CN104749118A - Variable intervene type biomarker concentration detection method and device - Google Patents
Variable intervene type biomarker concentration detection method and device Download PDFInfo
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- CN104749118A CN104749118A CN201510131626.0A CN201510131626A CN104749118A CN 104749118 A CN104749118 A CN 104749118A CN 201510131626 A CN201510131626 A CN 201510131626A CN 104749118 A CN104749118 A CN 104749118A
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Abstract
The invention relates to the field of detection of biomarkers and more particularly relates to a variable intervene type biomarker concentration detection method and a variable intervene type biomarker concentration detection device. A light receiving module receives polarized beams to form a light spectrum and outputs an electric signal Qn and a zero value Q0 of the electric signal Qn is set; an intervene variable An is introduced and the position of the light spectrum on the light receiving module is adjusted, meanwhile, an electric signal output value of the light receiving module is adjusted, wherein one intervene variable An corresponds to the electric signal output value Qn of one light receiving module; a corresponding relation between the intervene variable An and a biomarker concentration Bn in a detected object is set and the intervene variable An is adjusted to Am so that Qn is equal to Q0; a biomarker concentration Bm corresponding to the intervene variable Am is inquired to obtain the concentration of the biomarker in the detected object, wherein n and m are natural numbers, and n is more than m. The invention further provides the corresponding device which can be used for conveniently and rapidly obtaining effective information of biomarkers in the detected object.
Description
Technical field
The present invention relates to biomarker detection field, relate to variable in particular and intervene formula biomarker concentration detection method and device.
Background technology
Biomarker (Biomarker) refers to can Mk system, organ, tissue, cell and subcellular structure or the change of function or the biochemical indicator of contingent change, has purposes widely.Biomarker can be used for medical diagnosis on disease, judges staging or be used for evaluating new drug or the safety and efficacy of new treatment in target group.When detecting biomarker, commonly use surface plasma resonance technology SPR (Surface Plasmon Reson × ance), namely utilize the total reflection of metal film/liquid level interface light to connect a kind of physical optics phenomenon caused and carry out analysing biomolecules interaction, and measure biomarker concentration by infrared light in conjunction with SPR technique, specifically can refer to paper " application of surface plasma resonance technology in biomedicine "-Peking University's biomedical engineering 2004 grades of Zhang Rui Bin (10403048), and paper " application of surface plasma body resonant vibration immunosensor in protein detection and progress thereof "-" analytical chemistry " the 7th phase 1052-1059 in 2010.
At biomarker detection field, photometric method is the method comparatively commonly used, it is by mixing the component of the humoral specimen of human body with one or more testing reagents in vitro, repeatedly determine the concentration of analyte, cause biochemical reaction thus, this makes the optical characteristics of measured object that the change that can survey occur, photometric method detect and utilize light stream to pass light absorptive and/or the medium of astigmatism time the weakening of generation, but, this measuring method is owing to being subject to the type of sample itself and the impact of its interference material that may comprise, cause the easy generation systems mistake when measuring, make the measurement result of the concentration to biomarker not accurate enough, and, be difficult to control in the adjustment of measuring time flow path direction, often bring great puzzlement to gauger.As shown in fig. 1, when using optical detection unit 700 (will Optical Receivers be adopted in the present invention) to receive the light beam of sensing chip place injection, the spectrum with dark space can be formed above it, it can export electric signal simultaneously, when passing into the material in flow channel and being different, the position of spectrum can be different along with the existence of biomarker in material, and this positional information is extremely difficult to measure determine.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides that a kind of the variable of biomarker concentration intervenes formula biomarker concentration detection method, device fast, in Obtaining Accurate determinand.
The present invention for solving the problems of the technologies described above adopted technical scheme is: variable intervenes formula biomarker concentration detection method, comprise the following steps, Optical Receivers receives light beam, forms spectrum, and export electric signal Qn, set the null value Q0 that it exports electric signal; Introduce and intervene variables A n, by intervening the position of the spectrum that variable adjustment Optical Receivers is formed, adjust the electric signal output valve of Optical Receivers, each intervenes the electric signal output valve Qn of the corresponding Optical Receivers of variate-value An simultaneously; Variables A n and the corresponding relation detecting biomarker concentration Bn in thing are intervened in setting, and variables A n to Am is intervened in adjustment, makes Qn=Q0, and biomarker concentration Bm corresponding to variables A m is intervened in inquiry, obtains the concentration detecting biomarker in thing; Above-mentioned, n, m are natural number, and n>m.
