CN203469997U - Device for preparing key intermediate of trospium chloride - Google Patents
Device for preparing key intermediate of trospium chloride Download PDFInfo
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- CN203469997U CN203469997U CN201320555703.1U CN201320555703U CN203469997U CN 203469997 U CN203469997 U CN 203469997U CN 201320555703 U CN201320555703 U CN 201320555703U CN 203469997 U CN203469997 U CN 203469997U
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- reactor
- trospium chloride
- tank body
- preparing
- key intermediate
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Abstract
The utility model belongs to the field of pharmaceutical machinery, and in particular relates to a device for preparing a key intermediate of trospium chloride. The device comprises a bracket (1), wherein a reaction kettle (3) is arranged on the bracket; a stirring device and a lifting device are arranged on the upper part of the reaction kettle (3); a base plate (14) and a three-way discharge valve (15) are arranged at the bottom of the reaction kettle (3); a transfer pump (16) and a bag-type filter (17) are connected to the lower part of the three-way discharge valve; the transfer pump (16), the bag-type filter (17) and the three-way discharge valve are connected with a tank body (7) through a pipeline; the tank body (7) is connected to the reaction kettle (3). The device is easy to operate, high in yield and low in cost; a synthesis process is implemented in the closed tank body, so that the quality of a trospium chloride intermediate product is improved, high product stability is ensured, and the labor intensity is greatly lowered.
Description
Technical field
The utility model belongs to field of pharmaceutical machinery, is specifically related to a kind of device of preparing trospium chloride key intermediate.
Background technology
Trospium chloride (Trospium Chloride); chemistry chlorination-3-benziloyl nortropane-8-spiral shell-1-pyrrolidines by name; by German Madaus AG exploitation; be mainly used in treating various detrusor functions unstable or the hyperfunction frequent micturition causing of detrusor function, urgent urination and urinary incontinence medicine, the nineties is in country's listings such as Germany, Switzerland, Australia, France.In recent years, the price of trospium chloride is always higher, mainly because intermediate is unstable and synthesis yield is low, causes.
At present, the synthetic method of trospium chloride key intermediate tropeine mainly contains following three kinds: 1, ester-interchange method: first sour and simple alcohols generation esterification, then obtain tropeine with tropanol generation substitution reaction.The method reaction time is long, and yield is low, can cause the content of intermediate on the low side.2, chloride method: first sour and thionyl chloride generation acylation reaction, then obtain tropeine with tropanol esterification.The method relates to thionyl chloride, and accessory substance is unfriendly to environment, and may generate more impurity effect product quality.3, condensing agent activation method: adopt expensive condensing agent N, N-carbonyl dimidazoles is as acid activators, then obtains tropeine with alcohol generation esterification.The intermediate of the method gained is unstable, and the high suitability for industrialized production that is unsuitable for of cost.
Above synthetic method all operates at common response still and relevant synthesis device, and complex operation step easily causes that the intermediate moisture absorption is rotten and yield is low, and cost is high.
summary of the invention
The utility model is for above problem, provide a kind of easy and simple to handle, yield is high, cost is low, product quality and good stability, a kind of device of preparing trospium chloride intermediate that labour intensity is low.
For realizing above object, the technical solution adopted in the utility model is: a kind of device of preparing trospium chloride intermediate, comprise support, on described support, be provided with tank body, described tank body top is provided with agitating device and lowering or hoisting gear, and described tank base is provided with chassis and threeway outlet valve, described outlet valve bottom connects transfering material pump, described transfering material pump is connected with filter, and described filter is connected with tank body, and described tank body is connected with reactor.
As a kind of prioritization scheme, described agitating device comprises motor, decelerator, shaft and paddle, and described motor output end is connected with decelerator input, and described decelerator output is connected with shaft, on described shaft, is provided with paddle.
As a kind of prioritization scheme, described lowering or hoisting gear comprises hydraulic cylinder and guide cylinder, and described hydraulic cylinder piston rod is connected with shaft, and described guide cylinder is connected by link with hydraulic cylinder.
A concrete prioritization scheme, described tank body outer setting has heat-insulation layer.
A concrete prioritization scheme, described heat-insulation layer outer setting has overcoat.
A concrete prioritization scheme, described tank body top is provided with dust cover.
