CN104744310A - 包含亚氨基脂质的两性脂质体 - Google Patents
包含亚氨基脂质的两性脂质体 Download PDFInfo
- Publication number
- CN104744310A CN104744310A CN201510053094.3A CN201510053094A CN104744310A CN 104744310 A CN104744310 A CN 104744310A CN 201510053094 A CN201510053094 A CN 201510053094A CN 104744310 A CN104744310 A CN 104744310A
- Authority
- CN
- China
- Prior art keywords
- lipid
- liposome
- compound
- cell
- imino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09165106.7 | 2009-07-09 | ||
EP09165106A EP2277508B1 (en) | 2009-07-09 | 2009-07-09 | Emulation of lipoprotein structures |
EP09171102 | 2009-09-23 | ||
EP09171102.8 | 2009-09-23 | ||
CN201080031041.7A CN102481256B (zh) | 2009-07-09 | 2010-07-02 | 包含亚氨基脂质的两性脂质体 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201080031041.7A Division CN102481256B (zh) | 2009-07-09 | 2010-07-02 | 包含亚氨基脂质的两性脂质体 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN104744310A true CN104744310A (zh) | 2015-07-01 |
Family
ID=42555953
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510053094.3A Pending CN104744310A (zh) | 2009-07-09 | 2010-07-02 | 包含亚氨基脂质的两性脂质体 |
CN201080031041.7A Active CN102481256B (zh) | 2009-07-09 | 2010-07-02 | 包含亚氨基脂质的两性脂质体 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201080031041.7A Active CN102481256B (zh) | 2009-07-09 | 2010-07-02 | 包含亚氨基脂质的两性脂质体 |
Country Status (13)
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109414451A (zh) * | 2016-05-16 | 2019-03-01 | 德克萨斯大学系统董事会 | 用于作为纳米粒递送tRNA的组合物及其使用方法 |
CN110283223A (zh) * | 2018-03-19 | 2019-09-27 | 广州市锐博生物科技有限公司 | 一种阳离子脂质分子及其在核酸递送中的应用 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102344392B1 (ko) | 2008-11-10 | 2021-12-28 | 알닐람 파마슈티칼스 인코포레이티드 | 치료제 운반용 신규 지질 및 조성물 |
BR212012000255U2 (pt) † | 2009-07-09 | 2015-11-03 | Marina Biotech Inc | lipossomas anfotéricos compreendendo imino lípidos. |
DK2706988T3 (da) * | 2011-05-12 | 2020-01-20 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Liposomer omfattende polymer konjugerede lipider og relateret brug |
AU2012267578B2 (en) | 2011-06-08 | 2017-04-20 | Translate Bio, Inc. | Cleavable lipids |
US10722599B2 (en) | 2015-02-04 | 2020-07-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Lipid assemblies and uses thereof and some pH and electrostatic modulating lipids to be used in said assemblies |
CN109069654A (zh) * | 2016-03-28 | 2018-12-21 | 富士胶片株式会社 | 制剂、制剂用部件及它们的制造方法 |
WO2020154594A2 (en) * | 2019-01-25 | 2020-07-30 | Agenovir Corporation | Compositions and methods for treatment of human papillomavirus |
CN110974954B (zh) * | 2019-12-24 | 2021-03-16 | 珠海丽凡达生物技术有限公司 | 一种用于增强核酸疫苗免疫效果的脂质纳米颗粒及其制备方法 |
CN113546177A (zh) * | 2021-07-15 | 2021-10-26 | 郑州大学 | 一种胆固醇单胍偶联物及其制备方法和应用 |
CN116370437A (zh) * | 2023-05-26 | 2023-07-04 | 北京因诺惟康医药科技有限公司 | 包含胆固醇琥珀酸单酯的核酸脂质纳米颗粒组合物及其用途 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996020208A2 (de) * | 1994-12-28 | 1996-07-04 | Max-Delbrück-Centrum für Molekulare Medizin | Neues cholesterolderivat für den liposomalen gentransfer |
CN1509166A (zh) * | 2001-03-26 | 2004-06-30 | 用于改善治疗物质的细胞内传递的脂质体组合物 | |
