CN104710423A - Mk2抑制剂 - Google Patents

Mk2抑制剂 Download PDF

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Publication number
CN104710423A
CN104710423A CN201510037679.6A CN201510037679A CN104710423A CN 104710423 A CN104710423 A CN 104710423A CN 201510037679 A CN201510037679 A CN 201510037679A CN 104710423 A CN104710423 A CN 104710423A
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CN
China
Prior art keywords
pyridine
base
pyrrolo
spiral shell
piperidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510037679.6A
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English (en)
Chinese (zh)
Inventor
T.A.巴夫
A.欧布里
C.舒尔茨－费登雷希特
E.W.斯瓦特
N.胡根布姆
S.M.德维尔德
A.卡普泰因
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme BV
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MSD Oss BV
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Filing date
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Application filed by MSD Oss BV filed Critical MSD Oss BV
Publication of CN104710423A publication Critical patent/CN104710423A/zh
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Hematology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
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CN201510037679.6A 2009-12-14 2010-12-13 Mk2抑制剂 Pending CN104710423A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28609109P 2009-12-14 2009-12-14
EP09179043.6 2009-12-14
EP09179043 2009-12-14
US61/286091 2009-12-14

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201080056801.XA Division CN102712641B (zh) 2009-12-14 2010-12-13 Mk2抑制剂

Publications (1)

Publication Number Publication Date
CN104710423A true CN104710423A (zh) 2015-06-17

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ID=41565893

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201510037679.6A Pending CN104710423A (zh) 2009-12-14 2010-12-13 Mk2抑制剂
CN201080056801.XA Expired - Fee Related CN102712641B (zh) 2009-12-14 2010-12-13 Mk2抑制剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201080056801.XA Expired - Fee Related CN102712641B (zh) 2009-12-14 2010-12-13 Mk2抑制剂

Country Status (13)

Country Link
US (3) US8772286B2 (https=)
EP (1) EP2513111B1 (https=)
JP (2) JP5859454B2 (https=)
KR (1) KR20120104241A (https=)
CN (2) CN104710423A (https=)
AU (1) AU2010333024B2 (https=)
BR (1) BR112012013199A8 (https=)
CA (1) CA2780290C (https=)
HK (1) HK1210159A1 (https=)
IN (1) IN2012DN04978A (https=)
MX (1) MX2012006778A (https=)
RU (1) RU2012129887A (https=)
WO (1) WO2011073119A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108794496A (zh) * 2018-04-28 2018-11-13 北京施安泰医药技术开发有限公司 一类cdk抑制剂、其药物组合物、制备方法及用途
CN114105834A (zh) * 2022-01-26 2022-03-01 寿光诺盟化工有限公司 一种n,n,n,n-四烯丙基氧代双苯磺酰胺的制备方法
WO2024125464A1 (en) * 2022-12-11 2024-06-20 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Tetrahydroisoquinolin-one derivatives, preparation methods and medicinal uses thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2012129887A (ru) * 2009-12-14 2014-01-27 Мсд Осс Б.В. Ингибиторы мк2
CN102936216B (zh) * 2012-12-05 2015-03-04 南京药石药物研发有限公司 7,9-二氧代-2,6-氮杂-螺[3.5]壬-2-甲酸叔丁酯及其中间体的制备方法
CA2908098A1 (en) 2013-03-15 2014-09-25 Celgene Avilomics Research, Inc. Mk2 inhibitors and uses thereof
WO2015191630A1 (en) 2014-06-10 2015-12-17 Sanford-Burnham Medical Research Institute Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof
EP3820567A1 (en) * 2018-07-12 2021-05-19 UCB Biopharma SRL Spirocyclic indane analogues as il-17 modulators

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
ZA200504898B (en) * 2002-12-20 2006-11-29 Pharmacia Corp Acyclic pyrazole compounds
US20050043346A1 (en) * 2003-08-08 2005-02-24 Pharmacia Italia S.P.A. Pyridylpyrrole derivatives active as kinase inhibitors
JP2007501827A (ja) * 2003-08-08 2007-02-01 ファルマシア・イタリア・エス・ピー・エー キナーゼ阻害剤として活性なピリミジルピロール誘導体
JP5191391B2 (ja) * 2005-11-01 2013-05-08 ターゲジェン インコーポレーティッド キナーゼのビ−アリールメタ−ピリミジン阻害剤
MX2009014247A (es) * 2007-07-16 2010-01-28 Novartis Ag Compuestos heterociclicos utiles como inhibidores de mk2.
RU2012129887A (ru) * 2009-12-14 2014-01-27 Мсд Осс Б.В. Ингибиторы мк2

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108794496A (zh) * 2018-04-28 2018-11-13 北京施安泰医药技术开发有限公司 一类cdk抑制剂、其药物组合物、制备方法及用途
CN108794496B (zh) * 2018-04-28 2020-04-24 北京施安泰医药技术开发有限公司 一类cdk抑制剂、其药物组合物、制备方法及用途
CN114105834A (zh) * 2022-01-26 2022-03-01 寿光诺盟化工有限公司 一种n,n,n,n-四烯丙基氧代双苯磺酰胺的制备方法
WO2024125464A1 (en) * 2022-12-11 2024-06-20 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Tetrahydroisoquinolin-one derivatives, preparation methods and medicinal uses thereof

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HK1210159A1 (en) 2016-04-15
US20160159800A1 (en) 2016-06-09
AU2010333024B2 (en) 2014-09-18
JP2016128412A (ja) 2016-07-14
BR112012013199A2 (pt) 2016-03-01
US8772286B2 (en) 2014-07-08
US20140288109A1 (en) 2014-09-25
US9102676B2 (en) 2015-08-11
AU2010333024A1 (en) 2012-06-14
CA2780290A1 (en) 2011-06-23
CN102712641A (zh) 2012-10-03
BR112012013199A8 (pt) 2018-01-02
JP2013513585A (ja) 2013-04-22
RU2012129887A (ru) 2014-01-27
KR20120104241A (ko) 2012-09-20
WO2011073119A1 (en) 2011-06-23
JP5859454B2 (ja) 2016-02-10
IN2012DN04978A (https=) 2015-09-25
CN102712641B (zh) 2015-12-09
MX2012006778A (es) 2012-07-23
EP2513111A1 (en) 2012-10-24
CA2780290C (en) 2018-01-02
US20120245175A1 (en) 2012-09-27
EP2513111B1 (en) 2013-10-02

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