CN104667149A - Traditional Chinese medicine composition for constipation - Google Patents
Traditional Chinese medicine composition for constipation Download PDFInfo
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- CN104667149A CN104667149A CN201310620132.XA CN201310620132A CN104667149A CN 104667149 A CN104667149 A CN 104667149A CN 201310620132 A CN201310620132 A CN 201310620132A CN 104667149 A CN104667149 A CN 104667149A
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Abstract
The invention discloses a traditional Chinese medicine composition for constipation. The traditional Chinese medicine composition for constipation is characterized by being prepared from the following raw traditional Chinese medicine materials by mass: 20 parts to 30 parts of codonopsis pilosula, 10 parts to 56 parts of pollen typhae, 9 parts to 15 parts of rhizoma corydalis, 28 parts to 30 parts of mangnolia officinalis, 18 parts to 22 parts of colla corii asini, 9 parts to 15 parts of gizzard pepsin, 30 parts to 50 parts of charred triplet, 18 parts to 25 parts of spora lygodii, 5 parts to 9 parts of lalang grass rhizome, 15 parts to 17 parts of felwort, 12 parts to 15 parts of rhizoma alismatis, 15 parts to 20 parts of radix paeoniae alba, 6 parts to 9 parts of trogopterus dung, 10 parts to 12 parts of immature bitter orange, 10 parts to 12 parts of radix curcumae, 18 parts to 25 parts of szechwan Chinaberry fruits, 6 parts to 10 parts of scutellaria baicalensis, 9 parts to 12 parts of gardenia, 50 parts to 60 parts of liquorice, 25 parts to 30 parts of semen plantaginis, 28 parts to 32 parts of folium sennae and 18 parts to 22 parts of raw bighead atractylodes rhizome. The traditional Chinese medicine composition has the advantages of being good in effect, small in taking dosage, convenient to take, rapid in absorption, wide in crowd and free of adverse effect after being taken.
Description
Technical field
The present invention relates to a kind of Chinese medicine, the Chinese medicine composition of particularly a kind of constipation, belongs to field of medicaments.
Background technology
Modern society people do not move due to sitting, and operating pressure is large, and spirit is in tension for a long time, easily cause the autonomic nerve controlling intestinal peristalsis promoting to get muddled, thus affect digesting and assimilating of food in intestinal, and easily bring out constipation.Constipation often brings many miseries and worry to patient, has a strong impact on its healthy and quality of life.Existing constipation medicine is not too quickly is exactly not too take effect, and is suitable for crowd restricted.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of constipation, it has effective, and taking dose is little, taking convenience, absorption are fast, it is wide to be applicable to crowd, does not have untoward reaction after taking.
Technical scheme of the present invention is: a kind of Chinese medicine composition of constipation, it is characterized in that: it is formulated by the raw material of Chinese medicine of following mass parts: 20-30 part Radix Codonopsis, 10-56 part Pollen Typhae, 9-15 part Rhizoma Corydalis, 28-30 part Cortex Magnoliae Officinalis, 18-22 part Colla Corii Asini, 9-15 part Endothelium corneum, 30-50 part JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 18-25 part Spora Lygodii, 5-9 part Rhizoma Imperatae, 15-17 part Radix Gentianae, 12-15 part Rhizoma Alismatis, 15-20 part Radix Paeoniae Alba, 6-9 part Oletum Trogopterori, 10-12 part Fructus Aurantii Immaturus, 10-12 part Radix Curcumae, 18-25 part Fructus Toosendan, 6-10 part Radix Scutellariae, 9-12 part Fructus Gardeniae, 50-60 part Radix Glycyrrhizae, 25-30 part Semen Plantaginis, 28-32 part Folium Sennae and 18-22 part Rhizoma Atractylodis Macrocephalae.
