CN104721418A - Pharmaceutical composition for treating gynecological inflammation and preparation method and use thereof - Google Patents
Pharmaceutical composition for treating gynecological inflammation and preparation method and use thereof Download PDFInfo
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Abstract
The invention belongs to the field of Chinese traditional medicines and particularly relates to a pharmaceutical composition for treating gynecological inflammation and a preparation method and use thereof. The pharmaceutical composition for treating gynecological inflammation, provided by the invention, is prepared from the raw pharmaceutical materials in parts by weight: 3-9 parts of radix sophorae flavescentis, 8-16 parts of herba patriniae, 6-12 parts of herba violae, 6-15 parts of herba andrographitis, 10-30 parts of dandelions, 1-2 parts of pig gall powder, 5-15 parts of lithospermum erythrorhizon and 0.2-0.8 part of aloes; and the composition is prepared into capsules, tablets, granules, pills, powder, ointment, suppositories, oral liquid preparations, injections, lotion, liniment, aerosols, sprays and enemas. The pharmaceutical composition provided by the invention has the characteristics of good safety, good treatment effect, short treatment course, convenience in use and the like.
Description
[technical field]
The present invention relates to a kind of Chinese medicine composition, specifically a kind of pharmaceutical composition being used for the treatment of gynecological inflammation and preparation method thereof and purposes.
[background technology]
Pelvic inflammatory disease is the general designation of uterus, ovary, fallopian tube and surrounding connective tissue inflammation thereof, inflammation can be limited to and occurred in a position, also can involve multiple position to fall ill simultaneously simultaneously, can be divided into acute and chronic, chronic pelvic inflammatory disease is the most common with women's period of pregnancy, sickness rate is about 40%, and prevalence has ascendant trend gradually in recent years.Have that the course of disease is long, cure rate is low, relapse rate high, the mental health of severe jamming women, causes its body and mind to be had a strong impact on.Chronic pelvic inflammatory disease is more serious than acute pelvic inflammatory disease, treats more obstinate, and the state of an illness easily protracted course of disease repeatedly, patient suffering is large.Chronic pelvic inflammatory disease many due to acute stage not treatment in time or treatment thorough, also can be some patients because health is poor or individual variation does not have acutely inflamed process, morbidity is chronic.The pathological manifestations of chronic pelvic inflammatory disease is chronic endometritis, chronic salpingitis, chronic inflammation of connective tissue.Clinical common sympton is that leukorrhagia increases, lower abdominal pain, lumbosacral region are ached, the heating of urine urgency-frequency, fear of cold and menoxenia etc.Common method for the treatment of has the methods such as Drug therapy, physiotherapy, operative treatment, herbal enema and Guiding herbs guide clinically.Adopt broad ectrum antibiotic, easily cause untoward reaction, some untoward reaction such as anaphylactic shock also can threaten the life of patient.And antibiotic application causes possibility and the superinfection of alteration of intestinal flora and drug resistance in addition, some patients is caused to use effects of antibiotics unsatisfactory.The method of western medical treatment chronic pelvic inflammatory disease mainly uses antibiotic therapy or antibiotic and hormone to apply simultaneously.
