CN104739426A - Self-powered implantable blood glucose monitor - Google Patents
Self-powered implantable blood glucose monitor Download PDFInfo
- Publication number
- CN104739426A CN104739426A CN201310731419.XA CN201310731419A CN104739426A CN 104739426 A CN104739426 A CN 104739426A CN 201310731419 A CN201310731419 A CN 201310731419A CN 104739426 A CN104739426 A CN 104739426A
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- China
- Prior art keywords
- main body
- blood sugar
- generating main
- power generation
- sugar monitoring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0204—Operational features of power management
- A61B2560/0214—Operational features of power management of power generation or supply
Abstract
The invention provides a self-powered implantable blood glucose monitor. The self-powered implantable blood glucose monitor comprises a monitoring unit, a signal transmitting unit, a vitro receiving device and a power generating unit. The power generation unit comprises a power generation body, an output unit, an electrical energy storage unit, a fixing unit and an encapsulation layer. The power generation body is of a multilayer film structure and comprises a piezoelectric material layer arranged on the center of the power generation body and electrode layers arranged on both sides of the piezoelectric material layer. The power generation body is attached to the surface of the heart to collect heart energy for generating electric energy. The output unit is connected to the electrode layers to output the current generated by the power generation body to the electrical energy storage unit. The electrical energy storage unit is used for storing electrical energy and supplying the blood glucose monitoring unit and the signal transmitting unit with power. The fixing unit is arranged on the edge of the power generation body and used for fixing the power generation body to the epicardium. The encapsulation layer covers the surfaces of the power generation body, the output unit, the electrical energy storage unit and the fixing unit. The self-powered implantable blood glucose monitor needs no battery replacement and can achieve lifetime use.
Description
Technical field
The present invention relates to a kind of implanted blood sugar monitoring instrument, belong to medical instruments field.
Background technology
Diabetes are commonly encountered diseases and the frequently-occurring disease of middle-older patient, as a kind of lifelong participation disease, still lack the treatment means of thoroughly radical cure at present.Patient needs regular venous blood samples with Monitoring Blood Glucose level usually.Blood sugar monitoring instrument in implantable can the blood sugar concentration of Real-Time Monitoring tissue, does not need to carry out there be taking a blood sample of wound property at every turn.But no matter the implanted blood sugar monitoring instrument of which kind of type, all needs to use implantable minicell to provide electric energy.Once the energy content of battery is exhausted, just need replacing battery of again performing the operation.Both can cause on physiology and spiritual misery to patient, and also can increase the financial burden of patient and family thereof.
At inside of human body, the contractile motion of heart and the flowing of blood all have stable and continual kinetic energy.If wherein sub-fraction kinetic energy be converted into electric energy can be gathered, will be expected to for various implanted blood-sugar detecting instrument provides electric energy.But because heart is human body " electromotor ", inappropriate collection heart kinetic energy will inevitably affect the function of heart, even causes heart and injury.In addition, traditional induction electromotor volume based on Faraday's law is comparatively large, complex structure, is not suitable for et al. Ke.
Summary of the invention
The invention provides a kind of implanted self energizing blood sugar monitoring instrument, it is characterized in that, comprising: for the monitoring portion of Monitoring Blood Glucose; For signal wireless being transferred to the signal emission part of external receiving system; For receiving the external receiving system of described wireless signal; And be the Power Generation Section that described monitoring portion and described signal emission part are powered.Wherein, Power Generation Section comprises generating main body, output unit, energy storage unit, fixed cell and encapsulated layer.Generating main body is multi-layer film structure, and comprise the piezoelectric layer being positioned at generating main center, and be positioned at the electrode layer of piezoelectric layer both sides, described generating main body is by being attached at heart surface to gather cardiac energy for generation of electric energy.Output unit is connected with electrode layer, exports to energy storage unit for electric current generating main body produced.Energy storage unit is used for storage of electrical energy and powers for blood sugar monitoring portion and signal emission part.Fixed cell is positioned at the edge of generating main body, for generating main body is fixed on visceral pericardium.Encapsulated layer is covered in the surface of generating main body, output unit, energy storage unit and fixed cell.
In addition, in implanted self energizing blood sugar monitoring instrument of the present invention, can also have such feature: wherein, the shape of generating main body is tetragon, and fixed cell is positioned at the centre on two narrow limits of tetragon.
In addition, in implanted self energizing blood sugar monitoring instrument of the present invention, can also have such feature: wherein, the shape of generating main body is triangle, and fixed cell is positioned at leg-of-mutton three summits.
In addition, in implanted self energizing blood sugar monitoring instrument of the present invention, can also have such feature: wherein, the shape of generating main body is Long Circle.
