CN104755107A - 用在内窥镜诊断中的含染料的固体口服组合物 - Google Patents

用在内窥镜诊断中的含染料的固体口服组合物 Download PDF

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Publication number
CN104755107A
CN104755107A CN201380053741.XA CN201380053741A CN104755107A CN 104755107 A CN104755107 A CN 104755107A CN 201380053741 A CN201380053741 A CN 201380053741A CN 104755107 A CN104755107 A CN 104755107A
Authority
CN
China
Prior art keywords
unit dose
solid
dyestuff
composites
hours
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380053741.XA
Other languages
English (en)
Chinese (zh)
Inventor
卢吉·摩洛
亚历山德罗·雷皮奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cosmo Technologies Ltd
Original Assignee
Cosmo Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cosmo Technologies Ltd filed Critical Cosmo Technologies Ltd
Priority to CN202311335014.4A priority Critical patent/CN117462704A/zh
Priority to CN202110120798.3A priority patent/CN112891563A/zh
Publication of CN104755107A publication Critical patent/CN104755107A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/003—Thiazine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure
    • A61K49/0086—Polymersome, i.e. liposome with polymerisable or polymerized bilayered-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201380053741.XA 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物 Pending CN104755107A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202311335014.4A CN117462704A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物
CN202110120798.3A CN112891563A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261715981P 2012-10-19 2012-10-19
US61/715,981 2012-10-19
EP12189206.1A EP2722058A1 (en) 2012-10-19 2012-10-19 Solid oral composition containing dyes for use in endoscopic diagnosis
EP12189206.1 2012-10-19
PCT/EP2013/070060 WO2014060199A1 (en) 2012-10-19 2013-09-26 Solid oral composition containing dyes for use in endoscopic diagnosis

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202311335014.4A Division CN117462704A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物
CN202110120798.3A Division CN112891563A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物

Publications (1)

Publication Number Publication Date
CN104755107A true CN104755107A (zh) 2015-07-01

Family

ID=47137560

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202311335014.4A Pending CN117462704A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物
CN202110120798.3A Pending CN112891563A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物
CN201380053741.XA Pending CN104755107A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CN202311335014.4A Pending CN117462704A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物
CN202110120798.3A Pending CN112891563A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物

Country Status (27)

Country Link
US (4) US20150283268A1 (enExample)
EP (3) EP2722058A1 (enExample)
JP (1) JP6267210B2 (enExample)
KR (1) KR102207507B1 (enExample)
CN (3) CN117462704A (enExample)
AR (1) AR091984A1 (enExample)
AU (1) AU2013331964B2 (enExample)
BR (1) BR112015008772A2 (enExample)
CA (1) CA2886201C (enExample)
DK (2) DK2908866T3 (enExample)
ES (2) ES3030697T3 (enExample)
FI (1) FI3650048T3 (enExample)
HR (1) HRP20190710T1 (enExample)
HU (1) HUE043112T2 (enExample)
IL (1) IL237907A (enExample)
IN (1) IN2015DN02818A (enExample)
LT (1) LT2908866T (enExample)
MX (1) MX361737B (enExample)
NZ (1) NZ706363A (enExample)
PL (1) PL2908866T3 (enExample)
PT (1) PT2908866T (enExample)
RS (1) RS59152B1 (enExample)
RU (1) RU2649783C2 (enExample)
TR (1) TR201905800T4 (enExample)
TW (1) TWI651102B (enExample)
WO (1) WO2014060199A1 (enExample)
ZA (1) ZA201502370B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110234359A (zh) * 2016-11-28 2019-09-13 科斯莫科技有限公司 包含染料的固体口服组合物

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201900003113A1 (it) * 2019-03-04 2020-09-04 Azienda Ospedaliero Univ Policlinico S Orsola Malpighi Bologna Bevanda coadiuvante

