CN104758705A - Traditional Chinese medicine composition for treating chronic glomerulo nephritis and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic glomerulo nephritis. The traditional Chinese medicine composition is prepared from the following main raw materials in parts by weight: 10-15 parts of cornus officinalis, 12-17 parts of fructus forsythia, 8-13 parts of Japanese cayratia herb, 9-15 parts of rhizoma alismatis, 7-12 parts of delavay greenleaf elaeagnus leaves, 9-13 parts of stephania terandra, 7-13 parts of Philippine flemingia roots, 6-10 parts of golden cypress, 9-16 parts of christia obcordata, 12-18 parts of Chinese yams, 10-15 parts of corn stigma, 8-14 parts of herb of big striga, 12-17 parts of nightshades and 13-16 parts of lalang grass rhizome. The composition disclosed by the invention is prepared from various traditional Chinese medicinal materials which are reasonably combined and good in synergic effect, and can be used for changing the interior environment of the human body and eliminating toxic substances in the blood.

Description

The Chinese medicine composition for the treatment of chronic nephritis and preparation method

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine composition and preparation method for the treatment of chronic nephritis.

Background technology

Chronic glomerulonephritis, being called for short chronic nephritis, is a kind of allergic disease of streptococcal infection.Chronic nephritis morbidity minority is caused by acute nephritis protracted course of disease, and most onset is chronic.There is acute nephritis history in some patients with chronic glomerulonephritis past, nephritis symptom has disappeared for many years, think by mistake and fully recover, after in fact suffering from nephritis, kidney sustains damage and is continuing slowly to carry out always, after the several years, nephropathy damaged degree is more and more heavier, and renal function progressively declines, the symptom of its nephritis occurs again, becomes chronic glomerulonephritis.And the renal inflammation of majority from be invisible, patient is without the performance of obvious acute glomerulonephritis, but inflammation is in slowly development, after the several years, become chronic glomerulonephritis.

The clinical main manifestations of chronic nephritis has the symptoms such as edema, hypertension, albuminuria and hematuria, and because pathological change is various, Symptoms is different.May uremia be there is in severe patient.Chronic nephritis is changed by acute nephritis, is a kind of common chronic kidney disease, more with male patient, the course of disease continue more than 1 year, age of onset mostly 20-40 year.Acute nephritis onset is anxious, is the most common with edema, hematuria symptom.Chronic nephritis performance is different, and some non-evident symptons, what have has obvious hematuria, edema, hypertension, and has malaise, poor appetite abdominal distention, anemia etc.Most of patients is that Progressive symmetric erythrokeratodermia increases the weight of, but the symptom of some patient can partly or entirely be alleviated, and the course of disease reaches 20-30.If blood pressure continues to raise, the diseases such as visible dizzy, uncomfortable in chest, the blurred vision of having a headache.Clinical manifestation is in variation, and early stage patient can non-evident sympton, and also only can show as urine protein increases, Urine sediments analyzer erythrocytosis, visible cast.Sometimes accompany weak, asthenia, the soreness of waist, inappetence, edema to cut in and out, mostly be blepharoedema or lower limb pitting edema.Detection of glomeruli filtration function and renal tubules function of concentration and dilution normal or slightly impaired.Some patients can show as the moderate above hypertension of persistence, can occur retinal hemorrhage, ooze out, even papilloedema.Some patients can show as High-grade Proteinuria (urine protein > 3.5g/24h), the even performance in nephrotic syndrome.

The Measures compare of existing Chinese traditional treatment chronic nephritis is many, for the problems referred to above, publication number CN 102940766 A (application number 201210381352.7) patent document discloses a kind of Chinese medicine for the treatment of chronic nephritis, be made up of following component, the weight portion of each component is: Radix Ginseng Rubra 1-3, Radix Panacis Quinquefolii 3-5, white drum nail 10-12, Radix Notoginseng 3-5, Radix Angelicae Sinensis 8-10, Rhizoma Chuanxiong 5-8, Hirudo 3-5, Pericarppium arachidis hypogaeae 10-12, Herba Eupatorii 5-8, Herba Ludwigiae Prostratae 5-8, Fructus Crataegi (parched to brown) 10-12, Poria 10-12, Flos Camelliae Japonicae 5-8, Fructus Lycii 18-21, Bulbus Lilii 8-10, Herba Houttuyniae 10-12, Rhizoma Pinelliae Preparata 5-8.Publication number CN 103285307 A(application number 201310231939.4) patent document discloses a kind of Chinese medicine for the treatment of chronic nephritis, Pseudobulbus Bletillae (Rhizoma Bletillae) 0-30g is made by the material medicine of following weight, Endothelium Corneum Gigeriae Galli 0-15g, Fructus Citri 0-25g, Radix Angelicae Sinensis 0-15g, Rhizoma Chuanxiong 0-15g, Semen Persicae 5-15g, Sanguis Draxonis 0-10g, Rhizoma Corydalis 0-30g, Oletum Trogopterori 0-8g, Cortex Cinnamomi 0-28g, Radix Glycyrrhizae Preparata 0-30g, Radix Pseudostellariae 0-20g, Fructus Gardeniae 5-25g, Fructus Aurantii 3-30g, Fructus Forsythiae 0-30g, Periostracum Cicadae 0-15g, Bombyx Batryticatus 0-18g, Rhizoma Alpiniae Officinarum 0-20g, Herba Pogostemonis 0-35g, Herba Eupatorii 0-18g, Pericarpium Citri Reticulatae 0-20g, Rhizoma Pinelliae 0-15g, Radix Aucklandiae 0-15g, Fructus Amomi 0-15g.Publication number CN103520319A (application number 201310493719.9) patent document discloses a kind of Chinese medicine for the treatment of chronic nephritis, it is made up of the raw material of following weight parts proportioning: the Radix Astragali 45 parts, Radix Codonopsis 15 parts, Radix Salviae Miltiorrhizae 30 parts, each 15 parts of Semen Persicae, Flos Carthami, Radix Paeoniae Rubra, each 10 parts of Herba Leonuri, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis.

