CN204550440U - One prepares glycylglutamine process system - Google Patents
One prepares glycylglutamine process system Download PDFInfo
- Publication number
- CN204550440U CN204550440U CN201520174021.5U CN201520174021U CN204550440U CN 204550440 U CN204550440 U CN 204550440U CN 201520174021 U CN201520174021 U CN 201520174021U CN 204550440 U CN204550440 U CN 204550440U
- Authority
- CN
- China
- Prior art keywords
- glycylglutamine
- filtration unit
- process system
- unit
- outlet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 18
- PNMUAGGSDZXTHX-BYPYZUCNSA-N Gly-Gln Chemical compound NCC(=O)N[C@H](C(O)=O)CCC(N)=O PNMUAGGSDZXTHX-BYPYZUCNSA-N 0.000 title claims abstract description 17
- 108010010147 glycylglutamine Proteins 0.000 title claims abstract description 17
- 238000006243 chemical reaction Methods 0.000 claims abstract description 45
- 238000001914 filtration Methods 0.000 claims abstract description 20
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- 238000001728 nano-filtration Methods 0.000 claims 1
- 239000012535 impurity Substances 0.000 abstract description 3
- 239000000047 product Substances 0.000 description 5
- 238000002425 crystallisation Methods 0.000 description 4
- 230000008025 crystallization Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000013019 agitation Methods 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000016236 parenteral nutrition Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
Landscapes
- Peptides Or Proteins (AREA)
Abstract
This practicality provides one to prepare glycylglutamine process system, comprises reaction unit (1), whipping appts (2), Filter column (3), pump (4); Described whipping appts (2) is positioned at described synthetic reaction device (1); Outlet is arranged at the bottom of described reaction unit (1), this outlet is connected to threeway, other two ports of this threeway connect one end of outlet end (5) and described pump (4) respectively, also comprise filtration unit (6), collection device (7), the upstream extremity of this filtration unit (6) is connected with described outlet end (5) pipeline, and the downstream of this filtration unit (6) is connected with described collection device (7) pipeline; Glycylglutamine can be prepared according to this practicality.This practicability and effectiveness removes impurity, improves the purity of finished product; Simple to equipment requirements; Yield is high, and aftertreatment is simple, and cost is low.
Description
Technical field
The utility model relates to a kind of chemical reaction equipment, is specifically related to a kind of glycylglutamine process unit.
Background technology
Glycylglutamine is parenteral nutrition medicine, and vivo degradation goes out L-glutaminate, and the synthesis of supply body substance or energy expenditure use.Traditional enzyme catalysis connects peptide method, due to synthesis cost intensive, cannot realize industrialization and produce in Industrial processes.More external up-to-date synthetic methods, although simplified synthesis step, use the price of raw material higher, product cost is higher.
Summary of the invention
In order to solve the problem, the purpose of this utility model is to provide prepares glycylglutamine process system.
What the utility model provided prepares glycylglutamine process system technical scheme:
One prepares glycylglutamine process system, comprises reaction unit, whipping appts, Filter column, pump; Described whipping appts is positioned at described synthetic reaction device; Outlet is arranged at the bottom of described reaction unit, this outlet is connected to threeway, other two ports of this threeway connect one end of outlet end and described pump respectively, also comprise filtration unit, collection device, the upstream extremity of this filtration unit is connected with described outlet end pipeline, and the downstream of this filtration unit is connected with described collection device pipeline.
As preferably, described filtration unit is ultra-filtration equipment.
As preferably, have weighting material in described Filter column, this weighting material is the one in resin or gac.
Preparation method's technical scheme of the employing glycylglutamine process system that the utility model provides is:
The method of glycylglutamine process system is prepared in a kind of employing, reaction solution in described reaction unit is extracted into described Filter column by described pump, from the bottom of this Filter column upwards, and get back to described reaction unit from the top of described Filter column, complete a circulation; Described whipping appts Keep agitation reaction solution, reaction solution circulates through described Filter column, when in reaction solution, resultant of reaction reaches finite concentration, pump shuts down, reaction solution, from the filtration of outlet end through filtration unit, is collected in collection device, and solid matter is filtered device and dams collection.
