CN104688872A - Traditional Chinese medicine composition for treating hypothyroidism - Google Patents
Traditional Chinese medicine composition for treating hypothyroidism Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating hypothyroidism. The traditional Chinese medicine can effectively solve the therapeutic problem of hypothyroidism. According to the technical scheme, the traditional Chinese medicine composition is composed of, by weight, 5-15 parts of fructus psoraleae, 5-15 parts of herba epimedii, 10-30 parts of astragalus complanatus, 5-15 parts of cassia twigs, 10-30 parts of mulberry, 10-20 parts of herba ecliptae, 10-30 parts of spatholobus suberctu, 5-15 parts of rubia cordifolia, 10-30 parts of atractylodes macrocephala koidz and 10-30 parts of poria cocos. The raw materials of the traditional Chinese medicine composition are abundant, the price is low, the traditional Chinese medicine has the functions of warming yang, reinforcing qi, invigorating the spleen and kidney, dispersing blood stasis and discharging foul, and is used for treating hypothyroidism effectively, the treatment effect is good, the traditional Chinese medicine composition is safe to use, and the traditional Chinese medicine composition is innovation of medicine for treating hypothyroidism.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of Chinese medicine composition for the treatment of hypothyroidism.
Background technology
Hypothyroidism is called for short " hypothyroidism ", is the thyroxin synthesis because many reasons causes, secretion or the general metabolism syndrome caused by biological effect deficiency.With low metabolic rate, mucopolysaccharide is feature at skin and tissue accumulation, and severe patient shows as myxedema and myxedema coma.Main cause is autoimmune, thyroid operation and hyperthyroidism
131i treatments etc., account for more than 95% of whole hypothyroidism.Hypothyroidism sickness rate is more and more higher in recent years.Modern medicine mainly substitutes life-long therapy primary disease with thyroxine, although make most patients benefit, the multiple side effect that Long-term taking medicine may cause is very important, as serious arrhythmia, angina pectoris and heart failure and osteoporosis etc.Therefore, the improvement for the treatment of on hypothyroidism medicine is the problem needing solution at present badly.
Summary of the invention
For above-mentioned situation, for solving the defect of prior art, the object of the present invention is just to provide a kind of Chinese medicine composition of hypothyroidism, effectively can solve the medication problem of hypothyroidism.
Hypothyroidism, from its clinical manifestation analysis, similar in appearance to asthenia, edema, the kidney-wind syndrome, the goiter of the traditional Chinese medical science, five kinds of growth retardation etc., Chinese medicine thinks that this disease is just main mainly with insufficiency of kidney-YANG, gradually has deficiency of spleen-YANG and kidneyYANG, deficiency of heart-YANG and kidney-YANG, accumulate in expectorant is turbid, blood stasis resistance the stasis such as to close.Primary disease is mainly with empty, stagnant relevant.Therefore for hypothyroidism, total rule for the treatment of is warming and recuperating the spleen and kidney, row is turbid in blood stasis dispelling.Accordingly, the technical scheme that the present invention solves is, be made up of the material medicine of following weight parts: Fructus Psoraleae 5-15 part, Herba Epimedii 5-15 part, Semen Astragali Complanati 10-30 part, Ramulus Cinnamomi 5-20 part, Fructus Mori 10-30 part, Herba Ecliptae 10-20 part, Caulis Spatholobi 10-30 part, Radix Rubiae 5-15 part, Rhizoma Atractylodis Macrocephalae 10-30 part and Poria 10-30 part, by above-mentioned raw materials medicament mixed together, add the water soaking half an hour of material medicine 6-8 times weight, intense fire decocts to boiling, use slow fire boiling 30-45 minute instead, filter, obtain first time filtrate, medicinal residues add the water of material medicine 4-6 times weight again, intense fire decocts to boiling, use slow fire boiling 20-35 minute instead, filter, obtain second time filtrate, merge twice filtrate, mixing, .
Abundant raw material of the present invention, cheap, having warming YANG and invigorating QI, strengthening spleen, tonifying kidney, the turbid effect of blood stasis dispelling row, be effective to treat hypothyroidism, good effect, drug safety, is the innovation on treatment hypothyroidism medicine.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.
