CN104666678A - Medicament for treating prostatic hyperplasia and preparation method of medicament - Google Patents

Abstract

The invention relates to a method for preparing a medicament for treating prostatic hyperplasia. The method comprises the following steps: A) taking 17 parts by weight of balsam pear, 7 parts by weight of cape jasmine fruits, 4.5 parts by weight of green tangerine peel, 3.5 parts by weight of Indian mockstrawberrg herb, 9 parts by weight of plantain seeds, 6 parts by weight of linearstripe rabdosia herb, 6 parts by weight of inonotus obliquus, 12 parts by weight of rivier giantarum rhizome and 13 parts by weight of common mallow, and crushing; adding 75% ethanol according to the material-liquid ratio of 1: 7, performing reflux extraction three times, 2 hours per time, filtering and merging filtrates; and concentrating into a thick paste with relative density of 1.30-1.35 (20 DEG C); and B) mixing the thick paste in the step A) with 1.1 parts by weight of vitamin B2, then drying at 40-45 DEG C and preparing into powder. The powder is uniformly stirred and then loaded into capsules for preparing capsules, and each capsule contains 0.33g of the medicament. The administration method is as follows: taking 4 capsules respectively in the morning and evening with warm boiled water.

Description

A kind of medicine for the treatment of prostatic hyperplasia and preparation method thereof

Technical field

The invention belongs to Chinese medicine formula and preparing technical field, be specifically related to a kind of medicine for the treatment of prostatic hyperplasia and preparation method thereof.

Background technology

Row gland hypertrophy (BPH) is one of middle-aging male common disease, cumulative many with population in the world senescence onset of illness.The sickness rate of prostatic hyperplasia increased progressively with the age, but not necessarily had clinical symptoms when having preneoplastic lesions.Cities and towns sickness rate is higher than rural area, and race difference also affects hyperplasia degree.The Symptoms of prostatic hyperplasia is: 1, acraturesis, urine line attenuate and dribbling: cause urine line attenuate because urethra shrivels by hypertrophy prostate, controlled micturition will use larger strength to overcome resistance, along with the development of the state of an illness, also may there is interruption of urinating, the sound of rain pattering symptom such as not to the utmost after urinating., when blocking serious, acute urinary retention can be there is because reason such as urine overlong time or infection etc. of suffering from cold, drink, suppress causes urine to discharge in 2, urine retention: the patients with terminal that prostatic hyperplasia is heavier.3, hematuria: be with blood to be hematuria, also known as hematuria in urine.Under normal circumstances, be not erythrocytic in urine.Medically after patient urine centrifugation, check with microscope, if having the erythrocyte of more than 5 in each high power field, be just hematuria.The treatments such as the multiplex tamsulosin hydrochloride slow releasing capsule of doctor trained in Western medicine, Tamsulosin sheet, traditional Chinese medical science Duo Zhi is with reinforcing the kidney and supporting YANG, clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling etc.

Summary of the invention

The object of this invention is to provide a kind of medicine for the treatment of prostatic hyperplasia and preparation method thereof.

The present invention treats the medicine of prostatic hyperplasia; Be made up of the raw material of following parts by weight: 16 ~ 19 parts, Fructus Momordicae charantiae, SHANZHIZI 6 ~ 8 parts, 4 ~ 5 parts, Pericarpium Citri Reticulatae Viride, Serpentis bubble grass 3 ~ 4 parts, Semen Plantaginis 8 ~ 10 parts, Herba Rabdosiae Lophanthoidis 5 ~ 7 parts, Inonqqus obliquus 5 ~ 7 parts, Rhizoma amorphophalli 11 ~ 13 parts, Radix Malvae sylvestris 12 ~ 15 parts, vitamin B2 1 ~ 1.2 part.

