is overlapping with magnet 10, like this, when passing into electric current on coil 9, the coil 9 being in closure state forms a closed loop, when having electric current to pass through in the loop that this is closed, himself produces magnetic field under electromagnetic induction effect, have an effect power each other in the magnetic field that coil 9 produces and the magnetic field of magnet 10, now, change the size of current/direction passed in coil 9 and can change the magnetic field intensity and magnetic direction that coil 9 produces, the size and Orientation in the magnetic field produced due to magnet 10 is fixing, therefore, when the size of current changed in coil 9 and/or direction, under the effect in the magnetic field of magnet 10, coil 9 rotates, because coil 9 is fixed on gear 7, therefore, when coil 9 starts to rotate, gear 7 rotates along with coil 9 and rotates, gear 7 engages with the rack structure on batten 2 or tooth bar 6, therefore the rack structure on batten 2 or tooth bar 6 move along with the rotation of gear 7 (being vertical direction motion in figure), final batten 2 also can move along with the change of electric current in coil 9, for batten 2, because its straight-line segment 21 is fixed wtih in hinged mode, therefore, when passing into the change of electric current and change in batten 2 be along with coil 9, the straight-line segment 21 of batten 2 also will change with the angle of horizontal direction thereupon, and then, be fixed on the angle of Optical Receivers on batten 23 and horizontal direction also just along with change, the angle of the reflection ray above it also can change thereupon.
As shown in Figure 2, in order to improve the adjustment sensitivity of the horizontal sextant angle of the Optical Receivers 3 on batten 2 further, batten 2 connects a spring 4, the other end of spring 4 is fixed, set an initial position, make spring 4 whole device when this initial position be in a zero point, when needing the horizontal sextant angle adjusting Optical Receivers 3, can, by the elastic force of spring 4, Optical Receivers 3 be made to be more prone to return back to initial position.Above-mentioned detailed process shows as: when passing into electric current in coil 9, magnetic field is produced in coil, under the effect of magnet 10, coil 9 rotates around axle 8 under the mutual acting force in magnetic field, gear 7 also starts to rotate simultaneously, rack structure on batten 2 or hard-wired tooth bar 6 rise/fall under the rotation of gear 7, and then drive batten 2 to rise overally/decline, when batten 2 starts rise/fall, it also starts stretching/compressing spring 4 simultaneously, when need make batten 2 and above Optical Receivers 3 return back to the position of initial position or required setting time, when changing the size of current or direction that pass in coil 9 accordingly, batten 2 is when moving accordingly along with the rack structure above it or tooth bar 6, spring 4 can provide convergent force or tensile force accordingly, make batten 2 can be sensitiveer under the assistance of the acting force of spring 4, return back to initial position or desired location fast.
For the setting of spring 4 position, can refer to Fig. 2, be fixed on its one end on bending segment 22, the other end is fixed on corresponding position (such as platform or frame are first-class).
In fig. 2, one end of batten 2 is hinged being fixed wtih, and can adopt the multiple articulated mounting and hinged fixed form that comprise hinge, hinged ball etc. herein, namely only need guarantee that batten 2 can rotate with lower friction force around the strong point 1.
As shown in Figure 2, the shape of magnet 10 is in scheming, at vertical direction, (this direction is direction directly perceived in figure, the orientation that arranges of concrete material object is not limited thereto) magnet 10 is set, and make its N pole and its S pole reasonable layout, make coil 9 can in the reach in magnet 10 magnetic field, move between the N pole and S pole of magnet 10, for magnet 10, in order to enough strong magnetic field can be produced, preferably use neodium magnet, stronger magnetic field can be obtained, the motion impelling the coil 9 after energising that can be powerful.
Further, as shown in Figure 2, in order to improve the stability of coil 9 on gear 7, and improve the adjustment sensitivity of coil 9 further, gear 7 is fixed a balance device 5, this balance device 5 is arranged on gear 7, its position is corresponding with coil 9, namely balance device 5 and coil 9 is made to lay respectively at the both sides of gear, and make both it, to be positioned at same level height, play certain equilibrium activity each other, at this, balance device 5 can be arranged to coiled type, its part can be made to extend gear 7, so the weight of balance device 5 can be alleviated, simultaneously, balance device 5 can also by self gravitation, under leverage, good equilibrium activity is played to the position height of coil 9, namely when coil 9 is subject to the magnetic field force of magnet 10 (only to refer to orientation in figure to up/down, actual direction is not limited thereto) motion time, under the effect of balance device 5, coil 9 need overcome very little power and just can break away from stationary state and move, same, when coil 9 being adjusted to initial position, only need overcome less resistance can realize, namely can realize adjusting the position of coil 9 without the need to significantly changing the electric current passed in coil 9.