Current treatment chronic nephritis many employings Western medicine, Western medicine can mitigate the disease to a certain extent, but easily recurs, and easily occurs the symptoms such as anemia, severe hypertension, nausea and vomiting to the later stage, finally develops into uremia.Current Chinese medicine also exists that effect is bad, take effect the problem such as slow, effectively can not alleviate weak, edema, urine protein, renal dysfunction.

Summary of the invention

For the deficiency of existing treatment chronic nephritis, an object of the present invention is to provide a kind of Chinese medicine composition for the treatment of chronic nephritis, has antiinflammatory diuresis, heat-clearing and toxic substances removing, and spleen invigorating profit kidney, the effect of tonifying Qi of the kidney, treatment chronic nephritis is evident in efficacy.Another object is just to provide the preparation method of above-mentioned Chinese medicine composition.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

The Chinese medicine composition for the treatment of chronic nephritis, takes off the primary raw material stating weight proportion and is prepared from: Fructus Corni 10-15 part; Fructus Forsythiae 12-17 part; Herba Cayatiae Japonicae 8-13 part; Rhizoma Alismatis 9-15 part; Folium Elaeagni delavayi 7-12 part; Radix Stephaniae Tetrandrae 9-13 part; Radix Flemingiae Philippinensis 7-13 part; Cortex Phellodendri 6-10 part; Herba Christiae Obcordatae 9-16 part; Rhizoma Dioscoreae 12-18 part; Stigma Maydis 10-15 part; Herba Strigae masuriae 8-14 part; Herba Solani Nigri 12-17 part; Rhizoma Imperatae 13-16 part.

The Chinese medicine composition for the treatment of chronic nephritis, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Fructus Corni 11-14 part; Fructus Forsythiae 13-15 part; Herba Cayatiae Japonicae 9-12 part; Rhizoma Alismatis 11-13 part; Folium Elaeagni delavayi 8-10 part; Radix Stephaniae Tetrandrae 11-12 part; Radix Flemingiae Philippinensis 9-11 part; Cortex Phellodendri 7-9 part; Herba Christiae Obcordatae 11-14 part; Rhizoma Dioscoreae 14-16 part; Stigma Maydis 11-14 part; Herba Strigae masuriae 10-12 part; Herba Solani Nigri 14-16 part; Rhizoma Imperatae 14-15 part.

The Chinese medicine composition for the treatment of chronic nephritis, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Fructus Corni 12 parts; Fructus Forsythiae 14 parts; Herba Cayatiae Japonicae 11 parts; Rhizoma Alismatis 12 parts; Folium Elaeagni delavayi 9 parts; Radix Stephaniae Tetrandrae 11.5 parts; Radix Flemingiae Philippinensis 10 parts; Cortex Phellodendri 8 parts; Herba Christiae Obcordatae 12 parts; Rhizoma Dioscoreae 15 parts; Stigma Maydis 12 parts; Herba Strigae masuriae 11 parts; Herba Solani Nigri 15 parts; Rhizoma Imperatae 14.5 parts.

Present invention also offers and above-mentioned Chinese medicine composition is made pharmaceutically acceptable powder, the preparation method of decoction, tablet, oral liquid and capsule.

The preparation method of the Chinese medicine composition composition powders of described treatment chronic nephritis, step is as follows:

(1) Herba Cayatiae Japonicae, Folium Elaeagni delavayi, Radix Flemingiae Philippinensis, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot to extract twice, first time adds 80% ethanol extraction 2 hours, second time add 80% ethanol extraction 1 hour, merge extractive liquid, concentrating under reduced pressure is relative density 1.10-1.20(60 DEG C) thick paste, dry, pulverize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 30-50 minute and take out, be placed in boiling water and scald 3-5 minute, pull out, wash away mucus with clear water, dry, pulverize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) by Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Radix Stephaniae Tetrandrae, Cortex Phellodendri and Rhizoma Imperatae mix homogeneously, dry, pulverize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) by step (1)-(3) gained fine powder mix homogeneously, sterile packaged.

According to preparation method recited above, when step (2) is preferably dried, temperature is 60-70 DEG C, and when being more preferably oven dry, temperature is 65 DEG C.

Instructions of taking: each 20-30g, takes after mixing it with water with warm water, every day 3 times, 5 days courses for the treatment of.

The preparation method of the Chinese medicine composition decoction of described treatment chronic nephritis, step is as follows:

(1) Folium Elaeagni delavayi, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot and extract twice, first time adds 80% ethanol extraction 2 hours, and second time adds 80% ethanol extraction 1 hour, merge extractive liquid;

(2) Herba Cayatiae Japonicae, Radix Stephaniae Tetrandrae and Radix Flemingiae Philippinensis are cut into slices, be placed in glass container, soak 3-5 hour, decoct twice, each 40-60 minute, merge twice filtrate;

(3) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 30-50 minute and take out, be placed in boiling water and scald 3-5 minute, pull out, mucus is washed away with clear water, dry (preferable temperature is 60-70 DEG C, and being more preferably temperature is 65 DEG C), pulverize, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Cortex Phellodendri and Rhizoma Imperatae are placed in marmite, add step (1) gained extracting solution and step (2) gained filtrate, decoct twice, boil at every turn and (preferably boil 25-35 minute in 20-40 minute at every turn, be more preferably and boil 30 minutes at every turn), twice filtrate merges, and leaves standstill 3-5 hour, gets supernatant, add step (3) gained fine powder, mix homogeneously, filters, sterile packaged.

Instructions of taking: each 200-300ml, every day 3 times, 5 days courses for the treatment of.