The preparation method of the Chinese medicine composition of described a kind of constipation, comprises the steps:
1) raw material is taken by following mass parts:
20-30 part Radix Codonopsis, 10-56 part Pollen Typhae, 9-15 part Rhizoma Corydalis, 28-30 part Cortex Magnoliae Officinalis, 18-22 part Colla Corii Asini, 9-15 part Endothelium corneum, 30-50 part JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 18-25 part Spora Lygodii, 5-9 part Rhizoma Imperatae, 15-17 part Radix Gentianae, 12-15 part Rhizoma Alismatis, 15-20 part Radix Paeoniae Alba, 6-9 part Oletum Trogopterori, 10-12 part Fructus Aurantii Immaturus, 10-12 part Radix Curcumae, 18-25 part Fructus Toosendan, 6-10 part Radix Scutellariae, 9-12 part Fructus Gardeniae, 50-60 part Radix Glycyrrhizae, 25-30 part Semen Plantaginis, 28-32 part Folium Sennae and 18-22 part Rhizoma Atractylodis Macrocephalae;
2) Radix Codonopsis of above-mentioned mass parts, Pollen Typhae, Rhizoma Corydalis, Cortex Magnoliae Officinalis, Endothelium corneum, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Spora Lygodii, Rhizoma Imperatae, Radix Gentianae, Rhizoma Alismatis, the Radix Paeoniae Alba, Oletum Trogopterori, Fructus Aurantii Immaturus, Radix Curcumae, Fructus Toosendan, Radix Scutellariae, Fructus Gardeniae, Radix Glycyrrhizae, Semen Plantaginis and Folium Sennae are added 10 times of water soakings after 1 hour, decoct three times, decocting time is 1 hour, gradation is filtered, being concentrated into relative density after being merged by the medicinal liquid of acquisition is 1.15 thick pastes, is ground into fine powder after vacuum drying, crosses 80 mesh sieves, obtain fine powder, for subsequent use;
3) add the Colla Corii Asini of above-mentioned mass parts and powder is beaten in Rhizoma Atractylodis Macrocephalae mixing, cross 80 mesh sieves, obtain fine powder and join step 2) in fine powder mix homogeneously, be that 80% ethanol is made wetting agent and granulated with concentration, granulate, dry, cross 20 mesh sieves, granulation, subpackage and get final product.
Advantage of the present invention is: the Rhizoma Alismatis promoting diuresis to eliminate damp pathogen in formula of the present invention, expels the heat-evil, and change turbid, inducing diuresis for treating stranguria syndrome clears away heart-fire; Semen Plantaginis lung heat clearing profit bladder; Effect that Spora Lygodii clearing away heat-damp and promoting diuresis is treating stranguria; The Rhizoma Atractylodis Macrocephalae sweet temperature invigorating the spleen and benefiting QI dampness; Folium Sennae sweet-bitter flavor cold in nature, the heat clearing away of cold energy, the bitter energy eliminating stagnation therapeutic method to keep the adverse QI flowing downwards, sweet energy emergency, have the row that purges heat stagnant, the merit of relieving constipation is the product of regulating the flow of QI to relieve constipation first-selection; Colla Corii Asini grows the greasy fraud hindering transporting and transforming function of the spleen and stomach; Cortex Magnoliae Officinalis bitter in the mouth warm in nature is pungent, circulation of qi promoting removing food stagnancy, and dampness, except full, strengthened Folium Sennae by dredging mechanism of qi and to be expelled the heat-evil the stagnant power of row, can alleviate the hardship of abdominal part distension simultaneously; Radix Glycyrrhizae relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Raw material of the present invention is formed rationally, treatment anti-constipation effect is remarkable, and herbal nature is gentle, and full side moisturizes for method to regulate the flow of vital energy, and reaches the effect of softening the hard mass relieving constipation; Be applicable to patient that is older or that have a delicate constitution, after taking, there is no untoward reaction.
Detailed description of the invention
Clearly the present invention can be described further below by the specific embodiment provided, but not as a limitation of the invention.