TCM therapy for Chronic Pelvic Inflammation is subject to patient's most attention and welcome, and great mass of data proves, no matter is that traditional traditional Chinese medical science debates disease treating, or folk prescription proved prescription, all has good curative effect to pelvic inflammatory disease and prostatitis.As phoenix Setsuka etc. [Chinese medicine receive anus and external application for curing chronic pelvic inflammatory disease 87 example, folks of china therapy .1998,6 (4) .5-5] report have employed Radix Sophorae Flavescentis, Herba Violae, Radix Arnebiae (Radix Lithospermi), gallbladder powder, Aloe, Herba Andrographis, Herba Taraxaci etc. and makes suppository, treatment pelvic inflammatory disease; Yang Zongzhi etc. [the routine clinical observation of OPIN suppository agent treatment chronic pelvic inflammatory disease 30, Qingdao Medical College journal .1998,34 (2) .151-151] report have employed OPIN suppository agent treatment chronic pelvic inflammatory disease; Zou Qindi etc. [the routine pelvic inflammatory disease clinical analysis of herbal enema suppository in treatment 31, journal of shanghai Chinese medicine .1996 (9) .16-17] report have employed the suppository in treatment pelvic inflammatory disease that Radix Bupleuri, Radix Cynanchi Paniculati, Rhizoma Corydalis, Radix Angelicae Sinensis, Rhizoma Smilacis Glabrae, Flos Lonicerae, Fructus Forsythiae, Herba Patriniae, Herba Violae, Pollen Typhae etc. are made; Li Laiying etc. [observe by prostatitis urinary system bolt treatment chronic pelvic inflammatory disease 70 example, modern combination of Chinese and Western medicine magazine .2004,13 (4) .427-427] report the suppository in treatment pelvic inflammatory disease that have employed Radix Paeoniae Rubra, Herba Taraxaci, Herba Violae, Radix Salviae Miltiorrhizae, Sanguis Draxonis, Cortex Phellodendri, Borneolum Syntheticum etc. and make.Shi Yalan etc. [the routine observation of curative effect of yellow osmanthus enema treatment chronic pelvic inflammatory disease 69, assorted 2003,33 (6) .25-25 of Qinghai medicine] report and adopt Radix Et Rhizoma Rhei, Radix Scutellariae, Cortex Phellodendri, Ramulus Cinnamomi to make yellow osmanthus enema and be used for the treatment of chronic pelvic inflammatory disease; Si Yaxue [pelvic cavity spirit enema treatment effecton 100 cases of chronic pelvic inflammation, Henan pharmaceutical information .2002,10 (17) .71-71] reports pelvic cavity spirit enema treatment chronic pelvic inflammatory disease; Ji Yuanlan [yellow osmanthus enema treatment enclosed mass type chronic pelvic inflammatory disease 102 example, Shanxi traditional Chinese medical science .2002,18 (1) .25-25]; Gu Yayang [preparation of health woman enema and clinical observation on the therapeutic effect, time precious traditional Chinese medical science traditional Chinese medicines .2000,11 (12) .1098-1098] report Caulis Sargentodoxae, lose money grass, Herba Taraxaci, Rhizoma Corydalis, Herba Lobeliae Chinensis, Rhizoma Sparganii, Rhizoma Curcumae, Semen Persicae, Olibanum (processed), moxibustion Myrrha make health woman enema treatment chronic pelvic inflammatory disease.
[summary of the invention]
The object of the present invention is to provide that a kind of safety is good, good effect, short treating period, the easy to use pharmaceutical composition being used for the treatment of gynecological inflammation and preparation method thereof and the purposes in treatment gynecological inflammation.
For achieving the above object, the present invention is by the following technical solutions:
The invention provides a kind of pharmaceutical composition for the treatment of gynecological inflammation, be prepared from by the crude drug of following weight parts meter:
Radix Sophorae Flavescentis 3 ~ 9 parts of Herba Patriniae 8 ~ 16 parts of Herba Violaes 6 ~ 12 parts
Herba Andrographis 6 ~ 15 parts of Herba Taraxacis 10 ~ 30 parts of Pulvis Fellis Suiss 1 ~ 2 part
Radix Arnebiae (Radix Lithospermi) 5 ~ 15 portions of Aloes 0.2 ~ 0.8 part.
More preferably, be made up of the crude drug of following weight parts:
Radix Sophorae Flavescentis 4 ~ 8 parts of Herba Patriniae 10 ~ 16 parts of Herba Violaes 6 ~ 10 parts
Herba Andrographis 6 ~ 12 parts of Herba Taraxacis 10 ~ 25 parts of Pulvis Fellis Suiss 1 ~ 2 part
Radix Arnebiae (Radix Lithospermi) 5 ~ 13 portions of Aloes 0.2 ~ 0.8 part.
Best, be made up of the crude drug of following weight parts:
Radix Sophorae Flavescentis 7 parts of Herba Patriniae 12 parts of Herba Violaes 10 parts
Herba Andrographis 12 parts of Herba Taraxacis 23 parts of Pulvis Fellis Suiss 1 part
Radix Arnebiae (Radix Lithospermi) 10 portions of Aloes 0.3 part.