The preparation method of the Chinese medicine composition tablet of described treatment chronic nephritis, step is as follows:

(1) Folium Elaeagni delavayi, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot and extract twice, first time adds 80% ethanol extraction 2 hours, and second time adds 80% ethanol extraction 1 hour, merge extractive liquid;

(2) Herba Cayatiae Japonicae, Radix Stephaniae Tetrandrae and Radix Flemingiae Philippinensis are cut into slices, be placed in glass container, soak 3-5 hour, decoct twice, each 40-60 minute, merge twice filtrate;

(3) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 30-50 minute and take out, be placed in boiling water and scald 3-5 minute, pull out, mucus is washed away with clear water, dry (preferable temperature is 60-70 DEG C, and being more preferably temperature is 65 DEG C), pulverize, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Cortex Phellodendri and Rhizoma Imperatae are placed in marmite, add step (1) gained extracting solution and step (2) gained filtrate, decoct twice, boil at every turn and (preferably boil 25-35 minute in 20-40 minute at every turn, be more preferably and boil 30 minutes at every turn), twice filtrate merges, leave standstill 3-5 hour, get supernatant, add step (3) gained fine powder, mix homogeneously, being condensed into relative density is 1.10-1.20(45 DEG C) thick paste, make uniform granule, dry, be pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 5 days courses for the treatment of.

The preparation method of the Chinese medicine composition oral liquid of described treatment chronic nephritis, step is as follows:

(1) Folium Elaeagni delavayi, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot and extract twice, first time adds 80% ethanol extraction 2 hours, and second time adds 80% ethanol extraction 1 hour, merge extractive liquid;

(2) Herba Cayatiae Japonicae, Radix Stephaniae Tetrandrae and Radix Flemingiae Philippinensis are cut into slices, be placed in glass container, soak 3-5 hour, decoct twice, each 40-60 minute, merge twice filtrate;

(3) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 30-50 minute and take out, be placed in boiling water and scald 3-5 minute, pull out, mucus is washed away with clear water, dry (preferable temperature is 60-70 DEG C, and being more preferably temperature is 65 DEG C), pulverize, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) by Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Cortex Phellodendri and Rhizoma Imperatae are placed in marmite, add step (1) gained extracting solution and step (2) gained filtrate, decoct twice, boil at every turn and (preferably boil 25-35 minute in 20-40 minute at every turn, be more preferably and boil 30 minutes at every turn), twice filtrate merges, leave standstill 3-5 hour, get supernatant, add step (3) gained fine powder, be concentrated into 1/2 of original volume, add sodium benzoate, mixing, sterilize 10-20 minute (preferably sterilization 13-17 minute, be more preferably sterilization 15 minutes), sterile packaged is carried out with the dosage often propping up 6ml.

According to preparation method recited above, the consumption of step (4) preferred sodium benzoate is the 0.1%-0.3% of concentrated solution quality, and the consumption being more preferably sodium benzoate is 0.2% of concentrated solution quality.

Instructions of taking: each one, every day 3 times, 5 days courses for the treatment of.

The preparation method of the Chinese medicinal composition capsules of described treatment chronic nephritis, step is as follows:

(1) Folium Elaeagni delavayi, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot and extract twice, first time adds 80% ethanol extraction 2 hours, and second time adds 80% ethanol extraction 1 hour, merge extractive liquid;

(2) Herba Cayatiae Japonicae, Radix Stephaniae Tetrandrae and Radix Flemingiae Philippinensis are cut into slices, be placed in glass container, soak 3-5 hour, decoct twice, each 40-60 minute, merge twice filtrate;

(3) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 30-50 minute and take out, be placed in boiling water and scald 3-5 minute, pull out, mucus is washed away with clear water, dry (preferable temperature is 60-70 DEG C, and being more preferably temperature is 65 DEG C), pulverize, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Cortex Phellodendri and Rhizoma Imperatae are placed in marmite, add step (1) gained extracting solution and step (2) gained filtrate, decoct twice, boil at every turn and (preferably boil 25-35 minute in 20-40 minute at every turn, be more preferably and boil 30 minutes at every turn), twice filtrate merges, and leaves standstill 3-5 hour, get supernatant, add step (3) gained fine powder, being condensed into relative density is 1.10-1.20(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(5) step (4) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.

Using method: each 2-3 grain, every day 3 times, 5 days courses for the treatment of.

Beneficial effect of the present invention is mainly reflected in:

1, the present invention adopts several kinds of Chinese medicinal materials, dialectical compatibility, has antiinflammatory diuresis, heat-clearing and toxic substances removing, spleen invigorating profit kidney, and the effect of tonifying Qi of the kidney is evident in efficacy.

2, this compatibility of drugs is reasonable, and synergy is good, can change the internal environment of human body, gets rid of the noxious substance in blood.

3, the present invention for chronic nephritis treatment on evident in efficacy, good absorbing effect, drug effect holds length, and treatment cycle is short.

4, the present invention is pure Chinese medicinal preparation, has no side effect, and expense relative moderate, significantly reduces the burden of patient.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

The pharmacological effect of each raw material is respectively:

Fructus Corni: sour in the mouth, puckery, slightly warm in nature.Return liver, kidney channel.For the drying and ripening sarcocarp of Fructus Corni English section plant Fructus Corni.There is liver and kidney tonifying, effect of essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, sun is passed out semen repeatly, the enuresis, frequent micturition, bleeding not during menses, and profuse sweating is collapsed, and interior-heat is quenched one's thirst.

Fructus Forsythiae: bitter in the mouth, cold in nature.Return lung, the heart, small intestine meridian.For the dry fruit of Oleaceae plants Fructus Forsythiae.There is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, antibacterial, heart tonifying, diuresis, effect that town is told.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.

Herba Cayatiae Japonicae: bitter in the mouth, acid, cold in nature.GUIXIN, liver, stomach warp.For herb or the root of Vitaceae cayratia plant Herba Cayatiae Japonicae.Herb contains volatile oil, apigenin, luteolin, luteolin-7-O-glycoside, lupeol, cupreol, Palmic acid and arabinan, phlegmatic temperament, potassium nitrate, aminoacid etc.In root, prerun is containing alkaloid, tannin, starch, natural gum, phlegmatic temperament etc.There is clearing away heat-damp and promoting diuresis, effect of removing toxic substances and promoting subsidence of swelling.For pyretic toxicity carbuncle, furuncle, erysipelas, laryngopharynx swelling and pain, snake bite and insect sting, burn due to hot liquid or fire, rheumatic arthralgia, jaundice, dysentery, nebulousurine, hematuria.

