CN104666931B - Composition and its application with liver-protecting and alcoholism-relieving effect - Google Patents
Composition and its application with liver-protecting and alcoholism-relieving effect Download PDFInfo
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Abstract
The invention discloses the composition acted on liver-protecting and alcoholism-relieving and its application.Composition provided by the present invention with liver-protecting and alcoholism-relieving effect, it is characterised in that：It is mainly made up of the raw material of following weight parts：13 parts~18 parts of Phyllanthus embical fruit, 13 parts~18 parts of papaw, 10 parts~15 parts of Momordica grosvenori, 8 parts~12 parts of FLOS CHRYSANTHEMI from Hangzhou of China, 8 parts~12 parts of the stem of noble dendrobium, 8 parts~12 parts of plantain seed, 3 parts~8 parts of lemon, 3 parts~8 parts of grape pip, 3 parts~8 parts of dried orange peel.Said composition be using natural fruit and the Ministry of Public Health announcement food and medicament dual-purpose Chinese medicine or available for health food Chinese medicine as raw material, be prepared with suitable auxiliary material.It is demonstrated experimentally that said composition can effectively protect liver, there is preventing drunkenness, the drunk effect of solution.
Description
Technical field
The present invention relates to composition and its application, more particularly to the composition with liver-protecting and alcoholism-relieving effect and its application.
Background technology
Drunk is uncomfortable, a kind of state of insobriety after excessive consumption of alcohol.It is drunk be because drink into alcohol it is big
About a quarter can directly be absorbed by stomach, and the telangiectasis of coat of the stomach can be caused to make one the sensation having enough after absorption, meanwhile,
The normal creepage of gastrointestinal functions of stomach is influenceed, causes the generation of vomiting.Remaining alcohol carries out biological metabolism in liver, alcohol is converted into second
Aldehyde, acetic acid is then converted into, is finally decomposed to atriphos, water and carbon dioxide.After excessive consumption of alcohol, when liver needs longer
Between decomposing alcohol, and acetaldehyde has direct harm to liver cell, and the acetaldehyde of higher concentration can cause serious infringement to liver cell.
Although taking medicine, it is drunk rapidly to alleviate, medicine also has certain infringement to human body.
The content of the invention
It is an object of the present invention to provide a kind of composition with liver-protecting and alcoholism-relieving effect.
Composition provided by the present invention with liver-protecting and alcoholism-relieving effect, is made up of the raw material of following weight parts：Phyllanthus embical fruit
13 parts~18 parts, 13 parts~18 parts of papaw, 10 parts~15 parts of Momordica grosvenori, 8 parts~12 parts of FLOS CHRYSANTHEMI from Hangzhou of China, 8 parts~12 parts of the stem of noble dendrobium, car
First sub 8 parts~12 parts, 3 parts~8 parts of lemon, 3 parts~8 parts of grape pip, 3 parts~8 parts of dried orange peel.
The composition is made up of the raw material of following weight parts：13 parts~15 parts of Phyllanthus embical fruit, 13 parts~15 parts of papaw, sieve
10 parts~12 parts of Chinese fruit, 8 parts~10 parts of FLOS CHRYSANTHEMI from Hangzhou of China, 8 parts~10 parts of the stem of noble dendrobium, 8 parts~10 parts of plantain seed, 3 parts~5 parts of lemon, Portugal
3 parts~5 parts of grape seed, 3 parts~5 parts of dried orange peel.
The composition is made up of the raw material of following weight parts：13 parts of Phyllanthus embical fruit, 13 parts of papaw, 10 parts of Momordica grosvenori, Hangzhoupro
8 parts of chrysanthemum, 8 parts of the stem of noble dendrobium, 8 parts of plantain seed, 3 parts of lemon, 3 parts of grape pip, 3 parts of dried orange peel.
The composition is made up of the raw material of following weight parts：15 parts of Phyllanthus embical fruit, 15 parts of papaw, 12 parts of Momordica grosvenori, Hangzhoupro
10 parts of chrysanthemum, 10 parts of the stem of noble dendrobium, 10 parts of plantain seed, 5 parts of lemon, 5 parts of grape pip, 5 parts of dried orange peel.