TWI257924B (en) * | 2003-09-22 | 2006-07-11 | Lipotek Inc | Cationic lipid for delivery function, and nanoparticle comprising the same |
JP2007091657A (ja) * | 2005-09-29 | 2007-04-12 | Terumo Corp | アミジン誘導体およびそれを構成成分とする薬物担体 |
WO2007064857A2 (en) * | 2005-12-01 | 2007-06-07 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
WO2008155141A2 (en) * | 2007-06-20 | 2008-12-24 | Novosom Ag | Novel facultative catonic sterols |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
CA2156288C (en) | 1993-02-19 | 2005-10-18 | Junichi Yano | Glycerol derivative, device and pharmaceutical composition |
US5651981A (en) | 1994-03-29 | 1997-07-29 | Northwestern University | Cationic phospholipids for transfection |
US5777153A (en) * | 1994-07-08 | 1998-07-07 | Gilead Sciences, Inc. | Cationic lipids |
US5965434A (en) | 1994-12-29 | 1999-10-12 | Wolff; Jon A. | Amphipathic PH sensitive compounds and delivery systems for delivering biologically active compounds |
US6726894B1 (en) | 1995-07-25 | 2004-04-27 | Synvolux Ip B.V. | Transport vehicles for macromolecules |
US5980935A (en) * | 1996-05-15 | 1999-11-09 | Kirpotin; Dmitri | Cationic lipids and methods of use therefor |
DE19631189A1 (de) * | 1996-08-02 | 1998-02-05 | Max Delbrueck Centrum | Neuartige kationische Amphiphile für den liposomalen Gentransfer |
CA2217550A1 (en) * | 1996-10-22 | 1998-04-22 | F. Hoffmann-La Roche Ag | Cationic lipids for gene therapy |
DE19648625A1 (de) | 1996-11-13 | 1998-05-14 | Soft Gene Gmbh | Mikroprojektil für das Einbringen von Substanzen in Zellen durch ballistischen Transfer |
EP1027033B1 (en) | 1997-05-14 | 2009-07-22 | The University Of British Columbia | High efficiency encapsulation of nucleic acids in lipid vesicles |
DE19753182A1 (de) | 1997-11-21 | 1999-07-29 | Claas Junghans | Topologisch fixierte matrixgebundene Nukleinsäure |
DE19753132C5 (de) | 1997-11-29 | 2010-05-20 | Geze Gmbh | Brandschutzschiebetüranlage |
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
US6171862B1 (en) * | 1998-03-31 | 2001-01-09 | The Regents Of The University Of California | Transfection in serum-containing media |
DE10160151A1 (de) | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
MXPA02007248A (es) | 2000-01-28 | 2002-12-09 | Procter & Gamble | Compuestos de arginina con sabor aceptable y usos de los mismos para la salud cardiovascular. |
DE10109897A1 (de) † | 2001-02-21 | 2002-11-07 | Novosom Ag | Fakultativ kationische Liposomen und Verwendung dieser |
DE50214200D1 (de) | 2001-06-05 | 2010-03-25 | Curevac Gmbh | Stabilisierte Tumorantigen-mRNA mit erhöhtem G/C-Gehalt |
WO2007107304A2 (en) | 2006-03-17 | 2007-09-27 | Novosom Ag | An efficient method for loading amphoteric liposomes with nucleic acid active substances |
EP2094238A2 (en) | 2006-10-13 | 2009-09-02 | Novosom AG | Improvements in or relating to amphoteric liposomes |
DK2494993T3 (en) * | 2007-05-04 | 2018-11-12 | Marina Biotech Inc | Amino acid lipids and uses thereof |
AU2008295666B2 (en) * | 2007-09-07 | 2013-05-16 | Synvolux Ip B.V. | Improved liposomes and uses thereof |