Rhizoma Alismatis: sweet in the mouth, bitterly disappointed.Return kidney, urinary bladder channel.For the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.There is diuresis, effect of clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipidemia.

Folium Elaeagni delavayi: bitter in the mouth, acid, light, property is put down.Return lung, kidney, urinary bladder channel.For leaf and the root bark of Elaeangnaceae oleaster Folium Elaeagni delavayi.There is clearing away heat-damp and promoting diuresis, Tonglin Paishi, effect of relieving cough and asthma.For chronic nephritis, renal calculus, urinary tract infection, icterohepatitis, chronic bronchitis, bronchial asthma, stomachache.

Radix Stephaniae Tetrandrae: bitter in the mouth, cold in nature.Return bladder, spleen, kidney channel.For the dry root of menispermaceous plants Radix stephaniae tetrandrae.There is inducing diuresis to remove edema, wind-expelling pain-stopping, analgesia, antipyretic, antiinflammatory, of flaccid muscles, diuresis, antianaphylaxis shock and the effect reduced blood pressure.For edema beriberi, dysuria, eczema sore, rheumatic arthralgia, brothers' contraction is anxious, and flaccid pulmonary dyspnea is coughed, summer vomiting and diarrhea, and scabies skin ulcer swells, vascular hypertension.

Radix Flemingiae Philippinensis: sweet in the mouth, pungent, micro-puckery, property is put down.Return kidney, Liver Channel.For the root of pulse family Moghania plant Flemingia philippinensis.Containing multiple flavone compound, flemiphilippinin C, D, 5,7,3 ＇, 4 ＇-two prenyl isoflavones of tetrahydroxy-6,8-, Radix Flemingiae Philippinensis element D, lupeol, cupreol and carbon number are the positive alkanoic acid of 22-30.There is expelling wind and removing dampness, effect of promoting blood circulation and detoxication.For rheumatic arthralgia, lumbar muscle strain, extremity flaccidity is soft, traumatic injury, laryngopharynx swelling and pain.

Cortex Phellodendri: bitter in the mouth, cold in nature.Return kidney, urinary bladder channel.For the dry bark of rutaceae wampee.Have heat clearing and damp drying, pathogenic fire purging removes steams, effect of detoxification sore treatment.For inflammation damp-heat dysenteries such as acute bacillary dysentery, acute enteritis, acute icterohepatitis, urinary system infections, jaundice, pyretic stranguria, beriberi ， flaccidity of feet with lamenness, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.

Herba Christiae Obcordatae: bitter in the mouth, pungent, cold in nature.For the herb of pulse family Vespertilio grass platymiscium floor file Vespertilio grass.There is clearing away heat-damp and promoting diuresis, hemostasis, effect of removing toxic substances.For dysuria, stranguria caused by urinary stone, edema, leucorrhea, traumatic injury, spits blood, hemoptysis, metrorrhagia.Conjunctival congestion with ophthalmalgia, acute mastitis, venom.

Rhizoma Dioscoreae: sweet in the mouth, property is put down.Return spleen, lung, kidney channel.For the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Have spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, effect of the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst, anorexia and loose stool, and asthenia is breathed with cough, and quenches one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating, for insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.

Stigma Maydis: sweet in the mouth, light, property is put down.Return kidney, stomach, liver, gallbladder meridian.For the zeistic style of grass and stigma.Containing flavone and glycoside, sterol, alkaloid, saccharide, organic acid, volatile oil, trace element and multivitamin etc.There is inducing diuresis to remove edema, effect of liver heat removing function of gallbladder promoting.For edema, stranguria, nebulousurine, quenches one's thirst, jaundice, cholecystitis, cholelithiasis, hypertension, acute mastitis, galactostasis.

Herba Strigae masuriae: sweet in the mouth, light, cool in nature.For the herb of the large Herba Lobeliae Chinensis of Scrophulariaceae Herba Lobeliae Chinensis platymiscium.There is clearing away heat-damp and promoting diuresis, effect of spleen invigorating removing food stagnancy.For heat clearing away jaundice, dribbling urination, infantile malnutrition, inappetence.

Herba Solani Nigri: bitter in the mouth, micro-sweet, cold in nature.For the aerial parts of plant of Solanaceae Herba Solani Nigri.Containing solasonine, solamargine, β-solamargine etc.There is heat-clearing and toxic substances removing, effect of diuresis.For sore and toxic, skin eczema, dysuria, chronic senile tracheitis, leukorrhagia, prostatitis, dysentery.

Rhizoma Imperatae: sweet in the mouth, cold in nature.Return lung, stomach, urinary bladder channel.For the dry rhizome of grass Herba Imperatae, Arundoin, Coixol, fernenol, simiarenol, Isoarborinol, Anemonin, also containing sterols: stigmasterol, cupreol, campesterol, saccharide, volume sucrose, glucose and a small amount of fructose, xylose, simple acids: citric acid, oxalic acid and malic acid.There is cooling blood for hemostasis, effect of heat-clearing and toxic substances removing.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria, acute nephritis edema, dysuria, gastric heat is vomitted the sound of vomiting, coughs.

embodiment 1the Chinese medicine composition for the treatment of chronic nephritis, takes off and states primary raw material and be prepared from (getting 70g for every part): Fructus Corni 10 parts; Fructus Forsythiae 12 parts; Herba Cayatiae Japonicae 8 parts; Rhizoma Alismatis 9 parts; Folium Elaeagni delavayi 7 parts; Radix Stephaniae Tetrandrae 9 parts; Radix Flemingiae Philippinensis 7 parts; Cortex Phellodendri 6 parts; Herba Christiae Obcordatae 9 parts; Rhizoma Dioscoreae 12 parts; Stigma Maydis 10 parts; Herba Strigae masuriae 8 parts; Herba Solani Nigri 12 parts; Rhizoma Imperatae 13 parts.

