CN104739426B - Implanted self energizing blood sugar monitoring instrument - Google Patents

Implanted self energizing blood sugar monitoring instrument Download PDF

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Publication number
CN104739426B
CN104739426B CN201310731419.XA CN201310731419A CN104739426B CN 104739426 B CN104739426 B CN 104739426B CN 201310731419 A CN201310731419 A CN 201310731419A CN 104739426 B CN104739426 B CN 104739426B
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CN
China
Prior art keywords
power generation
main body
generation main
blood sugar
sugar monitoring
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Expired - Fee Related
Application number
CN201310731419.XA
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Chinese (zh)
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CN104739426A (en
Inventor
张�浩
曲丹
郎希龙
徐志云
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Second Military Medical University SMMU
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Second Military Medical University SMMU
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Priority to CN201310731419.XA priority Critical patent/CN104739426B/en
Publication of CN104739426A publication Critical patent/CN104739426A/en
Application granted granted Critical
Publication of CN104739426B publication Critical patent/CN104739426B/en
Expired - Fee Related legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0204—Operational features of power management
    • A61B2560/0214—Operational features of power management of power generation or supply

Abstract

The present invention provides a kind of implanted self energizing blood sugar monitoring instrument, including：Monitoring portion；Signal emission part；External reception device；And Power Generation Section.Wherein, Power Generation Section includes power generation main body, output unit, energy storage unit, fixed cell and encapsulated layer.Power generation main body is multi-layer film structure, including the piezoelectric layer positioned at power generation main body center, and the electrode layer positioned at piezoelectric layer both sides, and power generation main body is used to produce electricl energy by being attached at heart surface to gather cardiac energy.Output unit is connected with electrode layer, and the electric current that power generation main body produces is exported to energy storage unit.Energy storage unit is used to store electric energy and powers for blood sugar monitoring portion and signal emission part.Fixed cell is located at the edge of power generation main body, for power generation main body to be fixed on the external membrane of heart.Encapsulated layer is covered in the surface of power generation main body, output unit, energy storage unit and fixed cell.The implanted self energizing blood sugar monitoring instrument of the present invention can use all the life without battery is needed to change.

