CN102584611B - Production method for medical grade valine - Google Patents
Production method for medical grade valine Download PDFInfo
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- CN102584611B CN102584611B CN201210022335.4A CN201210022335A CN102584611B CN 102584611 B CN102584611 B CN 102584611B CN 201210022335 A CN201210022335 A CN 201210022335A CN 102584611 B CN102584611 B CN 102584611B
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- medical grade
- production method
- valine
- grade valine
- solution
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- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 title claims abstract description 68
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 title claims abstract description 39
- 239000004474 valine Substances 0.000 title claims abstract description 39
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 23
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 18
- 239000000243 solution Substances 0.000 claims abstract description 17
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000002425 crystallisation Methods 0.000 claims abstract description 13
- 239000012528 membrane Substances 0.000 claims abstract description 11
- 230000008025 crystallization Effects 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000013375 chromatographic separation Methods 0.000 claims abstract description 6
- 238000005227 gel permeation chromatography Methods 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 238000001816 cooling Methods 0.000 claims abstract description 5
- 238000001914 filtration Methods 0.000 claims abstract description 5
- 239000013078 crystal Substances 0.000 claims abstract description 4
- 239000000047 product Substances 0.000 claims description 17
- 239000000706 filtrate Substances 0.000 claims description 15
- 229920002401 polyacrylamide Polymers 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 239000012452 mother liquor Substances 0.000 claims description 8
- 238000005189 flocculation Methods 0.000 claims description 7
- 230000016615 flocculation Effects 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 3
- 230000004913 activation Effects 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 2
- 239000002158 endotoxin Substances 0.000 abstract description 9
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract description 4
- 229960000310 isoleucine Drugs 0.000 abstract description 4
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract description 4
- 102000004169 proteins and genes Human genes 0.000 abstract description 4
- 108090000623 proteins and genes Proteins 0.000 abstract description 4
- 239000002253 acid Substances 0.000 abstract description 3
- 239000008394 flocculating agent Substances 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 239000010413 mother solution Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 description 22
- 229940024606 amino acid Drugs 0.000 description 11
- 235000001014 amino acid Nutrition 0.000 description 11
- 150000001413 amino acids Chemical class 0.000 description 11
- 239000011347 resin Substances 0.000 description 7
- 229920005989 resin Polymers 0.000 description 7
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 5
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 5
- 238000000855 fermentation Methods 0.000 description 5
- 230000004151 fermentation Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 4
- 150000003863 ammonium salts Chemical class 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 238000002834 transmittance Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
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- 239000012634 fragment Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- CVLHGLWXLDOELD-UHFFFAOYSA-N 4-(Propan-2-yl)benzenesulfonic acid Chemical compound CC(C)C1=CC=C(S(O)(=O)=O)C=C1 CVLHGLWXLDOELD-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 206010010075 Coma hepatic Diseases 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000001019 Inborn Errors Metabolism Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 150000005693 branched-chain amino acids Chemical class 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 230000035614 depigmentation Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 201000001059 hepatic coma Diseases 0.000 description 1
- 208000007386 hepatic encephalopathy Diseases 0.000 description 1
- 208000016245 inborn errors of metabolism Diseases 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 208000015978 inherited metabolic disease Diseases 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000012716 precipitator Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Images
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (12)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210022335.4A CN102584611B (en) | 2012-02-01 | 2012-02-01 | Production method for medical grade valine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201210022335.4A CN102584611B (en) | 2012-02-01 | 2012-02-01 | Production method for medical grade valine |
Publications (2)
Publication Number | Publication Date |
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CN102584611A CN102584611A (en) | 2012-07-18 |
CN102584611B true CN102584611B (en) | 2014-03-12 |
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CN201210022335.4A Active CN102584611B (en) | 2012-02-01 | 2012-02-01 | Production method for medical grade valine |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113773215B (en) * | 2020-06-10 | 2024-02-02 | 安徽华恒生物科技股份有限公司 | L-valine with high bulk density and preparation method and application thereof |
CN112939795B (en) * | 2020-12-26 | 2023-12-26 | 安徽华恒生物科技股份有限公司 | High-purity granular L-valine crystal, and preparation method and application thereof |
CN117105833B (en) * | 2023-07-05 | 2024-05-14 | 峨眉山市龙腾生物科技有限公司 | Preparation method of L-cystine |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4263450A (en) * | 1979-07-19 | 1981-04-21 | Societe D'assistance Technique Pour Produits Nestle S.A. | Process for separating leucine, isoleucine and valine |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61178952A (en) * | 1985-02-04 | 1986-08-11 | Ajinomoto Co Inc | Method for purifying valine |
CN101434553B (en) * | 2008-11-12 | 2011-10-19 | 江苏神华药业有限公司 | Method for all-film extraction of valine |
CN101798273B (en) * | 2009-10-19 | 2013-05-01 | 广东肇庆星湖生物科技股份有限公司 | Valine purification method |
-
2012
- 2012-02-01 CN CN201210022335.4A patent/CN102584611B/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4263450A (en) * | 1979-07-19 | 1981-04-21 | Societe D'assistance Technique Pour Produits Nestle S.A. | Process for separating leucine, isoleucine and valine |
Non-Patent Citations (1)
Title |
---|
JP昭61-178952A 1986.08.11 |
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CN102584611A (en) | 2012-07-18 |
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Owner name: SHANTOU JIAHE BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: ZIGUANG GUHAN AMINO-ACID CO., LTD., SHANTOU Effective date: 20121219 |
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Effective date of registration: 20121219 Address after: Jinping District West Port Road 515064 Guangdong city of Shantou Province Wang No. 4 Applicant after: SHANTOU JIAHE BIOLOGICAL TECHNOLOGY CO.,LTD. Address before: Jinping District West Port Road 515064 Guangdong city of Shantou Province Wang 4, No. 5 Applicant before: Shantou Ziguang Guhan Amino Acid Co.,Ltd. |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Production method for medical grade valine Effective date of registration: 20170822 Granted publication date: 20140312 Pledgee: Shantou SME financing Company limited by guarantee Pledgor: SHANTOU JIAHE BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: 2017990000770 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20190108 Granted publication date: 20140312 Pledgee: Shantou SME financing Company limited by guarantee Pledgor: SHANTOU JIAHE BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: 2017990000770 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A production method for medicinal grade valine Effective date of registration: 20231214 Granted publication date: 20140312 Pledgee: Shantou Bay Rural Commercial Bank Co.,Ltd. Pledgor: SHANTOU JIAHE BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: Y2023980071776 |
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