In addition, in implanted self energizing blood sugar monitoring instrument of the present invention, can also have such feature: wherein, piezoelectric layer contains nanoscale piezoelectric, and nanoscale piezoelectric is any one in piezoquartz, piezoelectric ceramics and organic piezopolymer.
In addition, in implanted self energizing blood sugar monitoring instrument of the present invention, can also have such feature: wherein, piezoquartz is at least one deck zinc oxide nano-wire array.
In addition, in implanted self energizing blood sugar monitoring instrument of the present invention, can also have such feature: wherein, piezoquartz, piezoelectric ceramics, organic piezopolymer can be the single or multiple lift structure of nanoscale piezoelectric.
In addition, in implanted self energizing blood sugar monitoring instrument of the present invention, can also have such feature: wherein, output unit has output electrode and current rectifying and wave filtering circuit.
In addition, in implanted self energizing blood sugar monitoring instrument of the present invention, can also have such feature: wherein, described encapsulated layer is using the flexible macromolecule insulant of good biocompatibility as encapsulating material.
The effect of invention and effect
According to implanted self energizing blood sugar monitoring instrument of the present invention, because generating main body is directly attached at heart surface, therefore, it is possible to effectively the contraction of heart and diastole are made nanoscale piezoelectric generation deformation, thus be converted into electric energy.As long as therefore heartbeat, the present invention can utilize the bioenergy of patient self and provide electric energy, eliminates the necessity using battery as power supply, solves after the energy content of battery is exhausted and needs operation to change the problem of battery.
In addition, because generating main body of the present invention adopts point fixing mode that electricity generation system is fixed on visceral pericardium, effectively can gather the energy that heart movement produces on the one hand, also can not produce significantly impact to the contraction of heart and diastole campaign on the other hand.
Because the present invention adopts nanoscale piezoelectric as generating main body, not only effectively the bioenergy in body can be converted into electric energy, and volume is small, is more suitable for et al. Ke.
In addition, because the present invention adopts the flexible macromolecule insulant of good biocompatibility to encapsulate, therefore generating main body and internal milieu can be isolated, also the pressure that the heart-shaped sell of one's property is raw effectively can be conducted to piezoelectric.
Further, because generating main body of the present invention is positioned at heart exterior, directly do not contact with blood, thus there is not the risk of thrombosis and apoplexy (myocardial infarction or cerebral infarction).
Accompanying drawing explanation
Fig. 1 is the generating main body of the implanted self energizing blood sugar monitoring instrument of the embodiment of the present invention one is the schematic diagram of tetragon;
Fig. 2 is the partial section of the generating main body of the implanted self energizing blood sugar monitoring instrument of the embodiment of the present invention one;
Fig. 3 is the generating main body of the implanted self energizing blood sugar monitoring instrument of the embodiment of the present invention two is leg-of-mutton schematic diagram;
Fig. 4 is the generating main body of variation of the present invention is oblong schematic diagram; And
Fig. 5 is the circuit diagram of the embodiment of the present invention one.
Detailed description of the invention
The detailed description of the invention of implanted self energizing blood sugar monitoring instrument of the present invention is described below in conjunction with accompanying drawing,
< embodiment one >
Fig. 1 is the generating main body of implanted self energizing blood sugar monitoring instrument in embodiment 1 is the schematic diagram of tetragon, as shown in Figure 1, implanted self energizing blood sugar monitoring instrument 20 has Power Generation Section 200, monitoring portion 17 and signal emission part 18, and for receiving the external receiving system (not shown) from signal emission part 18.Wherein, Power Generation Section 200 comprises generating main body 21, output unit, energy storage unit 16, fixed cell 22 and encapsulated layer (see figure 2).Generating main body 21 is rectangle, two narrow limits of rectangle respectively has a fixed cell 22, for generating main body 11 is fixed on visceral pericardium with long axis direction along systaltic direction.When implanting generating main body, heart is manifested by operating mode, generating main body arranged along systaltic direction and be sewn on visceral pericardium by fixed part, generating main body and visceral pericardium are fitted, and now generating electricity main body can along with the generation deformation of beating of heart.
Fixed cell 22 is made up of encapsulated layer, and the inside of fixed cell 22 does not have the electrification structure such as electrode or piezoelectric, therefore can not destroy the electrification structure of generating main body 21 when using suture to fix.Generating main body remainder except fixing with fixed cell 22 is not fixed, and is beneficial in systaltic process, make generating main body better deformation can occur.Because generating main body have employed rectangle, and installation direction is consistent with systaltic direction, therefore can well gather the mechanical energy that heart contraction produces.
