CN104666544A - Traditional Chinese medicine for treating hepatitis - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating hepatitis. The traditional Chinese medicine is characterized by being prepared from the following raw materials in parts by weight: 10-50 parts of indigowoad root, 20-25 parts of Chinese angelica, 8-10 parts of white paeony root, 10-50 parts of common selfheal fruit-spike, 10-50 parts of virgate wormwood herb, 30-50 parts of radix bupleuri, 20-30 parts of lucid ganoderma, 10-15 parts of Danshen root, 8-12 parts of Chinese magnoliavine fruit, 9-15 parts of gardenia, 20-25 parts of fried amur corktree bark, 30-50 parts of Chinese gentian, 10-20 parts of abrus herb, 30-50 parts of rhubarb, 10-12 parts of plantain herb and 8-12 parts of giant knotweed rhizome. The medicine has the functions of soothing the liver, tonifying the spleen and promoting blood circulation, can be used for treating hepatitis and has good clinical treatment effects and high safety.

Description

A kind of Chinese medicine for the treatment of hepatitis

Technical field

The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine for the treatment of hepatitis.

Background technology

Viral hepatitis (viral heptitis) is that the common transmittable that caused by multiple hepatitis virus is sick, has that infectiousness is strong, route of transmission is complicated, popular wide general, and sickness rate is high comparatively.Main manifestations is weak, loss of appetite clinically, Nausea and vomiting, hepatomegaly and liver function injury, and some patients can have jaundice and heating.There is urticaria, arthralgia or upper airway symptoms in some patient, viral hepatitis divides A type, B-mode, the third type, fourth type and hepatitis E five kinds.Because the current removing to hepatitis virus still lacks ideal medicament, cause many conditions of patients protracteds course of disease, the life and health of serious harm extensive patients.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine for the treatment of hepatitis, this Chinese medicine have that therapeutic effect is good, safety is high, soothing the liver, spleen invigorating, the effect such as to invigorate blood circulation.

Technical scheme of the present invention is: a kind of Chinese medicine for the treatment of hepatitis, is characterized in that: it is made up of the raw material of following portions by weight: Radix Isatidis 10 ~ 50 parts, Radix Angelicae Sinensis 20 ~ 25 parts, the Radix Paeoniae Alba 8 ~ 10 parts, Spica Prunellae 10 ~ 50 parts, Herba Artemisiae Scopariae 10 ~ 50 parts, Radix Bupleuri 30 ~ 50 parts, Ganoderma 20 ~ 30 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Fructus Schisandrae Chinensis 8 ~ 12 parts, gardenia9 ~ 15 parts, cortex Phellodendri (parched)20 ~ 25 parts, radix Gentianae30 ~ 50 parts, herba Abri10 ~ 20 parts, Radix Et Rhizoma Rhei 30 ~ 50 parts, Herba Plantaginis 10 ~ 12 parts and Rhizoma Polygoni Cuspidati 8 ~ 12 parts.

Described a kind of preparation method for the treatment of the Chinese medicine of hepatitis comprises the steps:

1), raw material is taken by following portions by weight:

Radix Isatidis 10 ~ 50 parts, Radix Angelicae Sinensis 20 ~ 25 parts, the Radix Paeoniae Alba 8 ~ 10 parts, Spica Prunellae 10 ~ 50 parts, Herba Artemisiae Scopariae 10 ~ 50 parts, Radix Bupleuri 30 ~ 50 parts, Ganoderma 20 ~ 30 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Fructus Schisandrae Chinensis 8 ~ 12 parts, gardenia9 ~ 15 parts, cortex Phellodendri (parched)20 ~ 25 parts, radix Gentianae30 ~ 50 parts, herba Abri10 ~ 20 parts, Radix Et Rhizoma Rhei 30 ~ 50 parts, Herba Plantaginis 10 ~ 12 parts and Rhizoma Polygoni Cuspidati 8 ~ 12 parts;