The composition is made up of the raw material of following weight parts：17 parts of Phyllanthus embical fruit, 17 parts of papaw, 13 parts of Momordica grosvenori, Hangzhoupro
11 parts of chrysanthemum, 11 parts of the stem of noble dendrobium, 11 parts of plantain seed, 6 parts of lemon, 6 parts of grape pip, 6 parts of dried orange peel.
Pharmaceutically acceptable auxiliary material or carrier are added in the raw material, by the composition be made granule, capsule,
Tablet or oral liquid.
Application of the described composition in the product with liver-protecting and alcoholism-relieving effect is prepared falls within the protection model of the present invention
Enclose.
Said composition be with natural fruit and the Ministry of Public Health announcement food and medicament dual-purpose Chinese medicine or available in health food
Medicine is raw material, is prepared with suitable auxiliary material.It is demonstrated experimentally that said composition can effectively protect liver, there is preventing drunkenness, de-inebriating
Wine acts on.The preparation method of said composition simply, conveniently, is easily generalized to commercial scale.Proved through animal drug effect evaluation experimental,
Said composition protect liver, relieve the effect of alcohol, preventing drunkenness effect it is good, it is safe and non-toxic.
Embodiment
Embodiment 1, prepare the composition with liver-protecting and alcoholism-relieving effect
First, there is the composition of liver-protecting and alcoholism-relieving effect：
Raw material used is commercially commercially available in the embodiment.
The composition that the embodiment is prepared is as shown in the table：
2nd, the preparation method of the example composition is as follows：
(1) extraction of raw material：
By above composition and proportioning table, decocting method extracts three times, is first 1 by solid-liquid ratio：12 add water, soak 30min, boil
Boiling extraction 30min, 300 mesh filter-cloth filterings, filtrate are standby；The dregs of a decoction are 1 by solid-liquid ratio：10 add water, boil extraction 30min, 300 mesh
Filter-cloth filtering, filtrate are standby；The dregs of a decoction are 1 by solid-liquid ratio：10 add water, boil extraction 30min, 300 mesh filter-cloth filterings, merge three times
Filtrate, it is concentrated into 1:1, add ethanol alcohol content is stood 48h, filtering, it is 1.15 that filtrate, which is concentrated into relative density, i.e., up to 50%
Obtain the extract of raw material.
(2) preparation of granule：
Pharmaceutic adjuvant soluble starch is added into the above-mentioned raw extract being prepared, is directly made with dry granulating machine
Dried after grain or wet granulation, whole grain, packing, produce granule.
(3) preparation of capsule：
Pharmaceutic adjuvant soluble starch is added into the above-mentioned raw extract being prepared, is directly made with dry granulating machine
It dry, pulverize after grain or wet granulation, load capsule shells, obtain capsule.
(4) preparation of tablet：
Pharmaceutic adjuvant lactose, starch are added into the above-mentioned raw extract being prepared, is allowed to water or starch slurry
Bonding, directly pelletized with dry granulating machine or wet granulation after dry, granulation, add magnesium stearate, produced with tabletting machine
Tablet.
3rd, the functional evaluation of the present composition
Attached experimental method and result are as follows：
1 reagent and instrument
1.1 reagent
Present composition A high dose group is (referred to as：High dose group) compound method：Weigh a certain amount of present invention combination
Thing A, adds dissolved in purified water, is made into 0.36g/ml decoction, i.e. mouse dosage 7.2g/kg, equivalent to 19.6g (medicinal material)/kg；
Present composition A middle dose group is (referred to as：Middle dose group) compound method：Take the high agent of present composition A
Medicine amount liquid, pure water is added to be diluted to 0.18g/ml decoction, i.e. mouse dosage 3.6g/kg, equivalent to 9.8g (medicinal material)/kg；
Present composition A low dose group is (referred to as：Low dose group) compound method：Take agent in present composition A
Medicine amount liquid, pure water is added to be diluted to 0.09g/ml decoction, i.e. mouse dosage 1.8g/kg, equivalent to 4.9g (medicinal material)/kg.