The pharmaceutical composition for the treatment of gynecological inflammation of the present invention can be prepared as rectum or vaginal administration, to be prepared into suppository and enema, emulsifiable paste for the best.
The preparation method of the pharmaceutical composition for the treatment of gynecological inflammation of the present invention, comprises the steps:
A) will except Pulvis Fellis Suis, Aloe, all the other Six-element raw medicinal materials add 6 ~ 10 times amount soak by water 2 ~ 3 times, each 1 ~ 3h, collecting decoction, and when filtrate reduced in volume becomes 65 DEG C, relative density is 1.25 ~ 1.30 thick pastes;
B) by gained thick paste at 60 ~ 70 DEG C, under vacuum-0.06 ~-0.08Mpa, fine powder obtained after dry 9 ~ 12 hours mixes with Pulvis Fellis Suis and Aloe fine powder, and the customary adjuvant added pharmaceutically makes clinical acceptable dosage form.
Pharmaceutical composition of the present invention is used for the purposes of the medicine because of gynecological inflammation caused by damp and hot, noxious dampness.The flavour of a drug of the pharmaceutical composition for the treatment of gynecological inflammation of the present invention can increase or reduce.
The present invention has heat-clearing and toxic substances removing, dampness removing eliminating stagnation, killing parasites for relieving itching effect.For the leukorrheal diseases caused by damp and hot, noxious dampness, pudendal pruritus, the erosion of the vulva, disease sees inferior belly gas pain or waist sacrum distending pain, profuse leukorrhea, yellow skin, pudendal pruritus, or has low grade fever, spiritlessness and weakness, dry stool or half congealed and not well, yellow urine; Pelvic inflammatory disease, adnexitis, vaginitis, urethritis are shown in above-mentioned patient; Internal hemorrhoid, external hemorrhoid, mixed hemorrhoid.
We are damp and hot based on monarch drug Radix Sophorae Flavescentis Qinghua, rush down the heat of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, obtain the merit of parasite killing, dampness leukorrhagia stopping; Herba Andrographis, Radix Arnebiae (Radix Lithospermi) are ministerial drug, heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, detumescence; Herba Patriniae, Herba Taraxaci, Herba Violae are adjuvant drug, heat-clearing and toxic substances removing, removing heat from blood removing blood stasis, removing obstruction for relieving pain; Aloe, Pulvis Fellis Suis removing liver heat and toxic substances, dry.Many medicines are jointly assisted a ruler in governing a country principal agent and are forced pathogenic heat to go out, and reach effect of heat-clearing and toxic substances removing, dampness removing eliminating stagnation, killing parasites for relieving itching.The invention has the advantages that safety is good, good effect, short treating period, the feature such as easy to use.
Further illustrate Chinese medicine composition of the present invention below by way of test and there is heat-clearing and toxic substances removing, dampness removing eliminating stagnation, effect of killing parasites for relieving itching.
Chronic pelvic inflammatory disease is often aerobe and anaerobe mixed infection, with reference to " technical requirement of study of tcm new drug ", Pharmacodynamics experiment is carried out to pharmaceutical composition of the present invention, has observed staphylococcus aureus, staphylococcus epidermidis, escherichia coli, bacillus pyocyaneus, bacillus cereus, bacteroides fragilis, digestive tract streptococcus, Candida albicans and the smooth antibacterial action reading coccus by In vitro Bactericidal Experiments method.
Trial drug: Chinese medicine composition prescription 1 of the present invention, prescription 2, prescription 3, prescription 4, prescription 5, prescription 6.