The preparation method of the Chinese medicine composition composition powders of above-mentioned treatment chronic nephritis, step is as follows:

(1) Herba Cayatiae Japonicae, Folium Elaeagni delavayi, Radix Flemingiae Philippinensis, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot to extract twice, first time adds 80% ethanol extraction 2 hours, second time adds 80% ethanol extraction 1 hour, merge extractive liquid, concentrating under reduced pressure is relative density 1.15(60 DEG C) thick paste, dry, pulverize, cross 140 mesh sieves;

(2) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 40 minutes and take out, be placed in boiling water and scald 4 minutes, pull out, wash away mucus with clear water, dry, pulverize, cross 140 mesh sieves;

(3) by Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Radix Stephaniae Tetrandrae, Cortex Phellodendri and Rhizoma Imperatae mix homogeneously, dry, pulverize, cross 140 mesh sieves;

(4) by step (1)-(3) gained fine powder mix homogeneously, sterile packaged.

Instructions of taking: each 20-30g, takes after mixing it with water with warm water, every day 3 times, 5 days courses for the treatment of.

embodiment 2the Chinese medicine composition for the treatment of chronic nephritis, takes off and states primary raw material and be prepared from (getting 20g for every part): Fructus Corni 15 parts; Fructus Forsythiae 17 parts; Herba Cayatiae Japonicae 13 parts; Rhizoma Alismatis 15 parts; Folium Elaeagni delavayi 12 parts; Radix Stephaniae Tetrandrae 13 parts; Radix Flemingiae Philippinensis 13 parts; Cortex Phellodendri 10 parts; Herba Christiae Obcordatae 16 parts; Rhizoma Dioscoreae 18 parts; Stigma Maydis 15 parts; Herba Strigae masuriae 14 parts; Herba Solani Nigri 17 parts; Rhizoma Imperatae 16 parts.

The preparation method of the Chinese medicine composition decoction of above-mentioned treatment chronic nephritis, step is as follows:

(1) Folium Elaeagni delavayi, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot and extract twice, first time adds 80% ethanol extraction 2 hours, and second time adds 80% ethanol extraction 1 hour, merge extractive liquid;

(2) Herba Cayatiae Japonicae, Radix Stephaniae Tetrandrae and Radix Flemingiae Philippinensis are cut into slices, be placed in glass container, soak 4 hours, decoct twice, each 50 minutes, merge twice filtrate;

(3) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 40 minutes and take out, be placed in boiling water and scald 4 minutes, pull out, wash away mucus with clear water, dry (temperature is 65 DEG C), pulverize, cross 140 mesh sieves;

(4) Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Cortex Phellodendri and Rhizoma Imperatae are placed in marmite, add step (1) gained extracting solution and step (2) gained filtrate, decoct twice, boil 30 minutes at every turn, twice filtrate merges, leave standstill 4 hours, get supernatant, add step (3) gained fine powder, mix homogeneously, filter, sterile packaged.

Instructions of taking: each 200-300ml, every day 3 times, 5 days courses for the treatment of.

model case one:song XX, man, 34 years old, people from Suzhou City of Jiangsu Province.Started before more than ten day to occur heating without obvious inducement, body temperature reaches 38.8 degree, companion's cough, pharyngalgia, the soreness of waist is uncomfortable, and give anti-infective therapy's 4 days nothings in little outpatient service according to flu and be clearly better, just temperature recovery is to normal, so go to hospital, the routine that has urine examined is shown: erythrocyte +++, urine protein ++; Whole blood assay result: cent lymphocytes 41.6%, mononuclear cell percentage ratio 2.9%; Serology results: uric acid 514umol/L, has hypertension history, is diagnosed as chronic nephritis.

After taking 2 courses for the treatment of of Chinese medicine composition decoction (embodiment 2) of gained of the present invention treatment chronic nephritis, health is weak, and soreness of waist discomfort waits malaise symptoms slow to some extent, and the mental status is good.After continuing to take 2 courses for the treatment of, health is weak, and soreness of waist discomfort waits malaise symptoms to disappear, and every Index for examination all reaches clinical cure level.

embodiment 3the Chinese medicine composition for the treatment of chronic nephritis, takes off and states primary raw material and be prepared from (getting 30g for every part): Fructus Corni 11 parts; Fructus Forsythiae 13 parts; Herba Cayatiae Japonicae 9 parts; Rhizoma Alismatis 11 parts; Folium Elaeagni delavayi 8 parts; Radix Stephaniae Tetrandrae 11 parts; Radix Flemingiae Philippinensis 9 parts; Cortex Phellodendri 7 parts; Herba Christiae Obcordatae 11 parts; Rhizoma Dioscoreae 14 parts; Stigma Maydis 11 parts; Herba Strigae masuriae 10 parts; Herba Solani Nigri 14 parts; Rhizoma Imperatae 14 parts.

The preparation method of the Chinese medicine composition tablet of above-mentioned treatment chronic nephritis, step is as follows:

(1) Folium Elaeagni delavayi, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot and extract twice, first time adds 80% ethanol extraction 2 hours, and second time adds 80% ethanol extraction 1 hour, merge extractive liquid;

(2) Herba Cayatiae Japonicae, Radix Stephaniae Tetrandrae and Radix Flemingiae Philippinensis are cut into slices, be placed in glass container, soak 4 hours, decoct twice, each 50 minutes, merge twice filtrate;

(3) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 40 minutes and take out, be placed in boiling water and scald 4 minutes, pull out, wash away mucus with clear water, dry (temperature is 65 DEG C), pulverize, cross 140 mesh sieves;

(4) Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Cortex Phellodendri and Rhizoma Imperatae are placed in marmite, add step (1) gained extracting solution and step (2) gained filtrate, decoct twice, boil 30 minutes, twice filtrate merges, and leaves standstill 4 hours at every turn, get supernatant, add step (3) gained fine powder, mix homogeneously, being condensed into relative density is 1.15(45 DEG C) thick paste, make uniform granule, drying, is pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 5 days courses for the treatment of.

embodiment 4the Chinese medicine composition for the treatment of chronic nephritis, takes off and states primary raw material and be prepared from (getting 20g for every part): Fructus Corni 14 parts; Fructus Forsythiae 15 parts; Herba Cayatiae Japonicae 12 parts; Rhizoma Alismatis 13 parts; Folium Elaeagni delavayi 10 parts; Radix Stephaniae Tetrandrae 12 parts; Radix Flemingiae Philippinensis 11 parts; Cortex Phellodendri 9 parts; Herba Christiae Obcordatae 14 parts; Rhizoma Dioscoreae 16 parts; Stigma Maydis 14 parts; Herba Strigae masuriae 12 parts; Herba Solani Nigri 16 parts; Rhizoma Imperatae 15 parts.

