CN104705648A - Preparation process of carrot extract and epigallocatechin gallate (EGCG) capsules - Google Patents
Preparation process of carrot extract and epigallocatechin gallate (EGCG) capsules Download PDFInfo
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- CN104705648A CN104705648A CN201510168336.3A CN201510168336A CN104705648A CN 104705648 A CN104705648 A CN 104705648A CN 201510168336 A CN201510168336 A CN 201510168336A CN 104705648 A CN104705648 A CN 104705648A
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Abstract
The invention discloses carrot extract and epigallocatechin gallate (EGCG) capsules and a preparation process thereof. The carrot extract and EGCG capsules consist of the following raw materials in parts by weight: 5-90 parts of a carrot extract, 5-90 parts of EGCG (20-100%), 10-80 parts of soluble starch, 2-5 parts of talcum powder and 10-40 parts of dextrin. The capsules prepared by using the process disclosed by the invention are rich in nutrition and convenient to carry and take, and can be used for supplementing vitamin A deficiency, improving the body immunity, scavenging free radicals, indirectly killing cancer cells, reducing cholesterol in blood, delaying senescence and preventing the occurrence of heart diseases and tumors after being taken for a long time; the capsules are simple in production process and environment-friendly in solvent, and cannot cause environmental pollution; and carrot residues produced by extraction can be prepared into a pig feed, and thus waste utilization can be achieved.
Description
Technical field
The present invention relates to a kind of carrot extract and EGCG capsule and preparation technology thereof, belong to food processing technology field.
Background technology
Carrot is again yellow radish, carrot, and color is beautiful, tender and crisp succulence, and fragrance is sweet.There is many-sided health care to human body, be described as " glabrousleaf asiabell root ".The traditional Chinese medical science thinks that carrot is warm in nature, taste is sweet, and property is put down.Carrot has effect of reinforcing spleen to promote digestion, tonifying liver improving eyesight, clearing heat and detoxicating, promoting eruption, sending down abnormally ascending cough-relieving.Specific as follows:
1. carrot has liver-benefiting eye-brightening effect: carrot contains a large amount of carrotene, has the effect of tonifying liver improving eyesight, can treat yctalopia;
2. wide intestines effect of the favourable diaphragm of carrot: carrot contains string, water imbibition is strong, and in enteron aisle, volume easily expands, and is " full material " in enteron aisle, can strengthens the wriggling of enteron aisle, thus the wide intestines of sharp diaphragm, defaecation gives protection against cancer;
3. carrot has invigorating the spleen to remove infantile malnutrition due to digestive disturbances or intestinalparasites effect: vitamin A is the required material that bone normal growth is grown, and contributing to cell proliferation and growth, is the key element of body growth, to promoting that growing of infant is significant;
4. carrot can strengthen immunologic function: carrotene is transformed into vitamin A, contributes to the immunologic function strengthening body, in the process of prevention epithelial cell canceration, has important function.Lignin in carrot also can improve immunity of organism mechanism, indirectly eliminates cancer cell;
5. carrot has hypoglycemic effect: carrot containing sugar reducing substance, is also the good food of diabetes patient, some composition contained by it; As Quercetin, mountain mark phenol can increase coronary blood flow, reduce blood fat, promote adrenergic synthesis, also have step-down, cardiotonic is the dietotherapy good merchantable brand of hypertension, patients with coronary heart disease.
The traditional Chinese medical science thinks carrot common people all edibles.Especially cancer preferably, hypertension, yctalopia, patients with dry eye, malnutrition, poor appetite person, pachylosis person.