Prescription 1:
Radix Sophorae Flavescentis 7 parts of Herba Patriniae 12 parts of Herba Violaes 10 parts
Herba Andrographis 12 parts of Herba Taraxacis 23 parts of Pulvis Fellis Suiss 1 part
Radix Arnebiae (Radix Lithospermi) 12 portions of Aloes 0.3 part
Prescription 2:
Radix Sophorae Flavescentis 8 parts of Herba Patriniae 10 parts of Herba Violaes 9 parts
Herba Andrographis 13 parts of Herba Taraxacis 20 parts of Pulvis Fellis Suiss 1.5 parts
Radix Arnebiae (Radix Lithospermi) 10 portions of Aloes 0.2 part
Prescription 3:
Radix Sophorae Flavescentis 6 parts of Herba Patriniae 11 parts of Herba Violaes 11 parts
Herba Andrographis 11 parts of Herba Taraxacis 22 parts of Pulvis Fellis Suiss 1.1 parts
Radix Arnebiae (Radix Lithospermi) 15 portions of Aloes 0.4 part
Prescription 4:
Radix Sophorae Flavescentis 4 parts of Herba Patriniae 16 parts of Herba Violaes 10 parts
Herba Andrographis 12 parts of Herba Taraxacis 10 parts of Pulvis Fellis Suiss 2 parts
Radix Arnebiae (Radix Lithospermi) 5 portions of Aloes 0.3 part
Prescription 5:
Radix Sophorae Flavescentis 2 parts of Herba Patriniae 17 parts of Herba Violaes 5 parts
Herba Andrographis 49 parts of Herba Taraxacis 9 parts of Pulvis Fellis Suiss 0.5 part
Radix Arnebiae (Radix Lithospermi) 16 portions of Aloes 0.1 part.
Prescription 6:
Radix Sophorae Flavescentis 10 parts of Herba Patriniae 7 parts of Herba Violaes 15 parts
Herba Andrographis 5 parts of Herba Taraxacis 31 parts of Pulvis Fellis Suiss 2.5 parts
Radix Arnebiae (Radix Lithospermi) 3 portions of Aloes 1 part.
One, Antimicrobial test
Test liquid: get the extractum 20g not adding matrix composition, adds 0.9% aseptic sodium chloride solution 100ml.Be diluted to 1:10 test liquid, for subsequent use.
Measure minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC):
MIC is measured with Double broth dilution method.In the serial agar plate surface dibbling antibacterial containing test liquid, bacterium liquid ultimate density is 10
5cFU/ml, 18h is cultivated in aerobe 37 DEG C, and fungus 27 DEG C cultivates 24h, and anaerobe is put anaerobism incubator 37 DEG C and hatched 48h, and in the plate having no bacterial growth, the contained least concentration for reagent is its minimal inhibitory concentration (MIC, mg/L).With staphylococcus aureus in experiment, colon bacillus makes Quality-control strains.MIC is surveyed with meat soup doubling dilution, get again and have no bacterial growth pipe culture fluid 0.1ml in without medicine agar plate surface, push away with sterile glass rod even, cultivate (condition measures with MIC), lowest concentration of drug still without bacterial growth is its minimum bactericidal concentration (MBC), the results are shown in Table 1.
Table 1 antibacterial experiment result
As shown in Table 1, to 9 test strains such as testing staphylococcus aureus used, there is significantly antibacterial or bactericidal action.
The pharmaceutical composition that gynecological inflammation treated by prescription 1 ~ 4 of the present invention has significant antibacterial activity, and the sterilizing rate in 15 ~ 30 minutes is more than 90%.And prescription 5,6 antibacterial effect is not as prescription 1 ~ 4.
Two, clinical experiment
(1) case selection
Select pudendum, vagina, cervix uteri, uterus, adnexa and pelvic inflammation case and pelvic inflammatory disease block case.
Case scenario is as table 2,3.
Table 2 age distribution
Table 3 diseased region distributes
(2) Therapeutic Method
The state of an illness and diseased region is made a definite diagnosis according to medical history, sign, gynecologial examination etc.In 400 routine cases, 334 examples all make hemogram checking (leukocyte sum and layering) before and after diagnosis and treatment; Have the disease of enclosed mass after diagnosing, chronic pelvic inflammation is shown in case, all makes B ultrasonic before the treatment.
Application method: 7th be a course for the treatment of, every day two pieces, anal cleaning anus, pushes about 7 ~ 15 centimeters, rectum by suppository booster.
(3) the distribution course for the treatment of
The course for the treatment of, distribution was in table 4.