As optimization, the medicine of this treatment prostatic hyperplasia is made up of the raw material of following parts by weight: 17 parts, Fructus Momordicae charantiae, SHANZHIZI 7 parts, 4.5 parts, Pericarpium Citri Reticulatae Viride, Serpentis bubble grass 3.5 parts, Semen Plantaginis 9 parts, Herba Rabdosiae Lophanthoidis 6 parts, Inonqqus obliquus 6 parts, Rhizoma amorphophalli 12 parts, Radix Malvae sylvestris 13 parts, vitamin B2 1.1 parts.

Prepare the method for this treatment prostatic hyperplasia agents, comprise the following steps, by weight:

A, get 17 parts, Fructus Momordicae charantiae, SHANZHIZI 7 parts, 4.5 parts, Pericarpium Citri Reticulatae Viride, Serpentis bubble grass 3.5 parts, Semen Plantaginis 9 parts, Herba Rabdosiae Lophanthoidis 6 parts, Inonqqus obliquus 6 parts, Rhizoma amorphophalli 12 parts, Radix Malvae sylvestris 13 parts pulverize after; According to solid-liquid ratio 1:7, add 75% ethanol, reflux, extract, 3 times, each 2 hours, filter, merging filtrate; Be condensed into the thick paste that relative density is 1.30 ~ 1.35 (20 DEG C);

B, by thick paste in steps A with 1.1 parts vitamin B2 mixing, then 40 ~ 45 DEG C of oven dry, powder process.By powder, in incapsulating after stirring, make capsule.Every capsules explosive payload 0.33 gram.Instructions of taking is for sooner or later respectively taking 4, and warm water is taken.

In Chinese prescription of the present invention, Fructus Momordicae charantiae has clearing summer heat, improving eyesight removing toxic substances, reducing pressure and sugar, diuresis removing heat from blood, separate that labor clears away heart-fire, effect of QI invigorating tonifying YANG; There is cool, thirst-quenching, heat-clearing and toxic substances removing, the improving eyesight that clears away heart-fire, QI invigorating recover from fatigue, the effect of kidney tonifying diuresis; Containing multivitamin, mineral in Fructus Momordicae charantiae, the magistery containing fat eliminating, fat-reducing, can accelerate toxin expelling.

SHANZHIZI nature and flavor are bitter, cold, have heat clearing away, pathogenic fire purging, effect of removing heat from blood; Cure mainly that calentura is vexed, liver-fire conjunctival congestion, headache, damp and hot yellow infantile malnutrition, stranguria, dysentery hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprain and swell and ache.

Pericarpium Citri Reticulatae Viride bitter in the mouth, pungent, warm in nature.There is soothing the liver dispelling the stagnated QI, effect that removing food stagnancyization is stagnant.Can be used for distending pain in the chest and hypochondrium, hernia pain, nodules of the breast, acute mastitis, stagnation of QI due to dyspepsia, the treatment of abdominal distention.

Serpentis steeps careless heat clearing away, removing heat from blood, detumescence, removing toxic substances.Control calentura, infantile convulsion, cough, spit blood, laryngopharynx swelling and pain, dysentery, carbuncle, furuncle, snake bite and insect sting, burn.

Semen Plantaginis has clearing away heat and promoting diuresis treating stranguria, eliminating dampness by diuresis antidiarrheal, improving eyesight, the effect of eliminating the phlegm.Be mainly used in the puckery pain of pyretic stranguria, edema distension, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.For the disease such as edema, dysuria, also have and show effect.

Herba Rabdosiae Lophanthoidis is traditional herbal medicine, is commonly called as Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) etc., has effect of clearing away heat-damp and promoting diuresis, jaundice eliminating damp eliminating, cool the blood dissipate blood stasis, is used for the treatment of the diseases such as acute icterohepatitis, acute cholecystitis, dysentery, enteritis, traumatic injury stasis of blood pain.

Inonqqus obliquus is not only a kind of tonic, and is the cleaning agent of blood and the alleviant of pain; Improve and Polyglucan cortex; There is obvious therapeutical effect to hepatitis, gastritis, duodenal ulcer, nephritis, and have therapeutical effect to vomiting, diarrhoea, gastrointestinal dysfunction.