Intervene formula biomarker concentration detection method for the variable in the present invention, as further setting, described intervention variables A n=A+n × a, wherein, A is definite value, and a is the single adjusting range of intervening variable, and n is natural number.
Formula biomarker concentration detection method is intervened for the variable in the present invention, as a kind of situation that may occur in actual measurement, there is trickle change in biomarker concentration in measured determinand, and the concentration value Bm of the intervention variate-value Am after described Optical Receivers exports the null value Q0 of electric signal, adjustment and the biomarker of gained is interval value.
Intervene formula biomarker concentration detection method for the variable in the present invention, described intervention variables A n is the controlling of change, recordable curtage.
A kind of variable intervenes formula biomarker concentration detection device, comprise Optical Receivers, gear train, regulating device and control system, described Optical Receivers, regulating device are connected with described gear train respectively, and described control system receives the electrical signal information also corresponding regulating and controlling device motion that Optical Receivers exports.
Formula biomarker concentration detection device is intervened for the variable in the present invention, as a kind of optional embodiment for gear train and regulating device, described gear train comprises intermeshing rack and pinion, described regulating device comprises coil, magnet and base, described tooth bar is fixed on described Optical Receivers, described gear being rotatable be fixed on described base, described coil is fixed on described gear train, described magnet is near described coil, after making in described coil energising its can be driven by described gear train under the effect of described magnet described in Optical Receivers motion.
Intervene formula biomarker concentration detection device for the variable in the present invention, as the further setting of a kind of embodiment of above-mentioned gear train, it also comprises axle, and described geared sleeve is on described axle, and described axle is fixed on base.
Formula biomarker concentration detection device is intervened for the variable in the present invention, as a kind of optional embodiment for gear train and regulating device, described gear train comprises intermeshing worm gear and worm screw, described regulating device comprises coil, magnet and base, described worm screw is fixed on described Optical Receivers, described worm gear is rotating to be fixed on described base, described coil is fixed on described gear train, described magnet is near described coil, after making in described coil energising its can be driven by described gear train under the effect of described magnet described in Optical Receivers motion.
Intervene formula biomarker concentration detection device for variable above-mentioned in the present invention, as further setting, it also comprises spring, and described Optical Receivers is by described spring supporting.
Intervene formula biomarker concentration detection device for variable above-mentioned in the present invention, as further setting, described gear train is also provided with balance device, described balance device and described coil are distributed in the both sides of described gear train.
Intervene formula biomarker concentration detection device for variable above-mentioned in the present invention, as the optimal selection for magnet, described magnet is neodium magnet.
The technique effect that the present invention brings is: the present invention uses variable to intervene formula biomarker concentration detection method and adopts Optical Receivers reception special spectrum information, form spectrum, and set null position, by intervening the spectral position of variable adjustment determinand on Optical Receivers, calculated the concentration value information of the biomarker in determinand by this intervention variable correspondence, the concentration of the biomarker in determinand can be detected easily and fast, accurately; Variable in the present invention intervenes formula biomarker concentration pick-up unit, the adjustment of Optical Receivers is driven by recordable intervention Variable Control gear train, thus the position of spectrum on adjustment Optical Receivers, and obtain spectral position change information, when the electric signal that it exports be initially to time can draw the concentration detecting biomarker in thing accordingly, its structure is simple, cost of manufacture is cheap, and very easy to use, precisely can obtain the concentration detecting biomarker in thing fast.
Accompanying drawing explanation
Fig. 1 is the fundamental diagram of the surface plasma resonance technology that the present invention relates to;
Fig. 2 is the workflow diagram of the variable intervention formula biomarker concentration detection method in invention;
Fig. 3 is the corresponding relation mapping table that the variable in the present invention intervenes between the intervention variables A n of formula biomarker concentration detection method, the electric signal output valve Qn of Optical Receivers and biomarker concentration Bn;
Fig. 4 is the one-piece construction schematic diagram of the variable intervention formula biomarker concentration pick-up unit in the present invention.