The utility model is taked above technical scheme, has the following advantages: due between reactor and tank body, have transfering material pump to be connected, so the unstable intermediate that reaction obtains and insoluble accessory substance are squeezed in filter through transfering material pump, filtrate proceeds in tank body.Then unstable midbody solution is put into reactor, repeats above operation, until insoluble accessory substance is thoroughly removed in reactor.In reactor after the next step, obtain tropeine solution.Then, from being arranged on the threeway outlet valve discharging of reactor bottom.This device is simple to operate, and yield is high, and cost is low, and owing to completing in tank body airtight in building-up process, the product quality of trospium chloride intermediate is improved, and product stability is good, greatly reduces labour intensity.
Below in conjunction with drawings and Examples, the utility model is described further.
accompanying drawing explanation
Accompanying drawing 1 is a kind of structural representation of preparing trospium chloride key intermediate device in the utility model.
The specific embodiment
As shown in drawings, a kind of trospium chloride key intermediate device of preparing, comprise support (1), on support (1), be provided with reactor (3), reactor (3) top is provided with agitating device and lowering or hoisting gear, and reactor (3) bottom is provided with chassis (14) and threeway outlet valve (15), and threeway outlet valve below is connected to transfering material pump (16) and bag filter (17), three is connected with tank body (7) by pipeline, and reactor (3) is connected with tank body (7).
Agitating device comprises motor (9), decelerator (10), shaft (2) and paddle (14), motor (9) output is connected with decelerator (10) input, decelerator (10) output is connected with shaft (2), is provided with paddle (13) on shaft (2).
Lowering or hoisting gear comprises hydraulic cylinder (6) and guide cylinder (12); hydraulic cylinder (6) piston rod is connected with shaft (2); guide cylinder (12) is connected by link (11) with hydraulic cylinder (6); guide cylinder (12) can guarantee the synchronous operation of hydraulic cylinder (6) and guide cylinder (12), protection shaft (2).
On reactor (3), be also provided with protective cover (8), reactor (3) outer setting has heat-insulation layer (4), and heat-insulation layer (4) outer setting has overcoat (5).
The foregoing is only preferred embodiment of the present utility model; not in order to limit the utility model; all any modifications of doing within spirit of the present utility model and principle, be equal to and replace and improvement etc., within all should being included in protection domain of the present utility model.
Claims (4)
1. a device of preparing trospium chloride key intermediate, it is characterized in that: comprise support (1), on support (1), be provided with reactor (3), reactor (3) top is provided with agitating device and lowering or hoisting gear, reactor (3) bottom is provided with chassis (14) and threeway outlet valve (15), threeway outlet valve below is connected to transfering material pump (16) and bag filter (17), three is connected with tank body (7) by pipeline, and reactor (3) is connected with tank body (7).
2. the trospium chloride key intermediate device of preparing as claimed in claim 1, it is characterized in that: agitating device comprises motor (9), decelerator (10), shaft (2) and paddle (14), motor (9) output is connected with decelerator (10) input, decelerator (10) output is connected with shaft (2), is provided with paddle (13) on shaft (2).
3. the trospium chloride key intermediate device of preparing as claimed in claim 1; it is characterized in that: lowering or hoisting gear comprises hydraulic cylinder (6) and guide cylinder (12); hydraulic cylinder (6) piston rod is connected with shaft (2); guide cylinder (12) is connected by link (11) with hydraulic cylinder (6); guide cylinder (12) can guarantee the synchronous operation of hydraulic cylinder (6) and guide cylinder (12), protection shaft (2).
4. the trospium chloride key intermediate device of preparing as claimed in claim 1, it is characterized in that: on reactor (3), be also provided with protective cover (8), reactor (3) outer setting has heat-insulation layer (4), and heat-insulation layer (4) outer setting has overcoat (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320555703.1U CN203469997U (en) | 2013-09-03 | 2013-09-03 | Device for preparing key intermediate of trospium chloride |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320555703.1U CN203469997U (en) | 2013-09-03 | 2013-09-03 | Device for preparing key intermediate of trospium chloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203469997U true CN203469997U (en) | 2014-03-12 |
Family
ID=50218415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320555703.1U Expired - Lifetime CN203469997U (en) | 2013-09-03 | 2013-09-03 | Device for preparing key intermediate of trospium chloride |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203469997U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104725467A (en) * | 2015-03-26 | 2015-06-24 | 江苏诚信药业有限公司 | Process system for preparing glycyl glutamine and method thereof |
-
2013
- 2013-09-03 CN CN201320555703.1U patent/CN203469997U/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104725467A (en) * | 2015-03-26 | 2015-06-24 | 江苏诚信药业有限公司 | Process system for preparing glycyl glutamine and method thereof |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140312 |