CN104755091B - 预防哺乳动物骨质疏松的乳酸杆菌的选择和应用 - Google Patents

预防哺乳动物骨质疏松的乳酸杆菌的选择和应用 Download PDF

Info

Publication number
CN104755091B
CN104755091B CN201380029676.7A CN201380029676A CN104755091B CN 104755091 B CN104755091 B CN 104755091B CN 201380029676 A CN201380029676 A CN 201380029676A CN 104755091 B CN104755091 B CN 104755091B
Authority
CN
China
Prior art keywords
osteoporosis
lactobacillus
lactobacillus reuteri
base pair
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380029676.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN104755091A (zh
Inventor
埃蒙·康诺利
罗伯特·艾伦·布里顿
劳拉·雷·麦凯布
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogaia AB
Michigan State University
Original Assignee
Biogaia AB
Michigan State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogaia AB, Michigan State University filed Critical Biogaia AB
Publication of CN104755091A publication Critical patent/CN104755091A/zh
Application granted granted Critical
Publication of CN104755091B publication Critical patent/CN104755091B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201380029676.7A 2012-06-04 2013-06-04 预防哺乳动物骨质疏松的乳酸杆菌的选择和应用 Expired - Fee Related CN104755091B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261689338P 2012-06-04 2012-06-04
US61/689,338 2012-06-04
PCT/SE2013/050646 WO2013184064A1 (en) 2012-06-04 2013-06-04 Selection and use of lactic acid bacteria preventing bone loss in mammals

Publications (2)

Publication Number Publication Date
CN104755091A CN104755091A (zh) 2015-07-01
CN104755091B true CN104755091B (zh) 2020-07-21

Family

ID=49712339

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380029676.7A Expired - Fee Related CN104755091B (zh) 2012-06-04 2013-06-04 预防哺乳动物骨质疏松的乳酸杆菌的选择和应用

Country Status (16)

Country Link
US (4) US20150150917A1 (enExample)
EP (2) EP2854826B9 (enExample)
JP (1) JP6193981B2 (enExample)
KR (2) KR102191537B1 (enExample)
CN (1) CN104755091B (enExample)
AU (2) AU2013272330B2 (enExample)
CA (1) CA2875841C (enExample)
DK (2) DK3456334T3 (enExample)
ES (2) ES2847424T3 (enExample)
HR (1) HRP20190162T1 (enExample)
HU (1) HUE042643T2 (enExample)
LT (1) LT2854826T (enExample)
PL (2) PL2854826T3 (enExample)
SI (1) SI2854826T1 (enExample)
TR (1) TR201901771T4 (enExample)
WO (1) WO2013184064A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101915904B1 (ko) 2016-08-12 2018-11-06 한국식품연구원 락토바실러스 인테스티날리스를 포함하는 갱년기 예방 또는 치료용 조성물
KR102120479B1 (ko) * 2018-10-30 2020-06-09 주식회사 종근당바이오 프로바이오틱스를 유효 성분으로 포함하는 이차성 골다공증의 예방 또는 치료용 조성물
US12427174B2 (en) * 2019-02-05 2025-09-30 Biomedit, Inc. Probiotic compositions comprising lactobacillus reuteri strains and methods of use
KR102080498B1 (ko) * 2019-08-23 2020-02-24 정영옥 페룰산 및 유산균을 유효성분으로 포함하는 골감소증 개선 또는 예방용 식품 조성물
JP7596301B2 (ja) * 2019-12-02 2024-12-09 雪印メグミルク株式会社 骨強化剤
CN111718903A (zh) * 2020-06-24 2020-09-29 江南大学 一种筛选可预防和/或治疗骨质疏松的药物的方法
CN114711429B (zh) * 2021-06-08 2023-11-17 青岛蔚蓝生物股份有限公司 一株具有增强骨健康作用的罗伊氏乳杆菌及其应用
CN114634901B (zh) * 2022-05-18 2022-08-30 微康益生菌(苏州)股份有限公司 一种促进骨骼健康的干酪乳杆菌lc16及其培养方法与应用
KR102937770B1 (ko) * 2023-08-09 2026-03-12 국립한국교통대학교산학협력단 골다공증 억제 균주 및 이의 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003105893A2 (en) * 2002-06-13 2003-12-24 Alimentary Health Limited Probiotic therapies
CN101160134A (zh) * 2005-04-15 2008-04-09 生命大地女神有限公司 用于减轻哺乳动物炎症的乳酸菌的选择和应用
CN101233231A (zh) * 2005-07-26 2008-07-30 学校法人麻布兽医学园 抗肥胖剂及抗肥胖食品

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008028300A1 (en) * 2006-09-07 2008-03-13 Mcgill University Oral polymeric membrane feruloyl esterase producing bacteria formulation
US20080254011A1 (en) * 2007-04-11 2008-10-16 Peter Rothschild Use of selected lactic acid bacteria for reducing atherosclerosis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003105893A2 (en) * 2002-06-13 2003-12-24 Alimentary Health Limited Probiotic therapies
CN101160134A (zh) * 2005-04-15 2008-04-09 生命大地女神有限公司 用于减轻哺乳动物炎症的乳酸菌的选择和应用
CN101233231A (zh) * 2005-07-26 2008-07-30 学校法人麻布兽医学园 抗肥胖剂及抗肥胖食品