Rhizoma amorphophalli is cold in nature, pungent; Can blood circulation promoting and blood stasis dispelling, removing toxic substances and promoting subsidence of swelling, wide intestinal relieving constipation, resolving phlegm and softening hard masses; Cure mainly the disease such as blood pressure lowering, blood sugar lowering, scrofula sucutaneous nodule, damage congestive edema, constipation stomachache, laryngopharynx swelling and pain, gingival swelling and pain.In addition, Rhizoma amorphophalli also has and replenishes the calcium, balances the effects such as salinity, clean stomach, whole intestinal, toxin expelling.

Radix Malvae sylvestris is biennial or perennial vertical herbage, has diuresis relieving constipation, effect of heat-clearing and toxic substances removing.Not smooth to defecation; Leukorrhagia; Tuberculous lymphadenitis; The diseases such as laryngopharynx swelling and pain have significant curative effect.All medicine compatibilities, synergism is given prominence to, and YIN nourishing is detoxified, blood circulation promoting and blood stasis dispelling, clearing heat and freeing strangury, diuresis removing heat from blood; The various symptom Be very effective that treatment prostatic hyperplasia causes.

Pertinent clinical data is as follows:

Physical data: in 92 routine cases, the oldest 67 years old, minimum 29 years old, equal per anum referred to that the clinical examination diagnosis such as inspection, B ultrasonic are made a definite diagnosis, ultrasound diagnosis: slight loose 44 examples, loose 36 examples of moderate, loose 12 examples of severe.Residual urine <100mL person 42 example, 100 ~ 200mL person 39 example, 201 ~ 250mL person 10 example; Indwelling catheter person 1 example.

Diagnostic criteria: according to " prostatosis Chinese traditional medical diagnose ", symptom: frequent micturition, urinate and wait for and difficulty goes out, weak stream of urine, nocturia, dribble of urine not to the utmost.Rectal tonch: the prostate that can touch hypertrophy, smooth surface, quality is comparatively hard, and disappearence of central groove, has touched tenderness individually.Color ultrasound examination prompting prostate hypertrophy in various degree.

Therapeutic Method: sooner or later respectively take the embodiment of the present invention 1 capsule 4, warm water is taken, and one month is a course for the treatment of.

Efficacy evaluation: " the Chinese medical disease Standardization of diagnosis and curative effect " issued for 1994 with reference to State Administration of Traditional Chinese Medicine is drafted.Effective: urine is unobstructed, clinical symptoms and sign disappear; Take a turn for the better: clinical symptoms and sign are improved; Invalid: clinical symptoms is without improvement.

After case treatment, curative effect statistical result is as follows:

Detailed description of the invention

The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.

Embodiment 1:A, get 17 grams, Fructus Momordicae charantiae, SHANZHIZI 7 grams, 4.5 grams, Pericarpium Citri Reticulatae Viride, Serpentis bubble grass 3.5 grams, Semen Plantaginis 9 grams, Herba Rabdosiae Lophanthoidis 6 grams, Inonqqus obliquus 6 grams, Rhizoma amorphophalli 12 grams, Radix Malvae sylvestris 13 grams pulverize after; According to solid-liquid ratio 1:7, add 75% ethanol, reflux, extract, 3 times, each 2 hours, filter, merging filtrate; Be condensed into the thick paste that relative density is 1.30 ~ 1.35 (20 DEG C);

B, by thick paste in steps A with the vitamin B of 1.1 grams ₂mixing, then 40 ~ 45 DEG C of oven dry, powder process, after stirring, makes capsule in incapsulating.Every capsules explosive payload 0.33 gram.Instructions of taking is for sooner or later respectively taking 4, and warm water is taken.