Embodiment 1
The present invention in the specific implementation, be made up of the material medicine of following weight parts: Fructus Psoraleae 5 parts, Herba Epimedii 15 parts, Semen Astragali Complanati 10 parts, Ramulus Cinnamomi 20 parts, 10 parts, Fructus Mori, Herba Ecliptae 20 parts, Caulis Spatholobi 10 parts, 15 parts, Radix Rubiae, the Rhizoma Atractylodis Macrocephalae 10 parts and 30 parts, Poria, by above-mentioned raw materials medicament mixed together, add the water soaking half an hour of material medicine 6 times of weight, intense fire decocts to boiling, use slow fire boiling instead 30 minutes, filter, obtain first time filtrate, medicinal residues add the water of material medicine 6 times of weight again, intense fire decocts to boiling, use slow fire boiling instead 35 minutes, filter, obtain second time filtrate, merge twice filtrate, mixing, .
Embodiment 2
The present invention in the specific implementation, be made up of the material medicine of following weight parts: Fructus Psoraleae 10 parts, Herba Epimedii 10 parts, Semen Astragali Complanati 20 parts, Ramulus Cinnamomi 12 parts, 20 parts, Fructus Mori, Herba Ecliptae 15 parts, Caulis Spatholobi 20 parts, 13 parts, Radix Rubiae, the Rhizoma Atractylodis Macrocephalae 20 parts and 20 parts, Poria, by above-mentioned raw materials medicament mixed together, add the water soaking half an hour of material medicine 7 times of weight, intense fire decocts to boiling, use slow fire boiling instead 37 minutes, filter, obtain first time filtrate, medicinal residues add the water of material medicine 5 times of weight again, intense fire decocts to boiling, use slow fire boiling instead 27 minutes, filter, obtain second time filtrate, merge twice filtrate, mixing, .
Embodiment 3
The present invention in the specific implementation, be made up of the material medicine of following weight parts: Fructus Psoraleae 15 parts, Herba Epimedii 5 parts, Semen Astragali Complanati 30 parts, Ramulus Cinnamomi 5 parts, 30 parts, Fructus Mori, Herba Ecliptae 10 parts, Caulis Spatholobi 30 parts, 5 parts, Radix Rubiae, the Rhizoma Atractylodis Macrocephalae 30 parts and 10 parts, Poria, by above-mentioned raw materials medicament mixed together, add the water soaking half an hour of material medicine 8 times of weight, intense fire decocts to boiling, use slow fire boiling instead 45 minutes, filter, obtain first time filtrate, medicinal residues add the water of material medicine 4 times of weight again, intense fire decocts to boiling, use slow fire boiling instead 20 minutes, filter, obtain second time filtrate, merge twice filtrate, mixing, .
The foregoing is only best case study on implementation of the present invention; only illustrative for the purpose of the present invention; and it is nonrestrictive; those skilled in the art is understood; some equivalent or equivalent substituting or replacing can be carried out to it in the scope of the claims in the present invention; identical in essence, all belong to protection scope of the present invention.
Therapeutic Principle of the present invention is warming YANG and invigorating QI, strengthening spleen, tonifying kidney, row is turbid in blood stasis dispelling.Described Fructus Psoraleae, Herba Epimedii, Semen Astragali Complanati reinforcing the kidney and supporting YANG, Ramulus Cinnamomi warming the meridian is supporing yang, has and improves immunity of organism and the effect such as thyroid function, raising basal metabolic rate.The Rhizoma Atractylodis Macrocephalae, Poria invigorating the spleen and benefiting QI; Fructus Mori, Herba Ecliptae enriching yin and nourishing kidney, adjust the endocrine axis mending hypothalamic-pituitary-ovarian, make its function be tending towards normal.Caulis Spatholobi, Radix Rubiae blood circulation promoting and blood stasis dispelling.
Advantage of the present invention is: preparation is simple, low cost, evident in efficacy lasting, toxic and side effects is little, avoid the untoward reaction of taking caused by Western medicine.Meanwhile, Chinese medicine composition component science of the present invention, reasonable compatibility, support mutually, can reach the effect for the treatment of both the principal and secondary aspects of a disease, reinforcement and elimination in combination.Have warming YANG and invigorating QI, strengthening spleen, tonifying kidney, the turbid effect of blood stasis dispelling row, be effective to treat hypothyroidism, good effect, drug safety, and obtain sufficient proof through clinical experiment, pertinent clinical experimental data is as follows:
1 inclusion criteria
Select hypothyroidism patient 81 example of outpatient clinic, all meet the diagnostic criteria of the 11st edition " practical internal medicine " Primary hypothyroidism.Wherein man 30 example, female 51 example, the mean age (41.4 ± 12.7) year; The course of disease is the longest 10 years, the shortest 3 months, average course of disease (3.7 ± 0.8) year.Be divided into treatment group 41 example at random, matched group 40 example.Two groups of Genders, age, clinical syndrome, courses of disease etc. compare, and all without significant difference, have comparability.
therapeutic scheme
Medicine for treatment matched group: Euthyrox (production of Merck KGaA company) 25 ~ 100 μ g, every day 1 time.Treatment group: add with the present composition on matched group basis, sooner or later respectively once, decoction being taken warmly, each 200-300ml, all treats 1 month statistics curative effect for two groups.
criterion of therapeutical effect and observation index
Observation index health giving quality index with reference to " practical internal medicine diagnosis specification " [Huang Jun, Lu Fengxiang. practical internal medicine diagnosis specification [M]. Nanjing: Jiangsu science tech publishing house, 2002:581-583] in standard.
Effective: clinical symptoms and sign disappear or clinical manifestation significantly takes a turn for the better, T3, T4 recover normal, and TSH recovers normal;
Effective: clinical symptoms and sign take a turn for the better, and T3, T4 increase, and TSH decreases;
Invalid: clinical symptoms and sign are without improvement or slightly take a turn for the better, and T3, T4, TSH are without change;
Auxiliary examination index: serum thyroid stimulating hormone (TSH), free thyroxine (FT4), free serum 3 (FT3).
statistical procedures
Adopt SPSS13.0 statistical software, enumeration data adopts x2 inspection, and ranked data adopt Ridit inspection, and measurement data adopts t inspection.
Effective 21 examples for the treatment of group, effective 17 examples, invalid 3 examples, total effective rate is 92.7%, compares with matched group, has remarkable significant difference; Effective 12 examples of matched group, effective 19 examples, no effect 9, total effective rate is 77.5%.
table 1 liang group Clinical efficacy comparison
Compare with matched group, * P < 0.05, * * P < 0.01
before and after table 2 liang group treatment, thyroid function compares
Note: with organize treat before compare
* P<0.05
; * P< 0.01; △ is compared with after treatment of control group
p< 0.05
Treatment group treatment after, with organize treat before compare, the indexs such as TSH, FT3, FT4 be improved significantly, have remarkable significant difference (
p< 0.01); After treatment group treatment, compare with after treatment of control group, the index such as FT3, FT4 raises, have obvious significant difference (
p< 0.05).
conclusion
Component science of the present invention, abundant raw material, cheap, reasonable compatibility, mutual support, there is warming YANG and invigorating QI, strengthening spleen, tonifying kidney, the turbid effect of blood stasis dispelling row, be effective to treat hypothyroidism, good effect, drug safety, effective percentage is up to more than 92%, and having actual clinical meaning and very strong practical value, is that one on Chinese medicine is innovated greatly.
Claims (4)
1. treat the Chinese medicine composition of hypothyroidism for one kind, it is characterized in that, be made up of the material medicine of following weight parts: Fructus Psoraleae 5-15 part, Herba Epimedii 5-15 part, Semen Astragali Complanati 10-30 part, Ramulus Cinnamomi 5-20 part, Fructus Mori 10-30 part, Herba Ecliptae 10-20 part, Caulis Spatholobi 10-30 part, Radix Rubiae 5-15 part, Rhizoma Atractylodis Macrocephalae 10-30 part and Poria 10-30 part, by above-mentioned raw materials medicament mixed together, add the water soaking half an hour of material medicine 6-8 times weight, intense fire decocts to boiling, use slow fire boiling 30-45 minute instead, filter, obtain first time filtrate, medicinal residues add the water of material medicine 4-6 times weight again, intense fire decocts to boiling, use slow fire boiling 20-35 minute instead, filter, obtain second time filtrate, merge twice filtrate, mixing, .