Red Star Erguotou wine (56 °, Hongxing Co., Ltd. Beijing, lot number：20111101)；Hai Wangjin cup pieces (Shenzhen
Extra large Wang Jiankang developments in science and technology Co., Ltd, lot number：20120503)；Disodium hydrogen phosphate (analyzes pure, Chengdu section dragon chemical reagent
Factory, lot number：0120522)；Sodium dihydrogen phosphate (analyzes pure, Tianjin Bo Di chemical inc, lot number：20111006)；Examine
(Bioengineering Research Institute, lot number are built up in Nanjing to the bright blue testing cassete of Maas：20140113)；Alcohol dehydrogenase (ADH) testing cassete (group
Knit) (Bioengineering Research Institute, lot number are built up in Nanjing：20140115)；Glutamic-pyruvic transaminase (ALT/GPT) testing cassete (build up by Nanjing
Bioengineering Research Institute, 20131223)；Glutamic-oxalacetic transaminease (AST/GOT) testing cassete (Bioengineering Research Institute is built up in Nanjing,
20131228)；MDA (MDA) testing cassete (Nanjing build up Bioengineering Research Institute, 20140112)；Reduced glutathione
(GSH) testing cassete (Nanjing build up Bioengineering Research Institute, 20140111)；Triglyceride determination kit (enzyme coupling colorimetric method/
Single reagent type) (Zhejiang bowl diagnostic products Co., Ltd, 2013110023).
1.2 animal
Kunming mouse, it is purchased from Guangxi Medical University's Experimental Animal Center (experimental animal credit number：SCXK osmanthus 2009-
0002)。
1.3 equipment
TU-1901 dual-beam ultraviolet-visibles photometer (Beijing Pu Xi all purpose instruments Co., Ltd)；YN-80P type ice makings
Machine (Shanghai Ying Niute refrigerating equipment corporation, Ltds；ELIASA (U.S. EPOCH BIOTEK)；Disposable sterilized syringe
(Zhejiang Oujian Medical Equipment Co., Ltd)；Sampling container (test tube) (Jiangyan City Yongkang medical apparatus and instruments factory).
2 test methods
The determination of 2.1 mice drunk amounts
Take 20 ± 2g healthy male mices 30, be randomly divided into 3 groups, every group 10, each group respectively with 56 ° of strong, colourless liquor distilled from sorghum, with
0.12ml/10g, 0.14ml/10g, 0.16ml/10g gavage, mouse gait and active situation are observed, record righting reflex loss
And recovery time, mice drunk amount is determined according to experimental result.
2.2 effects of dispelling effects of alcohol and protecting liver researchs
20 ± 2g healthy male mices 84 are taken, are randomly divided into 6 groups, respectively blank control group, model control group, extra large king
Golden cup control group, high dose group, middle dose group, low dose group, every group 14.Each group is gavaged by the optimal of above-mentioned gained to capacity for liquor
Strong, colourless liquor distilled from sorghum, blank control group are gavaged with isometric pure water.After 30min, blank control group and model control group gavage pure
Water 20ml/kg, positive controls gavage extra large Wang Jin cups 2.0g/kg, and the high, medium and low dosage group of the present composition presses 7.2g/ respectively
Kg, 3.6g/kg, 1.8g/kg are gavaged.
Observe and record mouse gait situation, record mouse sleeping duration and recovery time, calculate tolerance
Time (time being wholly absent from gavage alcohol to righting reflex) and drunk hold time (from righting reflex loss to recovery
Time).12h fasting after drinking is filled, eyeball takes blood after 24h, 3500r/min centrifugation 5min, takes supernatant, is grasped by kit specification
Make glutamic-pyruvic transaminase (ALT) in measure serum, glutamic-oxalacetic transaminease (AST) activity.After eyeball takes blood, the neck that breaks puts to death mouse, immediately
Liver is taken out, is rinsed with PBS and is exhausted with filter paper, it is accurately weighed, shred and add PBS, with 3500r/ after homogenate
Min centrifuges 5min, takes supernatant that 10% liver homogenate supernatant, measure alcohol dehydrogenase (ADH) activity is made；And determine MDA
(MDA), glutathione (GSH), triglycerides (TG) content.Operated, determine and calculated by measure kit specification.
