CN104725467A - Process system for preparing glycyl glutamine and method thereof - Google Patents
Process system for preparing glycyl glutamine and method thereof Download PDFInfo
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- CN104725467A CN104725467A CN201510135286.9A CN201510135286A CN104725467A CN 104725467 A CN104725467 A CN 104725467A CN 201510135286 A CN201510135286 A CN 201510135286A CN 104725467 A CN104725467 A CN 104725467A
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Abstract
The invention provides a process system for preparing glycyl glutamine. The system comprises a reaction device (1), a stirring device (2), a filtering column (3) and a pump (4), wherein the stirring device (2) is located in the synthesis reaction device (1); an outlet is formed in the bottom of the reaction device (1), the outlet is connected with a tee, and the other two end ports of the tee are respectively connected with a liquid outlet end (5) and one end of the pump (4); the system further comprises a filtering device (6) and a collecting device (7), wherein the upstream end of the filtering device (6) is connected with the liquid outlet end (5) through a pipeline, and the downstream end of the filtering device (6) is connected with the collecting device (7) through a pipeline. Glycyl glutamine can be prepared according to the process system provided by the invention. The process system provided by the invention effectively removes impurities to improve the purity of a finished product, and is simple in equipment requirements, high in yield, simple in post treatment and low in cost.
Description
Technical field
The present invention relates to a kind of chemical reaction equipment, be specifically related to a kind of glycylglutamine process system and method thereof.
Background technology
Glycylglutamine is parenteral nutrition medicine, and vivo degradation goes out L-glutaminate, and the synthesis of supply body substance or energy expenditure use.Traditional enzyme catalysis connects peptide method, due to synthesis cost intensive, cannot realize industrialization and produce in Industrial processes.More external up-to-date synthetic methods, although simplified synthesis step, use the price of raw material higher, product cost is higher.
Summary of the invention
In order to solve the problem, first object of the present invention is to provide prepares glycylglutamine process system.
Second object of the present invention is to provide preparation to adopt the preparation method of glycylglutamine process system.
Provided by the inventionly prepare glycylglutamine process system technical scheme:
One prepares glycylglutamine process system, comprises reaction unit, whipping appts, Filter column, pump; Described whipping appts is positioned at described synthetic reaction device; Outlet is arranged at the bottom of described reaction unit, this outlet is connected to threeway, other two ports of this threeway connect one end of outlet end and described pump respectively, also comprise filtration unit, collection device, the upstream extremity of this filtration unit is connected with described outlet end pipeline, and the downstream of this filtration unit is connected with described collection device pipeline.
As preferably, described filtration unit is ultra-filtration equipment.
As preferably, described filtration unit is nanofiltration device.
As preferably, have weighting material in described Filter column, this weighting material is the one in resin or gac.
Preparation method's technical scheme of employing glycylglutamine process system provided by the invention is:
The method of glycylglutamine process system is prepared in a kind of employing, reaction solution in described reaction unit (1) is extracted into described Filter column by described pump, from the bottom of this Filter column upwards, and get back to described reaction unit from the top of described Filter column, complete a circulation; Described whipping appts Keep agitation reaction solution, reaction solution circulates through described Filter column, when in reaction solution, resultant of reaction reaches finite concentration, pump shuts down, reaction solution, from the filtration of outlet end through filtration unit, is collected in collection device, and solid matter is filtered device and dams collection.
Advantageous Effects of the present invention:
The present invention's pump as reaction solution transmitting power, can automatic continuous circulation by reaction solution from reaction unit to resin column, return reaction unit, also can visual response situation, stop the operation of pump.When in reaction solution, target product concentration reaches certain value, the operation of pump can be stopped, opening control valve, from outlet end collect reaction solution, be filtered device dam collect solid matter be crude product, can further crystallization purification; Collection liquid is mother liquor, can be used for secondary crystallization, or is cycled to used in reaction solution.Reaction solution, through Filter column, by resin or gac remove portion impurity, improves product quality.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of invention.
Embodiment
Below in conjunction with specific embodiment, set forth the present invention further.Should be understood that these embodiments are only not used in for illustration of the present invention to limit the scope of the invention.
Embodiment 1
As shown in Figure 1, one prepares glycylglutamine process system, comprises reaction unit 1, whipping appts 2, Filter column 3, pump 4; Described whipping appts 2 is positioned at described synthetic reaction device 1; Outlet is arranged at the bottom of described reaction unit 1, this outlet is connected to threeway, other two ports of this threeway connect one end of outlet end 5 and described pump 4 respectively, also comprise filtration unit 6, collection device 7, the upstream extremity of this filtration unit 6 is connected with described outlet end 5 pipeline, and the downstream of this filtration unit 6 is connected with described collection device 7 pipeline.
In the present embodiment, described filtration unit 6 is ultra-filtration equipment; Weighting material in Filter column 3 is gac.