The table 4 distribution course for the treatment of
(4) criterion of therapeutical effect and therapeutic outcome
Recovery from illness: dispenser pathological changes subjective symptoms disappearance in 7 ~ 14 days, pelvic inflammatory disease block and connective tissue thicken all disappearances or disappearance or slightly vestige substantially, and normally, leukocyte is down to less than 10,000 persons and is fully recovered for the scorching block disappearance of B-mode ultrasound tomography or slightly vestige, temperature recovery.
Effective: subjective symptoms obviously alleviates, inflammation reduces, inflammatory tissue deliquescing, removable, and rear alleviation of pain is light, the hemogram person of being clearly better.
Invalid: do not meet effect of fullying recover from an illness, effective standard person, namely symptom slightly takes a turn for the better, but do not disappear for invalid.Therapeutic effect is in table 5.
Table 5 therapeutic outcome
The suppository that this experiment adopts prescription 1 of the present invention obtained, by three routine clinical observations of group 400, therapeutic outcome is through statistical procedures, effective 389 examples, effective percentage 0.97(p), invalid 11 examples, inefficiency 0.0275(q), add up to n=400, use sample to estimate effective percentage 98% credibility interval of this medicine.
P±2.33×SP(95.35～99.15)
Its effective percentage: the credibility interval of 98% and have 99% trustworthiness, think the effective percentage of this medicine 95.35% ?within 99.15% scope.
Pharmaceutical composition provided by the invention has following beneficial effect:
1) comprehensive three routine clinical observation reports of group 400, the obtained suppository of proved invention all has obvious curative effect to urgent chronic pelvic inflammatory disease.Especially more distinguished to acute inflammation effect.Its effective percentage is more than 97%;
2) application process is easy, and patient is without the need to directly by other people or apparatus, and just it is applied voluntarily;
3) not yet find that there is side effect in the clinical observation process of 400 examples, although find when medication lower abdomen tenesmus and urine meaning high, need not dispose and get final product spontaneous remission;
4) medical material used can be gathered materials on the spot, and meets the requirement that letter is honest and clean;
5) by 400 routine clinical observations, antiinflammatory bolt of the present invention has really: heat-clearing and toxic substances removing, parasite killing dampness removing, dispersing swelling and dissipating binds, except the function of pain relieving of itching.
[detailed description of the invention]
Embodiment 1
The Chinese medicinal components of the present composition is made up of the crude drug of following weight parts:
Radix Sophorae Flavescentis 4 parts of Herba Patriniae 16 parts of Herba Violaes 10 parts
Herba Andrographis 12 parts of Herba Taraxacis 25 parts of Pulvis Fellis Suiss 1 part
Radix Arnebiae (Radix Lithospermi) 5 portions of Aloes 0.8 part.
Embodiment 2
The Chinese medicinal components of the present composition is made up of the crude drug of following weight parts:
Radix Sophorae Flavescentis 5 parts of Herba Patriniae 12 parts of Herba Violaes 8 parts
Herba Andrographis 9 parts of Herba Taraxacis 25 parts of Pulvis Fellis Suiss 2 parts
Radix Arnebiae (Radix Lithospermi) 5 portions of Aloes 0.2 part.
Embodiment 3
Radix Sophorae Flavescentis 8 parts of Herba Patriniae 12 parts of Herba Violaes 9 parts
Herba Andrographis 15 parts of Herba Taraxacis 20 parts of Pulvis Fellis Suiss 1 part
Radix Arnebiae (Radix Lithospermi) 10 portions of Aloes 0.5 part.
Embodiment 4
Radix Sophorae Flavescentis 3 parts of Herba Patriniae 9 parts of Herba Violaes 12 parts
Herba Andrographis 12 parts of Herba Taraxacis 30 parts of Pulvis Fellis Suiss 2 parts
Radix Arnebiae (Radix Lithospermi) 12 portions of Aloes 0.3 part.
Embodiment 5
Radix Sophorae Flavescentis 7 parts of Herba Patriniae 12 parts of Herba Violaes 10 parts
Herba Andrographis 12 parts of Herba Taraxacis 23 parts of Pulvis Fellis Suiss 1 part
Radix Arnebiae (Radix Lithospermi) 12 portions of Aloes 0.3 part
Embodiment 6
Radix Sophorae Flavescentis 6 parts of Herba Patriniae 8 parts of Herba Violaes 12 parts
Herba Andrographis 6 parts of Herba Taraxacis 30 parts of Pulvis Fellis Suiss 1.5 parts
Radix Arnebiae (Radix Lithospermi) 15 portions of Aloes 0.5 part.