Embodiment
For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly described, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Fig. 1 is the fundamental diagram of the surface plasma resonance technology that the present invention relates to, it is prior art, as shown in the figure, surface plasma resonance technology is utilized to detect the process of biomarker concentration, first, a flow channel 300 and sensing chip 400 are set, sensing chip 400 arranges one deck gold film, and the face portion making sensing chip 400 be provided with golden film is arranged in flow channel 300, make the thing to be detected flowed in flow channel 300 can touch sensing chip 400 with golden film, during measurement, thing to be detected with biomarker is passed into flow channel 300, thing to be detected is contacted with sensing chip, one deck antibody molecule is modified in advance in reaction interface, when after target antigen and antibody recognition, the refractive index of gold film surface dielectric changes, SPR resonance angle can change along with the change of refractive index, the change of refractive index again be combined in metal surface biomacromolecule quality be changing into direct ratio, large young pathbreaker's reflection of resonance peak displacement is fixed on the change of metal surface biotinylated molecular weight, and then realize immunoassay.In FIG, light beam is sent by light source 600, be irradiated on sensing chip 400, received by optical detection unit 700 (optical detection unit 700 will be substituted with Optical Receivers in the present invention) after its reflection, the change of the beam information received by it is responded to by optical detection unit 700, draw the corresponding relation of this change information and thing biomarker concentration to be detected, finally from this change information, draw biomarker concentration value in thing to be detected.For light source 600, can adopt monochromatic source, such as infrared beams light source, effect is better.
Variable in the present invention intervenes the process flow diagram of formula biomarker concentration detection method as shown in Figure 2, and it comprises following treatment step: S1, Optical Receivers receive light beam and export electric signal, sets the null value Q0 that it exports electric signal; Variables A n is intervened in S2, introducing, makes each intervene the electric signal output valve Qn of the corresponding Optical Receivers of variate-value An; Variables A n and the corresponding relation detecting biomarker concentration Bn in thing are intervened in S3, setting, and variables A n to Am is intervened in adjustment, makes Qn=Q0; The concentration Bm of biomarker corresponding to variables A m is intervened in S4, inquiry, namely obtains the concentration detecting biomarker in thing.Above-mentioned detailed process is: adopt Optical Receivers to receive light beam, spectrum can be formed above it, and export electric signal Qn, set the null value Q0 that it exports electric signal, the value of electrical signals of this null value for exporting after not receiving light beam containing Optical Receivers during biomarker in the thing to be detected that passes into, variables A n is intervened in setting afterwards, intervene the position that variable is used for adjusting the spectrum that Optical Receivers is formed, adjust the electric signal output valve of Optical Receivers simultaneously, intervention variable herein, it can be the variable quantity changing the drive current of the incident angle being irradiated to light beam on Optical Receivers or voltage etc., also can be the variable quantity of the curtage of the device of adjustment Optical Receivers position etc., each intervenes the electric signal output valve Qn of the corresponding Optical Receivers of variate-value An, variables A n and the corresponding relation detecting biomarker concentration Bn in thing are intervened in setting, owing to intervening variables A n, the position of the spectrum that Optical Receivers is formed is adjusted, the location overlap of the position being made the spectrum of light beam on Optical Receivers from sensing chip injection of detection thing by adjustment and the spectrum of detection thing on Optical Receivers not containing the biomarker that will detect to some extent, and the concrete condition of adjustment is determined by the value of electrical signals that Optical Receivers exports, when variables A n to Am is intervened in adjustment, make Qn=Q0, now only need inquire about and intervene biomarker concentration Bm corresponding to variables A m, the concentration detecting biomarker in thing can be obtained, above-mentioned n, m is natural number, and n>m.
The present invention is further, variables A n is intervened for the ease of regulating, described intervention variables A n can be carried out concrete refinement to arrange, such as make An=A+n × a, wherein, A is definite value, can be current value or magnitude of voltage etc. that zero also can be setting, a is that the single adjusting range of intervening variable (when for electric current, can be 0.01mA; When for voltage, can be 0.01mV etc., like this), the value of a is determined according to the accuracy requirement of detection system, and when detection system measuring accuracy requires higher, a should exhaust may the little and value that can realize, to meet the measuring accuracy requirement of measuring system, n is natural number.
Fig. 3 is the intervention variables A n of the variable intervention formula biomarker concentration detection method in the present invention, corresponding relation mapping table between the electric signal output valve Qn of Optical Receivers and biomarker concentration Bn, as shown in the figure, it is the concrete records of values after repeatedly regulating in the list of intervention variables A n, the value of electrical signals Qn that Optical Receivers exports changes the corresponding concrete numerical value drawn with it after intervening variables A n change, the numerical value of the biomarker Bn corresponding with said two devices also can antecedent be good in advance, when measuring, repeatedly can regulate An, by the time Optical Receivers Qn export value of electrical signals Qm=Q0 time, the intervention variables A m that record is corresponding, the concentration Bm of biomarker corresponding to (or calculating) can be found from above-mentioned table.