Embodiment 1
A preparation method for the Chinese medicine composition of constipation, comprises the steps:
1) raw material is taken by following quality:
20g Radix Codonopsis, 10g Pollen Typhae, 9g Rhizoma Corydalis, 28g Cortex Magnoliae Officinalis, 18g Colla Corii Asini, 9g Endothelium corneum, 30g JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 18g Spora Lygodii, 5g Rhizoma Imperatae, 15g Radix Gentianae, 12g Rhizoma Alismatis, the 15g Radix Paeoniae Alba, 6g Oletum Trogopterori, 10g Fructus Aurantii Immaturus, 10g Radix Curcumae, 18g Fructus Toosendan, 6g Radix Scutellariae, 9g Fructus Gardeniae, 50g Radix Glycyrrhizae, 25g Semen Plantaginis, 28g Folium Sennae and 18g Rhizoma Atractylodis Macrocephalae;
2) Radix Codonopsis of above-mentioned quality, Pollen Typhae, Rhizoma Corydalis, Cortex Magnoliae Officinalis, Endothelium corneum, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Spora Lygodii, Rhizoma Imperatae, Radix Gentianae, Rhizoma Alismatis, the Radix Paeoniae Alba, Oletum Trogopterori, Fructus Aurantii Immaturus, Radix Curcumae, Fructus Toosendan, Radix Scutellariae, Fructus Gardeniae, Radix Glycyrrhizae, Semen Plantaginis and Folium Sennae are added 10 times of water soakings after 1 hour, decoct three times, decocting time is 1 hour, gradation is filtered, being concentrated into relative density after being merged by the medicinal liquid of acquisition is 1.15 thick pastes, is ground into fine powder after vacuum drying, crosses 80 mesh sieves, obtain fine powder, for subsequent use;
3) add the Colla Corii Asini of 18g and powder is beaten in the mixing of 18g Rhizoma Atractylodis Macrocephalae, cross 80 mesh sieves, obtain fine powder and join step 2) in fine powder mix homogeneously, be that 80% ethanol is made wetting agent and granulated with concentration, granulate, dry, cross 20 mesh sieves, granulation, subpackage and get final product.Incapsulate as capsule.
Preparation of the present invention is not limited only to above-mentioned capsule, can also be prepared into the peroral dosage forms such as tablet, oral liquid, granule, pill.
Capsule of the present invention (0.35g/ grain) containing active ingredient 0.35g, oral one time 3,3 times on the 1st.
Embodiment 2
Substantially identical with embodiment 1, difference is: 25 g Radix Codonopsis, 20 g Pollen Typhaes, 10 g Rhizoma Corydalis, 29 g Cortex Magnoliae Officinalis, 20 g Colla Corii Asini, 10 g Endothelium corneum, 40 g JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 20 g Spora Lygodii, 6 g Rhizoma Imperataes, 16 g Radix Gentianaes, 13 g Rhizoma Alismatis, the 17 g Radix Paeoniae Albas, 8 g Oletum Trogopteroris, 11 g Fructus Aurantii Immaturuss, 11 g Radix Curcumaes, 20 g Fructus Toosendans, 9 g Radix Scutellariaes, 10 g Fructus Gardeniaes, 45 g Radix Glycyrrhizaes, 28 g Semen Plantaginiss, 30 g Folium Sennae and 20 g Rhizoma Atractylodis Macrocephalae.
Embodiment 3
Substantially identical with embodiment 1, difference is: 30g Radix Codonopsis, 56g Pollen Typhae, 15g Rhizoma Corydalis, 30g Cortex Magnoliae Officinalis, 22 g Colla Corii Asini, 15 g Endothelium corneum, 50g JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 25g Spora Lygodii, 9g Rhizoma Imperatae, 17g Radix Gentianae, 15g Rhizoma Alismatis, the 20g Radix Paeoniae Alba, 9g Oletum Trogopterori, 12g Fructus Aurantii Immaturus, 12g Radix Curcumae, 25g Fructus Toosendan, 10g Radix Scutellariae, 12g Fructus Gardeniae, 60g Radix Glycyrrhizae, 30g Semen Plantaginis, 32g Folium Sennae and 22g Rhizoma Atractylodis Macrocephalae.
pharmacological research
Constipation oral medicine of the present invention on the therapeutical effect of mice with constipation (product that constipation oral medicine adopts embodiment 2 to prepare) 1. constipation oral medicine of the present invention on the impact of mice with constipation Small intestine advance activity effect: get healthy male white mouse 70, laboratory sub-cage rearing 1 week, body weight (20 ± 2) g, be divided at random 7 groups (often organizing 10), wherein contrasting medicine A is that YIN nourishing intestine-moisturizing oral liquid is purchased from Beijing pharmaceutical Co. Ltd of Jia Shi Daheng; Contrast medicine B is purchased from Donga, Shandong Province county people's hospital.Above each group except constipation oral medicine high dose group all by 0. 2mL/ 10g body weight gastric infusion, constipation oral medicine high dose group of the present invention presses 0.4mL/10g body weight gastric infusion, every day 1 time, continuous 5d.After last administration except Normal group, all prohibit water non-fasting 72 h, cause Constipated mice.Give the prepared Chinese ink (activated carbon powder containing 5%, 10 % Radix Acaciae senegalis, 0. 2 ml/ 10 g body weight) containing corresponding given the test agent after prohibiting water 72 h respectively, normal and model control group gives prepared Chinese ink.Put to death animal through disconnected vertebra after 20 min, separation mesentery of cutting open the belly immediately, paves not tractive by small intestinal, measures small intestinal length and carbon powder forward position to pylorus distance (cm), by formulae discovery carbon powder propelling rate (%).