For the axle 8 in Fig. 2, it can be fixed by base 11, in embodiment given by Fig. 1 of the present invention, the bearing of the anchor portion of batten 2, the stiff end of spring 4 and base 11 is the platform with supporting role, such as: desk-top workbench or the support platform etc. be arranged in frame, but, also can set up a frame or shell, package unit is fixed on frame or shell.
In the present invention, for the rotating fixed form of gear 7 on axle 8, prior art can be adopted to solve, such as, can adopt and gear 7 is enclosed within the outer ring of bearing, make it can rotate around bearing, then the inner ring of bearing is fixed on axle 8, axle 8 is fixed on the pedestal 11; In addition, gear 7 also directly can use Bearing gear, it is directly fixed on axle 8; Other existing mode be rotationally connected, as hinged, socket, etc. can realize gear 7 rotatably fixing all of the present invention can within practical range.
Fig. 3 is the using state schematic diagram of a kind of biomarker detection of the present invention spectral position regulating device, as shown in FIG., in use, can first use not containing the detection liquid of biomarker, infrared light is used to irradiate pick-up unit, and make its reflected light be irradiated on Optical Receivers 3 by the direction shown in Fig. 2, determine the position of spectrum dark space, in such cases, a kind of biomarker detection of the present invention spectral position regulating device is set as initial position, accordingly, dark space in the banded light district that Optical Receivers 3 under this state is formed and banded light district is also corresponding as initial position, when change measured by detection thing time, owing to detecting the existence of biomarker in thing, antibody in pick-up unit absorbs antigen, the reflected light detecting the infrared light irradiated changes, namely the Infrared be irradiated on Optical Receivers 3 of the present invention changes, infrared light received by Optical Receivers 3 sends change, its spectrum formed on Optical Receivers 3 also sends change thereupon, the position of its dark space formed also just can offset by relative initial position.
With reference to Fig. 3, with the infrared external reflection light of incident ray wherein for detected detection thing, when adjusting the position, dark space of the spectrum that Optical Receivers 3 is formed, during to obtain the details further about biomarker, the size of current that change passes in coil 9 is or/and direction, the intensity in the magnetic field that the coil 9 closed produces is or/and direction is also along with transmission change, like this, under the effect of magnet 10, coil 9 driven gear 7 rotates (in the balancing brake effect lower coil 9 of balance device 5 than being easier to move under the magneticaction of magnet 10), and then gear 7 drives the rack structure on batten 2 or tooth bar 6 to move, batten 2 also setting in motion, the angle of Optical Receivers 3 and horizontal direction changes along with the motion of batten 2, so, the position of the dark space that Optical Receivers 3 is formed also can change, namely the size of electric current in coil 9 is passed into or/and direction according to adjustment, the position of the dark space that corresponding control Optical Receivers 3 is formed, metrical information needed for being obtained by the change of this position, dark space and the change that passes into the electric current in coil 9.
It should be noted that, enforcement of the present invention is not limited to above-mentioned embodiment, such as, wherein realize the rack structure on gear 7 that batten 2 moves and the batten 2 that engages with it or tooth bar 6, can by intermeshing turbine, worm screw or the nut of installation can be socketed, screw rod carries out entirety and replaces, and is modified in the position of required change on demand accordingly, such as can worm screw or nut be directly fixed on batten or Optical Receivers 3, worm gear or screw rod are fixed on base, other art for those skilled in the art and in conjunction with existing mechanical field common practise all very easyly can make above-mentioned variation, and in the present invention, the position of spring 4 is also not limited to the position shown in figure, also can be moved near the strong point 1, and the action effect of such spring 4 may be better.
And the batten 2 in the present invention is omissible in fact, Optical Receivers 3 can be directly used to make it be fixedly connected with to the worm screw in tooth bar 6 or corresponding embodiment or nut.
By reference to the accompanying drawings the specific embodiment of the present invention is explained in detail above, but the present invention is not limited to above-mentioned embodiment, in the ken that those skilled in the art possess, various change can also be made under the prerequisite not departing from present inventive concept.