Embodiment 2:A, get 16 grams, Fructus Momordicae charantiae, SHANZHIZI 6 grams, 4 grams, Pericarpium Citri Reticulatae Viride, Serpentis bubble grass 3 grams, Semen Plantaginis 8 grams, Herba Rabdosiae Lophanthoidis 5 grams, Inonqqus obliquus 5 grams, Rhizoma amorphophalli 11 grams, Radix Malvae sylvestris 12 grams pulverize after; According to solid-liquid ratio 1:7, add 75% ethanol, reflux, extract, 3 times, each 2 hours, filter, merging filtrate; Be condensed into the thick paste that relative density is 1.30 ~ 1.35 (20 DEG C);

B, by thick paste in steps A with the vitamin B of 1 gram ₂mixing, then 40 ~ 45 DEG C of oven dry, powder process, after stirring, makes capsule in incapsulating.Every capsules explosive payload 0.33 gram.Instructions of taking is for sooner or later respectively taking 4, and warm water is taken.

After embodiment 3:A, 19 grams, Fructus Momordicae charantiae, SHANZHIZI 8 grams, 5 grams, Pericarpium Citri Reticulatae Viride, Serpentis bubble grass 4 grams, Semen Plantaginis 10 grams, Herba Rabdosiae Lophanthoidis 7 grams, Inonqqus obliquus 7 grams, Rhizoma amorphophalli 13 grams, Radix Malvae sylvestris 15 grams are pulverized; According to solid-liquid ratio 1:7, add 75% ethanol, reflux, extract, 3 times, each 2 hours, filter, merging filtrate; Be condensed into the thick paste that relative density is 1.30 ~ 1.35 (20 DEG C);

B, by thick paste in steps A with the vitamin B of 1.2 grams ₂mixing, then 40 ~ 45 DEG C of oven dry, powder process, after stirring, makes capsule in incapsulating.Every capsules explosive payload 0.33 gram.Instructions of taking is for sooner or later respectively taking 4, and warm water is taken.

Claims (3)

1. treat the medicine of prostatic hyperplasia for one kind; It is characterized in that being made up of the raw material of following weight fraction: 16 ~ 19 parts, Fructus Momordicae charantiae, SHANZHIZI 6 ~ 8 parts, 4 ~ 5 parts, Pericarpium Citri Reticulatae Viride, Serpentis bubble grass 3 ~ 4 parts, Semen Plantaginis 8 ~ 10 parts, Herba Rabdosiae Lophanthoidis 5 ~ 7 parts, Inonqqus obliquus 5 ~ 7 parts, Rhizoma amorphophalli 11 ~ 13 parts, Radix Malvae sylvestris 12 ~ 15 parts, vitamin B ₂1 ~ 1.2 part.

2. treat the medicine of prostatic hyperplasia according to claim 1, it is characterized in that being made up of the raw material of following parts by weight: 17 parts, Fructus Momordicae charantiae, SHANZHIZI 7 parts, 4.5 parts, Pericarpium Citri Reticulatae Viride, Serpentis bubble grass 3.5 parts, Semen Plantaginis 9 parts, Herba Rabdosiae Lophanthoidis 6 parts, Inonqqus obliquus 6 parts, Rhizoma amorphophalli 12 parts, Radix Malvae sylvestris 13 parts, vitamin B ₂1.1 part.

3. prepare a method for the treatment of prostatic hyperplasia agents described in claim 2, it is characterized in that comprising the following steps, by weight:

A, get 17 parts, Fructus Momordicae charantiae, SHANZHIZI 7 parts, 4.5 parts, Pericarpium Citri Reticulatae Viride, Serpentis bubble grass 3.5 parts, Semen Plantaginis 9 parts, Herba Rabdosiae Lophanthoidis 6 parts, Inonqqus obliquus 6 parts, Rhizoma amorphophalli 12 parts, Radix Malvae sylvestris 13 parts pulverize after; According to solid-liquid ratio 1:7, add 75% ethanol, reflux, extract, 3 times, each 2 hours, filter, merging filtrate; Be condensed into the thick paste that relative density is 1.30 ~ 1.35 (20 DEG C);

B, by thick paste in steps A with the vitamin B of 1.1 parts ₂mixing, then 40 ~ 45 DEG C of oven dry, powder process.