2.3 statistical method
Experimental data withRepresent, mean difference is examined using t between two groups, P<0.05 is statistically significant.
3 experimental results
The determination result of 3.1 mice drunk amounts
As shown in Table 1, mouse fills after drinking, instability of gait occurs, and activity reduces situation, and the 1st group mouse is shallow sleeps, and abdomen is exhaled
Inhale obvious；2nd group of whole righting reflex loss, there is phenomenon of being sunk into sleep, the 3rd group has death, therefore, this reality after drinking in filling in 24h
The 2nd group of 0.14ml/10g of selection is tested suitably to fill capacity for liquor.
The mice drunk amount of table 1 determination result (N=10)
Note：Tolerance time --- the time being wholly absent from gavage alcohol to righting reflex；It is drunk to hold time --- from
Time of the righting reflex loss to recovery
3.2 mouse effects of dispelling effects of alcohol and protecting liver results of study
As shown in table 2~5, with model group ratio, high dose group can shorten the drunk of mouse and hold time, and have significant difference
(P<0.05)；High, middle dose group can make ADH vigor in murine liver tissue significantly raise (P<0.05) GSH contents (P, is significantly improved
<0.05) MDA and TG content (P, is significantly reduced<0.05)；Significantly reduce AST, ALT vigor (P in serum<0.05).
Influences of the present composition A of table 2 to the mice drunk time
| Group | n | Tolerance time (min) | It is drunk to hold time (min) |
| Blank group | 14 | - | - |
| Model group | 14 | 14.21±10.71 | 212.57±22.49 |
| Positive group | 14 | 26.33±40.00 | 167.33±61.11△△ |
| High dose group | 14 | 27.93±22.72 | 167.14±41.46△ |
| Middle dose group | 14 | 28.54±4.73 | 192.23±57.10 |
| Low dose group | 14 | 17.36±0.96 | 188.34±35.62 |
Compared with model group：△P<0.05,△△P<0.01
Influences of the present composition A of table 3 to ADH vigor in murine liver tissue
| Group | n | ADH vigor (U/mgprot) |
| Blank group | 14 | 27.78±16.02 |
| Model group | 14 | 17.61±5.01* |
| Positive group | 14 | 27.77±17.25△ |
| High dose group | 14 | 26.58±8.36△ |
| Middle dose group | 14 | 27.27±10.79△ |
| Low dose group | 14 | 24.99±9.58 |
Compared with blank group：*P<0.05, * * P<0.01；Compared with model group：△P<0.05,△△P<0.01
Influences of the present composition A of table 4 to AST, ALT vigor in mice serum
Compared with blank group：*P<0.05,**P<0.01；Compared with model group：△P<0.05,△△P<0.01
Influences of the present composition A of table 5 to GSH, MDA, TG content in murine liver tissue
| Group | n | GSH(mg/gprot) | MDA(nmol/mgprot) | TG(mmol/gprot) |
| Blank group | 14 | 0.078±0.047 | 1.494±1.235 | 0.128±0.052 |
| Model group | 14 | 0.041±0.027* | 2.784±1.077* | 0.205±0.077* |
| Positive group | 14 | 0.077±0.049△ | 1.648±1.415△ | 0.144±0.063△ |
| High dose group | 14 | 0.076±0.033△ | 1.578±1.321△ | 0.142±0.036△ |
| Middle dose group | 14 | 0.076±0.046△ | 1.737±0.686△△ | 0.152±0.064△ |
| Low dose group | 14 | 0.074±0.084 | 1.764±0.639△ | 0.165±0.070 |
Compared with blank group：*P<0.05,**P<0.01；Compared with model group：△P<0.05,△△P<0.01
Shown in above experimental result table 2-5, present composition A height, middle dose group significantly improve murine liver tissue
Middle ADH vigor (P<0.05)；High, middle dose group significantly lowers the AST vigor in mice serum；High, middle dose group significantly lowers
ALT vigor (P in mice serum<0.05, P<0.01)；High, medium and low dosage group significantly inhibits TG, MDA in murine liver tissue
Rise (P<0.05 or P<0.01)；High, middle dose group dramatically increases the content (P of GSH in murine liver tissue<0.05).