Description

Implanted self energizing blood sugar monitoring instrument
Technical field
The present invention relates to a kind of implanted blood sugar monitoring instrument, belong to medical instruments field.
Background technology
Diabetes are the common disease and frequently-occurring disease of middle-older patient, as a kind of lifelong disease, are still lacked at present thoroughly The treatment means of radical cure.Patient usually requires regular venous blood samples to monitor blood sugar level.Blood sugar monitoring in implantable Instrument is capable of the blood sugar concentration of monitoring tissue in real time, it is not necessary to carries out invasive take a blood sample every time.But no matter which kind of type Implanted blood sugar monitoring instrument, be required for providing electric energy using implantable minicell.Once the energy content of battery is exhausted, it is necessary to Battery is replaced in operation again.Both can cause physiologically can also increase the warp of patient and its family with spiritual pain to patient Ji burden.
In inside of human body, the flowing of the contractile motion and blood of heart, which all has, stablizes and continual kinetic energy.If energy Enough collections wherein sub-fraction kinetic energy is simultaneously converted into electric energy, will be expected to provide electric energy for various implanted blood-sugar detecting instruments.However, Since heart is human body " engine ", inappropriate collection heart kinetic energy will necessarily influence the function of heart, even result in the heart Dirty damage.In addition, traditional induction generator volume based on Faraday's law is larger, complicated, it is uncomfortable fit It is implanted into.
The content of the invention
The present invention provides a kind of implanted self energizing blood sugar monitoring instrument, it is characterised in that including：For monitoring the prison of blood glucose Survey portion；For signal to be radioed to the signal emission part of external reception device；For receiving the body of the wireless signal Infrared receiving device；And it is the monitoring portion and the Power Generation Section of signal emission part power supply.Wherein, Power Generation Section includes hair Electric main body, output unit, energy storage unit, fixed cell and encapsulated layer.Power generation main body is multi-layer film structure, including position Piezoelectric layer in power generation main body center, and the electrode layer positioned at piezoelectric layer both sides, the power generation main body is by being attached at heart Surface is used to produce electricl energy to gather cardiac energy.Output unit is connected with electrode layer, for the electricity for producing power generation main body Stream output is to energy storage unit.Energy storage unit is used to store electric energy and powers for blood sugar monitoring portion and signal emission part. Fixed cell is located at the edge of power generation main body, for power generation main body to be fixed on the external membrane of heart.Encapsulated layer is covered in power generation main body, defeated Go out the surface of unit, energy storage unit and fixed cell.
In addition, in the implanted self energizing blood sugar monitoring instrument of the present invention, can also have the feature that：Wherein, send out The shape of electric main body is quadrangle, and fixed cell is located at the centre of two narrow sides of quadrangle.
In addition, in the implanted self energizing blood sugar monitoring instrument of the present invention, can also have the feature that：Wherein, send out The shape of electric main body is triangle, and fixed cell is located at three vertex of triangle.
In addition, in the implanted self energizing blood sugar monitoring instrument of the present invention, can also have the feature that：Wherein, send out The shape of electric main body is oval.
In addition, in the implanted self energizing blood sugar monitoring instrument of the present invention, can also have the feature that：Wherein, press Electric layer contains nanoscale piezoelectric, and nanoscale piezoelectric is in piezo-electric crystal, piezoelectric ceramics and organic piezopolymer Any one.
In addition, in the implanted self energizing blood sugar monitoring instrument of the present invention, can also have the feature that：Wherein, press Transistor is at least one layer of zinc oxide nano-wire array.
In addition, in the implanted self energizing blood sugar monitoring instrument of the present invention, can also have the feature that：Wherein, press Transistor, piezoelectric ceramics, organic piezopolymer can be the single or multi-layer structure of nanoscale piezoelectric.
In addition, in the implanted self energizing blood sugar monitoring instrument of the present invention, can also have the feature that：Wherein, it is defeated Going out unit has output electrode and current rectifying and wave filtering circuit.
In addition, in the implanted self energizing blood sugar monitoring instrument of the present invention, can also have the feature that：Wherein, institute The flexible macromolecule insulating materials for stating encapsulated layer using good biocompatibility is used as encapsulating material.
The effect of invention
Implanted self energizing blood sugar monitoring instrument according to the present invention, since power generation main body is attached directly to heart surface, because The contraction of heart and diastole effectively can deform upon nanoscale piezoelectric by this, so as to be converted into electric energy.Therefore only Heartbeat is wanted, the present invention provides electric energy using the biological energy source of patient itself, eliminates using battery and be used as power supply Necessity, needs operation to replace battery after solving the problems, such as energy content of battery exhaustion.
Further, since electricity generation system is fixed on the external membrane of heart, a side by the power generation main body of the present invention by the way of point is fixed Face can effectively gather the energy of heart movement generation, and contraction and diastole campaign generation that on the other hand will not be to heart is bright Aobvious influence.
, not only can be effectively by internal biological energy source due to the present invention using nanoscale piezoelectric as power generation main body Electric energy is converted into, and volume is small, is more suitable for et al. Ke.
Further, since the present invention is encapsulated using the flexible macromolecule insulating materials of good biocompatibility, therefore will can send out Electric main body is isolated with vivo environment, can also effectively conduct the heart-shaped pressure for becoming generation to piezoelectric.
Also, since the power generation main body of the present invention is located at heart exterior, do not contacted directly with blood, because thrombus may be not present Formation and apoplexy（Miocardial infarction or cerebral infarction）Risk.
Brief description of the drawings
Fig. 1 is that the power generation main body of the implanted self energizing blood sugar monitoring instrument of the embodiment of the present invention one is the signal of quadrangle Figure；