CA2702103A1 (en) | 2007-10-12 | 2009-04-16 | Novosom Ag | Improvements in or relating to amphotaric liposomes comprising neutral lipids |
CA3044134A1 (en) | 2008-01-02 | 2009-07-09 | Arbutus Biopharma Corporation | Improved compositions and methods for the delivery of nucleic acids |
ES2816639T3 (es) | 2008-03-18 | 2021-04-05 | Mk Systems Usa Inc | Un servidor VOD de velocidad controlada |
US8389768B2 (en) | 2008-05-19 | 2013-03-05 | The University Of North Carolina At Chapel Hill | Methods and compositions comprising novel cationic lipids |
BR212012000255U2 (pt) † | 2009-07-09 | 2015-11-03 | Marina Biotech Inc | lipossomas anfotéricos compreendendo imino lípidos. |
-
2010
- 2010-07-02 BR BR212012000255U patent/BR212012000255U2/pt not_active Application Discontinuation
- 2010-07-02 CA CA2765694A patent/CA2765694C/en active Active
- 2010-07-02 EP EP10734065.5A patent/EP2451440B2/en active Active
- 2010-07-02 JP JP2012518924A patent/JP5851399B2/ja active Active
- 2010-07-02 US US13/378,484 patent/US20120237589A1/en not_active Abandoned
- 2010-07-02 CN CN201510053094.3A patent/CN104744310A/zh active Pending
- 2010-07-02 SG SG2012001673A patent/SG177590A1/en unknown
- 2010-07-02 ES ES10734065.5T patent/ES2527220T5/es active Active
- 2010-07-02 AU AU2010270337A patent/AU2010270337B2/en active Active
- 2010-07-02 BR BR112012000255-4A patent/BR112012000255B1/pt active IP Right Grant
- 2010-07-02 WO PCT/EP2010/059487 patent/WO2011003834A1/en active Application Filing
- 2010-07-02 CN CN201080031041.7A patent/CN102481256B/zh active Active
- 2010-07-02 KR KR1020127003373A patent/KR101954912B1/ko active IP Right Grant
- 2010-07-02 EP EP14188521.0A patent/EP2823810B9/en active Active
- 2010-07-02 DK DK14188521.0T patent/DK2823810T3/da active
-
2011
- 2011-12-15 IL IL216996A patent/IL216996A0/en unknown
-
2016
- 2016-02-22 US US15/050,416 patent/US10039714B2/en active Active
-
2018
- 2018-08-01 US US16/051,728 patent/US20180338919A1/en not_active Abandoned
-
2020
- 2020-05-04 US US16/866,363 patent/US11541010B2/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996020208A2 (de) * | 1994-12-28 | 1996-07-04 | Max-Delbrück-Centrum für Molekulare Medizin | Neues cholesterolderivat für den liposomalen gentransfer |
CN1509166A (zh) * | 2001-03-26 | 2004-06-30 | 用于改善治疗物质的细胞内传递的脂质体组合物 | |
TWI257924B (en) * | 2003-09-22 | 2006-07-11 | Lipotek Inc | Cationic lipid for delivery function, and nanoparticle comprising the same |
JP2007091657A (ja) * | 2005-09-29 | 2007-04-12 | Terumo Corp | アミジン誘導体およびそれを構成成分とする薬物担体 |
WO2007064857A2 (en) * | 2005-12-01 | 2007-06-07 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
WO2008155141A2 (en) * | 2007-06-20 | 2008-12-24 | Novosom Ag | Novel facultative catonic sterols |
Non-Patent Citations (2)
Title |
---|
ALLMANN, R.等: "Photochemical synthesis of 1,2-diazepines. VI. Molecular and crystal structure of 1,2-diazepines and their conformational mobility in solution", 《TETRAHEDRON》 * |