Distance (cm)/small intestinal total length (pylorus is to ileocecus) (cm) × 100 % of carbon powder propelling rate (%)=carbon powder forward position and pylorus.
Table 1 constipation oral medicine of the present invention on the impact of mice with constipation Small intestine advance activity effect (n=10,
s)
Compared with normal group: * P < 0. 05, * * P < 0. 01; Compared with model group: ## P < 0. 01; △ P < 0. 05, △ △ P < 0. 01 compared with contrast medicine B group
Table 1 is visible, and compared with Normal group, model group mice carbon powder advance distance and propelling rate obviously reduce (P < 0.05, P < 0. 01); And each administration group all obviously can increase small intestinal prepared Chinese ink advance distance and ink propulsive rate (P < 0. 01), in addition, in constipation oral medicine, the therapeutic effect of dosage and high dose group is obviously better than contrast medicine B group.
2. constipation oral medicine of the present invention is on the impact of dryness accumulated in the stomach and intestine dehydration Constipation Model mice defecation: get healthy male white mouse 70, laboratory sub-cage rearing 1 week, body weight (21 ± 2) g, be divided at random 7 groups (often organizing 10), wherein contrasting medicine A is that YIN nourishing intestine-moisturizing oral liquid is purchased from Beijing pharmaceutical Co. Ltd of Jia Shi Daheng; Contrast medicine B is purchased from Donga, Shandong Province county people's hospital.Except Normal group, the equal feed rice of each treated animal also prohibits water 54 h, fasting subsequently 18 h (water is can't help in matched group fasting).Within 4th day, each treated animal gavage gives relative medicine (Normal group and model group animal gavage equivalent distilled water), and after 30 min, gavage gives prepared Chinese ink.Only be placed in the observation cage being covered with filter paper observe single for animal, observe and record the efflux time of each little mouse's head grain melena, 8h interior arrange fecal grains.
Table 2 constipation oral medicine of the present invention on the impact of dryness accumulated in the stomach and intestine dehydration Constipation Model mice defecation (n=10,
s)
Compared with Normal group: * P < 0. 05, * * P < 0. 01; Compared with model group: △ P < 0. 05, △ △ P < 0. 01; △ P < 0. 05, △ △ P < 0. 01 compared with contrast medicine B group
Table 2 is visible, compared with Normal group, the first grain melena time of model group mice obviously extends (P <0.01), and the first grain melena time of each dosage group is significantly lower than model control group (P < 0.05 or P < 0.01); The fecal grains of model group mice is significantly lower than Normal group (P < 0.01), compared with model group, the middle and high dosage group of constipation oral medicine obviously can increase animal row's melena grain number (P < 0.01); In addition, compared with contrast medicine B group, in constipation oral medicine of the present invention, dosage and high dose group can significantly improve therapeutic effect.
Simultaneously, the constipation oral medicine adopting embodiment 1 and embodiment 3 to prepare is carried out the impact of mice with constipation Small intestine advance activity effect and constipation oral medicine the test of pesticide effectiveness of the impact of dryness accumulated in the stomach and intestine dehydration Constipation Model mice defecation, the drug effect of its effect and employing embodiment 2 is basically identical, wherein, the best results of embodiment 2.
Patient by inclusive criteria enter to organize patient 50 example, be divided into treatment group and matched group at random, the constipation oral medicine of the oral embodiment of the present invention 2 for the treatment of group, oral one time 3,3 times on the 1st; Matched group takes constipation relieving preparation, oral one time 3,3 times on the 1st.Take 2 days.
Efficacy assessment standard is cured: free movement of the bowels; Do not heal: symptom does not alleviate.To cure statistics total effective rate, the results are shown in Table 3.