2. the Chinese medicine composition for the treatment of hypothyroidism according to claim 1, it is characterized in that, be made up of the material medicine of following weight parts: Fructus Psoraleae 5 parts, Herba Epimedii 15 parts, Semen Astragali Complanati 10 parts, Ramulus Cinnamomi 20 parts, 10 parts, Fructus Mori, Herba Ecliptae 20 parts, Caulis Spatholobi 10 parts, 15 parts, Radix Rubiae, the Rhizoma Atractylodis Macrocephalae 10 parts and 30 parts, Poria, by above-mentioned raw materials medicament mixed together, add the water soaking half an hour of material medicine 6 times of weight, intense fire decocts to boiling, use slow fire boiling instead 30 minutes, filter, obtain first time filtrate, medicinal residues add the water of material medicine 6 times of weight again, intense fire decocts to boiling, use slow fire boiling instead 35 minutes, filter, obtain second time filtrate, merge twice filtrate, mixing, .
3. the Chinese medicine composition for the treatment of hypothyroidism according to claim 1, it is characterized in that, the present invention in the specific implementation, be made up of the material medicine of following weight parts: Fructus Psoraleae 10 parts, Herba Epimedii 10 parts, Semen Astragali Complanati 20 parts, Ramulus Cinnamomi 12 parts, 20 parts, Fructus Mori, Herba Ecliptae 15 parts, Caulis Spatholobi 20 parts, 13 parts, Radix Rubiae, the Rhizoma Atractylodis Macrocephalae 20 parts, 20 parts, Poria, by above-mentioned raw materials medicament mixed together, add the water soaking half an hour of material medicine 7 times of weight, intense fire decocts to boiling, use slow fire boiling instead 37 minutes, filter, obtain first time filtrate, medicinal residues add the water of material medicine 5 times of weight again, intense fire decocts to boiling, use slow fire boiling instead 27 minutes, filter, obtain second time filtrate, merge twice filtrate, mixing, .
4. the Chinese medicine composition for the treatment of hypothyroidism according to claim 1, it is characterized in that, the present invention in the specific implementation, be made up of the material medicine of following weight parts: Fructus Psoraleae 15 parts, Herba Epimedii 5 parts, Semen Astragali Complanati 30 parts, Ramulus Cinnamomi 5 parts, 30 parts, Fructus Mori, Herba Ecliptae 10 parts, Caulis Spatholobi 30 parts, 5 parts, Radix Rubiae, the Rhizoma Atractylodis Macrocephalae 30 parts and 10 parts, Poria, by above-mentioned raw materials medicament mixed together, add the water soaking half an hour of material medicine 8 times of weight, intense fire decocts to boiling, use slow fire boiling instead 45 minutes, filter, obtain first time filtrate, medicinal residues add the water of material medicine 4 times of weight again, intense fire decocts to boiling, use slow fire boiling instead 20 minutes, filter, obtain second time filtrate, merge twice filtrate, mixing, .
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106110112A (en) * | 2016-08-09 | 2016-11-16 | 张志红 | A kind of Chinese medicine composition treating hypothyroidism |
| CN112316031A (en) * | 2020-12-04 | 2021-02-05 | 玉林市卫生学校附属医院 | Composition for treating hypothyroidism |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103340921A (en) * | 2013-07-12 | 2013-10-09 | 武汉市健恒药业有限公司 | Traditional Chinese medicine for treating insufficiency of both the spleen and the kidney and preparation method thereof |
-
2015
- 2015-03-30 CN CN201510143359.9A patent/CN104688872A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103340921A (en) * | 2013-07-12 | 2013-10-09 | 武汉市健恒药业有限公司 | Traditional Chinese medicine for treating insufficiency of both the spleen and the kidney and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 李凤红: ""甲状腺功能减退症的中医治疗体会"", 《四川中医》 * |
| 高洁等: ""中医补阳法在治疗甲减中应用"", 《辽宁中医药大学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106110112A (en) * | 2016-08-09 | 2016-11-16 | 张志红 | A kind of Chinese medicine composition treating hypothyroidism |
| CN112316031A (en) * | 2020-12-04 | 2021-02-05 | 玉林市卫生学校附属医院 | Composition for treating hypothyroidism |
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Application publication date: 20150610 |