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm;Jens Walter等;《PNAS》;20110315;第108卷(第1期);4645–4652 *
Prebiotics,Probiotics,and Synbiotics Affect Mineral Absorption, Bone Mineral Content,and Bone Structure;Katharina E. Scholz-Ahrens等;《Effects of Probiotics and Prebiotics》;20080922;第838S-846S页 *
维生素D缺乏与骨质疏松;夏维波等;《中华骨质疏松和骨矿盐疾病杂志》;20090920;第2卷(第3期);第145-154页 *

Also Published As

Publication number Publication date
KR20150028968A (ko) 2015-03-17
EP2854826A1 (en) 2015-04-08
HRP20190162T1 (hr) 2019-04-05
HUE042643T2 (hu) 2019-07-29
KR20200044134A (ko) 2020-04-28
US20180200313A1 (en) 2018-07-19
US9968643B2 (en) 2018-05-15
EP2854826B9 (en) 2019-05-08
CN104755091A (zh) 2015-07-01
ES2711427T3 (es) 2019-05-03
EP2854826B1 (en) 2018-11-14
AU2013272330B2 (en) 2017-11-02
PL2854826T3 (pl) 2019-06-28
EP2854826A4 (en) 2016-07-06
AU2013272330A1 (en) 2015-01-15
DK2854826T3 (en) 2019-03-11
AU2018200524B2 (en) 2019-07-18
SI2854826T1 (sl) 2019-03-29
US20150150917A1 (en) 2015-06-04
CA2875841C (en) 2021-02-02
JP2015526389A (ja) 2015-09-10
PL3456334T3 (pl) 2021-05-04
HK1211847A1 (en) 2016-06-03
JP6193981B2 (ja) 2017-09-06
EP3456334A1 (en) 2019-03-20
CA2875841A1 (en) 2013-12-12
AU2018200524A1 (en) 2018-02-15
US10232001B2 (en) 2019-03-19
US10537598B2 (en) 2020-01-21
LT2854826T (lt) 2019-02-11
ES2711427T8 (es) 2019-06-20
DK3456334T3 (da) 2021-01-25
TR201901771T4 (tr) 2019-03-21
WO2013184064A1 (en) 2013-12-12
KR102191537B1 (ko) 2020-12-16
ES2847424T3 (es) 2021-08-03
US20170128501A1 (en) 2017-05-11
US20190142879A1 (en) 2019-05-16
EP3456334B1 (en) 2020-11-11

Similar Documents

Publication Publication Date Title
US10537598B2 (en) Selection and use of lactic acid bacteria preventing bone loss in mammals
Caballero-Franco et al. The VSL# 3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells
CN112672749B (zh) 具有肥胖预防或治疗效果的新的长双歧杆菌菌株或鼠李糖乳杆菌菌株及其用途
CN104546940A (zh) 平常拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用
TWI604052B (zh) 促進骨質再生的植物乳桿菌菌株ｇｍｎｌ－６６２及其組合物
CN104546932A (zh) 卵形拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用
CN104546933A (zh) 粪拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用
CN108567800A (zh) 副干酪乳杆菌菌株gmnl-653用于制备抗骨质流失的组合物的用途
Wang et al. Effects of dietary supplementation with epidermal growth factor-expressing Saccharomyces cerevisiae on duodenal development in weaned piglets
Loo et al. A current overview of next-generation probiotics and their prospects in health and disease management
CN108624520A (zh) 促进骨质再生的植物乳杆菌菌株gmnl-662及其组合物
Liu et al. The effects of Bacillus subtilis QST713 and β-mannanase on growth performance, intestinal barrier function, and the gut microbiota in weaned piglets
CN104546945A (zh) 两歧双歧杆菌在治疗或预防类风湿性关节炎或其相关疾病中的用途
CN110839693A (zh) 吉氏副拟杆菌在预防或治疗肥胖或其相关疾病中的应用
Wang et al. Probiotics: Can it modulate fracture healing?
Li et al. The role of probiotics and prebiotics in osteolastogenesis and immune relevance
KR20210142692A (ko) 칼슘의 흡수를 촉진하는 신규 락트산 박테리아 균주 - 펩티드 및 연관 생성물
TWI607759B (zh) 副乾酪乳桿菌菌株ｇｍｎｌ－６５３用於製備抗骨質流失的組合物的用途
HK1211847B (en) Selection and use of lactic acid bacteria preventing bone loss in mammals
Lawenius et al. Gut microbiota transplantation from young adult mice fails to restore low bone and muscle mass in old mice
CN104546943A (zh) 沙氏别样杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用
Class et al. Patent application title: Use of Bifidobacterium Animalis for Treating or Preventing Body Weight Gain and Insulin Resistance Inventors: Jian Shen (Shanghai, CN) Jingjing Wang (Shanghai, CN) Liping Zhao (Shanghai, CN) Martin Saul Obin (West Newton, MA, US) Muriel Derrien (Bures Sur Yvette, FR) Emilie Rocher (Massy, FR) Johan Van Hylckama Vlieg (Marly Le Roi, FR) Assignees: TUFTS UNIVERSITY COMPAGNIE GERVAIS DANONE
HK1209355A1 (en) Use of coprococcus catus in the treatment or prevention of rheumatoid arthritis or related diseases
HK1209368A1 (en) Use of prevotella maculosa in the treatment or prevention of rheumatoid arthritis

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1211847

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20200721

CF01 Termination of patent right due to non-payment of annual fee