CN104740714A - Self-powered implantable insulin pump - Google Patents
Self-powered implantable insulin pump Download PDFInfo
- Publication number
- CN104740714A CN104740714A CN201310733133.5A CN201310733133A CN104740714A CN 104740714 A CN104740714 A CN 104740714A CN 201310733133 A CN201310733133 A CN 201310733133A CN 104740714 A CN104740714 A CN 104740714A
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- Prior art keywords
- main body
- generating main
- insulin pump
- power generation
- self energizing
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14212—Pumping with an aspiration and an expulsion action
- A61M5/14216—Reciprocating piston type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0272—Electro-active or magneto-active materials
- A61M2205/0294—Piezoelectric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/04—General characteristics of the apparatus implanted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/201—Glucose concentration
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- External Artificial Organs (AREA)
Abstract
The invention provides a self-powered implantable insulin pump. The self-powered implantable insulin pump comprises a blood glucose monitoring unit, an insulin infusion pump, an infusion catheter, a control unit and a power generation unit. The power generation unit comprises a power generation body, an output unit, an electrical energy storage unit, a fixing unit and an encapsulation layer. The power generation body is of a multilayer film structure and comprises a piezoelectric material layer arranged on the center of the power generation body and electrode layers arranged on both sides of the piezoelectric material layer. The power generation body is attached to the surface of the heart to collect heart energy for generating electric energy. The output unit is connected to the electrode layers to output the current generated by the power generation body to the electrical energy storage unit. The fixing unit is arranged on the edge of the power generation body and used for fixing the power generation body to the epicardium. The encapsulation layer covers the surfaces of the power generation body, the output unit, the electrical energy storage unit and the fixing unit. The self-powered implantable insulin pump needs no battery replacement and can achieve lifetime use.
Description
Technical field
The present invention relates to a kind of implantable insulin pump, belong to medical instruments field.
Background technology
Diabetes are commonly encountered diseases and the frequently-occurring disease of middle-older patient, as a kind of lifelong participation disease, still lack the treatment means of thoroughly radical cure at present.For serious diabetics, usually need to take intensive insulin therapy.Because intensive treatment needs 3 even more insulin injections every day, considerably increase the probability that hypoglycemic risk and body weight rising occur.
Implantable insulin pump in research and development in recent years or clinical trial is conducive to continuing, controlling blood glucose stably, and reduces the relevant complication of diabetes.But implantable insulin pump, as a kind of electronic equipment of et al. Ke, needs the supply of electrical energy continued.And the power-on time of existing minicell is general shorter, once the energy content of battery is exhausted after implanting, just need replacing battery of again performing the operation.This both can cause physiological misery and psychological fear and anxiety to patient, also can increase the financial burden of patient and family thereof.
At inside of human body, the contractile motion of heart and the flowing of blood all have stable and continual kinetic energy.If wherein sub-fraction kinetic energy be converted into electric energy can be gathered, the ideal capacity source becoming implantable insulin pump will be expected to.But because heart is human body " electromotor ", inappropriate collection heart kinetic energy will inevitably affect the function of heart, even causes heart and injury.In addition, traditional induction electromotor volume based on Faraday's law is comparatively large, complex structure, is not suitable for et al. Ke.
Summary of the invention
For solving the problem, the invention provides a kind of implanted self energizing insulin pump, it is characterized in that, comprise blood sugar monitoring portion, the syringe pump of insulin injection, infusion catheter, control part and Power Generation Section.Power Generation Section comprises generating main body, output unit, energy storage unit, fixed cell and encapsulated layer.Wherein, generating main body is multi-layer film structure, and comprise the piezoelectric material layer being positioned at generating main center, and be positioned at the electrode layer of piezoelectric material layer both sides, described generating main body is by being attached at heart surface to gather cardiac energy for generation of electric energy.Output unit is connected with electrode layer, exports to energy storage unit for electric current generating main body produced.Energy storage unit is used for storage of electrical energy and is that blood sugar monitoring portion, syringe pump and signal emission part are powered.Fixed cell is positioned at the edge of generating main body, for generating main body is fixed on visceral pericardium.Encapsulated layer is covered in the surface of generating main body, output unit, energy storage unit and fixed cell.
In addition, in implanted self energizing insulin pump of the present invention, can also have such feature: wherein, the shape of generating main body is tetragon, and fixed cell is positioned at the centre on two narrow limits of tetragon.
In addition, in implanted self energizing insulin pump of the present invention, can also have such feature: wherein, the shape of generating main body is triangle, and fixed cell is positioned at leg-of-mutton three summits.
In addition, in implanted self energizing insulin pump of the present invention, can also have such feature: wherein, the shape of generating main body is Long Circle.