Claims (10)
1. a biomarker detects and uses spectral position regulating device, it is characterized in that: comprise Optical Receivers (3), gear train, coil (9), magnet (10) and base (11), described gear train one place is fixed on described Optical Receivers (3), another place is fixed on described base (11), described coil (9) is fixed on described gear train, described magnet (10) is near described coil (9), rear its of energising in described coil (9) can be moved by the Optical Receivers (3) described in the drive of described gear train under the effect of described magnet (10).
2. a kind of biomarker detection spectral position regulating device according to claim 1, it is characterized in that: also comprise spring (4), described Optical Receivers (3) is supported by described spring (4).
3. a kind of biomarker detection spectral position regulating device according to claim 2, it is characterized in that: described gear train comprises intermeshing tooth bar (6) and gear (7), described tooth bar (6) is fixed on described Optical Receivers (3), and described gear (7) is rotating to be fixed on described base (11).
4. a kind of biomarker detection spectral position regulating device according to claim 3, it is characterized in that: also comprise axle (8), described gear (7) is enclosed within described axle (8), and described axle (8) is rotating to be fixed on base (11).
5. a kind of biomarker detection spectral position regulating device according to claim 2, it is characterized in that: described gear train comprises intermeshing worm gear and worm screw, described worm screw is fixed on described Optical Receivers (3), and described worm gear is rotating to be fixed on described base (11).
6. a kind of biomarker detection spectral position regulating device according to claim 4 or 5, it is characterized in that: on described gear train, be also provided with balance device (5), described balance device (5) and described coil (9) are distributed in the both sides of described gear train.
7. a kind of biomarker detection spectral position regulating device according to claim 2, it is characterized in that: be also provided with batten (2), described Optical Receivers (3) is arranged on batten (2).
8. a kind of biomarker detection spectral position regulating device according to claim 7, it is characterized in that: described batten (2) comprises straight-line segment (21) and bending segment (22), described Optical Receivers (3) is fixed on described straight-line segment (21), described bending segment (22) comprises horizontal segment and vertical section, and described rack structure is arranged in the vertical section of described bending segment (22).
9. a kind of biomarker detection spectral position regulating device according to claim 8, it is characterized in that: described spring (4) one end is fixed, the other end is connected with the horizontal segment of the bending segment (22) of described batten (2).
10. a kind of biomarker detection spectral position regulating device according to any one of claim 1-4,7-9, is characterized in that: described magnet (10) is neodium magnet.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510131585.5A CN104777137B (en) | 2015-03-25 | 2015-03-25 | Biological marker analyte detection light spectral position regulating device |
| PCT/CN2015/078014 WO2016149989A1 (en) | 2015-03-25 | 2015-04-30 | Spectral position adjusting apparatus for biomarker testing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510131585.5A CN104777137B (en) | 2015-03-25 | 2015-03-25 | Biological marker analyte detection light spectral position regulating device |
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| CN104777137A true CN104777137A (en) | 2015-07-15 |
| CN104777137B CN104777137B (en) | 2018-06-19 |
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| CN201510131585.5A Expired - Fee Related CN104777137B (en) | 2015-03-25 | 2015-03-25 | Biological marker analyte detection light spectral position regulating device |
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| WO (1) | WO2016149989A1 (en) |
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| CA3034326A1 (en) | 2016-08-19 | 2018-02-22 | Beigene, Ltd. | Use of a combination comprising a btk inhibitor for treating cancers |
| KR20200020902A (en) | 2017-06-26 | 2020-02-26 | 베이진 엘티디 | Immune treatment for hepatocellular carcinoma (HCC) |
| WO2019108795A1 (en) | 2017-11-29 | 2019-06-06 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors |
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| CN201075777Y (en) * | 2007-08-31 | 2008-06-18 | 上海世科嘉车辆技术研发有限公司 | Electric angle regulating system of rear view mirror single electric machine |
| CN201212871Y (en) * | 2008-04-30 | 2009-03-25 | 中国科学院金属研究所 | Test system for dynamic bending fatigue performance of thin-film material |
| CN102967934B (en) * | 2012-12-04 | 2016-08-03 | 中国科学院苏州纳米技术与纳米仿生研究所 | A kind of Electromagnetic-drivmicro micro mirror |
| CN103528683B (en) * | 2013-10-25 | 2015-09-02 | 武汉大学 | A kind of movinglens scanning device for Fourier transformation infrared spectrometer |
| CN204536918U (en) * | 2015-03-25 | 2015-08-05 | 深圳市易特科信息技术有限公司 | For the spectral position regulating device that biomarker detects |
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| CN104777137B (en) | 2018-06-19 |
| WO2016149989A1 (en) | 2016-09-29 |
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