This test result indicates that, present composition A have significantly relieve the effect of alcohol, liver protection effect.
Functional evaluation, experimental result and composition A are carried out to the present composition B, C and D with method same as described above
Result without significant difference, show composition B, C and D have significantly relieve the effect of alcohol, liver protection effect.
4th, the acute toxicity testing of the present composition
Experimental method：The present composition is taken to be made into most dense decoction 3.8g/ml, from kunming mouse 40, ♀Respectively
Half, it is divided into blank control group and administration group, every group 20, fasting 12h before experiment.Using each gavage amount as 40ml/kg, to animal
Gavage.Pay attention to observation mouse without toxic reaction, subsequent 1 feeding for examining mouse of observation daily and drinking-water situation, spiritual shape in 24h
State, autonomic activities, excrement etc., and make a record in time, Continuous Observation 14d ensures that feeding conditions are constant after medication during observing
Put to death all for trying the disconnected neck of mouse within 15th day, the heart, liver, spleen, lung, kidney, stomach, thymus gland and the blank control group of cut open inspection mouse relatively have
It is without exception.
Experimental result：Administration group does not have death state, and compared with blank control group, the administration group state of mind is good, activity
Independently, feeding, drinking-water and excrement situation are normal, and the heart, liver, spleen, lung, kidney, stomach, thymus gland and blank control group are more without exception.Then
Present composition maximal tolerance dose is 152g (crude drug amount)/kg, is 42 times of effective dose.
Claims (8)
- A kind of 1. composition with liver-protecting and alcoholism-relieving effect, it is characterised in that：It is made up of the raw material of following weight parts：Phyllanthus embical fruit 13 parts~18 parts, 13 parts~18 parts of papaw, 10 parts~15 parts of Momordica grosvenori, 8 parts~12 parts of FLOS CHRYSANTHEMI from Hangzhou of China, the stem of noble dendrobium 8 parts~12 Part, 8 parts~12 parts of plantain seed, 3 parts~8 parts of lemon, 3 parts~8 parts of grape pip, 3 parts~8 parts of dried orange peel.
- 2. the composition according to claim 1 with liver-protecting and alcoholism-relieving effect, it is characterised in that：The composition is by following The raw material of parts by weight is made：13 parts~15 parts of Phyllanthus embical fruit, 13 parts~15 parts of papaw, 10 parts~12 parts of Momordica grosvenori, 8 parts of FLOS CHRYSANTHEMI from Hangzhou of China ~10 parts, 8 parts~10 parts of the stem of noble dendrobium, 8 parts~10 parts of plantain seed, 3 parts~5 parts of lemon, 3 parts~5 parts of grape pip, dried orange peel 3 parts~5 Part.
- 3. the composition according to claim 2 with liver-protecting and alcoholism-relieving effect, it is characterised in that：The composition is by following The raw material of parts by weight is made：13 parts of Phyllanthus embical fruit, 13 parts of papaw, 10 parts of Momordica grosvenori, 8 parts of FLOS CHRYSANTHEMI from Hangzhou of China, 8 parts of the stem of noble dendrobium, plantain seed 8 Part, 3 parts of lemon, 3 parts of grape pip, 3 parts of dried orange peel.
- 4. the composition with liver-protecting and alcoholism-relieving effect according to claim 2, it is characterised in that：The composition is under The raw material for stating parts by weight is made：15 parts of Phyllanthus embical fruit, 15 parts of papaw, 12 parts of Momordica grosvenori, 10 parts of FLOS CHRYSANTHEMI from Hangzhou of China, 10 parts of the stem of noble dendrobium, Chinese herbaceous peony 10 parts of son, 5 parts of lemon, 5 parts of grape pip, 5 parts of dried orange peel.