Advantageous Effects of the present utility model:
This practicality with pump as reaction solution transmitting power, can automatic continuous circulation by reaction solution from reaction unit to resin column, return reaction unit, also can visual response situation, stop the operation of pump.When in reaction solution, target product concentration reaches certain value, the operation of pump can be stopped, opening control valve, from outlet end collect reaction solution, be filtered device dam collect solid matter be crude product, can further crystallization purification; Collection liquid is mother liquor, can be used for secondary crystallization, or is cycled to used in reaction solution.Reaction solution, through Filter column, by resin or gac remove portion impurity, improves product quality.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of utility model.
Embodiment
Below in conjunction with specific embodiment, set forth the utility model further.Should be understood that these embodiments are only not used in restriction scope of the present utility model for illustration of the utility model.
Embodiment 1
As shown in Figure 1, one prepares glycylglutamine process system, comprises reaction unit 1, whipping appts 2, Filter column 3, pump 4; Described whipping appts 2 is positioned at described synthetic reaction device 1; Outlet is arranged at the bottom of described reaction unit 1, this outlet is connected to threeway, other two ports of this threeway connect one end of outlet end 5 and described pump 4 respectively, also comprise filtration unit 6, collection device 7, the upstream extremity of this filtration unit 6 is connected with described outlet end 5 pipeline, and the downstream of this filtration unit 6 is connected with described collection device 7 pipeline.
In the present embodiment, described filtration unit 6 is ultra-filtration equipment; Weighting material in Filter column 3 is gac.
A kind ofly adopt the above-mentioned method preparing glycylglutamine process system, reaction solution in described reaction unit 1 is extracted into described Filter column 3 by described pump 4, from the bottom of this Filter column 3 upwards, and get back to described reaction unit 1 from the top of described Filter column 3, complete a circulation; Described whipping appts 2 Keep agitation reaction solution, reaction solution circulates through described Filter column 3, when in reaction solution, resultant of reaction reaches finite concentration, pump 4 shuts down, reaction solution is from the filtration of outlet end 5 through filtration unit 6, be collected in collection device 7, solid matter is filtered device 6 and dams collection.
The utility model with pump 4 as reaction solution transmitting power, can automatic continuous circulation by reaction solution from reaction unit 1 to Filter column 3, return reaction unit 1, also can visual response situation, stop the operation of pump 4.When in reaction solution, target product concentration reaches certain value, the operation of pump 4 can be stopped, opening control valve, collect reaction solution from outlet end 5, be filtered device 6 dam collect solid matter be crude product, can further crystallization purification; Collection liquid is mother liquor, can be used for secondary crystallization, or is cycled to used in reaction solution.Reaction solution, through Filter column 3, by gac remove portion impurity, improves product quality.
Present specification describes some embodiments, but should be understood that those skilled in the art pass through to read this specification sheets and can know the various improvement not deviating from design of the present utility model and scope.Therefore, these other embodiments also should be included within the scope of appended claims.
Claims (4)
1. prepare a glycylglutamine process system, it is characterized by: comprise reaction unit (1), whipping appts (2), Filter column (3), pump (4); Described whipping appts (2) is positioned at described synthetic reaction device (1); Outlet is arranged at the bottom of described reaction unit (1), this outlet is connected to threeway, other two ports of this threeway connect one end of outlet end (5) and described pump (4) respectively, also comprise filtration unit (6), collection device (7), the upstream extremity of this filtration unit (6) is connected with described outlet end (5) pipeline, and the downstream of this filtration unit (6) is connected with described collection device (7) pipeline.
2. according to claim 1ly prepare glycylglutamine process system, it is characterized by: described filtration unit (6) is ultra-filtration equipment.
3. according to claim 1ly prepare glycylglutamine process system, it is characterized by: described filtration unit (6) is nanofiltration device.
4. according to claim 1ly prepare glycylglutamine process system, it is characterized by: have weighting material in described Filter column (3), this weighting material is the one in resin or gac.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520174021.5U CN204550440U (en) | 2015-03-26 | 2015-03-26 | One prepares glycylglutamine process system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520174021.5U CN204550440U (en) | 2015-03-26 | 2015-03-26 | One prepares glycylglutamine process system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204550440U true CN204550440U (en) | 2015-08-12 |
Family
ID=53825576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520174021.5U Expired - Fee Related CN204550440U (en) | 2015-03-26 | 2015-03-26 | One prepares glycylglutamine process system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204550440U (en) |
-
2015
- 2015-03-26 CN CN201520174021.5U patent/CN204550440U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150812 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |