CN103301295A - Kangfu anti-inflammatory vaginal expansion suppository as well as preparation method and detection method thereof - Google Patents
Kangfu anti-inflammatory vaginal expansion suppository as well as preparation method and detection method thereof Download PDFInfo
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- CN103301295A CN103301295A CN2013102484118A CN201310248411A CN103301295A CN 103301295 A CN103301295 A CN 103301295A CN 2013102484118 A CN2013102484118 A CN 2013102484118A CN 201310248411 A CN201310248411 A CN 201310248411A CN 103301295 A CN103301295 A CN 103301295A
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Abstract
The invention relates to a Kangfu anti-inflammatory vaginal expansion suppository. The expansion suppository comprises active ingredients prepared from raw material medicines such as radix sophorae flavescentis, patrinia and Chinese violet, a matrix and an expansion carrier. The suppository is fully expanded, so that the medicine-containing matrix is fully contacted with the inner wall of the vagina, and external flow of the liquid medicine is avoided; the medicine-containing matrix in the expansion suppository also comprises a dispersing carrier, so that release of the active ingredients can be promoted, and the dissolution rate is improved. The invention also provides a preparation method and a detection method of the expansion suppository. The provided Kangfu anti-inflammatory vaginal expansion suppository employs seven ingenious advanced technologies and has the beneficial effects that the external flow of the liquid medicine is avoided, the stability is high, the effect is fast, the drug action time is long, and secondary infection is avoided.
Description
Technical field
The invention belongs to the vaginal suppository field, particularly a kind of health woman's antiinflammatory vagina expansible plug and preparation method thereof and detection method.
Background technology
Health woman's antiinflammatory bolt records in " the Sanitation Ministry medicine standard Traditional Chinese medicine historical preparation " the 17, also include in Chinese Pharmacopoeia simultaneously the vaginal suppository that it is made by Radix Sophorae Flavescentis, Herba Patriniae, Herba Violae, Herba Andrographis, Herba Taraxaci, Pulvis Fellis Suis, Radix Arnebiae (Radix Lithospermi) (lithospermum euchromum Royle) and Aloe eight flavor medicines; In the side with Radix Sophorae Flavescentis as monarch drug, heat clearing and damp drying, parasite killing rushes down the heat of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, and can the dampness leukorrhagia stopping; Herba Andrographis, Radix Arnebiae (Radix Lithospermi) are ministerial drug, heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, detumescence; Herba Patriniae, Herba Taraxaci, Herba Violae, heat-clearing and toxic substances removing, the removing heat from blood removing blood stasis, removing obstruction for relieving pain, three medicines are adjuvant drug; Aloe, Pulvis Fellis Suis have antibacterial, insecticidal action.Many medicines are jointly assisted a ruler in governing a country principal agent and are forced pathogenic heat to go out, and reach heat-clearing and toxic substances removing, the effect of dampness removing eliminating stagnation, killing parasites for relieving itching; Be used for leukorrheal diseases, pudendal pruritus, the erosion of the vulva due to damp and hot, the noxious dampness, disease is seen inferior belly gas pain or waist sacrum distending pain, profuse leukorrhea, and yellow skin, pudendal pruritus, or low grade fever is arranged, spiritlessness and weakness, dry stool or half congealed and not well, yellow urine; Pelvic inflammatory disease, adnexitis, vaginitis are seen above-mentioned disease person.
Prior art adopts semi-synthetic fatty acid glyceride to mix with above-mentioned 8 flavor crude drug, adopts hot melt to prepare suppository; (the Li Fengqin such as Li Fengqin, Li Fengzhi, Shi Dongxia, Deng. health woman's antiinflammatory bolt Study on Forming [J], contemporary Chinese Chinese medicine, 2006,8 (10): 19-21) take mixed fatty glycerides as substrate and above-mentioned 8 the flavor crude drug make suppository, in order to increase the dissolution of medicine, also added the surfactant polyoxyethylene sorbitan monoleate in its prescription.Above-mentioned two kinds of substrate are all inhomogeneous with mixing of 8 flavor crude drug, and viscosity is inadequate, not easy-formation; Because the dissolution of above-mentioned 8 flavor crude drug is bad, Li Fengqin etc. have added polyoxyethylene sorbitan monoleate, but show through the inventor's test, its to dissolution to improve effect still undesirable.
In addition, health woman's antiinflammatory bolt is the following problem of ubiquity also: 1. and not easy to clean, easy pollution clothes; 2. active medicine and people's contact level are little, cause absorbing insufficient, do not bring into play the optimum curative effect of prescription; 3. drug effect is fast, and effectively administration time is short.
Summary of the invention
In order to solve the problems of the technologies described above, improve the dissolution of health woman antiinflammatory suppository, the optimum curative effect of performance prescription, the invention provides a kind of prove effective health woman's antiinflammatory vagina expansible plug and method for making thereof fast, that drug release time prolongs, a kind of science detection method that can control above-mentioned health woman's antiinflammatory vagina expansible plug product quality also is provided simultaneously.
The concrete technical scheme of the present invention is as follows:
The invention provides a kind of health woman's antiinflammatory vagina expansible plug, described expansible plug comprises active component and substrate, described expansible plug also comprises expandable expansion carrier, described active component and substrate formed pastille substrate are coated in the expansion carrier surface, the swell value of described expansion carrier after saturated suction is greater than 1.1, and described active component is mainly made by the crude drug of following weight portion:
Radix Sophorae Flavescentis 200-800 Herba Patriniae 50-300 Herba Taraxaci 50-300
Radix Arnebiae (Radix Lithospermi) 150-500 Pulvis Fellis Suis 30-90 Aloe 30-90
Herba Violae 50-300 Herba Andrographis 0-100.
Further, active component of the present invention is mainly made by the crude drug of following weight portion:
Radix Sophorae Flavescentis 400-600 Herba Patriniae 100-200 Herba Taraxaci 100-200
Radix Arnebiae (Radix Lithospermi) 200-300 Pulvis Fellis Suis 40-70 Aloe 40-70
Herba Violae 100-200 Herba Andrographis 20-40.
Further, active component of the present invention is mainly made by the crude drug of following weight portion:
Radix Sophorae Flavescentis 450 Herba Patriniae 150 Herba Taraxacis 150
Radix Arnebiae (Radix Lithospermi) 250 Pulvis Fellis Suiss 50 Aloes 50
Herba Violae 150 Herba Andrographis 30.
Health woman antiinflammatory vaginal suppository is made by Radix Sophorae Flavescentis, Herba Patriniae, Herba Violae, Herba Andrographis, Herba Taraxaci, Pulvis Fellis Suis, Radix Arnebiae (Radix Lithospermi) (lithospermum euchromum Royle) and Aloe eight flavor crude drug in the prior art; Learn the 1599th page of introduction of voluminous dictionary through modern Chinese medicine, Herba Andrographis has heat-clearing and toxic substances removing, the effect of removing heat from blood detumescence; CHUANXINLIAN JIAONANG (every contains crude drug 0.5g), every night 1-2 grain are used in clinical research, fill in vagina, 6-8 days is a course for the treatment of, treats 210 routine patients, female vagina 70 examples wherein, trichomonal vaginitis 54 examples, acute cervicitis 82 examples, colpitis mycotica 4 examples, recovery from illness 81 examples after the treatment, 119 examples take a turn for the better, totally 200 examples effectively, the highest with the vaginitis curative effect, invalid without 1 example, so Herba Andrographis and preparation thereof have good curative effect to gynaecopathia.Herba Andrographis plays a role as ministerial drug in health woman antiinflammatory vaginal suppository, lacks the curative effect that this one-tenth branch affects health woman antiinflammatory vaginal suppository.The present invention is through great many of experiments, draws not add Herba Andrographis in the health woman antiinflammatory vagina expansible plug or the consumption of Herba Andrographis is controlled in 100 weight portions, and to the leukorrheal diseases due to damp and hot, the noxious dampness, the effective percentage of pudendal pruritus, the erosion of the vulva still can reach more than 95%; The consumption of Herba Andrographis is during greater than 100 weight portion, and the curative effect of health woman's antiinflammatory vagina expansible plug increases thereupon.In the prior art also with no specific disclosure of the parts by weight of each crude drug in the health woman antiinflammatory vaginal suppository, the present invention is on the basis of original composition, parts by weight to each crude drug screen, draw the crude drug that meets above-mentioned parts by weight and can give full play to curative effect, reduced the consumption of medicine, some drug doses have been overcome excessive, the shortcoming that curative effect does not improve thereupon.
Simultaneously, the present invention has adopted " the intravaginal sticking type medicine-feeding technology " of original creation, and this technology realizes by add the expansion carrier in suppository.Ordinary suppository is because the relation of gravity, no matter user be stand, under sitting posture or the formula position of lying, always have vagina can not or the less pastille substrate that touches, after described expansion carrier expands, pastille substrate can be 360 ° and contact with vaginal walls, fully administration, 6 times of administration enlarged areas, medicine directly attaches to lesions position, makes the position that originally can't contact medicine also can effectively be attached treatment; And because the buffer action that stype plays in the middle of vagina makes between the wound surface no longer to contact with each other, thereby avoids superinfection, it is shown effect no longer repeatedly.In addition, " anti-side leakage key " design concept has been used in the introducing of expansion carrier, because the expansion of expansion carrier tail end (non-pastille substrate) can be close to vaginal wall, and then prevent the outflow of medicine and substrate, reduce the pollution of medicated clothing and keep the valid density of medicine.And by " inner core coefficient of expansion control technology ", can make the swell value of expansion carrier after saturated suction greater than 1.1.
The pastille substrate of health woman's antiinflammatory vagina expansible plug of the present invention comprises that also weight portion is the lanoline of 1-10 part; The parts by weight of described substrate are 80-200 part, and the parts by weight of described expansion carrier are 50-400 part; Described substrate is selected from Adeps Solidus, Cebes Pbarma16, Cotomar, ButyrumTego G, S-70XX
95, S-70XX
AHydrokote25, Hgdrokote711, Hhdrokote SP, Idropostal, Massa Estarinum A, Massa Estarinum AS, Massa Estarinum B, Massa Estarinum C, Massa Estarinum D, Massa Estarinum E, Massa Estarinum I, Massa Estarinum T, Massa Mf13, Massuppol, Massuppol15, Paramonnt B, Suppocire OSI, Suppocire OSIx Suppocire A, Suppocire B, Suppocire C, Suppocire D, Suppocire DM, Suppocire H, Suppocire L, Suppository Base W, Suppository Base AB, Suppository Base A, Suppository Base B, Suppository Base BC, Suppository Base BD, Suppository Base BBC, Suppository Base E, Suppository Base BCF, Suppository Base C, Suppository Base D, Suppository Base299, Suppostal-N, Suppostal-Es, Tegester Triglyceride Bases-95, Tegester Triglyceride Bases-MA, Tegester Triglyceride Bases-57, Wecobee W, Wecobee K, Wecobee S, Wecobee M, Wecobee ES, Witepsol H12, Witepsol H15, Witepsol W35, Witepsol S55, Witepsol E75, WitepsolE85, the Cortex Sapii Radicis ester, fractional distillation Petiolus Trachycarpi ester, fractional distillation cocos nucifera oil ester, Brazil wax, cocoa butter, the Ke Kemu ester, white beeswax, Cera Chinensis, gelatin, poloxamer, Cera Flava, stearic, polysorbate60, polysorbate65, semi-synthetic fatty acid glyceride, semi-synthetic cocos nucifera oil ester, semi-synthetic Fructus Litseae grease, semi-synthetic Petiolus Trachycarpi grease, propylene glycol stearate, Macrogol 4000, in polyethylene glycol 6000 or the polyoxyethylene monostearate one or more; The swell value of described expansion carrier after saturated suction is greater than 1.5, and described swell value is swell value radially.The substrate of English name of the present invention include in " industrial pharmacy theory and practice " book (J.L. card Buddhist nun is uncommon for L. La Heman, the sharp Berman of H.A.. industrial pharmacy theory and practice, Chemical Industry Press, second edition: 215-217).
The pastille substrate of described health woman's antiinflammatory vagina expansible plug also comprises lanoline, and described lanoline can play the effect of binding agent, prevents the suppository division, if but the consumption of described lanoline surpasses 10 weight portions, and can cause suppository really up to the mark, affect its application.
Further, the pastille substrate of health woman's antiinflammatory vagina expansible plug of the present invention comprises that also weight portion is the wax work of 10-25 part, the absorption blocker of the dispersible carrier of 20-40 part and 10-25 part; Described wax work is selected from one or more in Cera Flava, spermaceti or the Brazil wax; Described dispersible carrier is selected from one or more in polyvinylpyrrolidone, xylitol, poloxamer or the mannitol; Described absorption blocker is selected from one or more in sodium alginate, carbomer or the hypromellose.
Substrate of the present invention can make active component well be discharged, and in order further to increase the stability of described expansion suppository, has added preferred wax work in pastille substrate, mixes with substrate, can increase the fusing point of substrate, improves suppository stability.
Active component of the present invention is prepared through pulverizing or extract processes such as making thick paste by the multi-flavor crude drug, so the dissolution of active component is bad, in order to improve dissolution, the present invention makes solid dispersion with active component and the dispersible carrier that each flavor crude drug makes, increase the dissolution of active component, improved the bioavailability of active component.
Curative effect for further prolong drug, make " prolonged drug layering release ", expansible plug of the present invention further comprises the absorption blocker, the adding prolong drug of described absorption blocker is to the action time of vagina, prolong curative effect, be administered once in one day, drug effect reaches 24 hours, improves patient compliance.
Expansion carrier of the present invention includes but not limited to cotton sliver, also can comprise the sterilizable material that other can expand, such as non-woven fabrics, elastic fiber etc.
Pastille substrate of the present invention is the front end 1/5-4/5 place that Semi surrounding type is coated in described expansion carrier, according to " human engineering suppository " shape, is designed to the shapes such as duckbill, sphere, avette, bullet shaped, torpedo, cylindrical, taper shape or clavate.
The expansion carrier rear end of health woman's antiinflammatory vagina expansible plug of the present invention is connected with backguy, stype after the expansion, by the rear end backguy of tractive expansion carrier, the dead bark that be adsorbed on the virus that is killed on the expansion carrier, toxin, comes off is also pulled out external in the lump, change dressings at every turn and just equal to do once thoroughly cleaning to vagina, fundamentally prevention of inflammation recurs again, and this expansible plug belongs to " integrated dosage form is cleaned in treatment ".
Meet the effect that water can expand rapidly in order to reach health woman's antiinflammatory vagina expansible plug of the present invention, after the described expansion carrier suction, every maximum water absorption is not less than 1.5 milliliters.Suitable water absorption can guarantee the swell value that suits, crosses low or too high water absorption, all can cause bad impact, and water absorption is crossed when low, can not guarantee health woman's antiinflammatory vagina expansible plug of the present invention meet the characteristics that water namely expands and make expand insufficient; When water absorption was too high, the expansion carrier was understood too much absorption ingredient and is limited its diffusion.Therefore, water absorption is crossed low or too high, is not the desired expansion carrier of the present invention.
The invention provides the preparation method of health woman antiinflammatory vagina expansible plug, described method comprises the steps:
1) preparation of pastille substrate:
A. with substrate, lanoline and wax work heating and melting in water-bath, make fused mass;
B. the preparation of active component:
I. take by weighing Radix Sophorae Flavescentis, Herba Patriniae, Herba Violae, Herba Andrographis, Herba Taraxaci and the Radix Arnebiae (Radix Lithospermi) of recipe quantity, decoct with water twice, decoct 2-3h for the first time, decoct for the second time 1-2h, decocting liquid merges, and filters, be condensed into clear paste, add 25%-50% ethanol, leave standstill 12-24h, filter, Recycled ethanol liquid, be condensed into thick paste, in 20-70 ℃ of drying, be ground into fine powder; For the first time, decoct for the second time 6-10 that water consumption is respectively Radix Sophorae Flavescentis, Herba Patriniae, Herba Violae, Herba Andrographis, Herba Taraxaci and Radix Arnebiae (Radix Lithospermi) gross weight doubly and 2-5 doubly; The ethanol consumption is 4-5 times of clear paste;
II. take by weighing Pulvis Fellis Suis and the Aloe of recipe quantity, be ground into fine powder;
III. the fine powder of step I and II is crossed the 50-100 mesh sieve, mix homogeneously makes active component;
C. with the dispersible carrier heating and melting;
D. under stirring active component is added in the c step, make molten mixture;
E. cool off the molten mixture of d step, grind, cross the 100-120 mesh sieve, make solid dispersion;
F. take by weighing the absorption blocker of recipe quantity, with the solid dispersion mix homogeneously, make mixture;
G. with the fused mass mix homogeneously of f step mixture and a step;
2) insert the expansion carrier, cooling and shaping is made suppository.
The preparation method of health woman's antiinflammatory vagina expansible plug of the present invention has adopted " the integrally formed technology of the disposable fill of stype ".
The present invention also provides the detection method of described health woman's antiinflammatory vagina expansible plug on the other hand, and described detection method comprises swell value assay method, weight differential detection method, assay etc.
Wherein said swell value assay method comprises:
A. along described health woman's antiinflammatory vagina expansible plug radially choose one section or some sections, measure the initial length H of described expansion carrier;
B. after the saturated suction of described health woman's antiinflammatory vagina expansible plug, be determined at a and locate the rear length h of expansion carrier expansion in the selected location in the step;
When c. calculating described swell value, calculate according to the I formula;
（I）
Wherein, p represents that axial swell value, h represent to expand rear length, H represents initial length; Or described swell value assay method comprises:
A. along described health woman's antiinflammatory vagina expansible plug axially choose a place or some positions, measure the initial diameter R of described expansion carrier;
B. after the saturated suction of described health woman's antiinflammatory vagina expansible plug, be determined at a and locate the rear diameter r of expansion carrier expansion in the selected location in the step;
When c. calculating described swell value, press the II formula and calculate;
（II）
Wherein, P represents that radially swell value, r represent to expand rear diameter, R represents initial diameter;
Described weight differential assay method comprises:
A. get described health woman's antiinflammatory vagina expansible plug, take by weighing weight M;
B. get the expansion carrier in the described health woman's antiinflammatory vagina expansible plug that scrapes pastille substrate, drying takes by weighing weight m, according to the weight X of pastille substrate as described in calculating such as the III formula:
X=M-m
（Ⅲ）。
Further, described swell value assay method comprises that melting the change time limit detects, and also comprises the following steps:
A. first along described health woman's antiinflammatory vagina expansible plug radially choose one section or some sections, measure the initial length H of described expansion carrier after, the different angles of rolling are again measured several times, Hi averages;
B. after described health woman's antiinflammatory vagina expansible plug melts the detection of change time limit, be determined at a and locate the rear length h of expansion carrier expansion in the selected location in the step; The different angles of rolling are again measured several times, ask the rear average length hi that expands;
When c. calculating described swell value, calculate according to the I formula;
（I）
Wherein, pi represents that axial swell value, hi represent to expand rear average length, Hi represents average initial length;
Or described swell value assay method is as follows:
A. first an angle along described health woman's antiinflammatory vagina expansible plug axially choose a place or some positions, measure the initial diameter R of described expansion carrier after, the different angles of rolling are again measured several times, Ri averages;
B. after described health woman's antiinflammatory vagina expansible plug melts the detection of change time limit, be determined at a and locate the rear diameter r of expansion carrier expansion in the selected location in the step; The different angles of rolling are again measured several times, ask the rear average diameter ri that expands;
When c. calculating described swell value, press the II formula and calculate;
（II）
Wherein, Pi represents that radially swell value, ri represent to expand rear average diameter, Ri represents average initial diameter.
The wherein said change time limit assay method (two appendix of existing Chinese Pharmacopoeia) that melts comprising: get 3 of described health woman's antiinflammatory vagina expansible plugs, after room temperature is placed 1 hour, be placed on respectively on lower floor's plectane of 3 metal rack, in separately the sleeve pipe of packing into, and fixing with hook.Except as otherwise herein provided, said apparatus is dipped vertically into respectively in the container that fills 37.0 ± 0.5 ℃ of water that are no less than 4L, its upper end position should fill a rot at underwater 90mm place in the container, overturns this device once in solution every 10 minutes.Above numerical range should not be construed as limitation of the present invention, and the technical scheme in above-mentioned numerical range is not in protection scope of the present invention yet.
Further, described weight differential assay method comprises:
A. get described health woman's antiinflammatory vagina expansible plug, take by weighing weight M;
B. scrape pastille substrate, the expansion carrier is placed 20-90 ℃ of organic solvent, take out, in 50-150 ℃ of dry 1-10h, take by weighing weight m, according to the weight X of pastille substrate as described in calculating such as the III formula
X=M-m（Ⅲ）
Wherein, described organic solvent is selected from one or more in ethanol, methanol or the isopropyl alcohol.
Further, described swell value assay method comprises that melting the change time limit detects, and also comprises the following steps:
Get 3 of described health woman's antiinflammatory vagina expansible plugs, survey its afterbody cotton sliver diameter with slide gauge, roll approximately 90 ° and survey once again, survey twice for every, obtain 2 meansigma methods Ri of every mensuration; Above-mentioned 3 bolts are remained cotton sliver for melting to become to take out immediately after time limit mensuration finishes, treat disconnected of water, all gently place on the glass plate, measure two ends and middle three positions of each cotton sliver with slide gauge, roll approximately and to measure again three positions after 90 °, each cotton sliver obtains six data altogether, obtains 6 meansigma methods r of mensuration
i, calculate every swell value P
i, the swell value of three bolts all should be greater than 1.5.
Further, described weight differential assay method comprises:
Get 10 of described health woman's antiinflammatory vagina expansible plugs, accurately weighed every the gross weight of difference, gently scrape pastille substrate, not hinder (dew) cotton sliver as main, cotton sliver placed 80 ℃ 300ml ethanol, and 80khz frequency ultrasonic cleaning 5 minutes, the remaining stromatolysis in cotton sliver surface is removed, take out cotton sliver and firmly extract, inhale 3 times with filter paper again, in 105 ℃ of dryings 2 hours, take out, room temperature is placed every cotton sliver weight of difference weighing after 1 hour, deducts corresponding cotton sliver weight with every gross weight, namely gets every pastille substrate weight, and calculate average pastille substrate weight, every pastille substrate weight and average pastille substrate weight ratio, the pastille substrate weight that exceeds average pastille substrate weight ± 10% must not be more than 2, and must not overrun 1 times.
The assay method of the swell value of health woman's antiinflammatory vagina expansible plug provided by the present invention adopts repeatedly measuring method of multi-angle, has improved the accuracy of measuring, and has increased the operability of measuring, and method is easier to judge; When carrying out standard detection health woman's antiinflammatory of the present invention vagina expansible plug of state-promulgated pharmacopoeia appendix weight differential, need substrate is scraped off, because the scraping degree that operator grasp is different, cause every scraping degree difference larger, so the present invention adopts the substrate on dissolution with solvents expansible plug surface, through verification experimental verification, when adopting hot ethanol to clean the substrate on expansible plug surface, the result is better, and repeatability is higher, and described weight differential assay method is more convenient stable.
Described content assaying method is according to Chinese Pharmacopoeia appendix VI D high effective liquid chromatography for measuring.
Chromatographic condition and system suitability are take octadecylsilane chemically bonded silica as filler; Take acetonitrile-0.1% phosphoric acid solution (20:80) (regulating ester pH8.0 with triethylamine) as mobile phase; The detection wavelength is 220nm.Number of theoretical plate calculates by the matrine peak should be not less than 4000.
It is an amount of that the matrine reference substance is got in the preparation of reference substance solution, accurately weighed, adds mobile phase and make the solution that every 1ml contains 0.2mg, and get final product.
The pastille substrate under the weight differential item is got in the preparation of need testing solution, chopping, mixing is got approximately 3.6g, and is accurately weighed, put in the tool plug conical flask, accurate 0.1mol/L hydrochloric acid solution 50ml, weighed weight, the heating and refluxing extraction 30 minutes of adding, let cool, weighed weight again, supply the weight of less loss with the 0.1mol/L hydrochloric acid solution.0-4 ℃ of placement spent the night, and filters, and precision measures filtrate 20ml, put in the separatory funnel, regulate pH value to 9-10 with strong ammonia solution, extract 4 times with the chloroform jolting, each 15ml, merge chloroform extraction liquid, evaporate to dryness, residue dissolves with an amount of mobile phase, put in the l0ml measuring bottle, be diluted to scale with mobile phase, shake up, and get final product.
Algoscopy is accurate reference substance solution and each 10 μ l of need testing solution of drawing respectively, and the injection liquid chromatography is measured, and be get final product.
Health woman's antiinflammatory vagina expansible plug provided by the present invention have prove effective fast, pharmaceutical release time prolongs, the high beneficial effect of stability, and this health woman antiinflammatory vagina expansible plug has adopted seven leading technologies of original creation, " the disposable fill of stype is integrally formed " technology of original creation has been used in the adding of the expansion carrier in described health woman's antiinflammatory vagina expansible plug, " control of the inner core coefficient of expansion " technology, " human engineering bolt type " technology, " the treatment cleaning is integrated " dosage form, " administration of intravaginal sticking type " technology, " anti-side leakage key design " six technology, this expansion carrier can make the pastille substrate of health woman antiinflammatory vagina expansible plug fully contact with vaginal walls, and prevents the medicinal liquid outflow; Also has the effect that the cleaning vagina prevents superinfection; The present invention makes solid dispersion with active component with dispersible carrier, has improved the stripping of active component; Absorption blocker in health woman's antiinflammatory vagina expansible plug of the present invention has been used " prolonged drug layering release " technology, but the action time of its prolong drug, the prolong drug curative effect.
Description of drawings
Fig. 1 is the Dissolution Rate Testing result of the described health woman's antiinflammatory of embodiment 5-10 vagina expansible plug.
The specific embodiment
Embodiment 1
Preparation method:
1) preparation of pastille substrate:
A. with semi-synthetic Fructus Litseae grease heating and melting in water-bath, make fused mass;
B. the preparation of active component:
I takes by weighing Radix Sophorae Flavescentis, Herba Patriniae, Herba Violae, Herba Taraxaci, Herba Andrographis and the Radix Arnebiae (Radix Lithospermi) of recipe quantity, decocts with water twice, decocts 2h for the first time, decoct for the second time 2h, decocting liquid merges, and filters, be condensed into clear paste, add 25% ethanol, leave standstill 24h, filter, Recycled ethanol liquid, be condensed into thick paste, in 70 ℃ of dryings, be ground into fine powder; For the first time, decoct for the second time water consumption and be respectively Radix Sophorae Flavescentis, Herba Patriniae, Herba Violae, Herba Andrographis, Herba Taraxaci and Radix Arnebiae (Radix Lithospermi) gross weight 10 times and 2 times; The ethanol consumption is 5 times of clear paste;
II takes by weighing Pulvis Fellis Suis and the Aloe of recipe quantity, is ground into fine powder;
III crosses 50 mesh sieves with the fine powder of step I and II, and mix homogeneously makes active component;
C. with the fused mass mix homogeneously of active component and a step;
2) insert cotton sliver, cooling and shaping is made 1000 pieces of avette suppositorys, every piece of heavily about 5.0g.
Preparation method: make 1000 pieces of spherical suppositorys by embodiment 1 method, every piece of heavily about 1.7g.
Embodiment 3
Preparation method:
1) preparation of pastille substrate:
A. the heating and melting in water-bath with semi-synthetic fatty acid glyceride and lanoline makes fused mass;
B. the preparation of active component:
IV takes by weighing Radix Sophorae Flavescentis, Herba Patriniae, Herba Violae, Herba Taraxaci and the Radix Arnebiae (Radix Lithospermi) of recipe quantity, decocts with water twice, decocts 3h for the first time, decoct for the second time 1h, decocting liquid merges, and filters, be condensed into clear paste, add 50% ethanol, leave standstill 16h, filter, Recycled ethanol liquid, be condensed into thick paste, in 50 ℃ of dryings, be ground into fine powder; For the first time, decoct for the second time water consumption and be respectively Radix Sophorae Flavescentis, Herba Patriniae, Herba Violae, Herba Taraxaci and Radix Arnebiae (Radix Lithospermi) gross weight 6 times and 5 times; The ethanol consumption is 4 times of clear paste;
V takes by weighing Pulvis Fellis Suis and the Aloe of recipe quantity, is ground into fine powder;
VI crosses 100 mesh sieves with the fine powder of step I and II, and mix homogeneously makes active component;
C. with the fused mass mix homogeneously of active component and a step;
2) insert cotton sliver, cooling and shaping is made 1000 pieces of bullet shaped suppositorys, every piece of heavily about 4.3g.
Preparation method: make 1000 pieces of torpedo suppositorys by embodiment 3 methods, every piece of heavily about 4.0g.
Embodiment 5
Preparation method:
1) preparation of pastille substrate:
A. with polyoxyethylene monostearate, lanoline and spermaceti heating and melting in water-bath, make fused mass;
B. the preparation of active component:
I takes by weighing Radix Sophorae Flavescentis, Herba Patriniae, Herba Violae, Herba Andrographis, Herba Taraxaci and the Radix Arnebiae (Radix Lithospermi) of recipe quantity, decocts with water twice, decocts 3h for the first time, decoct for the second time 1h, decocting liquid merges, and filters, be condensed into clear paste, add 40% ethanol, leave standstill 12h, filter, Recycled ethanol liquid, be condensed into thick paste, in 20 ℃ of dryings, be ground into fine powder; For the first time, decoct for the second time water consumption and be respectively Radix Sophorae Flavescentis, Herba Patriniae, Herba Violae, Herba Andrographis, Herba Taraxaci and Radix Arnebiae (Radix Lithospermi) gross weight 8 times and 3 times; The ethanol consumption is 4 times of clear paste;
II takes by weighing Pulvis Fellis Suis and the Aloe of recipe quantity, is ground into fine powder;
III crosses 80 mesh sieves with the fine powder of step I and II, and mix homogeneously makes active component;
C. with poloxamer and mannitol heating and melting;
D. under stirring active component is added in the c step, make molten mixture;
E. cool off the molten mixture of d step, grind, cross 120 mesh sieves, make solid dispersion;
F. take by weighing the hypromellose of recipe quantity, with the solid dispersion mix homogeneously, make mixture;
G. with the fused mass mix homogeneously of f step mixture and a step;
2) insert cotton sliver, cooling and shaping is made 1000 pieces of bullet shaped suppositorys, every piece of heavily about 2.6g.
Preparation method: make 1000 pieces of duckbill suppositorys by embodiment 5 methods, every piece of heavily about 3.5g.
Embodiment 7
Preparation method: make 1000 pieces of torpedo suppositorys by embodiment 5 methods, every piece of heavily about 3.1g.
Preparation method: make 1000 pieces of cylindrical suppositorys by embodiment 5 methods, every piece of heavily about 4.6g.
Embodiment 9
Preparation method: make 1000 pieces of clavate suppositorys by embodiment 5 methods, every piece of heavily about 4.5g.
Preparation method: make 1000 pieces of conical suppositorys by embodiment 5 methods, every piece of heavily about 4.8g.
Test example 1 stability test
Health woman's antiinflammatory vagina expansible plug with above-described embodiment 5-10, under 25 ℃ of constant temperature, relative humidity is to place a period of time under 75% the condition, regularly sampling is observed, detect content (quite labelled amount) % of matrine by high-efficient liquid phase technique, and the suppository rip cutting checked the phenomenon such as do not find distortion, variable color, break; Prepared expansible plug reliable in quality, stability is high, and observed result sees Table 1.
Table 1 embodiment sample is 75% result of the test at relative humidity
The test of test example 2 dissolution determinations
The drug release rate of suppository detects: " Chinese pharmacopoeia appendix XIXD vitro drug release degree checks with reference to 2010 editions versions.
Get respectively health woman's antiinflammatory vagina expansible plug and the reference substance health woman antiinflammatory bolt of above embodiment 5-10, put in the medicament dissolution instrument, take a sample respectively in 1h, 2h, 4h, 6h, 12h, 16h, 24h, detect the stripping percentage rate with high performance liquid chromatography, and the cumulative release percentage rate of calculating medicine, the results are shown in Figure 1.
Compare with ordinary suppository, it is fast that health woman's antiinflammatory vagina expansible plug of the present invention has drug release rate, the characteristics that drug treating time prolongs.
Test example 3: swell value determination test
Get 3 of described health woman's antiinflammatory vagina expansible plugs, survey its afterbody cotton sliver diameter with slide gauge, roll approximately 90 ° and survey once again, survey twice for every, obtain 2 meansigma methods Ri of every mensuration; Above-mentioned 3 bolts are remained cotton sliver for melting to become to take out immediately after time limit mensuration finishes, treat disconnected of water, all gently place on the glass plate, measure two ends and middle three positions of each cotton sliver with slide gauge, roll approximately and to measure again three positions after 90 °, each cotton sliver obtains six data altogether, obtains 6 meansigma methods r of mensuration
i, calculate every swell value P
i, the swell value of three bolts is all greater than 1.5.
The swell value of measuring the described health woman's antiinflammatory of embodiment 1-10 vagina expansible plug according to above-mentioned swell value assay method is as described in Table 2.
The swell value of the described health woman's antiinflammatory of table 2 embodiment 1-10 vagina expansible plug
| Embodiment | Average diameter (cm) before expanding | Average diameter (cm) after expanding | Swell value (doubly) | The result |
| Embodiment 1 | 12.21 | 19.56 | 1.60 | |
| Embodiment | ||||
| 2 | 12.02 | 18.29 | 1.52 | Qualified |
| Embodiment 3 | 12.16 | 21.05 | 1.73 | |
| Embodiment | ||||
| 4 | 12.08 | 20.48 | 1.69 | Qualified |
| Embodiment 5 | 11.95 | 22.20 | 1.86 | |
| Embodiment | ||||
| 6 | 12.18 | 21.97 | 1.80 | Qualified |
| Embodiment 7 | 12.09 | 23.06 | 1.91 | |
| Embodiment | ||||
| 8 | 11.95 | 20.44 | 1.71 | Qualified |
| Embodiment 9 | 12.14 | 22.35 | 1.84 | |
| Embodiment | ||||
| 10 | 12.18 | 21.74 | 1.78 | Qualified |
Test example 4: weight differential determination test
Get 10 of described health woman's antiinflammatory vagina expansible plugs, accurately weighed every the gross weight of difference, gently scrape pastille substrate, not hinder (dew) cotton sliver as main, cotton sliver placed 80 ℃ 300ml ethanol, and 80khz frequency ultrasonic cleaning 5 minutes, the remaining stromatolysis in cotton sliver surface is removed, take out cotton sliver and firmly extract, inhale 3 times with filter paper again, in 105 ℃ of dryings 2 hours, take out, room temperature is placed every cotton sliver weight of difference weighing after 1 hour, deducts corresponding cotton sliver weight with every gross weight, namely gets every pastille substrate weight, and calculate average pastille substrate weight, every pastille substrate weight and average pastille substrate weight ratio, the pastille substrate weight that exceeds average pastille substrate weight ± 10% must not be more than 2, and must not overrun 1 times.
Repeat aforesaid operations, detect the described health woman's antiinflammatory of embodiment 1-10 vagina expansible plug, the equal conformance with standard of its weight differential.
Test example 5: clinical trial
One, research method
(1) research approach is formulated with reference to relevant " clinical verification of the department of obstetrics and gynecology urogenital tract infection local application " content of Ministry of Health of the People's Republic of China's new drug clinical guidance principle.
(2) diagnostic criteria
1, symptom: inferior belly gas pain or waist sacrum distending pain, the leucorrhea amount is many, yellow skin, pudendal pruritus, yellow urine;
2, gynecologial examination: swelling of external genitals, the leucorrhea amount is many, yellow skin, and vaginal mucosa and cervix uteri are congested red and swollen or rotten to the corn, and secretions is unusual.
(3) test case standard
Include the case history standard in: 21-50 year, meet the married woman of gynaecopathia diagnosis.
(4) Therapeutic Method
1, treatment group: use embodiment 7 described health woman's antiinflammatory vagina expansible plugs, one of every day, being used in conjunction 7 days is a course for the treatment of.
2, matched group: use the treatment of health woman antiinflammatory bolt, one of every day, being used in conjunction 7 days is a course for the treatment of.
(5) observation item
Therapeutic is observed
(1) symptom: whether take a turn for the better or disappear;
(2) gynecologial examination: comprise pudendum, vagina, cervix uteri and vaginal secretions inspection
(6) curative effect determinate standard
1, recovery from illness: transference cure, the gynecologial examination inspection is normal;
2, produce effects: symptom obviously alleviates, and gynecologial examination is clearly better;
3, effective: symptom alleviates to some extent, and gynecologial examination takes a turn for the better;
4, invalid: unchanged before and after the treatment.
Two, therapeutic outcome
(1) total effects sees Table 3
Table 3 total effects table
Two groups relatively there were significant differences (P＜0.01).
(2) two groups relatively see Table 4 to the leukorrheal diseases therapeutic effect due to damp and hot, the noxious dampness
Table 4 liang group is to the therapeutic effect of the leukorrheal diseases due to damp and hot, the noxious dampness
Two groups of curative effect comparison treatment groups obviously are better than matched group (P＜0.01).
(3) two groups relatively see Table 5 to pudendal pruritus, erosion of the vulva therapeutic effect
Table 5 liang group is to the therapeutic effect of pudendal pruritus, the erosion of the vulva
Two groups of curative effect comparison treatment groups are better than matched group (P＜0.01).
Three, conclusion
Health woman's antiinflammatory vagina expansible plug total effects be 95.1% with matched group total effects 88.9% relatively there were significant differences (P＜0.01).Effective percentage to the leukorrheal diseases due to damp and hot, the noxious dampness is 96.4%; To the effective percentage of pudendal pruritus, the erosion of the vulva up to more than 96%, comparing with matched group, all there were significant differences (P＜0.01).In its curative effect process of checking, do not find toxic and side effects, safe and reliable, evident in efficacy.
Claims (10)
1. health woman antiinflammatory vagina expansible plug, comprise active component and substrate, it is characterized in that, described expansible plug also comprises expandable expansion carrier, described active component and substrate formed pastille substrate are coated in the expansion carrier surface, and the swell value of described expansion carrier after saturated suction is greater than 1.1; Described active component is mainly made by the crude drug of following weight portion:
Radix Sophorae Flavescentis 200-800 Herba Patriniae 50-300 Herba Taraxaci 50-300
Radix Arnebiae (Radix Lithospermi) 150-500 Pulvis Fellis Suis 30-90 Aloe 30-90
Herba Violae 50-300 Herba Andrographis 0-100.
2. health woman's antiinflammatory vagina expansible plug as claimed in claim 1 is characterized in that, described active component is mainly made by the crude drug of following weight portion:
Radix Sophorae Flavescentis 400-600 Herba Patriniae 100-200 Herba Taraxaci 100-200
Radix Arnebiae (Radix Lithospermi) 200-300 Pulvis Fellis Suis 40-70 Aloe 40-70
Herba Violae 100-200 Herba Andrographis 20-40.
3. health woman's antiinflammatory vagina expansible plug as claimed in claim 2 is characterized in that, described active component is mainly made by the crude drug of following weight portion:
Radix Sophorae Flavescentis 450 Herba Patriniae 150 Herba Taraxacis 150
Radix Arnebiae (Radix Lithospermi) 250 Pulvis Fellis Suiss 50 Aloes 50
Herba Violae 150 Herba Andrographis 30.
4. such as the arbitrary described health woman's antiinflammatory vagina expansible plug of claim 1-3, it is characterized in that, described pastille substrate comprises that also weight portion is the lanoline of 1-10 part; The parts by weight of described substrate are 80-200 part, and the parts by weight of described expansion carrier are 50-400 part; Described substrate is selected from Adeps Solidus, Cebes Pbarma16, Cotomar, ButyrumTego G, S-70XX
95, S-70XX
AHydrokote25, Hgdrokote711, Hhdrokote SP, Idropostal, Massa Estarinum A, Massa Estarinum AS, Massa Estarinum B, Massa Estarinum C, Massa Estarinum D, Massa Estarinum E, Massa Estarinum I, Massa Estarinum T, Massa Mf13, Massuppol, Massuppol15, Paramonnt B, Suppocire OSI, Suppocire OSIx Suppocire A, Suppocire B, Suppocire C, Suppocire D, Suppocire DM, Suppocire H, Suppocire L, Suppository Base W, Suppository Base AB, Suppository Base A, Suppository Base B, Suppository Base BC, Suppository Base BD, Suppository Base BBC, Suppository Base E, Suppository Base BCF, Suppository Base C, Suppository Base D, Suppository Base299, Suppostal-N, Suppostal-Es, Tegester Triglyceride Bases-95, Tegester Triglyceride Bases-MA, Tegester Triglyceride Bases-57, Wecobee W, Wecobee K, Wecobee S, Wecobee M, Wecobee ES, Witepsol H12, Witepsol H15, Witepsol W35, Witepsol S55, Witepsol E75, Witepsol E85, the Cortex Sapii Radicis ester, fractional distillation Petiolus Trachycarpi ester, fractional distillation cocos nucifera oil ester, Brazil wax, cocoa butter, the Ke Kemu ester, white beeswax, Cera Chinensis, gelatin, poloxamer, Cera Flava, stearic, polysorbate60, polysorbate65, semi-synthetic fatty acid glyceride, semi-synthetic cocos nucifera oil ester, semi-synthetic Fructus Litseae grease, semi-synthetic Petiolus Trachycarpi grease, propylene glycol stearate, Macrogol 4000, in polyethylene glycol 6000 or the polyoxyethylene monostearate one or more; The swell value of described expansion carrier after saturated suction is greater than 1.5, and described swell value is swell value radially.
5. health woman's antiinflammatory vagina expansible plug as claimed in claim 4 is characterized in that, described pastille substrate comprises that also weight portion is the wax work of 10-25 part, the absorption blocker of the dispersible carrier of 20-40 part and 10-25 part; Described wax work is selected from one or more in Cera Flava, spermaceti or the Brazil wax; Described dispersible carrier is selected from one or more in polyvinylpyrrolidone, xylitol, poloxamer or the mannitol; Described absorption blocker is selected from one or more in sodium alginate, carbomer or the hypromellose.
6. such as claim 1-3 or 5 arbitrary described health woman's antiinflammatory vagina expansible plugs, it is characterized in that, described expansion carrier is cotton sliver; Described pastille substrate is the front end 1/5-4/5 place that Semi surrounding type is coated in described expansion carrier, and the rear end of described expansion carrier is connected with backguy; After the described expansion carrier suction, every maximum water absorption is not less than 1.5 milliliters.
7. the preparation method of health woman's antiinflammatory vagina expansible plug as claimed in claim 5 is characterized in that, described method comprises the steps:
1) preparation of pastille substrate:
A. with substrate, lanoline and wax work heating and melting in water-bath, make fused mass;
B. the preparation of active component:
I takes by weighing Radix Sophorae Flavescentis, Herba Patriniae, Herba Violae, Herba Andrographis, Herba Taraxaci and the Radix Arnebiae (Radix Lithospermi) of recipe quantity, decocts with water twice, decocts 2-3h for the first time, decoct for the second time 1-2h, decocting liquid merges, and filters, be condensed into clear paste, add 25%-50% ethanol, leave standstill 12-24h, filter, Recycled ethanol liquid, be condensed into thick paste, in 20-70 ℃ of drying, be ground into fine powder; For the first time, decoct for the second time 6-10 that water consumption is respectively Radix Sophorae Flavescentis, Herba Patriniae, Herba Violae, Herba Andrographis, Herba Taraxaci and Radix Arnebiae (Radix Lithospermi) gross weight doubly and 2-5 doubly; The ethanol consumption is 4-5 times of clear paste;
II takes by weighing Pulvis Fellis Suis and the Aloe of recipe quantity, is ground into fine powder;
III crosses the 50-100 mesh sieve with the fine powder of step I and II, and mix homogeneously makes active component;
C. with the dispersible carrier heating and melting;
D. under stirring active component is added in the c step, make molten mixture;
E. cool off the molten mixture of d step, grind, cross the 100-120 mesh sieve, make solid dispersion;
F. take by weighing the absorption blocker of recipe quantity, with the solid dispersion mix homogeneously, make mixture;
G. with the fused mass mix homogeneously of f step mixture and a step;
2) insert the expansion carrier, cooling and shaping is made suppository.
8. such as the detection method of claim 1-3,5 or 7 arbitrary described health woman's antiinflammatory vagina expansible plugs, it is characterized in that, comprise following at least a method:
1) the swell value assay method is as follows:
A. along described health woman's antiinflammatory vagina expansible plug radially choose one section or some sections, measure the initial length H of described expansion carrier;
B. after the saturated suction of described health woman's antiinflammatory vagina expansible plug, be determined at a and locate the rear length h of expansion carrier expansion in the selected location in the step;
When c. calculating described swell value, calculate according to the I formula;
（I）
Wherein, p represents that axial swell value, h represent to expand rear length, H represents initial length; Or the swell value assay method is as follows:
A. along described health woman's antiinflammatory vagina expansible plug axially choose a place or some positions, measure the initial diameter R of described expansion carrier;
B. after the saturated suction of described health woman's antiinflammatory vagina expansible plug, be determined at a and locate the rear diameter r of expansion carrier expansion in the selected location in the step;
When c. calculating described swell value, press the II formula and calculate;
（II）
Wherein, P represents that radially swell value, r represent to expand rear diameter, R represents initial diameter;
2) weight differential assay method:
A. get described health woman's antiinflammatory vagina expansible plug, take by weighing weight M;
B. get the expansion carrier in the described health woman's antiinflammatory vagina expansible plug that scrapes pastille substrate, drying takes by weighing weight m, according to the weight X of pastille substrate as described in calculating such as the III formula:
X=M-m
（Ⅲ）。
9. the detection method of health woman's antiinflammatory vagina expansible plug as claimed in claim 8 is characterized in that, melts to become after the time limit detects, and carries out following at least a detection method again:
1) the swell value assay method is as follows:
A. first along described health woman's antiinflammatory vagina expansible plug radially choose one section or some sections, measure the initial length H of described expansion carrier after, the different angles of rolling are again measured several times, Hi averages;
B. after described health woman's antiinflammatory vagina expansible plug melts the detection of change time limit, be determined at a and locate the rear length h of expansion carrier expansion in the selected location in the step; The different angles of rolling are again measured several times, ask the rear average length hi that expands;
When c. calculating described swell value, calculate according to the I formula;
（I）
Wherein, pi represents that axial swell value, hi represent to expand rear average length, Hi represents average initial length;
Or the swell value assay method is as follows:
A. first an angle along described health woman's antiinflammatory vagina expansible plug axially choose a place or some positions, measure the initial diameter R of described expansion carrier after, the different angles of rolling are again measured several times, Ri averages;
B. after described health woman's antiinflammatory vagina expansible plug melts the detection of change time limit, be determined at a and locate the rear diameter r of expansion carrier expansion in the selected location in the step; The different angles of rolling are again measured several times, ask the rear average diameter ri that expands;
When c. calculating described swell value, press the II formula and calculate;
（II）
Wherein, Pi represents that radially swell value, ri represent to expand rear average diameter, Ri represents average initial diameter;
2) weight differential assay method:
A. get described health woman's antiinflammatory vagina expansible plug, take by weighing weight M;
B. scrape pastille substrate, the expansion carrier is placed 20-90 ℃ of organic solvent, take out, in 50-150 ℃ of dry 1-10h, take by weighing weight m, according to the weight X of pastille substrate as described in calculating such as the III formula
X=M-m（Ⅲ）
Wherein, described organic solvent is selected from one or more in ethanol, methanol or the isopropyl alcohol.
10. the detection method of health woman's antiinflammatory vagina expansible plug as claimed in claim 9 is characterized in that, melts to become after the time limit detects, and carries out following at least a detection method: 1) swell value assay method again:
Get 3 of described health woman's antiinflammatory vagina expansible plugs, survey its afterbody cotton sliver diameter with slide gauge, roll approximately 90 ° and survey once again, survey twice for every, obtain 2 meansigma methods Ri of every mensuration; Above-mentioned 3 bolts are remained cotton sliver for melting to become to take out immediately after time limit mensuration finishes, treat disconnected of water, all gently place on the glass plate, measure two ends and middle three positions of each cotton sliver with slide gauge, roll approximately and to measure again three positions after 90 °, each cotton sliver obtains six data altogether, obtains 6 meansigma methods r of mensuration
i, calculate every swell value P
i, the swell value of three bolts all should be greater than 1.5;
2) weight differential assay method:
Get 10 of described health woman's antiinflammatory vagina expansible plugs, accurately weighed every the gross weight of difference, gently scrape pastille substrate, not hinder (dew) cotton sliver as main, cotton sliver placed 80 ℃ 300ml ethanol, and 80khz frequency ultrasonic cleaning 5 minutes, the remaining stromatolysis in cotton sliver surface is removed, take out cotton sliver and firmly extract, inhale 3 times with filter paper again, in 105 ℃ of dryings 2 hours, take out, room temperature is placed every cotton sliver weight of difference weighing after 1 hour, deducts corresponding cotton sliver weight with every gross weight, namely gets every pastille substrate weight, and calculate average pastille substrate weight, every pastille substrate weight and average pastille substrate weight ratio, the pastille substrate weight that exceeds average pastille substrate weight ± 10% must not be more than 2, and must not overrun 1 times.
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| CN103784682B (en) * | 2013-12-31 | 2016-06-01 | 哈尔滨欧替药业有限公司 | Rotten two fragrant vaginal expansion plug of dispelling and its preparation method and detection method |
| CN104983616A (en) * | 2015-06-26 | 2015-10-21 | 东方福尚福养生有限公司 | Human body lubricating fluid and preparation method thereof |
| CN104983616B (en) * | 2015-06-26 | 2018-09-25 | 东方福尚福养生有限公司 | A kind of body lotion and preparation method thereof |
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| CN103301295B (en) | 2014-12-31 |
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Effective date of registration: 20211116 Address after: 150040 office building 7, Bohai Third Road, haping road concentration area, Harbin Economic Development Zone, Harbin, Heilongjiang Province Patentee after: Harbin Tianmei Pharmaceutical Co.,Ltd. Address before: 150069 No. 7, Bohai Third Road, Pingfang Industrial Zone, economic and Technological Development Zone, Harbin, Heilongjiang Province Patentee before: HARBIN OT PHARMACEUTICALS Co.,Ltd. Patentee before: Qiu Mingshi |
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Denomination of invention: Kangfu Xiaoyan Vaginal Expansion Suppository and Its Preparation and Detection Method Effective date of registration: 20230908 Granted publication date: 20141231 Pledgee: China Merchants Bank Co.,Ltd. Harbin Branch Pledgor: Harbin Tianmei Pharmaceutical Co.,Ltd. Registration number: Y2023230000075 |