The preparation method of the Chinese medicine composition oral liquid of above-mentioned treatment chronic nephritis, step is as follows:

(1) Folium Elaeagni delavayi, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot and extract twice, first time adds 80% ethanol extraction 2 hours, and second time adds 80% ethanol extraction 1 hour, merge extractive liquid;

(2) Herba Cayatiae Japonicae, Radix Stephaniae Tetrandrae and Radix Flemingiae Philippinensis are cut into slices, be placed in glass container, soak 4 hours, decoct twice, each 50 minutes, merge twice filtrate;

(3) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 40 minutes and take out, be placed in boiling water and scald 4 minutes, pull out, wash away mucus with clear water, dry (temperature is 65 DEG C), pulverize, cross 140 mesh sieves;

(4) Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Cortex Phellodendri and Rhizoma Imperatae are placed in marmite, add step (1) gained extracting solution and step (2) gained filtrate, decoct twice, boil 30 minutes at every turn, twice filtrate merges, and leaves standstill 4 hours, gets supernatant, add step (3) gained fine powder, be concentrated into 1/2 of original volume, add sodium benzoate, mixing, sterilize 15 minutes, carry out sterile packaged with the dosage often propping up 6ml.

Instructions of taking: each one, every day 3 times, 5 days courses for the treatment of.

model case two:grandson XX, man, 41 years old, people from Qingdao of Shandong province.Urinary system infection recurrent exerbation for many years, is often felt weak at ordinary times, the soreness of waist, waist is swollen.A little more than a month ago, there is edema of pair of lower extremities in exacerbation of symptoms, so remove examination in hospital, biochemical analysis shows: serum creatinine 103.1umol/L, blood urea nitrogen 8.25mmol/L, ERY (+++), urine protein (+++), hemoglobin 111g/L, albumin 21g/L, total protein 37g/L.Two kidney ECT shows: glomerular filtration rate 65ml/min, diagnosis taste chronic nephritis.Take western drug treatment first quarter moon, less effective.

After taking 2 courses for the treatment of of Chinese medicine composition oral liquid (embodiment 4) of gained of the present invention treatment chronic nephritis, the malaise symptoms such as weak, the soreness of waist, waist are swollen is eased, and edema obviously alleviates.After continuing to take 2 courses for the treatment of, blood test creatinine 56.50umol/L, blood urea nitrogen 2.830mmol/L, ERY (-).Two kidney ECT shows: glomerular filtration rate 104ml/min, reaches clinical cure.Later stage visits and learns and do not recur.

embodiment 5the Chinese medicine composition for the treatment of chronic nephritis, takes off and states primary raw material and be prepared from (getting 40g for every part): Fructus Corni 12 parts; Fructus Forsythiae 14 parts; Herba Cayatiae Japonicae 11 parts; Rhizoma Alismatis 12 parts; Folium Elaeagni delavayi 9 parts; Radix Stephaniae Tetrandrae 11.5 parts; Radix Flemingiae Philippinensis 10 parts; Cortex Phellodendri 8 parts; Herba Christiae Obcordatae 12 parts; Rhizoma Dioscoreae 15 parts; Stigma Maydis 12 parts; Herba Strigae masuriae 11 parts; Herba Solani Nigri 15 parts; Rhizoma Imperatae 14.5 parts.

The preparation method of the Chinese medicinal composition capsules of above-mentioned treatment chronic nephritis, step is as follows:

(1) Folium Elaeagni delavayi, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot and extract twice, first time adds 80% ethanol extraction 2 hours, and second time adds 80% ethanol extraction 1 hour, merge extractive liquid;

(2) Herba Cayatiae Japonicae, Radix Stephaniae Tetrandrae and Radix Flemingiae Philippinensis are cut into slices, be placed in glass container, soak 4 hours, decoct twice, each 50 minutes, merge twice filtrate;

(3) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 40 minutes and take out, be placed in boiling water and scald 4 minutes, pull out, wash away mucus with clear water, dry (temperature is 65 DEG C), pulverize, cross 140 mesh sieves;

(4) Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Cortex Phellodendri and Rhizoma Imperatae are placed in marmite, add step (1) gained extracting solution and step (2) gained filtrate, decoct twice, boil 30 minutes at every turn, twice filtrate merges, leave standstill 4 hours, get supernatant, add step (3) gained fine powder, being condensed into relative density is 1.15(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(5) step (4) gained medicated powder is measured according to 0.5g/ grain, be processed into capsule according to the preparation for processing of capsule.

Instructions of taking: each 2-3 grain, every day 3 times, 5 days courses for the treatment of.

test example:in order to verify the curative effect of the Chinese medicine composition (embodiment 5) of gained of the present invention treatment chronic nephritis, we have done contrast test in May ,-2010 in November, 2008.

General data: screening 200 routine patients with chronic glomerulonephritis, man 123 example, female 77 example; Minimal ages 22 years old, max age 65 years old, 49.4 years old mean age; 22-35 year 69 people, 36-50 year 85 people, 51-65 year 46 people; Be divided into experimental group and matched group Liang Ge group (wherein, experimental group 150 people, matched group 50 people) at random.Two groups of ordinary circumstances compare, no significant difference.