Embodiment 7
Radix Sophorae Flavescentis 7 parts of Herba Patriniae 15 parts of Herba Violaes 9 parts
Herba Andrographis 10 parts of Herba Taraxacis 30 parts of Pulvis Fellis Suiss 1 part
Radix Arnebiae (Radix Lithospermi) 10 portions of Aloes 0.3 part.
Embodiment 8
Radix Sophorae Flavescentis 8 parts of Herba Patriniae 15 parts of Herba Violaes 12 parts
Herba Andrographis 9 parts of Herba Taraxacis 15 parts of Pulvis Fellis Suiss 1.5 parts
Radix Arnebiae (Radix Lithospermi) 13 portions of Aloes 0.7 part.
Embodiment 9 prepares Chinese medicinal components
Example 1 ~ 8 any embodiment, except Pulvis Fellis Suis, Aloe, all the other Six-elements add 10 times amount soak by water secondaries, 2 hours first times, second time adds water 8 times of water gagings 1.5 hours, and collecting decoction, filters, filtrate reduced in volume becomes thick paste, control baking temperature 65 DEG C, vacuum-0.07Mpa, dry 10 hours, be ground into fine powder, mix homogeneously with Pulvis Fellis Suis, Aloe fine powder.Embodiment 10 prepares suppository
After embodiment 9 being processed, final obtained medicinal mixture powder, gets fatty glyceride 1800g and melts at 45 DEG C, add mix powder, mixing, moulding, and cooling makes 1000.
Fatty glyceride can use cocoa butter, polyoxyethylene 8 stearate fat, hydrogenated vegetable oil, polyethylene glycols or other appropriate substrate to substitute.
Embodiment 11 prepares enema
After embodiment 9 being processed, final obtained medicinal mixture powder, is suspended in obtained enema in normal saline (20L).
Embodiment 12 prepares pill (micropill, the watered pill, coated pill)
After embodiment 9 being processed, final obtained medicinal mixture powder, carries out general ball with Mel or syrup or rubber cement solution, and dry, add the Pulvis Fumi Carbonisatus powder coating of its total amount 5 ~ 9%, dry, film coating, polishing, to obtain final product.
Embodiment 13 prepares capsule
After embodiment 9 being processed, final obtained medicinal mixture powder, adds the starch of its total amount 3%, and mixing, dry, pulverize after granulation, filled capsules, make the capsule of 0.3g/ grain.
Embodiment 14 prepares mixture
After embodiment 9 being processed, final obtained medicinal mixture powder, adds the sodium benzoate of appropriate purified water and total amount 0.1% thereof, fully mixes, and after filtering fill, to obtain final product.
Embodiment 15 prepares tablet
After embodiment 9 is processed, final obtained medicinal mixture powder, in add the starch of its total amount 5%, mixing, tabletting after granulating, makes the tablet of 0.3g/ sheet.
Embodiment 16 prepares granule
After embodiment 9 being processed, final obtained medicinal mixture powder, adds appropriate dextrin or sucrose, granulates, dry, dresses up the granule of 4g/ bag.
Embodiment 17 prepares aerosol
After embodiment 9 being processed, the drug microparticles that final obtained medicinal mixture powder is broken to below 5um adds Fel Ursi aqueous solution and Polyethylene Glycol fully mixes porphyrize in colloid mill, makes stable suspension, and subpackage, filling propellant, to obtain final product.
Embodiment 18
Appoint ××, female, 27 years old, married.
Main suit: hypogastric region severe pain, the high heat of companion one day.
Medical history: aversion to cold suddenly, the shiver with cold of companion, body temperature 40 DEG C, 110 beats/min, pulse, bilateral hypogastric region severe pain, frequency of bowel movement band thickness.
Check: face of acute ill, face order is red red, and pain (+++) after hypogastric region, rebound tenderness (+), labia is opened (+).