2), by the Radix Isatidis of above-mentioned weight portion, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Spica Prunellae, Herba Artemisiae Scopariae, Radix Bupleuri, Ganoderma, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis 150 object fine powders were broken into, and mix homogeneously, for subsequent use;

3), by above-mentioned weight portion gardenia, cortex Phellodendri (parched), radix Gentianae, herba Abri, Radix Et Rhizoma Rhei, Herba Plantaginis and Rhizoma Polygoni Cuspidati be broken into 100 object coarse powder, and by after its mix homogeneously, adding is 85% ethanol of its weight 8-12 times amount, heating-up temperature 65 DEG C, reflux, extract, 1-3 time, each extraction 0.5-2 hour, filter, merging filtrate, reclaims ethanol, and is concentrated in 60 DEG C the thick paste that relative density is 1.36-1.38;

4), by step 2) after the thick paste that obtains of the fine powder that mixes, step 3) stirs, adding is 85% ethanol of its weight 2 times amount, heating-up temperature 65 DEG C, reflux, extract, 1-3 time, each extraction 0.5 hour, filters, merging filtrate, reclaim ethanol, and be concentrated in 60 DEG C the thick paste that relative density is 1.36-1.38;

5), by the thick paste of step 4) gained dry, pulverize into 150 object fine powders.

Advantage of the present invention is: Chinese medicine of the present invention can be applicable to treat hepatitis, particularly chronic hepatitis B, has effect of soothing liver and strengthening spleen, " Fuzheng Huoxue.Chinese medicine of the present invention selects Radix Bupleuri to be that monarch's dispersing the stagnated live-QI to relieve the stagnation of QI is with suitable liver property, minister is with Ganoderma lucidum (Leyss. Ex Fr.) Karst., and invigorating middle warmer strengthening the spleen is with ridging, and get the meaning of " seeing the disease of liver; tonifying the spleen in the ban; knowing the liver disease will be transmitted into the spleen ", Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling is helped mutually with Radix Bupleuri, gas one blood, QI and blood is adjusted smooth, in addition " simply, merit is with four things for Radix Salviae Miltiorrhizae ", nourishing blood and promoting blood circulation; Assistant is with Fructus Schisandrae Chinensis, and the five tastes are known all, and acid is salty is main, sour to enter liver, YIN nourishing nourishing the liver, suitable walk kidney, replenishing the kidney(water)to nourish the liver(wood), Liver and kidney yi and Kui are derived from the same origin, essence and blood provides mutually, 5, one loose one receives mutually with Radix Bupleuri, pungent with loose strange gas, acid, to hold back liver kidney tonifying, is opposed each other and yet also complement each other, and has both made irritability adjust smooth, has made again essence and blood abundant; radix Gentianaebitter in the mouth, cold in nature, return liver, gallbladder meridian; Function: clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; The Chinese angelica blood supplementing effect of invigorating blood circulation; All medicines share, giving consideration to both the incidental and fundamental, eliminating evil and just do not hinder, righting and do not love heresy, gather the merit of soothing liver and strengthening spleen " Fuzheng Huoxue altogether.

Detailed description of the invention

Can the present invention be further illustrated below by the specific embodiment provided, but not as a limitation of the invention.

embodiment 1

A kind of preparation method for the treatment of the Chinese medicine of hepatitis comprises the steps:

1), raw material is taken by following portions by weight:

Radix Isatidis 10g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 8g, Spica Prunellae 10g, Herba Artemisiae Scopariae 10g, Radix Bupleuri 30g, Ganoderma 20g, Radix Salviae Miltiorrhizae 10g, Fructus Schisandrae Chinensis 8g, gardenia9g, cortex Phellodendri (parched)20g, radix Gentianae30g, herba Abri10g, Radix Et Rhizoma Rhei 30g, Herba Plantaginis 10g and Rhizoma Polygoni Cuspidati 8g;