- 5. the composition according to claim 1 with liver-protecting and alcoholism-relieving effect, it is characterised in that：The composition is by following The raw material of parts by weight is made：17 parts of Phyllanthus embical fruit, 17 parts of papaw, 13 parts of Momordica grosvenori, 11 parts of FLOS CHRYSANTHEMI from Hangzhou of China, 11 parts of the stem of noble dendrobium, plantain seed 11 parts, 6 parts of lemon, 6 parts of grape pip, 6 parts of dried orange peel.
- 6. the composition according to claim 1, it is characterised in that：The composition is made up of the raw material of following weight parts： 18 parts of Phyllanthus embical fruit, 18 parts of papaw, 15 parts of Momordica grosvenori, 12 parts of FLOS CHRYSANTHEMI from Hangzhou of China, 12 parts of the stem of noble dendrobium, 12 parts of plantain seed, 8 parts of lemon, grape 8 parts of seed, 8 parts of dried orange peel.
- 7. according to any described composition that there is liver-protecting and alcoholism-relieving to act in claim 1-6, it is characterised in that：The original Pharmaceutically acceptable auxiliary material or carrier are added in material, granule, capsule, tablet or oral liquid is made in the composition.
- 8. any described composition with liver-protecting and alcoholism-relieving effect is being prepared with liver-protecting and alcoholism-relieving effect in claim 1-7 Product in application.
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| CN106474380A (en) * | 2016-12-19 | 2017-03-08 | 广州市协裕中药科技有限公司 | There is Chinese medicine composition, preparation of liver-protecting and alcoholism-relieving effect and preparation method thereof |
| CN115715558A (en) * | 2022-11-21 | 2023-02-28 | 淮阴工学院 | Solid beverage for dispelling effects of alcohol and protecting liver and preparation method thereof |
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| CN101703134A (en) * | 2009-12-07 | 2010-05-12 | 刘惠娟 | Health protection tea |
| CN101822402A (en) * | 2010-03-17 | 2010-09-08 | 孙松 | Natural beverage with double effects of sobering-up and dispelling alcohol and preparation method thereof |
| CN102335379A (en) * | 2010-07-20 | 2012-02-01 | 张立中 | Traditional Chinese preparation for relieving alcoholism and protecting livers |
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| CN101703134A (en) * | 2009-12-07 | 2010-05-12 | 刘惠娟 | Health protection tea |
| CN101822402A (en) * | 2010-03-17 | 2010-09-08 | 孙松 | Natural beverage with double effects of sobering-up and dispelling alcohol and preparation method thereof |
| CN102335379A (en) * | 2010-07-20 | 2012-02-01 | 张立中 | Traditional Chinese preparation for relieving alcoholism and protecting livers |
| CN103584077A (en) * | 2012-08-14 | 2014-02-19 | 广西玉林制药集团巨安保健品有限公司 | Health food composition |
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Effective date of registration: 20181218 Address after: 530103 the Guangxi Zhuang Autonomous Region Nanning (Wuming) Yilin Industrial Concentration Zone No. B-2 Patentee after: GUANGXI JIANHUA HEALTH INDUSTRY Co.,Ltd. Address before: 530200 No. 13 Wuhe Avenue, Qingxiu District, Nanning City, Guangxi Zhuang Autonomous Region Patentee before: Guangxi University of Chinese Medicine |
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Address after: 530100 No. B-2, Yiling Industrial Cluster, Nanning (Wuming), Guangxi Zhuang Autonomous Region Patentee after: Guangxi Jianhua Health Industry Co.,Ltd. Address before: 530103 the Guangxi Zhuang Autonomous Region Nanning (Wuming) Yilin Industrial Concentration Zone No. B-2 Patentee before: GUANGXI JIANHUA HEALTH INDUSTRY Co.,Ltd. |
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