Gynecologial examination: secretions is pus and blood, volume, and posterior fornix is full, cervix uteri redness lifts pain (+), and palace body is slightly large, slightly soft.Tenderness (+), double accessory all thickens, tenderness (+).
Hemogram: leukocyte 32000 ∕ mm
3
Diagnosis: acute pelvic inflammatory disease
Treatment: the suppository using the embodiment of the present invention 5 to prepare, treat treatment one week (two pieces, the first five sky, later every day one piece) third body temperature drop to 37.2 DEG C, stomachache disappears, leukocyte 14800 ∕ mm
3, to five days, subjective symptoms disappeared, body temperature 37 DEG C, 80 beats/min, pulse, leukocyte 6600 ∕ mm
3, cure, stop treatment.
The course for the treatment of: one week.
Embodiment 19
Wu ×, female, 25 years old.
Diagnosis: acute pelvic inflammatory disease, pelvic inflammatory disease sexually transmitted disease (STD)
Main suit: the high heat of right lower abdomen severe pain companion one day.
Check: patient's face of acute ill, lift into ward, body temperature 39.2 DEG C, hypogastric region tenderness and jumping pain.
Gynecologial examination: vagina burning sensation, secretions purulence, amount is many, taste smelly (+), lifting pain (+), and posterior fornix is full, touches a tender spot (+), retroposition of uterus, slightly greatly, rear pain (+).The large tag of an ovum gallinaceum is touched in upper right side, uterus, movable not good enough, tenderness (+).
B ultrasonic is pointed out: inflammatory masses of pelvic cavity 2.4 × 2.0cm
2
Hemogram: leukocyte 19000 ∕ mm
3
Diagnosis: 1. acute pelvic inflammatory disease 2. inflammatory masses of pelvic cavity
Treatment: the suppository using the embodiment of the present invention 5 to prepare, day two pieces, treats two days, and body temperature is normal, and stomachache obviously alleviates, and can step into ward.Treat four days, hemogram 12000/mm
3, stomachache disappears.Treat six days, B ultrasonic is pointed out: scorching block disappears.But hemogram 11400/mm
3, continue, with the treatment of the embodiment of the present invention 5 antiinflammatory bolt, to treat the tenth day, the normal 6800/mm of hemogram
3, subjective symptoms disappears.
B ultrasonic is pointed out: normal pelvic cavity.
Gynecologial examination: normal pelvic cavity.Treatment drug withdrawal.
The course for the treatment of: two weeks.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, although the present invention discloses as above with preferred embodiment, but and be not used to limit the present invention, any those skilled in the art, do not departing within the scope of technical solution of the present invention, make a little change when the technology contents of above-mentioned announcement can be utilized or be modified to the Equivalent embodiments of equivalent variations, in every case be do not depart from technical solution of the present invention content, according to any simple modification that technical spirit of the present invention is done above embodiment, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (10)
1. treat a pharmaceutical composition for gynecological inflammation, it is characterized in that being prepared from by the crude drug of following weight parts meter:
Radix Sophorae Flavescentis 3 ~ 9 parts of Herba Patriniae 8 ~ 16 parts of Herba Violaes 6 ~ 12 parts
Herba Andrographis 6 ~ 15 parts of Herba Taraxacis 10 ~ 30 parts of Pulvis Fellis Suiss 1 ~ 2 part
Radix Arnebiae (Radix Lithospermi) 5 ~ 15 portions of Aloes 0.2 ~ 0.8 part.
2. the pharmaceutical composition for the treatment of gynecological inflammation as claimed in claim 1, is characterized in that the more excellent proportioning of described crude drug is:
Radix Sophorae Flavescentis 4 ~ 8 parts of Herba Patriniae 10 ~ 16 parts of Herba Violaes 6 ~ 10 parts
Herba Andrographis 6 ~ 12 parts of Herba Taraxacis 10 ~ 25 parts of Pulvis Fellis Suiss 1 ~ 2 part
Radix Arnebiae (Radix Lithospermi) 5 ~ 13 portions of Aloes 0.2 ~ 0.8 part.
3. the pharmaceutical composition for the treatment of gynecological inflammation as claimed in claim 1, is characterized in that the optimum proportioning of described crude drug is:
Radix Sophorae Flavescentis 7 parts of Herba Patriniae 12 parts of Herba Violaes 10 parts
Herba Andrographis 12 parts of Herba Taraxacis 23 parts of Pulvis Fellis Suiss 1 part
Radix Arnebiae (Radix Lithospermi) 12 portions of Aloes 0.3 part.
4. the rectum prepared of any one pharmaceutical composition of claims 1 to 3 or vaginal administration.
5. the pharmaceutical composition for the treatment of gynecological inflammation as claimed in claim 4, is characterized in that described compositions is prepared as suppository, unguentum, enema.
6. the preparation method of the pharmaceutical composition of the treatment gynecological inflammation as described in as arbitrary in claims 1 to 3, comprises the steps:
A) described in except Pulvis Fellis Suis and Aloe, all the other Six-element raw medicinal materials add 6 ~ 10 times amount soak by water 2 ~ 3 times, each 1 ~ 3h, collecting decoction, filter, and when concentrating under reduced pressure becomes 65 DEG C, relative density is the thick paste of 1.25 ~ 1.30;
B) by gained thick paste at 60 ~ 70 DEG C, after fine powder obtained after dry 9 ~ 12 hours under vacuum-0.06 ~-0.08Mpa mixes with Pulvis Fellis Suis and Aloe fine powder, then add and pharmaceutically accept adjuvant and make dosage form.
7. the pharmaceutical composition as described in as arbitrary in claims 1 to 3 is for the preparation of the purposes for the treatment of gynecological inflammation medicine.
8. the pharmaceutical composition for the treatment of gynecological inflammation as claimed in claim 7, is characterized in that: this Chinese medicine composition can add adjuvant and make any one dosage form on pharmaceutics.
9. the pharmaceutical composition for the treatment of gynecological inflammation as claimed in claim 8, is characterized in that: described dosage form is capsule, tablet, granule, pill, powder, unguentum, suppository, oral liquid, injection, lotion, liniment, aerosol, spray, enema.
10. the flavour of a drug of the pharmaceutical composition of the treatment gynecological inflammation as described in as arbitrary in claims 1 to 3 can increase or reduce.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943802A (en) * | 2016-07-07 | 2016-09-21 | 王瑜琳 | External used traditionalChinese medicine composition for treating gynecological inflammation |
| CN108524866A (en) * | 2018-05-08 | 2018-09-14 | 中商华夏物产（贵州）贵和堂药业有限公司 | A kind of Traditional Chinese medicine bacteriostatic gelling agent and preparation method thereof |
| CN109771595A (en) * | 2018-12-28 | 2019-05-21 | 合肥卡迪尔生物科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating gynaecological imflammation |
| CN111450176A (en) * | 2019-01-18 | 2020-07-28 | 上海德上生物医药科技有限公司 | Gynecological antibacterial gel |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301295A (en) * | 2013-06-21 | 2013-09-18 | 哈尔滨欧替药业有限公司 | Kangfu anti-inflammatory vaginal expansion suppository as well as preparation method and detection method thereof |
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2013
- 2013-12-24 CN CN201310718752.7A patent/CN104721418B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301295A (en) * | 2013-06-21 | 2013-09-18 | 哈尔滨欧替药业有限公司 | Kangfu anti-inflammatory vaginal expansion suppository as well as preparation method and detection method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943802A (en) * | 2016-07-07 | 2016-09-21 | 王瑜琳 | External used traditionalChinese medicine composition for treating gynecological inflammation |
| CN108524866A (en) * | 2018-05-08 | 2018-09-14 | 中商华夏物产（贵州）贵和堂药业有限公司 | A kind of Traditional Chinese medicine bacteriostatic gelling agent and preparation method thereof |
| CN109771595A (en) * | 2018-12-28 | 2019-05-21 | 合肥卡迪尔生物科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating gynaecological imflammation |
| CN111450176A (en) * | 2019-01-18 | 2020-07-28 | 上海德上生物医药科技有限公司 | Gynecological antibacterial gel |
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| Publication number | Publication date |
|---|---|
| CN104721418B (en) | 2017-11-10 |
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