In addition, in implanted self energizing insulin pump of the present invention, can also have such feature: wherein, piezoelectric material layer contains nanoscale piezoelectric, and nanoscale piezoelectric is any one in piezoquartz, piezoelectric ceramics and organic piezopolymer.
In addition, in implanted self energizing insulin pump of the present invention, can also have such feature: wherein, piezoquartz is at least one deck zinc oxide nano-wire array.
In addition, in implanted self energizing insulin pump of the present invention, can also have such feature: wherein, piezoquartz, piezoelectric ceramics, organic piezopolymer can be the single or multiple lift structure of nanoscale piezoelectric.
In addition, in implanted self energizing insulin pump of the present invention, can also have such feature: wherein, output unit has output electrode and current rectifying and wave filtering circuit.
In addition, in implanted self energizing insulin pump of the present invention, can also have such feature: wherein, encapsulated layer is using the flexible macromolecule insulant of good biocompatibility as encapsulating material.
The effect of invention and effect
According to implanted self energizing insulin pump of the present invention, because generating main body is directly attached at heart surface, therefore, it is possible to effectively the contraction of heart and diastole are made nanoscale piezoelectric generation deformation, thus be converted into electric energy.As long as therefore heartbeat, the present invention can utilize the bioenergy of patient self and provide electric energy, eliminates the necessity using battery as power supply, solves after the energy content of battery is exhausted and needs operation to change the problem of battery.
In addition, because generating main body of the present invention adopts point fixing mode that electricity generation system is fixed on visceral pericardium, effectively can gather the energy that heart movement produces on the one hand, also can not produce significantly impact to the contraction of heart and diastole campaign on the other hand.
Because the present invention adopts nanoscale piezoelectric as generating main body, not only effectively the bioenergy in body can be converted into electric energy, and volume is small, is more suitable for et al. Ke.
In addition, because the present invention adopts the flexible macromolecule insulant of good biocompatibility to encapsulate, therefore generating main body and internal milieu can be isolated, also the pressure that the heart-shaped sell of one's property is raw effectively can be conducted to piezoelectric.
Further, because generating main body of the present invention is positioned at heart exterior, directly do not contact with blood, thus there is not the risk of thrombosis and apoplexy (myocardial infarction or cerebral infarction).
Accompanying drawing explanation
Fig. 1 is the generating main body of the implanted self energizing insulin pump of the embodiment of the present invention one is the schematic diagram of tetragon;
Fig. 2 is the partial section of the generating main body of the implanted self energizing insulin pump of the embodiment of the present invention one;
Fig. 3 is the generating main body of the implanted self energizing insulin pump of the embodiment of the present invention two is leg-of-mutton schematic diagram;
Fig. 4 is the generating main body of variation of the present invention is oblong schematic diagram; And
Fig. 5 is the circuit diagram of the embodiment of the present invention.
Detailed description of the invention
The detailed description of the invention of implanted self energizing insulin pump of the present invention is described below in conjunction with accompanying drawing,
< embodiment one >
Fig. 1 is the generating main body of implanted self energizing insulin pump in embodiment 1 is the schematic diagram of tetragon, as shown in Figure 1, implanted self energizing insulin pump 20 there is Power Generation Section 200, comprise for Monitoring Blood Glucose monitoring portion 173, for the syringe pump 17 of insulin injection in human body, the infusion catheter 171 be connected with syringe pump, for signal wireless is transferred to external receiving system signal emission part 172, be used for the signal receiving part (not shown) of Received signal strength and control the control part 18 of above each several part.Wherein, Power Generation Section 200 comprises generating main body 21, output unit, energy storage unit 16, fixed cell 22 and encapsulated layer.Generating main body 21 is rectangle, two narrow limits of rectangle respectively has a fixed cell 22, for generating main body 21 is fixed on visceral pericardium with long axis direction along systaltic direction.When implanting generating main body, heart is manifested by operating mode, generating main body arranged along systaltic direction and be sewn on visceral pericardium by fixed part, generating main body and visceral pericardium are fitted, and now generating electricity main body can along with the generation deformation of beating of heart.
Fixed cell 22 is formed after being extended by encapsulated layer, and the inside of fixed cell 22 does not have the electrification structure such as electrode or piezoelectric, therefore can not destroy the electrification structure of generating main body 21 when using suture to fix.Generating main body 21 remainder except fixing with fixed cell 22 is not fixed, and is beneficial in systaltic process, make generating main body 21 better deformation can occur.Because generating main body have employed rectangle, and installation direction is consistent with systaltic direction, therefore can well gather the mechanical energy that heart contraction produces.