Epigallo-catechin gallate (EGCG) (EGCG) is a kind of composition extracted from Chinese green tea, it is the main activity of green tea and water-soluble components, is the component that in catechin, content is the highest, accounts for the 9%-13% of green tea gross weight, there is special stereochemical structure, have a wide range of applications:
1. hypoglycemic activity
Multiple test data confirms that Tea Polyphenols is the inhibitor of invertase, and therefore it can suppress sucrose to the conversion of glucose, and blood sugar is declined.In addition, also have a small amount of report to show, Tea Polyphenols can be used for anti-caries, removes halitosis, fat-reducing, beauty treatment etc.Tea Polyphenols anticancer, anti-ageing, hypoglycemic, prevent and treat the effect such as artery sclerosis, liver protecting may anti-oxidant with it, the effect of harmful free radicals in body of removing is relevant.Current Tea Polyphenols has gone through to apply as a kind of food antioxidant.In Hungary, catechin is gone on the market as hepatic.At home, Tea Polyphenols also puts into production as treating cardiovascular disease.But also need researcher to carry out more deep research to Tea Polyphenols in the pharmacological action of other side at present, make it play a role in clinical treatment as soon as possible.
2. antivirus action
The researcher of Japan finds: the extract of green tea and black tea has the effect suppressing first, influenza B virus, and Switzerland also there are some researches show that catechin is closed spore precursor virus (RSV) to human respiratory and had inhibitory action.In addition, Tea Polyphenols also has stronger antagonism inhibitory action for marcy agent, hepatitis A virus, plant virus.In recent years, many countries as English, U.S., day, in tea polyphenols material suppress HIV-I reverse transcription ester (HI-IRT) effect carried out large quantifier elimination.Japanese scholars research confirms the potent inhibitor of Tea Polyphenols a kind of novel HIV-IRT really.Chinese scholar then demonstrate catechin-derived thing to HIV-IRT and archaeal dna polymerase inhibited, and point out that EGCG inhibitory action is also eager to excel than the effect of repeatedly azathymidine triphosphoric acid (AIT).Analyze from structure-activity relationship, ECG improves 86 times than the activity of EC, and EGCG exceeds 12 times than the activity of ECG.A new field has been opened up in this treatment being AIDS from now on and research work.
3. anticancer, antimutagenic effect
Can give protection against cancer to tealeaves, the research of anticancer, anti-sudden change at home and abroad many countries have report.Large quantifier elimination confirms, the sudden change that tealeaves not only can suppress number of chemical carcinogenic substance to be led to, and can also suppress the mutagenesis of some mixing carcinogenic substance (tobacco mistiness contracting medicine, coal tar, smoked fish extract, X-ray).Therefore tealeaves is for kinds cancer: cancer of the esophagus, cancer of the stomach, liver cancer, intestinal cancer, lung cancer, cutaneum carcinoma, breast cancer, clone's cancer etc. all have preventive and therapeutic action in various degree.
4. antioxidation
People, in normal vital movement, understands metabolism in body and constantly produces harmful free radical.The character of free radical is active, has extremely strong oxidability, can bring out the oxidation of unrighted acid in body, produces lipid peroxide.Its generation and accumulation, can restrict the normal function with disrupting biofilm, affect the eubolism of active material, inspires hepatitis, cancer, aging and cardiovascular etc. permitted many-sided illness.Therefore remove harmful free radicals in body, guarantee the healthy of people is extremely important.The Tea Polyphenols extracted from tealeaves is the chemical substance that a class contains polyphenol hydroxyl, is very easily oxidized into ester class and provides proton H, therefore it has the anti-oxidant feature shown.The antioxidant capacity of Tea Polyphenols is 18 times of vitamin E, is ascorbic 3 ~ 10 times.This strong anti-oxidation ability of Tea Polyphenols eliminates free radical in vivo, block the synthesis of N-nitroso compound, suppress activity and the lipid peroxidation of LOX, make it at anti-cancer, anticancer, anti-sudden change, anti-ageing, prevention and cure of cardiovascular disease, many aspects such as treatment hepatitis show superior diseases prevention, therapeutic efficiency.