Fig. 2 is the partial section of the power generation main body of the implanted self energizing blood sugar monitoring instrument of the embodiment of the present invention one；
Fig. 3 is that the power generation main body of the implanted self energizing blood sugar monitoring instrument of the embodiment of the present invention two is the signal of triangle Figure；
Fig. 4 is that the power generation main body of variation of the present invention is the schematic diagram of oval；And
Fig. 5 is the circuit diagram of the embodiment of the present invention one.
Embodiment
Illustrate the embodiment of implanted self energizing blood sugar monitoring instrument of the present invention below in conjunction with attached drawing,
<Embodiment one>
Fig. 1 be implanted self energizing blood sugar monitoring instrument in embodiment 1 power generation main body be quadrangle schematic diagram, such as Fig. 1 Shown, implanted self energizing blood sugar monitoring instrument 20 has Power Generation Section 200, monitoring portion 17 and signal emission part 18, and for connecing Receive the external reception device from signal emission part 18（Do not shown in figure）.Wherein, Power Generation Section 200 includes power generation main body 21, defeated Go out unit, energy storage unit 16, fixed cell 22 and encapsulated layer（See Fig. 2）.Power generation main body 21 is rectangle, the two of rectangle Respectively there is a fixed cell 22, for power generation main body 11 to be fixed with long axis direction along systaltic direction in bar narrow side In on the external membrane of heart.When being implanted into power generation main body, heart is manifested by way of surgical operation, by power generation main body along heart contraction Direction set and fixed part is sewn on the external membrane of heart so that power generation main body fits with the external membrane of heart, at this time power generation main body meeting Deformation is produced with the bounce of heart.
Fixed cell 22 is made of encapsulated layer, and the inside of fixed cell 22 does not have the power generation knot such as electrode or piezoelectric Structure, therefore the electrification structure of power generation main body 21 will not be destroyed when being fixed using suture.Power generation main body is except with fixed cell 22 Remainder and it is not fixed outside fixation, in favor of enabling power generation main body that shape preferably occurs during heart contraction Become.Since power generation main body employs rectangle, and installation direction is consistent with systaltic direction, therefore can be very good to gather The mechanical energy that heart contraction produces.
Output electrode 14 is used to export the electric energy that power generation main body produces to energy storage unit 16, in energy storage unit Also there is current rectifying and wave filtering circuit 15 before 16, the electric current for being exported to output electrode 14 carries out rectifying and wave-filtering, so that defeated The electric current gone out is more stablized.Electric energy is supplied to the monitoring of implanted implanted self energizing blood sugar monitoring instrument by energy storage unit 16 Portion 17 and signal emission part 16, monitoring portion 17 read the blood glucose value in blood in real time, and by signal emission part 16 by blood glucose value It is wirelessly sent to external reception device（Do not shown in figure）.
Fig. 2 is the sectional view of the power generation main body part of the implanted self energizing blood sugar monitoring instrument of the embodiment of the present invention, such as Fig. 2 Shown, power generation main body 21 is multi-layer film structure, its central core is piezoelectric layer 31, and piezoelectric layer 31 is by ZnO nanowire array group Both sides into, piezoelectric layer 31 are respectively electrode layer 32 and electrode layer 33, electrode layer 32 and electrode layer 33 respectively with output electrode 14 It is connected（Do not shown in figure）.Encapsulated layer 34 is located at the outside of electrode layer 32 and electrode layer 33, and encapsulated layer 34 has well exhausted Edge and biocompatibility.
Fig. 5 is the circuit diagram of the embodiment of the present invention, as shown in figure 5, power generation main body 21 is connected with current rectifying and wave filtering circuit 15, The electric energy that power generation main body 21 produces charges energy storage unit 16 after current rectifying and wave filtering circuit 15, energy storage unit 16 are used to be the blood sugar monitoring portion in electrical appliance, that is, the present embodiment and the power supply of signal emission part.
<Embodiment two>
Fig. 3 be the embodiment of the present invention Power Generation Section be triangle implanted self energizing blood sugar monitoring instrument schematic diagram, such as Fig. 3 Shown, the power generation main body 12 of implanted self energizing blood sugar monitoring instrument 11 of the invention is triangle, each vertex position of triangle Put and be respectively provided with a fixed cell 13, output electrode 14 and electrode layer（See Fig. 2）It is connected, current rectifying and wave filtering circuit 15 and output electricity Pole 14 is connected, and energy storage unit 16 is used to store the electricity that power generation main body 12 produces after being connected to current rectifying and wave filtering circuit 15 Energy.
The shape of power generation main body 12 is triangle, when being installed on the external membrane of heart, is pushed up using positioned at Atria Power generation main body 12 is fixed on the external membrane of heart by the fixed cell 13 on point.Wherein the apex of the heart is directed toward on a vertex of triangle, in addition Two vertex and heart and each side of the triangle of power generation main body 12 are simultaneously not fixed, so both the contraction without limitation on heart and Diastole, additionally aids piezoelectric layer as the movement of heart deforms upon so as to produce electricl energy.
The advantages of power generation main body 12 is fabricated to triangle is the energy that can more gather heartbeat, this is because Not only there are horizontal contraction and diastole during heartbeat, also there is longitudinal contraction and diastole, when using triangle During shape, a vertex of triangle is arranged to the direction towards the apex of the heart, and two other vertex is arranged to laterally receive with heart The direction of contracting is parallel, and so whether heart cross-direction shrinkage is longitudinal contraction, power generation main body 12 can be driven to deform.Therefore The shape of triangle can more utilize the energy of heartbeat generation than the shape of quadrangle.
<Variation>
This variation is compared with embodiment one, and in addition to the shape of power generation main body is oval, others set homogeneous Together.As shown in figure 4, the shape of power generation main body 42 is oval, there is fixed cell 41 in two apexes of oval, generate electricity The advantages of shape of main body 42 is oval is no sharp corner, helps to reduce the probability of impair cardiac.
Certainly, the shape of the power generation main body of implanted self energizing blood sugar monitoring instrument of the invention can be various shapes, no Triangle, quadrangle and the oval being only limitted in above-mentioned two embodiment.