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107945A1 (en) * 2010-03-04 2011-09-09 Cosmo Technologies Ltd. Solid composition for the oral administration of dyes and diagnostic use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2129273C1 (ru) * 1997-11-26 1999-04-20 Московский научно-исследовательский онкологический институт им.П.А.Герцена Способ эндоскопической флюоресцентной диагностики злокачественных опухолей полых органов
ITMI991316A1 (it) 1999-06-14 2000-12-14 Cip Ninety Two 92 S A Composizioni farmaceutiche orali a rilascio modificato di mesalazina
WO2000076478A1 (en) 1999-06-14 2000-12-21 Cosmo S.P.A. Controlled release and taste masking oral pharmaceutical compositions
US7230088B2 (en) * 2001-07-03 2007-06-12 Mallinckrodt, Inc. Compounds for dual photodiagnosis and therapy
GB0224909D0 (en) * 2002-10-25 2002-12-04 Norgine Europe Bv Colon cleansing compositions
RU2253350C2 (ru) * 2003-06-30 2005-06-10 Государственное учреждение здравоохранения Иркутский Областной Диагностический Центр Способ эндоскопического исследования желудка
US20050244368A1 (en) * 2004-04-29 2005-11-03 Pashankar Dinesh S Pre-endoscopic use of polyethylene glycol compositions
US20070077202A1 (en) * 2005-06-12 2007-04-05 Pentax Corporation Histostain composition for endoscope

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107945A1 (en) * 2010-03-04 2011-09-09 Cosmo Technologies Ltd. Solid composition for the oral administration of dyes and diagnostic use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110234359A (zh) * 2016-11-28 2019-09-13 科斯莫科技有限公司 包含染料的固体口服组合物

Also Published As

Publication number Publication date
KR102207507B1 (ko) 2021-01-27
JP6267210B2 (ja) 2018-01-24
ES2721916T3 (es) 2019-08-06
TR201905800T4 (tr) 2019-05-21
PL2908866T3 (pl) 2019-10-31
NZ706363A (en) 2019-03-29
LT2908866T (lt) 2019-06-10
EP3650048B1 (en) 2025-03-05
AU2013331964B2 (en) 2018-03-29
RS59152B1 (sr) 2019-10-31
RU2649783C2 (ru) 2018-04-04
EP2722058A1 (en) 2014-04-23
AU2013331964A1 (en) 2015-04-09
AR091984A1 (es) 2015-03-18
ZA201502370B (en) 2016-11-30
IN2015DN02818A (enExample) 2015-09-11
DK3650048T3 (da) 2025-05-26
MX2015004935A (es) 2015-12-01
KR20150068412A (ko) 2015-06-19
CA2886201C (en) 2021-03-23
IL237907A (en) 2017-06-29
PT2908866T (pt) 2019-05-24
BR112015008772A2 (pt) 2017-07-04
US20250186626A1 (en) 2025-06-12
CN112891563A (zh) 2021-06-04
EP2908866B1 (en) 2019-02-27
ES3030697T3 (en) 2025-07-01
EP3650048A1 (en) 2020-05-13
HUE043112T2 (hu) 2019-08-28
MX361737B (es) 2018-12-14
DK2908866T3 (da) 2019-05-06
FI3650048T3 (fi) 2025-05-26
US20150283268A1 (en) 2015-10-08
HRP20190710T1 (hr) 2019-08-23
WO2014060199A1 (en) 2014-04-24
HK1211465A1 (en) 2016-05-27
US20230130628A1 (en) 2023-04-27
US20200129643A1 (en) 2020-04-30
CN117462704A (zh) 2024-01-30
TWI651102B (zh) 2019-02-21
CA2886201A1 (en) 2014-04-24
TW201420131A (zh) 2014-06-01
JP2015534956A (ja) 2015-12-07
RU2015118584A (ru) 2016-12-10
EP2908866A1 (en) 2015-08-26

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20150701

RJ01 Rejection of invention patent application after publication