5. for angiocardiopathy
The research of scientist in recent years proves that tea polyphenols material has anti-freezing, short fibrinolytic, anti-platelet aggregation, the effects such as hypotensive, reducing blood lipid, prevents and treats atherosclerotic, protection cardiac muscle.China utilizes Tea Polyphenols to treat atherosclerotic and also enters clinical stage.Also it was reported that Tea Polyphenols can improve renal function, treatment kidney failure and chronic renal insufficiency, suppress thickening of GBM, treatment primary and renal hypertension.Someone raises experimental hyperlipidemia rat model with Tea Polyphenols, and after six weeks, ex vivo thrombosis, ED, the many indexs such as plasma fibrinogen content, all show Tea Polyphenols and be improved effect to animal blood rheology.
6. antiallergy and antiinflammation
Research shows that Tea Polyphenols has the inhibitory action shown to hyaluronic acid enzyme, and wherein the exterminate inhibit activities of gallate-based of theaflavin reaches 99.1%.Catechin mainly suppresses quick allergic reaction, and little to tardus allergic reaction effect.At present, people are also only limited to zoopery level to the research that the anti-inflammatory, antiallergy etc. of Tea Polyphenols act on.Therefore, this pharmacological property for it also needs further investigation further and inquires into.
7. stomach and intestine defencive function
Catechin can suppress the H-K-ATP enzyme on gastric mucosa, thus fundamentally inhibits the secretion of hydrochloric acid in gastric juice, alleviates hydrochloric acid in gastric juice and can also treat ulcer to catechin while of the stimulation of gastric mucosa and damage .In addition catechin also has certain mitigation for gastrointestinal convulsion.Tea Polyphenols being used for the treatment of constipation, control intestinal flora, improve in regulating intestinal canal environment and also have suitable curative effect.
8. antibacterial action
Tea Polyphenols as a kind of wide spectrum, potent, low toxicity antimicrobial generally acknowledge by the scholar of many countries in the world.In numerous antibacterial tests, it is found that it is to many pathogenic bacteria such as proteus vulgaris, staphylococcus aureus, MRSE, streptococcus mutans, clostridium botulinum, Bacillus acidi lactici, comma bacillus, especially to pathogenic entero becteria, there is suppression in various degree and lethal effect.It can also prevent the staphy lococcus infection of antibiotic-resistant effectively simultaneously, also has inhibit activities for hemolysin ECG and EGCG.In addition, Tea Polyphenols to the disease fungus that can cause human body skin disease, as head tinea alba, plaque-like bubble tinea alba, the sweat shape bubble parasitic fungi such as tinea alba and stubborn dermatitis also have very strong inhibitory action.Although Tea Polyphenols has stronger killing and wounding and inhibitory action to the bacterium in enteron aisle.But protective effect is played to the beneficial bacterium in enteron aisle, as it can promote the Growth and reproduction of Bifidobacterium, improves the microorganism structure in human body intestinal canal, improve the immunologic function of enteron aisle, have positive effect to enhancement health.
Capsule is that a certain amount of medicine (or medicinal substances extract) and suitable auxiliary material (also can not add auxiliary material) are made uniform powder or particle, loads and makes in empty hard capsule.Capsule can be covered adverse drug and smells taste or improve medicine stability: be isolated from the outside because medicine is contained in capsule shells; avoid the impact of moisture, air, light, the bad medicine smelling taste or instability of tool is had covering to a certain extent, protected and stabilization.The bioavilability of medicine is higher: the medicine in capsule directly loads in softgel shell with powder or graininess, the impact of the factor such as not to be stressed, so dispersion, stripping and absorption rapidly in the gastrointestinal tract, its bioavilability will higher than ball, tablets and other formulations.The disintegration time of general capsule is within 30 minutes, and tablet, pill are within 1 hour.In addition this formulation portably uses very convenient.
Summary of the invention
The object of the present invention is to provide a kind of carrot extract and EGCG capsule, it is characterized in that: be made up of the raw material of following weight portion, carrot extract 5-90, EGCG (20-100%) 5-90, soluble starch 10-80, talcum powder 2-5, dextrin 10-40.