Output electrode 14 exports to energy storage unit 16 for electric energy generating main body 21 produced, and also has current rectifying and wave filtering circuit 15, carried out rectifying and wave-filtering for the electric current exported output electrode 14 before energy storage unit 16.Energy storage unit 16 is powered for control part 18 and implanted self energizing insulin pump 17 and signal emission part 172.When blood sugar monitoring portion 173 experiences blood glucose value in body higher than threshold value, control part 18 can control syringe pump 17 and in blood, input appropriate insulin by infusion catheter 171, meanwhile, the duty of the blood glucose information in body and implanted self energizing insulin pump can be exported to and be positioned over external signal receiving part (not shown) and carry out showing and record by signal emission part 172.
Fig. 2 is the sectional view of the generating main part of the implanted self energizing insulin pump of the embodiment of the present invention, as shown in Figure 2, generating main body 21 is multi-layer film structure, its central core is piezoelectric material layer 31, piezoelectric material layer 31 is made up of ZnO nanowire array, the both sides of piezoelectric material layer 31 are respectively electrode layer 32 and electrode layer 33, and electrode layer 32 and electrode layer 33 are connected with output electrode 14 (not shown) respectively.Encapsulated layer 34 is positioned at the outside of electrode layer 32 and electrode layer 33, and encapsulated layer 34 has good insulating properties and biocompatibility.
Fig. 5 is the circuit diagram of the embodiment of the present invention, as shown in Figure 5, generating main body 21 is connected with current rectifying and wave filtering circuit 15, the electric energy that generating main body 21 produces charges to energy storage unit 16 after current rectifying and wave filtering circuit 15, and energy storage unit 16 is for powering for the monitoring portion in electrical appliance and the present embodiment, syringe pump and signal emission part.
< embodiment two >
Fig. 3 is the Power Generation Section of the embodiment of the present invention is leg-of-mutton implanted self energizing insulin pump schematic diagram, as shown in Figure 3, the generating main body 12 of implanted self energizing insulin pump 11 of the present invention is triangle, leg-of-mutton each vertex position all has a fixed cell 13, output electrode 14 is connected with electrode layer (see figure 2), current rectifying and wave filtering circuit 15 is connected with output electrode 14, and energy storage unit 16 is connected to current rectifying and wave filtering circuit 15 afterwards for storing the electric energy that generating main body 12 produces.
The shape of generating main body 12 is triangle, when being installed on visceral pericardium, utilizes the fixed cell 13 be positioned on an Atria summit generating main body 12 to be fixed on visceral pericardium.Wherein, the apex of the heart is pointed on a leg-of-mutton summit, and the line on all the other two summits is parallel with systaltic direction.And each limit leg-of-mutton of the main body 12 that generates electricity is not fixed, so both can not limit contraction and the diastole of heart, also contribute to piezoelectric material layer along with the motion generation deformation of heart thus produce electric energy.
Generating main body 12 is made into the energy that leg-of-mutton advantage is more to gather heartbeat, this is because not only have horizontal contraction and diastole in the process of heartbeat, also longitudinal contraction and diastole is had, when adopting leg-of-mutton shape, a leg-of-mutton summit is set to the direction towards the apex of the heart, and two other summit is set to parallel with the direction of heart cross-direction shrinkage, no matter being heart cross-direction shrinkage is like this longitudinal contraction, generating main body 12 all can be driven to be out of shape.Therefore the leg-of-mutton shape energy that can more utilize heartbeat to produce than the shape of tetragon.
Fixed cell 13 is extended in corresponding position by encapsulated layer and is formed, and damage piezoelectric material layer and electrode layer when sewing up, not containing piezoelectric and electrode material, therefore can be avoided in the inside of fixed cell 13.
< variation >
This variation is compared with embodiment one, and except the shape of the main body that generates electricity is except Long Circle, arranging of other is all identical.As shown in Figure 4, the shape of generating main body 42 is Long Circle, and on oblong two summits, place has fixed cell 41, and the shape of generating main body 42 is that oblong advantage is do not have sharp-pointed corner, contributes to the probability reducing impair cardiac.
Certainly, the shape of the generating main body of implanted self energizing insulin pump of the present invention can be various shape, is not limited only to triangle, tetragon and Long Circle in above-mentioned two embodiments.