In the present invention, Optical Receivers exports the null value Q0 of electric signal, the concentration value Bm of the intervention variate-value Am after adjustment and the biomarker of gained all can be interval value, because, for the content of the various compositions detected in thing, after accuracy of detection acquires a certain degree, the determinand detected in thing there will be floating to a certain degree in flow process, in the present invention, determinand is in testing process, certain floatability is there is because antibody is combined with antigen, this makes its light beam also there will be the change of trace, therefore the null value of the electric signal of Optical Receivers output may have floating (interval of the mathematical value of such as Q0 can be 0.0015-0.0016) among a small circle, therefore, the concentration value Bm of intervention variate-value Am related to this and the biomarker of correspondence all there will be the interval value similar with Q0, but, comparatively speaking, when the interval value that there is slight change is mapped with fixed-point values, the effect of the two is identical.
Variable in the present invention is intervened to the above-mentioned intervention variable of formula biomarker concentration detection method, as long as can reach, trace is adjustable to be recorded, such as, adopt the change of recordable micro-current, micro-voltage etc. to realize the adjustment of the spectral position on Optical Receivers.
There is provided a kind of device using electric current to regulate Optical Receivers below, but it should be noted that, the embodiment below enumerated is just based on the one of the above-mentioned principle of the present invention, and other interchangeable scheme is more, and the present invention will will not enumerate.
Variable intervenes the one-piece construction schematic diagram of formula biomarker concentration pick-up unit as shown in Figure 4, comprise Optical Receivers 3, spring 4, gear 7, coil 9, magnet 10 and control system (not shown), one end of batten 2 is fixed in hinged mode, the other end is fixedly connected with tooth bar 6, a gear 7 is provided with on the side of tooth bar 6, gear 7 and tooth bar 6 are in engagement, gear 7 is rotating to be fixed on axle 8, axle 8 is fixed on support 11, conveniently stationary rack 6 on Optical Receivers 3, Optical Receivers 3 can be arranged on (but batten 2 also can save) on a batten 2, then tooth bar 6 is set on batten 2.Coil 9 is fixed on gear 7, and magnet 10 is positioned at coil 9 side, when passing into electric current during control system is to coil 9, the magnetic field that magnet 10 produces can make coil 9 rotate, thus driven gear 7 moves, the position of adjustment Optical Receivers 3, makes the position of the spectrum above it change.
As shown in Figure 4, tooth bar 6 and gear 7 are in engagement, and when rotating under the effect of gear 7 in external force, tooth bar 6 rotates along with the rotation of gear 7, thus drives Optical Receivers 3 to move.In order to control/rotation of adjusting gear 7, gear 7 is fixed a closed coil 9, this coil 9 will extend the body of gear 7, and the segment distance that stretches out, the magnet be fixed wtih 10 is being set with coil 9 side, a part for coil 9 is overlapping with magnet 10, like this, when passing into electric current on coil 9, the coil 9 being in closure state forms a closed loop, when having electric current to pass through in the loop that this is closed, himself produces magnetic field under electromagnetic induction effect, have an effect power each other in the magnetic field that coil 9 produces and the magnetic field of magnet 10, now, control system changes the size of current/direction passed in coil 9 can change the magnetic field intensity and magnetic direction that coil 9 produces, the size and Orientation in the magnetic field produced due to magnet 10 is fixing, therefore, when the size of current changed in coil 9 and/or direction, under the effect in the magnetic field of magnet 10, coil 9 rotates, because coil 9 is fixed on gear 7, therefore, when coil 9 starts to rotate, gear 7 rotates along with coil 9 and rotates, gear 7 engages with the rack structure on Optical Receivers 3 or tooth bar 6, therefore Optical Receivers 3 moves (being vertical direction motion in figure) along with the rotation of gear 7.