Another object of the present invention is to provide the preparation method of this carrot extract and EGCG capsule, and concrete steps are as follows:
1) fresh carrot water is cleaned up, after being placed in disintegrating apparatus fragmentation, add solvent extraction, obtain carrot crude extract;
2) carrot crude extract is revolved steaming, obtain carrot concentrate;
3) in carrot concentrate, add solvent extraction again, filtering insoluble matter, obtains filtrate;
4) by 3) gained filtrate revolves steaming, and obtain concentrate, be placed in vacuum drying chamber drying, obtain carrot extract;
5) took carrot extract 5-90, EGCG (20-100%) 5-90, the soluble starch 10-80 of 100 mesh sieves by component proportion, talcum powder 2-5, dextrin 10-40 carry out conjunction expect, stir, mix after be packaged in hard shell capsules and get final product.
The invention has the beneficial effects as follows: be utilize carrot conventional in daily life to be removed crudely and store essence by suitable extraction and preparation technique, add commercially available EGCG again and make carrot extract and EGCG capsule, have replenishing vitamins A not enough, improve immunity of organisms, scavenging free radicals, indirectly eliminate cancer cell, reduce blood cholesterol, to delay senility and preventing heart disease and tumour occur.The useful health of long-term taking, promotes longevity.Reducing these vegetables amounts after making capsule, improve the stability of medicine, covering the bad smell of some compositions in various extract when taking, carry in addition take all very convenient.This product has and is easy to industry and changes into product, the advantages such as low cost of manufacture.This product processes solvent for use can repeatedly use, non-environmental-pollution.In addition carrot is extracted rear remaining residue and can make pig feed, fully can realize twice laid.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but scope is not limited to described content.
Embodiment 1
A kind of carrot extract described in the present embodiment and EGCG capsule are obtained by following raw material, and each raw material and percentage by weight are: carrot extract 20, EGCG (20%) 5, soluble starch 50, talcum powder 5, dextrin 20.
The preparation method of the carrot extract described in the present embodiment and EGCG capsule comprises the steps:
1) fresh carrot water is cleaned up, after being placed in disintegrating apparatus fragmentation, add solvent extraction, obtain carrot crude extract;
2) carrot crude extract is revolved steaming, obtain carrot concentrate;
3) in carrot concentrate, add solvent extraction again, filtering insoluble matter, obtains filtrate;
4) by 3) gained filtrate revolves steaming, and obtain concentrate, be placed in vacuum drying chamber drying, obtain carrot extract;
5) took the carrot extract of 100 mesh sieves by component proportion, EGCG (20-100%), soluble starch, talcum powder, dextrin carry out conjunction expect, stir, mix after be packaged in hard shell capsules and get final product.
Embodiment 2
A kind of carrot extract described in the present embodiment and EGCG capsule are obtained by following raw material, and each raw material and percentage by weight are: carrot extract 40, EGCG (50%) 30, soluble starch 18, talcum powder 2, dextrin 10.
The preparation method of the carrot extract described in the present embodiment and EGCG capsule comprises the steps:
1) fresh carrot water is cleaned up, after being placed in disintegrating apparatus fragmentation, add solvent extraction, obtain carrot crude extract;
2) carrot crude extract is revolved steaming, obtain carrot concentrate;
3) in carrot concentrate, add solvent extraction again, filtering insoluble matter, obtains filtrate;
4) by 3) gained filtrate revolves steaming, and obtain concentrate, be placed in vacuum drying chamber drying, obtain carrot extract;
5) took the carrot extract of 100 mesh sieves by component proportion, EGCG (20-100%), soluble starch, talcum powder, dextrin carry out conjunction expect, stir, mix after be packaged in hard shell capsules and get final product.
Embodiment 3
A kind of carrot extract described in the present embodiment and EGCG capsule are obtained by following raw material, and each raw material and percentage by weight are: carrot extract 70, EGCG (100%) 10, soluble starch 10, talcum powder 2, dextrin 8.