Output electrode 14 exports to energy storage unit 16 for electric energy generating main body produced, before energy storage unit 16, also there is current rectifying and wave filtering circuit 15, electric current for exporting output electrode 14 carries out rectifying and wave-filtering, thus makes the electric current of output more stable.Energy storage unit 16 by supply of electrical energy to the monitoring portion 17 of implanted implanted self energizing blood sugar monitoring instrument and signal emission part 16, monitoring portion 17 reads the blood glucose value in blood in real time, and by signal emission part 16, blood glucose value is wirelessly sent to external receiving system (not shown).
Fig. 2 is the sectional view of the generating main part of the implanted self energizing blood sugar monitoring instrument of the embodiment of the present invention, as shown in Figure 2, generating main body 21 is multi-layer film structure, its central core is piezoelectric layer 31, piezoelectric layer 31 is made up of ZnO nanowire array, the both sides of piezoelectric layer 31 are respectively electrode layer 32 and electrode layer 33, and electrode layer 32 and electrode layer 33 are connected with output electrode 14 (not shown) respectively.Encapsulated layer 34 is positioned at the outside of electrode layer 32 and electrode layer 33, and encapsulated layer 34 has good insulating properties and biocompatibility.
Fig. 5 is the circuit diagram of the embodiment of the present invention, as shown in Figure 5, generating main body 21 is connected with current rectifying and wave filtering circuit 15, the electric energy that generating main body 21 produces charges to energy storage unit 16 after current rectifying and wave filtering circuit 15, and energy storage unit 16 is for powering for the blood sugar monitoring portion in electrical appliance and the present embodiment and signal emission part.
< embodiment two >
Fig. 3 is the Power Generation Section of the embodiment of the present invention is leg-of-mutton implanted self energizing blood sugar monitoring instrument schematic diagram, as shown in Figure 3, the generating main body 12 of implanted self energizing blood sugar monitoring instrument 11 of the present invention is triangle, leg-of-mutton each vertex position all has a fixed cell 13, output electrode 14 is connected with electrode layer (see figure 2), current rectifying and wave filtering circuit 15 is connected with output electrode 14, and energy storage unit 16 is connected to current rectifying and wave filtering circuit 15 afterwards for storing the electric energy that generating main body 12 produces.
The shape of generating main body 12 is triangle, when being installed on visceral pericardium, utilizes the fixed cell 13 be positioned on an Atria summit generating main body 12 to be fixed on visceral pericardium.Wherein the apex of the heart is pointed on a leg-of-mutton summit, two other summit and heart and each limit leg-of-mutton of the main body 12 that generates electricity are not fixed, so both can not limit contraction and the diastole of heart, also contribute to piezoelectric layer along with the motion generation deformation of heart thus produce electric energy.
Generating main body 12 is made into the energy that leg-of-mutton advantage is more to gather heartbeat, this is because not only have horizontal contraction and diastole in the process of heartbeat, also longitudinal contraction and diastole is had, when adopting leg-of-mutton shape, a leg-of-mutton summit is set to the direction towards the apex of the heart, and two other summit is set to parallel with the direction of heart cross-direction shrinkage, no matter being heart cross-direction shrinkage is like this longitudinal contraction, generating main body 12 all can be driven to be out of shape.Therefore the leg-of-mutton shape energy that can more utilize heartbeat to produce than the shape of tetragon.
< variation >
This variation is compared with embodiment one, and except the shape of the main body that generates electricity is except Long Circle, arranging of other is all identical.As shown in Figure 4, the shape of generating main body 42 is Long Circle, and on oblong two summits, place has fixed cell 41, and the shape of generating main body 42 is that oblong advantage is do not have sharp-pointed corner, contributes to the probability reducing impair cardiac.
Certainly, the shape of the generating main body of implanted self energizing blood sugar monitoring instrument of the present invention can be various shape, is not limited only to triangle, tetragon and Long Circle in above-mentioned two embodiments.
Claims (9)
1. an implanted self energizing blood sugar monitoring instrument, is characterized in that, comprising:
For the monitoring portion of Monitoring Blood Glucose;
For signal wireless being transferred to the signal emission part of external receiving system;
For receiving the external receiving system of described wireless signal; And
For the Power Generation Section that described blood sugar monitoring portion and described signal emission part are powered,
Wherein, described Power Generation Section comprises generating main body, output unit, energy storage unit, fixed cell and encapsulated layer,
Described generating main body is multi-layer film structure, comprises the piezoelectric layer being positioned at described generating main center, and is positioned at the electrode layer of piezoelectric layer both sides, described generating main body by being attached at heart surface to gather the energy of heartbeat and to be converted into electric energy,
Described output unit is connected with described electrode layer, exports to described energy storage unit for electric current generating main body produced,
Described energy storage unit is used for storage of electrical energy and powers for described blood sugar monitoring portion and described signal emission part,
Described fixed cell is positioned at the edge of described generating main body, for generating main body is fixed on visceral pericardium,
Described encapsulated layer is covered in the surface of described generating main body, described output unit, described energy storage unit and described fixed cell.