As shown in Figure 4, in order to improve the adjustment sensitivity of the horizontal sextant angle of Optical Receivers 3 further, Optical Receivers 3 connects a spring 4, the other end of spring 4 is fixed, set an initial position, make spring 4 whole device when this initial position be in a zero point, when needing the horizontal sextant angle adjusting Optical Receivers 3, can, by the elastic force of spring 4, Optical Receivers 3 be made to be more prone to return back to initial position.Above-mentioned detailed process shows as: when passing into electric current in coil 9, magnetic field is produced in coil, under the effect of magnet 10, coil 9 rotates around axle 8 under the mutual acting force in magnetic field, gear 7 also starts to rotate simultaneously, Optical Receivers 3 rise/fall under the rotation of gear 7, also start stretching/compressing spring 4 simultaneously, when Optical Receivers 3 need be made to return back to the position of initial position or required setting, control system changes accordingly and passes into size of current in coil 9 or direction, Optical Receivers 3 is when moving accordingly, spring 4 can provide convergent force or tensile force accordingly, make Optical Receivers 3 can be sensitiveer under the assistance of the acting force of spring 4, return back to initial position or desired location fast.
In the diagram, when arranging batten 2, one end of batten 2 is hinged being fixed wtih, and can adopt the multiple articulated mounting and hinged fixed form that comprise hinge, hinged ball etc. herein, namely only need guarantee that batten 2 can rotate with lower friction force around the strong point 1.
The shape of magnet 10 is in scheming, make its N pole and its S pole reasonable layout, make coil 9 can in the reach in magnet 10 magnetic field, move between the N pole and S pole of magnet 10, for magnet 10, in order to enough strong magnetic field can be produced, preferably use neodium magnet, stronger magnetic field can be obtained, the motion impelling the coil 9 after energising that can be powerful.
In order to improve the stability of coil 9 on gear 7, and improve the adjustment sensitivity of coil 9 further, gear 7 is fixed a balance device 5, this balance device 5 is arranged on gear 7, its position is corresponding with coil 9, namely balance device 5 and coil 9 is made to lay respectively at the both sides of gear, and make both it, to be positioned at same level height, play certain equilibrium activity each other, at this, balance device 5 can be arranged to coiled type, its part can be made to extend gear 7, so the weight of balance device 5 can be alleviated, simultaneously, balance device 5 can also by self gravitation, under leverage, good equilibrium activity is played to the position height of coil 9, namely when coil 9 is subject to the magnetic field force of magnet 10 (only to refer to orientation in figure to up/down, actual direction is not limited thereto) motion time, under the effect of balance device 5, coil 9 need overcome very little power and just can break away from stationary state and move, same, when coil 9 being adjusted to initial position, only need overcome less resistance can realize, namely can realize adjusting the position of coil 9 without the need to significantly changing the electric current passed in coil 9.
For the axle 8 in Fig. 3, it can be fixed by support 11, in the present invention, the bearing of the anchor portion of batten 2, the stiff end of spring 4 and support 11 is the platform with supporting role, such as: desk-top workbench or the support platform etc. be arranged in frame, but, also can set up a frame or shell, package unit is fixed on frame or shell.
For the rotating fixed form of gear 7 on axle 8, prior art can be adopted to solve, such as, can adopt and gear 7 is enclosed within the outer ring of bearing, make it can rotate around bearing, then the inner ring of bearing is fixed on axle 8, axle 8 is fixed on support 11; In addition, gear 7 also directly can use Bearing gear, it is directly fixed on axle 8; Other existing mode be rotationally connected, as hinged, socket, etc. can realize gear 7 rotatably fixing all of the present invention can within practical range.
It should be noted that, variable in the present invention is intervened formula biomarker concentration pick-up unit and is implemented to be not limited to above-mentioned embodiment, such as, wherein realize the gear 7 that Optical Receivers 3 moves and the tooth bar 6 engaged with it, can by intermeshing turbine, worm screw or the nut of installation can be socketed, screw rod carries out entirety and replaces, and is modified in the position of required change on demand accordingly, such as, can worm screw or nut be fixed on Optical Receivers 3, worm gear or nut are fixed on base, other art for those skilled in the art and in conjunction with existing mechanical field common practise all very easyly can make above-mentioned variation, here illustrate no longer one by one, and in the present invention, the position of spring 4 is also not limited to the position shown in figure, also can be moved near the strong point 1, and the action effect of such spring 4 may be better.
By reference to the accompanying drawings the specific embodiment of the present invention is explained in detail above, but the present invention is not limited to above-mentioned embodiment, in the ken that those skilled in the art possess, various change can also be made under the prerequisite not departing from present inventive concept.