INOUE, KAZUHIKO等: "Design of New Organic Gelators Stabilized by a Host-Guest Interaction", 《 JOURNAL OF ORGANIC CHEMISTRY》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109414451A (zh) * | 2016-05-16 | 2019-03-01 | 德克萨斯大学系统董事会 | 用于作为纳米粒递送tRNA的组合物及其使用方法 |
CN110283223A (zh) * | 2018-03-19 | 2019-09-27 | 广州市锐博生物科技有限公司 | 一种阳离子脂质分子及其在核酸递送中的应用 |
CN110283223B (zh) * | 2018-03-19 | 2022-01-04 | 广州市锐博生物科技有限公司 | 一种阳离子脂质分子及其在核酸递送中的应用 |
Also Published As
Publication number | Publication date |
---|---|
EP2823810B1 (en) | 2019-03-27 |
ES2527220T5 (es) | 2018-06-05 |
US10039714B2 (en) | 2018-08-07 |
CN102481256A (zh) | 2012-05-30 |
EP2451440B1 (en) | 2014-11-12 |
IL216996A0 (en) | 2012-02-29 |
BR112012000255A2 (US06268391-20010731-C00042.png) | 2015-11-03 |
CA2765694A1 (en) | 2011-01-13 |
KR101954912B1 (ko) | 2019-03-08 |
AU2010270337A1 (en) | 2012-02-23 |
EP2451440B2 (en) | 2018-03-14 |
US20120237589A1 (en) | 2012-09-20 |
DK2823810T3 (da) | 2019-05-27 |
JP2012532839A (ja) | 2012-12-20 |
JP5851399B2 (ja) | 2016-02-03 |
AU2010270337B2 (en) | 2016-09-22 |
CN102481256B (zh) | 2015-02-25 |
KR20120046737A (ko) | 2012-05-10 |
EP2823810A1 (en) | 2015-01-14 |
CA2765694C (en) | 2021-05-18 |
EP2823810B9 (en) | 2019-10-30 |
US20180338919A1 (en) | 2018-11-29 |
WO2011003834A1 (en) | 2011-01-13 |
SG177590A1 (en) | 2012-03-29 |
EP2451440A1 (en) | 2012-05-16 |
ES2527220T3 (es) | 2015-01-21 |
US20160338957A1 (en) | 2016-11-24 |
BR112012000255B1 (pt) | 2022-11-29 |
BR212012000255U2 (pt) | 2015-11-03 |
US11541010B2 (en) | 2023-01-03 |
US20200330384A1 (en) | 2020-10-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102481256B (zh) | 包含亚氨基脂质的两性脂质体 | |
EP1019365B1 (en) | Novel compositions for the delivery of negatively charged molecules | |
US6287591B1 (en) | Charged therapeutic agents encapsulated in lipid particles containing four lipid components | |
EP3239132B1 (en) | Cationic lipid | |
EP2211840B1 (en) | Amphoteric liposomes comprising neutral lipids | |
WO2012024233A2 (en) | Zwitterionic lipids | |
WO2008155141A2 (en) | Novel facultative catonic sterols | |
US20080145413A1 (en) | Lipids and lipid assemblies comprising transfection enhancer elements | |
EP3461487A1 (en) | Compositions and methods for the delivery of mrna to hepatic cells | |
CN114945555A (zh) | 用于荷电材料递送的脂质、其制剂及其制备方法 | |
AU2013380825A1 (en) | Lipidosome preparation, preparation method and application thereof | |
Maiti et al. | Liposomal n anoparticles based on steroids and isoprenoids for nonviral gene delivery | |
EP1938843A1 (en) | Lipids and lipid assemblies comrising transfection enhancer elements | |
CN117623978A (zh) | 可生物降解的氨基酸衍生可电离脂质及其制备方法与应用 | |
EP2277508B1 (en) | Emulation of lipoprotein structures | |
Leblond et al. | Lipopolythiourea transfecting agents: Lysine thiourea derivatives | |
CN116082184B (zh) | 基于环己二胺的可电离脂质、脂质纳米颗粒及其制备方法与应用 | |
CN117257965A (zh) | 一种核酸递送载体组合物及其应用 | |
CN117615789A (zh) | 一类可用于活性分子递送的可降解脂质体及其纳米复合物 | |
Dorasamy | Novel siRNA lipoplexes: their targeted and untargeted delivery to mammalian cells in culture. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150701 |
|
WD01 | Invention patent application deemed withdrawn after publication |