2. implanted self energizing blood sugar monitoring instrument as claimed in claim 1, is characterized in that:
Wherein, the shape of described generating main body is tetragon, and described fixed cell is positioned at the centre on two narrow limits of tetragon.
3. implanted self energizing blood sugar monitoring instrument as claimed in claim 1, is characterized in that:
Wherein, the shape of described generating main body is triangle, and described fixed cell is positioned at leg-of-mutton three summits.
4. implanted self energizing blood sugar monitoring instrument as claimed in claim 1, is characterized in that:
Wherein, the shape of described generating main body is Long Circle.
5. implanted self energizing blood sugar monitoring instrument as claimed in claim 1, is characterized in that:
Wherein, described piezoelectric layer contains nanoscale piezoelectric, and described nanoscale piezoelectric is any one in piezoquartz, piezoelectric ceramics and organic piezopolymer.
6. implanted self energizing blood sugar monitoring instrument as claimed in claim 5, is characterized in that:
Wherein, described piezoquartz is at least one deck zinc oxide nano-wire array.
7. implanted self energizing blood sugar monitoring instrument as claimed in claim 5, is characterized in that:
Wherein, described piezoquartz, piezoelectric ceramics, organic piezopolymer can be the single or multiple lift structure of nanoscale piezoelectric.
8. implanted self energizing blood sugar monitoring instrument as claimed in claim 1, is characterized in that:
Wherein, output unit has output electrode and current rectifying and wave filtering circuit.
9. implanted self energizing blood sugar monitoring instrument as claimed in claim 1, is characterized in that:
Wherein, described encapsulated layer is using the flexible macromolecule insulant of good biocompatibility as encapsulating material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310731419.XA CN104739426B (en) | 2013-12-26 | 2013-12-26 | Implanted self energizing blood sugar monitoring instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310731419.XA CN104739426B (en) | 2013-12-26 | 2013-12-26 | Implanted self energizing blood sugar monitoring instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104739426A true CN104739426A (en) | 2015-07-01 |
| CN104739426B CN104739426B (en) | 2018-04-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310731419.XA Expired - Fee Related CN104739426B (en) | 2013-12-26 | 2013-12-26 | Implanted self energizing blood sugar monitoring instrument |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108141154A (en) * | 2015-09-15 | 2018-06-08 | 密执安州立大学董事会 | Collection of energy without lead pacemaker |
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| US20100160994A1 (en) * | 2007-01-04 | 2010-06-24 | Board Of Regents, The University Of Texas System | Cardiovascular power source for automatic implantable cardioverter defibrillators |
| US20100228312A1 (en) * | 2005-03-25 | 2010-09-09 | Robert White | Implantable Cardiac Motion Powered Piezoelectric Energy Source |
| CN102202563A (en) * | 2008-09-23 | 2011-09-28 | 因库博实验室有限责任公司 | Energy harvesting-mechanism for medical devices |
| CN102931879A (en) * | 2012-11-28 | 2013-02-13 | 浙江大学 | Thermoelectric-piezoelectric combined flexible micro-generating device |
| CN103108672A (en) * | 2010-08-09 | 2013-05-15 | Pi收割控股公司 | Medical system, piezoelectric kit, related methods and medical procedures |
| CN204072105U (en) * | 2013-12-26 | 2015-01-07 | 中国人民解放军第二军医大学 | Implanted self energizing blood sugar monitoring instrument |
-
2013
- 2013-12-26 CN CN201310731419.XA patent/CN104739426B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100228312A1 (en) * | 2005-03-25 | 2010-09-09 | Robert White | Implantable Cardiac Motion Powered Piezoelectric Energy Source |
| US20100160994A1 (en) * | 2007-01-04 | 2010-06-24 | Board Of Regents, The University Of Texas System | Cardiovascular power source for automatic implantable cardioverter defibrillators |
| CN102202563A (en) * | 2008-09-23 | 2011-09-28 | 因库博实验室有限责任公司 | Energy harvesting-mechanism for medical devices |
| CN103108672A (en) * | 2010-08-09 | 2013-05-15 | Pi收割控股公司 | Medical system, piezoelectric kit, related methods and medical procedures |
| CN102931879A (en) * | 2012-11-28 | 2013-02-13 | 浙江大学 | Thermoelectric-piezoelectric combined flexible micro-generating device |
| CN204072105U (en) * | 2013-12-26 | 2015-01-07 | 中国人民解放军第二军医大学 | Implanted self energizing blood sugar monitoring instrument |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108141154A (en) * | 2015-09-15 | 2018-06-08 | 密执安州立大学董事会 | Collection of energy without lead pacemaker |
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| CN104739426B (en) | 2018-04-13 |
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