Claims (9)

  1. A kind of 1. implanted self energizing blood sugar monitoring instrument, it is characterised in that including：
    For monitoring the monitoring portion of blood glucose；
    For signal to be radioed to the signal emission part of external reception device；
    For receiving the external reception device of the wireless signal；And
    The Power Generation Section to power for the blood sugar monitoring portion and the signal emission part,
    Wherein, the Power Generation Section includes power generation main body, output unit, energy storage unit, fixed cell and encapsulated layer,
    The power generation main body is multi-layer film structure, including the piezoelectric layer positioned at the power generation main body center, and positioned at piezoelectricity The electrode layer of layer both sides, the power generation main body are attached directly to heart surface and are used to produce electricl energy to gather cardiac energy,
    The output unit is connected with the electrode layer, and the electric current for power generation main body to be produced is exported to the power storage Unit,
    The energy storage unit is used to store electric energy and powers for the blood sugar monitoring portion and the signal emission part,
    The fixed cell is located at the edge of the power generation main body, is pasted for power generation main body to be fixed along systaltic direction Together in the external membrane of heart,
    The encapsulated layer is covered in the power generation main body, the output unit, the energy storage unit and the fixed list The surface of member.
  2. 2. implanted self energizing blood sugar monitoring instrument as claimed in claim 1, it is characterised in that：
    Wherein, the shape of the power generation main body is quadrangle, and the centre that the fixed cell is located at two narrow sides of quadrangle makes The power generation main body is fixed along the systaltic direction with long axis direction and fits in the external membrane of heart.
  3. 3. implanted self energizing blood sugar monitoring instrument as claimed in claim 1, it is characterised in that：
    Wherein, the shape of the power generation main body is triangle, and the fixed cell is located on three vertex of triangle, during installation One vertex of the power generation main body is arranged to the direction towards the apex of the heart, two other described vertex is arranged to horizontal with heart It is parallel to the direction of contraction.
  4. 4. implanted self energizing blood sugar monitoring instrument as claimed in claim 1, it is characterised in that：
    Wherein, the shape of the power generation main body is oval, the fixed cell be located at the oval two vertex make it is described Power generation main body is fixed along the systaltic direction with long axis direction and fits in the external membrane of heart.
  5. 5. implanted self energizing blood sugar monitoring instrument as claimed in claim 1, it is characterised in that：
    Wherein, the piezoelectric layer contains nanoscale piezoelectric, the nanoscale piezoelectric is piezo-electric crystal, piezoelectric ceramics and Any one in organic piezopolymer.
  6. 6. implanted self energizing blood sugar monitoring instrument as claimed in claim 5, it is characterised in that：
    Wherein, the piezo-electric crystal is at least one layer of zinc oxide nano-wire array.
  7. 7. implanted self energizing blood sugar monitoring instrument as claimed in claim 5, it is characterised in that：
    Wherein, the piezo-electric crystal, piezoelectric ceramics, organic piezopolymer can be the single or multiple lift of nanoscale piezoelectric Structure.
  8. 8. implanted self energizing blood sugar monitoring instrument as claimed in claim 1, it is characterised in that：
    Wherein, output unit has output electrode and current rectifying and wave filtering circuit.
  9. 9. implanted self energizing blood sugar monitoring instrument as claimed in claim 1, it is characterised in that：
    Wherein, the flexible macromolecule insulating materials of the encapsulated layer using good biocompatibility is used as encapsulating material.
CN201310731419.XA 2013-12-26 2013-12-26 Implanted self energizing blood sugar monitoring instrument Expired - Fee Related CN104739426B (en)

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CN104739426B true CN104739426B (en) 2018-04-13

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10463864B2 (en) * 2015-09-15 2019-11-05 The Regents Of The University Of Michigan Energy harvesting for leadless pacemakers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7729768B2 (en) * 2005-03-25 2010-06-01 Proteus Biomedical, Inc. Implantable cardiac motion powered piezoelectric energy source
US20100160994A1 (en) * 2007-01-04 2010-06-24 Board Of Regents, The University Of Texas System Cardiovascular power source for automatic implantable cardioverter defibrillators
US9026212B2 (en) * 2008-09-23 2015-05-05 Incube Labs, Llc Energy harvesting mechanism for medical devices
US9259580B2 (en) * 2010-08-09 2016-02-16 Pi-Harvest Holding Ag Medical system, piezoelectric kit, related methods and medical procedures
CN102931879B (en) * 2012-11-28 2014-12-17 浙江大学 Thermoelectric-piezoelectric combined flexible micro-generating device
CN204072105U (en) * 2013-12-26 2015-01-07 中国人民解放军第二军医大学 Implanted self energizing blood sugar monitoring instrument

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Granted publication date: 20180413

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