Claims (10)
1. variable intervenes formula biomarker concentration detection method, it is characterized in that: Optical Receivers receives light beam, forms spectrum, and exports electric signal Qn, sets the null value Q0 that it exports electric signal; Introduce and intervene variables A n, by intervening the position of the spectrum that variable adjustment Optical Receivers is formed, adjust the electric signal output valve of Optical Receivers, each intervenes the electric signal output valve Qn of the corresponding Optical Receivers of variate-value An simultaneously; Variables A n and the corresponding relation detecting biomarker concentration Bn in thing are intervened in setting, and variables A n to Am is intervened in adjustment, makes Qn=Q0, and biomarker concentration Bm corresponding to variables A m is intervened in inquiry, obtains the concentration detecting biomarker in thing;
Above-mentioned, n, m are natural number, and n>m.
2. variable according to claim 1 intervenes formula biomarker concentration detection method, and it is characterized in that: described intervention variables A n=A+n × a, wherein, A is definite value, and a is the single adjusting range of intervening variable, and n is natural number.
3. variable according to claim 1 intervenes formula biomarker concentration detection method, it is characterized in that: the concentration value Bm of the intervention variate-value Am after described Optical Receivers exports the null value Q0 of electric signal, adjustment and the biomarker of gained is interval value.
4. variable according to any one of claim 1-3 intervenes formula biomarker concentration detection method, it is characterized in that: described intervention variables A n is the controlling of change, recordable curtage.
5. a variable intervenes formula biomarker concentration detection device, it is characterized in that: comprise Optical Receivers, gear train, regulating device and control system, described Optical Receivers, regulating device are connected with described gear train respectively, and described control system receives the electrical signal information also corresponding regulating and controlling device motion that Optical Receivers exports.
6. variable according to claim 5 intervenes formula biomarker concentration detection device, it is characterized in that: described gear train comprises intermeshing tooth bar (6) and gear (7), described regulating device comprises coil (9), magnet (10) and base (11), described tooth bar (6) is fixed on described Optical Receivers (3), described gear (7) is rotating to be fixed on described base (11), described coil (9) is fixed on described gear train, described magnet (10) is near described coil (9), rear its of energising in described coil (9) can be moved by the Optical Receivers (3) described in the drive of described gear train under the effect of described magnet (10).
7. variable according to claim 6 intervenes formula biomarker concentration detection device, it is characterized in that: described gear train also comprises axle (8), described gear (7) is enclosed within described axle (8), and described axle (8) is fixed on base (11).
8. variable according to claim 6 intervenes formula biomarker concentration detection device, it is characterized in that: described gear train comprises intermeshing worm gear and worm screw, described regulating device comprises coil (9), magnet (10) and base (11), described worm screw is fixed on described Optical Receivers (3), described worm gear is rotating to be fixed on described base (11), described coil (9) is fixed on described gear train, described magnet (10) is near described coil (9), rear its of energising in described coil (9) can be moved by the Optical Receivers (3) described in the drive of described gear train under the effect of described magnet (10).
9. the variable according to any one of claim 5-8 intervenes formula biomarker concentration detection device, it is characterized in that: described variable is intervened formula biomarker concentration detection device and also comprised spring (4), and described Optical Receivers (3) is supported by described spring (4).
10. variable according to claim 9 intervenes formula biomarker concentration detection device, it is characterized in that: on described gear train, be also provided with balance device (5), described balance device (5) and described coil (9) are distributed in the both sides of described gear train.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510131626.0A CN104749118B (en) | 2015-03-25 | 2015-03-25 | Variable intervenes formula biomarker concentration detection method and device |
| PCT/CN2015/077441 WO2016149980A1 (en) | 2015-03-25 | 2015-04-24 | Variable invasive biomarker concentration testing method and apparatus |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510131626.0A CN104749118B (en) | 2015-03-25 | 2015-03-25 | Variable intervenes formula biomarker concentration detection method and device |
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| CN104749118A true CN104749118A (en) | 2015-07-01 |
| CN104749118B CN104749118B (en) | 2018-06-19 |
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| WO (1) | WO2016149980A1 (en) |
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| CN201075777Y (en) * | 2007-08-31 | 2008-06-18 | 上海世科嘉车辆技术研发有限公司 | Electric angle regulating system of rear view mirror single electric machine |
| CN103984091A (en) * | 2013-11-21 | 2014-08-13 | 苏州浩创信息科技有限公司 | Scanner oscillating mirror apparatus |
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| WO2016149980A1 (en) | 2016-09-29 |
| CN104749118B (en) | 2018-06-19 |
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