Diagnostic criteria: 1. routine urinalysis: specific gravity of urine is on the low side, how below 1.020; Urine protein trace+~ ++++not etc.; Erythrocyte and cast is often had in urine.2. blood test: often have light, moderate normochromic anemia, erythrocyte and hemoglobin ratio decline, and erythrocyte sedimentation rate speeds, and can have hypoproteinemia.3. kidney function test: glomerular filtration rate, endogenous creatinine clearance rate reduce, blood urea nitrogen and creatinine raise, and phenol red excretion test and urine function of concentration and dilution go down.

Exclusion standard: 1. except Secondary cases Patients With Kidney Diseases, as lupus nephritis, henoch Schonlein purpura nephritis, is associated with cardiovascular, liver or the serious disease person such as hemopoietic system, hormonal system.2. suffer from other diseases to need to take the capable medicine for the treatment of other diseases simultaneously simultaneously.3. intentionally, the organic disease person such as liver, kidney.4. anemia of pregnant woman, infant, child, old man, critical or end-stage patients etc.

Usage and dosage: two groups of patients unify dietary standards.Experimental group takes the Chinese medicinal composition capsules of gained of the present invention treatment chronic nephritis, each 2, every day 3 times, 5 days courses for the treatment of.Matched group: adopt other treatment mode (as SHENFUKANG JIAONANG, SHENYAN SIWEI PIAN etc.), wherein SHENFUKANG JIAONANG: oral, a 4-6 grain, 3 times on the one; SHENYAN SIWEI PIAN: oral, each 8,3 times on the one.

Criterion of therapeutical effect: cure: the diseases such as edema, lumbago, hematuria disappear, urine protein examination continues negative, under the observation of high power lens, finds that urine erythrocyte disappears, Urine sediments analyzer counting is normal, normal renal function.Effective: the symptoms such as edema are clearly better, urine protein examination continues to be reduced to 1, and under high power lens, urine erythrocyte counting is lower than 5, and renal function has certain recovery.Invalid: symptom, sign, lab testing are all not improved.

4 courses for the treatment of of medication treatment, observe latter 6 months for the treatment of.Adopt the matched group of other treatment mode and take the Comparison of therapeutic that gained of the present invention treats the experimental group of the Chinese medicine composition of chronic nephritis, result is as shown in table 1:

Table 1

efficacy analysis:as can be seen from Table 1, take the effective percentage of the Chinese medicine composition of gained of the present invention treatment chronic nephritis up to 96.67%, and adopt other treatment mode only reach 80%, and take the cure rate of the Chinese medicine composition of gained of the present invention treatment chronic nephritis up to 71.34%, and adopt the cure rate of other treatment mode only to reach 44%.Can find out that the curative effect of the Chinese medicine composition of gained of the present invention treatment chronic nephritis is more remarkable.

After 4 courses for the treatment of of continuous medication treatment, 24h urine protein quantitation before and after two groups of treatments, serum creatinine, plasma albumin (Alb) (Scr), blood urea nitrogen (BUN) relatively in table 2.Wherein, 24h urine protein quantitation (adult normal: 20-80mg/24h), serum creatinine (Scr) are (normal: 40-120ummol/L), plasma albumin (Alb) (adult normal: 35-50g/L), blood urea nitrogen (BUN) be (normal: 3.2-7.1mmol/L).

Before and after table 2 liang group treatment, indices compares

As can be seen from Table 2, experimental group is taken medicine after 4 courses for the treatment of, the content of 24h urine protein quantitation, serum creatinine, plasma albumin (Alb) (Scr), blood urea nitrogen (BUN) all reaches normal level, and in matched group, the content of 24h urine protein quantitation, serum creatinine, plasma albumin, blood urea nitrogen does not all reach normal level.Therefore the curative effect of experimental group is obviously better than matched group.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. treat the Chinese medicine composition of chronic nephritis, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Fructus Corni 10-15 part; Fructus Forsythiae 12-17 part; Herba Cayatiae Japonicae 8-13 part; Rhizoma Alismatis 9-15 part; Folium Elaeagni delavayi 7-12 part; Radix Stephaniae Tetrandrae 9-13 part; Radix Flemingiae Philippinensis 7-13 part; Cortex Phellodendri 6-10 part; Herba Christiae Obcordatae 9-16 part; Rhizoma Dioscoreae 12-18 part; Stigma Maydis 10-15 part; Herba Strigae masuriae 8-14 part; Herba Solani Nigri 12-17 part; Rhizoma Imperatae 13-16 part.

2. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Fructus Corni 11-14 part; Fructus Forsythiae 13-15 part; Herba Cayatiae Japonicae 9-12 part; Rhizoma Alismatis 11-13 part; Folium Elaeagni delavayi 8-10 part; Radix Stephaniae Tetrandrae 11-12 part; Radix Flemingiae Philippinensis 9-11 part; Cortex Phellodendri 7-9 part; Herba Christiae Obcordatae 11-14 part; Rhizoma Dioscoreae 14-16 part; Stigma Maydis 11-14 part; Herba Strigae masuriae 10-12 part; Herba Solani Nigri 14-16 part; Rhizoma Imperatae 14-15 part.

3. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Fructus Corni 12 parts; Fructus Forsythiae 14 parts; Herba Cayatiae Japonicae 11 parts; Rhizoma Alismatis 12 parts; Folium Elaeagni delavayi 9 parts; Radix Stephaniae Tetrandrae 11.5 parts; Radix Flemingiae Philippinensis 10 parts; Cortex Phellodendri 8 parts; Herba Christiae Obcordatae 12 parts; Rhizoma Dioscoreae 15 parts; Stigma Maydis 12 parts; Herba Strigae masuriae 11 parts; Herba Solani Nigri 15 parts; Rhizoma Imperatae 14.5 parts.

4., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, the preparation method of described powder, step is as follows:

(1) Herba Cayatiae Japonicae, Folium Elaeagni delavayi, Radix Flemingiae Philippinensis, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot to extract twice, first time adds 80% ethanol extraction 2 hours, second time add 80% ethanol extraction 1 hour, merge extractive liquid, concentrating under reduced pressure is relative density 1.10-1.20(60 DEG C) thick paste, dry, pulverize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 30-50 minute and take out, be placed in boiling water and scald 3-5 minute, pull out, wash away mucus with clear water, dry, pulverize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) by Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Radix Stephaniae Tetrandrae, Cortex Phellodendri and Rhizoma Imperatae mix homogeneously, dry, pulverize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) by step (1)-(3) gained fine powder mix homogeneously, sterile packaged.