Table 3 Clinical efficacy comparison
Group | n | Cure | Do not heal | Total effective rate (%) is uncomfortable | |
Treatment group | 25 | 24 | 1 | 96 0 | |
Matched group | 25 | 20 | 8 | 80 3 |
From result, 2 groups of total effective rates compare, and embodiments of the invention 2 curative effect is better than matched group, and in addition, treatment group does not find obvious adverse reaction; Mild nausea 3 example is there is in matched group after taking medicine, after drug withdrawal, and spontaneous remission.It is consistent with embodiment 2 that embodiment 1 and embodiment 3 do same clinical trial result.
Claims (2)
1. the Chinese medicine composition of a constipation, it is characterized in that: it is formulated by the raw material of Chinese medicine of following mass parts: 20-30 part Radix Codonopsis, 10-56 part Pollen Typhae, 9-15 part Rhizoma Corydalis, 28-30 part Cortex Magnoliae Officinalis, 18-22 part Colla Corii Asini, 9-15 part Endothelium corneum, 30-50 part JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 18-25 part Spora Lygodii, 5-9 part Rhizoma Imperatae, 15-17 part Radix Gentianae, 12-15 part Rhizoma Alismatis, 15-20 part Radix Paeoniae Alba, 6-9 part Oletum Trogopterori, 10-12 part Fructus Aurantii Immaturus, 10-12 part Radix Curcumae, 18-25 part Fructus Toosendan, 6-10 part Radix Scutellariae, 9-12 part Fructus Gardeniae, 50-60 part Radix Glycyrrhizae, 25-30 part Semen Plantaginis, 28-32 part Folium Sennae and 18-22 part Rhizoma Atractylodis Macrocephalae.
2. the preparation method of the Chinese medicine composition of a kind of constipation according to claim 1, is characterized in that: it comprises the steps:
1) raw material is taken by following mass parts:
20-30 part Radix Codonopsis, 10-56 part Pollen Typhae, 9-15 part Rhizoma Corydalis, 28-30 part Cortex Magnoliae Officinalis, 18-22 part Colla Corii Asini, 9-15 part Endothelium corneum, 30-50 part JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 18-25 part Spora Lygodii, 5-9 part Rhizoma Imperatae, 15-17 part Radix Gentianae, 12-15 part Rhizoma Alismatis, 15-20 part Radix Paeoniae Alba, 6-9 part Oletum Trogopterori, 10-12 part Fructus Aurantii Immaturus, 10-12 part Radix Curcumae, 18-25 part Fructus Toosendan, 6-10 part Radix Scutellariae, 9-12 part Fructus Gardeniae, 50-60 part Radix Glycyrrhizae, 25-30 part Semen Plantaginis, 28-32 part Folium Sennae and 18-22 part Rhizoma Atractylodis Macrocephalae;
2) Radix Codonopsis of above-mentioned mass parts, Pollen Typhae, Rhizoma Corydalis, Cortex Magnoliae Officinalis, Endothelium corneum, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Spora Lygodii, Rhizoma Imperatae, Radix Gentianae, Rhizoma Alismatis, the Radix Paeoniae Alba, Oletum Trogopterori, Fructus Aurantii Immaturus, Radix Curcumae, Fructus Toosendan, Radix Scutellariae, Fructus Gardeniae, Radix Glycyrrhizae, Semen Plantaginis and Folium Sennae are added 10 times of water soakings after 1 hour, decoct three times, decocting time is 1 hour, gradation is filtered, being concentrated into relative density after being merged by the medicinal liquid of acquisition is 1.15 thick pastes, is ground into fine powder after vacuum drying, crosses 80 mesh sieves, obtain fine powder, for subsequent use;
3) add the Colla Corii Asini of above-mentioned mass parts and powder is beaten in Rhizoma Atractylodis Macrocephalae mixing, cross 80 mesh sieves, obtain fine powder and join step 2) in fine powder mix homogeneously, be that 80% ethanol is made wetting agent and granulated with concentration, granulate, dry, cross 20 mesh sieves, granulation, subpackage and get final product.
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CN105395979A (en) * | 2015-12-17 | 2016-03-16 | 济南舜祥医药科技有限公司 | Health-care tea used for treating constipation |
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CN105395979A (en) * | 2015-12-17 | 2016-03-16 | 济南舜祥医药科技有限公司 | Health-care tea used for treating constipation |
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Application publication date: 20150603 |