A kind ofly adopt the method preparing glycylglutamine process system according to claim 1, reaction solution in described reaction unit 1 is extracted into described Filter column 3 by described pump 4, from the bottom of this Filter column 3 upwards, and get back to described reaction unit 1 from the top of described Filter column 3, complete a circulation; Described whipping appts 2 Keep agitation reaction solution, reaction solution circulates through described Filter column 3, when in reaction solution, resultant of reaction reaches finite concentration, pump 4 shuts down, reaction solution is from the filtration of outlet end 5 through filtration unit 6, be collected in collection device 7, solid matter is filtered device 6 and dams collection.
The present invention with pump 4 as reaction solution transmitting power, can automatic continuous circulation by reaction solution from reaction unit 1 to Filter column 3, return reaction unit 1, also can visual response situation, stop the operation of pump 4.When in reaction solution, target product concentration reaches certain value, the operation of pump 4 can be stopped, opening control valve, collect reaction solution from outlet end 5, be filtered device 6 dam collect solid matter be crude product, can further crystallization purification; Collection liquid is mother liquor, can be used for secondary crystallization, or is cycled to used in reaction solution.Reaction solution, through Filter column 3, by gac remove portion impurity, improves product quality.
Present specification describes some embodiments, but should be understood that those skilled in the art pass through to read this specification sheets and can know the various improvement not deviating from the spirit and scope of the present invention.Therefore, these other embodiments also should be included within the scope of appended claims.
Claims (5)
1. prepare a glycylglutamine process system, it is characterized by: comprise reaction unit (1), whipping appts (2), Filter column (3), pump (4); Described whipping appts (2) is positioned at described synthetic reaction device (1); Outlet is arranged at the bottom of described reaction unit (1), this outlet is connected to threeway, other two ports of this threeway connect one end of outlet end (5) and described pump (4) respectively, also comprise filtration unit (6), collection device (7), the upstream extremity of this filtration unit (6) is connected with described outlet end (5) pipeline, and the downstream of this filtration unit (6) is connected with described collection device (7) pipeline.
2. according to claim 1ly prepare glycylglutamine process system, it is characterized by: described filtration unit (6) is ultra-filtration equipment.
3. according to claim 1ly prepare glycylglutamine process system, it is characterized by: described filtration unit (6) is nanofiltration device.
4. according to claim 1ly prepare glycylglutamine process system, it is characterized by: have weighting material in described Filter column (3), this weighting material is the one in resin or gac.
5. one kind adopts the method preparing glycylglutamine process system according to claim 1, it is characterized by: the reaction solution in described reaction unit (1) is extracted into described Filter column (3) by described pump (4), from the bottom of this Filter column (3) upwards, and get back to described reaction unit (1) from the top of described Filter column (3), complete a circulation; Described whipping appts (2) Keep agitation reaction solution, reaction solution circulates through described Filter column (3), when in reaction solution, resultant of reaction reaches finite concentration, pump (4) shuts down, reaction solution is from outlet end (5) filtration through filtration unit (6), be collected in collection device (7), solid matter is filtered device (6) and dams collection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510135286.9A CN104725467A (en) | 2015-03-26 | 2015-03-26 | Process system for preparing glycyl glutamine and method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510135286.9A CN104725467A (en) | 2015-03-26 | 2015-03-26 | Process system for preparing glycyl glutamine and method thereof |
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| Publication Number | Publication Date |
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| CN104725467A true CN104725467A (en) | 2015-06-24 |
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| CN201510135286.9A Pending CN104725467A (en) | 2015-03-26 | 2015-03-26 | Process system for preparing glycyl glutamine and method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1775730A (en) * | 2005-11-22 | 2006-05-24 | 浙江大学 | Alkali decremental waste water terephthalic acid recovery device |
| CN203295415U (en) * | 2013-06-19 | 2013-11-20 | 重庆惠森驰恒医疗器械有限公司 | Production equipment for carboxylation glycosaminoglycan medical biological glue |
| CN203389645U (en) * | 2013-07-31 | 2014-01-15 | 东木奥森科技（天津）有限公司 | Reaction kettle with circulating filtering device |
| CN203469997U (en) * | 2013-09-03 | 2014-03-12 | 寿光富康制药有限公司 | Device for preparing key intermediate of trospium chloride |
| CN203725153U (en) * | 2014-03-21 | 2014-07-23 | 连云港市三联化工有限公司 | Reaction kettle capable of carrying out desalinating operation |
-
2015
- 2015-03-26 CN CN201510135286.9A patent/CN104725467A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1775730A (en) * | 2005-11-22 | 2006-05-24 | 浙江大学 | Alkali decremental waste water terephthalic acid recovery device |
| CN203295415U (en) * | 2013-06-19 | 2013-11-20 | 重庆惠森驰恒医疗器械有限公司 | Production equipment for carboxylation glycosaminoglycan medical biological glue |
| CN203389645U (en) * | 2013-07-31 | 2014-01-15 | 东木奥森科技（天津）有限公司 | Reaction kettle with circulating filtering device |
| CN203469997U (en) * | 2013-09-03 | 2014-03-12 | 寿光富康制药有限公司 | Device for preparing key intermediate of trospium chloride |
| CN203725153U (en) * | 2014-03-21 | 2014-07-23 | 连云港市三联化工有限公司 | Reaction kettle capable of carrying out desalinating operation |
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Application publication date: 20150624 |
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