Claims (9)
1. an implanted self energizing insulin pump, is characterized in that, comprising:
Blood sugar monitoring portion;
The syringe pump of insulin injection;
The infusion catheter be connected with syringe pump;
Control part; And
For the Power Generation Section that described blood sugar monitoring portion, described syringe pump are powered,
Wherein, described Power Generation Section comprises generating main body, output unit, energy storage unit, fixed cell and encapsulated layer,
Described generating main body is multi-layer film structure, comprises the piezoelectric material layer being positioned at described generating main center, and is positioned at the electrode layer of piezoelectric material layer both sides, described generating main body by being attached at heart surface to gather the energy of heartbeat and to be converted into electric energy,
Described output unit is connected with described electrode layer, exports to described energy storage unit for electric current generating main body produced,
Described energy storage unit is used for storage of electrical energy and powers for described blood glucose sensor, described syringe pump and described signal emission part,
Described fixed cell is positioned at the edge of described generating main body, for generating main body is fixed on visceral pericardium,
Described encapsulated layer is covered in the surface of described generating main body, described output unit, described energy storage unit and described fixed cell.
2. implanted self energizing insulin pump as claimed in claim 1, is characterized in that:
Wherein, the shape of described generating main body is tetragon, and described fixed cell is positioned at the centre on two narrow limits of tetragon.
3. implanted self energizing insulin pump as claimed in claim 1, is characterized in that:
Wherein, the shape of described generating main body is triangle, and described fixed cell is positioned at leg-of-mutton three summits.
4. implanted self energizing insulin pump as claimed in claim 1, is characterized in that:
Wherein, the shape of described generating main body is Long Circle.
5. implanted self energizing insulin pump as claimed in claim 1, is characterized in that:
Wherein, described piezoelectric material layer contains nanoscale piezoelectric, and described nanoscale piezoelectric is any one in piezoquartz, piezoelectric ceramics and organic piezopolymer.
6. implanted self energizing insulin pump as claimed in claim 5, is characterized in that:
Wherein, described piezoquartz is at least one deck zinc oxide nano-wire array.
7. implanted self energizing insulin pump as claimed in claim 5, is characterized in that:
Wherein, described piezoquartz, piezoelectric ceramics, organic piezopolymer can be the single or multiple lift structure of nanoscale piezoelectric.
8. implanted self energizing insulin pump as claimed in claim 1, is characterized in that:
Wherein, output unit has output electrode and current rectifying and wave filtering circuit.
9. implanted self energizing insulin pump as claimed in claim 1, is characterized in that:
Wherein, described encapsulated layer is using the flexible macromolecule insulant of good biocompatibility as encapsulating material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310733133.5A CN104740714B (en) | 2013-12-26 | 2013-12-26 | Implanted self energizing insulin pump |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310733133.5A CN104740714B (en) | 2013-12-26 | 2013-12-26 | Implanted self energizing insulin pump |
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| CN104740714A true CN104740714A (en) | 2015-07-01 |
| CN104740714B CN104740714B (en) | 2018-08-28 |
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| CN201310733133.5A Expired - Fee Related CN104740714B (en) | 2013-12-26 | 2013-12-26 | Implanted self energizing insulin pump |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107921211A (en) * | 2015-07-31 | 2018-04-17 | 赛诺菲-安万特德国有限公司 | Sensor, cartridge case and delivery device |
| CN108310477A (en) * | 2018-01-24 | 2018-07-24 | 张海军 | A kind of chargeable implanted automatic Regulation separate system with programmable function |
| US20190022322A1 (en) * | 2015-07-31 | 2019-01-24 | Sanofi-Aventis Deutschland Gmbh | Sensor for a drug delivery device |
| CN110402155A (en) * | 2016-12-07 | 2019-11-01 | 格勒诺布尔-阿尔卑斯大学 | Implantable device |
| US10895487B2 (en) | 2015-07-31 | 2021-01-19 | Sanofi-Aventis Deutschland Gmbh | Sensor, cartridge and drug delivery device |
| US10898647B2 (en) | 2015-07-31 | 2021-01-26 | Sanofi-Aventis Deutschland Gmbh | Sensor, cartridge and drug delivery device |
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| CN203989258U (en) * | 2013-12-26 | 2014-12-10 | 中国人民解放军第二军医大学 | Implanted self energizing insulin pump |
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Cited By (13)
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| US11020529B2 (en) | 2015-07-31 | 2021-06-01 | Sanofi-Aventis Deutschland Gmbh | Sensor for a drug delivery device |
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| CN108310477A (en) * | 2018-01-24 | 2018-07-24 | 张海军 | A kind of chargeable implanted automatic Regulation separate system with programmable function |
| CN108310477B (en) * | 2018-01-24 | 2020-12-11 | 山东百多安医疗器械股份有限公司 | Rechargeable implanted automatic voltage regulation and distribution system with program control function |
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| CN104740714B (en) | 2018-08-28 |
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Granted publication date: 20180828 Termination date: 20181226 |