5. the preparation method of Chinese medicine composition composition powders according to claim 4, is characterized in that: when step (2) is preferably dried, temperature is 60-70 DEG C, and when being more preferably oven dry, temperature is 65 DEG C.

6., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, the preparation method of described decoction, step is as follows:

(1) Folium Elaeagni delavayi, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot and extract twice, first time adds 80% ethanol extraction 2 hours, and second time adds 80% ethanol extraction 1 hour, merge extractive liquid;

(2) Herba Cayatiae Japonicae, Radix Stephaniae Tetrandrae and Radix Flemingiae Philippinensis are cut into slices, be placed in glass container, soak 3-5 hour, decoct twice, each 40-60 minute, merge twice filtrate;

(3) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 30-50 minute and take out, be placed in boiling water and scald 3-5 minute, pull out, mucus is washed away with clear water, dry (preferable temperature is 60-70 DEG C, and being more preferably temperature is 65 DEG C), pulverize, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Cortex Phellodendri and Rhizoma Imperatae are placed in marmite, add step (1) gained extracting solution and step (2) gained filtrate, decoct twice, boil at every turn and (preferably boil 25-35 minute in 20-40 minute at every turn, be more preferably and boil 30 minutes at every turn), twice filtrate merges, and leaves standstill 3-5 hour, gets supernatant, add step (3) gained fine powder, mix homogeneously, filters, sterile packaged.

7., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, the preparation method of described tablet, step is as follows:

(1) Folium Elaeagni delavayi, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot and extract twice, first time adds 80% ethanol extraction 2 hours, and second time adds 80% ethanol extraction 1 hour, merge extractive liquid;

(2) Herba Cayatiae Japonicae, Radix Stephaniae Tetrandrae and Radix Flemingiae Philippinensis are cut into slices, be placed in glass container, soak 3-5 hour, decoct twice, each 40-60 minute, merge twice filtrate;

(3) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 30-50 minute and take out, be placed in boiling water and scald 3-5 minute, pull out, mucus is washed away with clear water, dry (preferable temperature is 60-70 DEG C, and being more preferably temperature is 65 DEG C), pulverize, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Cortex Phellodendri and Rhizoma Imperatae are placed in marmite, add step (1) gained extracting solution and step (2) gained filtrate, decoct twice, boil at every turn and (preferably boil 25-35 minute in 20-40 minute at every turn, be more preferably and boil 30 minutes at every turn), twice filtrate merges, leave standstill 3-5 hour, get supernatant, add step (3) gained fine powder, mix homogeneously, being condensed into relative density is 1.10-1.20(45 DEG C) thick paste, make uniform granule, dry, be pressed into lamellar, sugar coating.

8., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, the preparation method of described oral liquid, step is as follows:

(1) Folium Elaeagni delavayi, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot and extract twice, first time adds 80% ethanol extraction 2 hours, and second time adds 80% ethanol extraction 1 hour, merge extractive liquid;

(2) Herba Cayatiae Japonicae, Radix Stephaniae Tetrandrae and Radix Flemingiae Philippinensis are cut into slices, be placed in glass container, soak 3-5 hour, decoct twice, each 40-60 minute, merge twice filtrate;

(3) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 30-50 minute and take out, be placed in boiling water and scald 3-5 minute, pull out, mucus is washed away with clear water, dry (preferable temperature is 60-70 DEG C, and being more preferably temperature is 65 DEG C), pulverize, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) by Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Cortex Phellodendri and Rhizoma Imperatae are placed in marmite, add step (1) gained extracting solution and step (2) gained filtrate, decoct twice, boil at every turn and (preferably boil 25-35 minute in 20-40 minute at every turn, be more preferably and boil 30 minutes at every turn), twice filtrate merges, leave standstill 3-5 hour, get supernatant, add step (3) gained fine powder, be concentrated into 1/2 of original volume, add sodium benzoate, mixing, sterilize 10-20 minute (preferably sterilization 13-17 minute, be more preferably sterilization 15 minutes), sterile packaged is carried out with the dosage often propping up 6ml.

9. the preparation method of Chinese medicine composition oral liquid according to claim 8, is characterized in that: the consumption of step (4) preferred sodium benzoate is the 0.1%-0.3% of concentrated solution quality, and the consumption being more preferably sodium benzoate is 0.2% of concentrated solution quality.

10., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, the preparation method of described capsule, step is as follows:

(1) Folium Elaeagni delavayi, Herba Christiae Obcordatae, Stigma Maydis, Herba Strigae masuriae and Herba Solani Nigri are smashed, be placed in extraction pot and extract twice, first time adds 80% ethanol extraction 2 hours, and second time adds 80% ethanol extraction 1 hour, merge extractive liquid;

(2) Herba Cayatiae Japonicae, Radix Stephaniae Tetrandrae and Radix Flemingiae Philippinensis are cut into slices, be placed in glass container, soak 3-5 hour, decoct twice, each 40-60 minute, merge twice filtrate;

(3) by section after Rhizoma Dioscoreae cleaning, be placed in container, soak after 30-50 minute and take out, be placed in boiling water and scald 3-5 minute, pull out, mucus is washed away with clear water, dry (preferable temperature is 60-70 DEG C, and being more preferably temperature is 65 DEG C), pulverize, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) Fructus Corni, Fructus Forsythiae, Rhizoma Alismatis, Cortex Phellodendri and Rhizoma Imperatae are placed in marmite, add step (1) gained extracting solution and step (2) gained filtrate, decoct twice, boil at every turn and (preferably boil 25-35 minute in 20-40 minute at every turn, be more preferably and boil 30 minutes at every turn), twice filtrate merges, and leaves standstill 3-5 hour, get supernatant, add step (3) gained fine powder, being condensed into relative density is 1.10-1.20(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(5) step (4) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.