The preparation method of the carrot extract described in the present embodiment and EGCG capsule comprises the steps:
1) fresh carrot water is cleaned up, after being placed in disintegrating apparatus fragmentation, add solvent extraction, obtain carrot crude extract;
2) carrot crude extract is revolved steaming, obtain carrot concentrate;
3) in carrot concentrate, add solvent extraction again, filtering insoluble matter, obtains filtrate;
4) by 3) gained filtrate revolves steaming, and obtain concentrate, be placed in vacuum drying chamber drying, obtain carrot extract;
5) took the carrot extract of 100 mesh sieves by component proportion, EGCG (20-100%), soluble starch, talcum powder, dextrin carry out conjunction expect, stir, mix after be packaged in hard shell capsules and get final product.
Claims (5)
1. carrot extract and EGCG capsule and a preparation technology thereof, is characterized in that: be made up of the raw material of following weight portion: carrot extract 5-90, EGCG (20-100%) 5-90, soluble starch 10-80, talcum powder 2-5, dextrin 10-40.
2., according to the method for carrot extract a kind of described in claim 1 and EGCG capsule, it is characterized in that: comprise the following steps,
1) fresh carrot water is cleaned up, after being placed in disintegrating apparatus fragmentation, add solvent extraction, obtain carrot crude extract;
2) carrot crude extract is revolved steaming, obtain carrot concentrate;
3) in carrot concentrate, add solvent extraction again, filtering insoluble matter, obtains filtrate;
4) by 3) gained filtrate revolves steaming, and obtain concentrate, be placed in vacuum drying chamber drying, obtain carrot extract;
5) took carrot extract 5-90, EGCG (20-100%) 5-90, the soluble starch 10-80 of 100 mesh sieves by component proportion, talcum powder 2-5, dextrin 10-40 carry out conjunction expect, stir, mix after be packaged in hard shell capsules and get final product.
3. the preparation method of a kind of carrot extract according to claim 2 and EGCG capsule, is characterized in that, described solvent is one or more in water, methyl alcohol, ethanol, acetone, carrene, chloroform, ethyl acetate and benzinum.
4. the preparation method of a kind of carrot extract according to claim 1 and EGCG capsule, is characterized in that, the ratio of described solvent and carrot is 0.5-20(mL/m).
5. the preparation method of a kind of carrot extract according to claim 1 and EGCG capsule, is characterized in that: by the carrot residue through extracting, after oven dry, pack as pig feed.
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| CN201510168336.3A CN104705648A (en) | 2015-04-11 | 2015-04-11 | Preparation process of carrot extract and epigallocatechin gallate (EGCG) capsules |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070292560A1 (en) * | 2004-06-24 | 2007-12-20 | Danyi Quan | Green tea formulations and methods of preparation |
| CN101204228A (en) * | 2006-12-21 | 2008-06-25 | 张洪义 | Processing method for dried black fungus fiber, colloid and beta-carotene |
| CN101779788A (en) * | 2010-04-09 | 2010-07-21 | 郭文开 | Method for extracting nutrient components of carrot through CO2 supercritical extraction |
| CN102600212A (en) * | 2012-03-31 | 2012-07-25 | 石药集团中奇制药技术（石家庄）有限公司 | Medicinal health product for immunity enhancement and adjuvant treatment of tumor |
-
2015
- 2015-04-11 CN CN201510168336.3A patent/CN104705648A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070292560A1 (en) * | 2004-06-24 | 2007-12-20 | Danyi Quan | Green tea formulations and methods of preparation |
| CN101204228A (en) * | 2006-12-21 | 2008-06-25 | 张洪义 | Processing method for dried black fungus fiber, colloid and beta-carotene |
| CN101779788A (en) * | 2010-04-09 | 2010-07-21 | 郭文开 | Method for extracting nutrient components of carrot through CO2 supercritical extraction |
| CN102600212A (en) * | 2012-03-31 | 2012-07-25 | 石药集团中奇制药技术（石家庄）有限公司 | Medicinal health product for immunity enhancement and adjuvant treatment of tumor |
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Application publication date: 20150617 |
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