CN104768944B - 2‑吡啶酮化合物 - Google Patents

2‑吡啶酮化合物 Download PDF

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Publication number
CN104768944B
CN104768944B CN201380059272.2A CN201380059272A CN104768944B CN 104768944 B CN104768944 B CN 104768944B CN 201380059272 A CN201380059272 A CN 201380059272A CN 104768944 B CN104768944 B CN 104768944B
Authority
CN
China
Prior art keywords
compound
medicine
cyclopropyl
phenyl
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380059272.2A
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English (en)
Chinese (zh)
Other versions
CN104768944A (zh
Inventor
黑田翔
黑田翔一
今井佑大
河口尚则
伏木启子
坊野匡宏
浅沼肇
长南具通
佐藤长明
门马壮
门马壮一
笹子滋正
水谷茉莉衣
伊藤晋
冈田匠
太田博史
石山圣志
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Original Assignee
Nissan Chemical Corp
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp, Taisho Pharmaceutical Co Ltd filed Critical Nissan Chemical Corp
Publication of CN104768944A publication Critical patent/CN104768944A/zh
Application granted granted Critical
Publication of CN104768944B publication Critical patent/CN104768944B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
CN201380059272.2A 2012-11-13 2013-11-12 2‑吡啶酮化合物 Expired - Fee Related CN104768944B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012249792 2012-11-13
JP2012-249792 2012-11-13
PCT/JP2013/080517 WO2014077235A1 (ja) 2012-11-13 2013-11-12 ２－ピリドン化合物

Publications (2)

Publication Number Publication Date
CN104768944A CN104768944A (zh) 2015-07-08
CN104768944B true CN104768944B (zh) 2017-03-29

Family

ID=50731146

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380059272.2A Expired - Fee Related CN104768944B (zh) 2012-11-13 2013-11-12 2‑吡啶酮化合物

Country Status (25)

Country Link
US (1) US9695148B2 (cg-RX-API-DMAC10.html)
EP (1) EP2921489B1 (cg-RX-API-DMAC10.html)
JP (1) JP5963025B2 (cg-RX-API-DMAC10.html)
KR (1) KR102160841B1 (cg-RX-API-DMAC10.html)
CN (1) CN104768944B (cg-RX-API-DMAC10.html)
AU (1) AU2013345930B2 (cg-RX-API-DMAC10.html)
BR (1) BR112015010823A2 (cg-RX-API-DMAC10.html)
CA (1) CA2891406C (cg-RX-API-DMAC10.html)
DK (1) DK2921489T3 (cg-RX-API-DMAC10.html)
ES (1) ES2641469T3 (cg-RX-API-DMAC10.html)
HU (1) HUE034557T2 (cg-RX-API-DMAC10.html)
IL (1) IL238701B (cg-RX-API-DMAC10.html)
IN (1) IN2015DN03869A (cg-RX-API-DMAC10.html)
MX (1) MX361479B (cg-RX-API-DMAC10.html)
MY (1) MY173812A (cg-RX-API-DMAC10.html)
NO (1) NO2921489T3 (cg-RX-API-DMAC10.html)
NZ (1) NZ707832A (cg-RX-API-DMAC10.html)
PH (1) PH12015501056B1 (cg-RX-API-DMAC10.html)
PL (1) PL2921489T3 (cg-RX-API-DMAC10.html)
PT (1) PT2921489T (cg-RX-API-DMAC10.html)
RU (1) RU2662157C2 (cg-RX-API-DMAC10.html)
SG (1) SG11201503716RA (cg-RX-API-DMAC10.html)
TW (1) TWI591064B (cg-RX-API-DMAC10.html)
WO (1) WO2014077235A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201503323B (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6048533B2 (ja) * 2014-05-12 2016-12-21 日産化学工業株式会社 ２−ピリドン化合物を含有する医薬
JPWO2015174377A1 (ja) * 2014-05-13 2017-04-20 日産化学工業株式会社 ２−ピリドン化合物の製造方法
BR112020024269A2 (pt) * 2018-05-31 2021-02-23 Hua Medicine (Shanghai) Ltd. combinação farmacêutica, composição e formulação de combinação contendo ativador de glucoquinase e ativador de receptor ppar e métodos de preparação e usos dos mesmos

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011068211A1 (ja) * 2009-12-04 2011-06-09 大正製薬株式会社 ２－ピリドン化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275069A (en) 1979-01-22 1981-06-23 The Upjohn Company Anti-diabetic 1,2-dihydro-2-oxo-6-alkyl-nicotinic acids
HK1046139B (zh) 1999-03-29 2004-12-10 霍夫曼-拉罗奇有限公司 葡糖激酶活化剂
US6353111B1 (en) 1999-12-15 2002-03-05 Hoffmann-La Roche Inc. Trans olefinic glucokinase activators
UA95480C2 (uk) 2006-06-08 2011-08-10 Елі Ліллі Енд Компані Заміщені карбоксаміди
JP5419706B2 (ja) 2006-12-20 2014-02-19 タケダ カリフォルニア インコーポレイテッド グルコキナーゼアクチベーター
PL2170864T3 (pl) * 2007-07-17 2012-02-29 Bristol Myers Squibb Co Agoniści receptora gpr119 sprężonego z białkiem g - pirydon
CA2729581A1 (en) 2008-07-29 2010-02-04 Pfizer Inc. Fluorinated heteroaryls
JP2013010750A (ja) * 2011-06-02 2013-01-17 Taisho Pharmaceutical Co Ltd ２−ピリドン化合物を含有する医薬

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011068211A1 (ja) * 2009-12-04 2011-06-09 大正製薬株式会社 ２－ピリドン化合物

Also Published As

Publication number Publication date
WO2014077235A1 (ja) 2014-05-22
MX2015005884A (es) 2015-12-09
EP2921489B1 (en) 2017-09-06
IN2015DN03869A (cg-RX-API-DMAC10.html) 2015-10-02
JPWO2014077235A1 (ja) 2017-01-05
NO2921489T3 (cg-RX-API-DMAC10.html) 2018-02-03
BR112015010823A2 (pt) 2017-07-11
JP5963025B2 (ja) 2016-08-03
PH12015501056A1 (en) 2015-07-27
MX361479B (es) 2018-12-06
TWI591064B (zh) 2017-07-11
TW201434826A (zh) 2014-09-16
ZA201503323B (en) 2016-08-31
PL2921489T3 (pl) 2018-01-31
PT2921489T (pt) 2017-12-01
RU2015122717A (ru) 2017-01-10
CA2891406C (en) 2021-03-16
AU2013345930A1 (en) 2015-06-04
SG11201503716RA (en) 2015-06-29
CN104768944A (zh) 2015-07-08
US9695148B2 (en) 2017-07-04
NZ707832A (en) 2019-03-29
US20160289208A1 (en) 2016-10-06
HK1207856A1 (en) 2016-02-12
HUE034557T2 (en) 2018-02-28
AU2013345930B2 (en) 2017-08-24
ES2641469T3 (es) 2017-11-10
PH12015501056B1 (en) 2015-07-27
RU2662157C2 (ru) 2018-07-24
MY173812A (en) 2020-02-24
KR102160841B1 (ko) 2020-09-28
EP2921489A4 (en) 2016-04-06
KR20150082301A (ko) 2015-07-15
CA2891406A1 (en) 2014-05-22
IL238701A0 (en) 2015-06-30
DK2921489T3 (en) 2017-10-16
IL238701B (en) 2018-10-31
EP2921489A1 (en) 2015-09-23

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