2), by the Radix Isatidis of above-mentioned weight, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Spica Prunellae, Herba Artemisiae Scopariae, Radix Bupleuri, Ganoderma, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis 150 object fine powders were broken into, and mix homogeneously, for subsequent use;

3), by above-mentioned weight gardenia, cortex Phellodendri (parched), radix Gentianae, herba Abri, Radix Et Rhizoma Rhei, Herba Plantaginis and Rhizoma Polygoni Cuspidati be broken into 100 object coarse powder, and by after its mix homogeneously, adding is 85% ethanol of its weight 8-12 times amount, heating-up temperature 65 DEG C, reflux, extract, 1-3 time, each extraction 0.5-2 hour, filter, merging filtrate, reclaims ethanol, and is concentrated in 60 DEG C the thick paste that relative density is 1.36-1.38;

4), by step 2) after the thick paste that obtains of the fine powder that mixes, step 3) stirs, adding is 85% ethanol of its weight 2 times amount, heating-up temperature 65 DEG C, reflux, extract, 1-3 time, each extraction 0.5 hour, filters, merging filtrate, reclaim ethanol, and be concentrated in 60 DEG C the thick paste that relative density is 1.36-1.38;

5), by the thick paste of step 4) gained dry, pulverize into 150 object fine powders, and incapsulated, make capsule.

Preparation of the present invention is not limited only to above-mentioned capsule, can also be prepared into tablet, oral liquid, granule and pill.

Capsule of the present invention (0.35g/ grain) is containing active ingredient 0.35g, and an oral 5-6 grain, 3 times on the 1st, serveing on 4 weeks was 1 course for the treatment of.

embodiment 2

Substantially identical with embodiment 1, difference is: the Chinese medicine for the treatment of hepatitis is made up of the raw material of following portions by weight: Radix Isatidis 20g, Radix Angelicae Sinensis 22g, Radix Paeoniae Alba 9g, Spica Prunellae 30g, Herba Artemisiae Scopariae 30g, Radix Bupleuri 35g, Ganoderma 25g, Radix Salviae Miltiorrhizae 12g, Fructus Schisandrae Chinensis 10g, gardenia10g, cortex Phellodendri (parched)22g, radix Gentianae35g, herba Abri15g, Radix Et Rhizoma Rhei 35g, Herba Plantaginis 11g and Rhizoma Polygoni Cuspidati 10g.

embodiment 3

Substantially identical with embodiment 11, difference is: the Chinese medicine for the treatment of hepatitis is made up of the raw material of following portions by weight: Radix Isatidis 50g, Radix Angelicae Sinensis 25g, Radix Paeoniae Alba 10g, Spica Prunellae 50g, Herba Artemisiae Scopariae 50g, Radix Bupleuri 50g, Ganoderma 30g, Radix Salviae Miltiorrhizae 15g, Fructus Schisandrae Chinensis 12g, gardenia15g, cortex Phellodendri (parched)25g, radix Gentianae50g, herba Abri20g, Radix Et Rhizoma Rhei 50g, Herba Plantaginis 12g and Rhizoma Polygoni Cuspidati 12g.

In order to show the therapeutic effect of medicine of the present invention, invention has been animal experiment.In test, medicine of the present invention used is the capsule adopting embodiment 1 obtained, and specification is every and contains active ingredient 0.35g.Show that the present invention can resist the hepatic necrosis caused by the lipid peroxidation of CCl4 effectively, significantly can block the hepatic injury of D-GalN induced murine chronic, reduce D-GalN, LPS induced damage primary rat hepatocyte significantly.The mediated damage of blocks cellular factor pair hepatocyte effectively.The present invention can alleviate liver tissue injury, alanine aminotransferase (ALT) and Aspartic Acid transferring enzyme (AST) activity in remarkable suppression immunological liver injury, raise liver homogenate NO level simultaneously, make it to be tending towards normal, in hepatic tissue, TNF shows strong positive, Fn shows the weak positive, and Kupffer cellular mast hypertrophy, endotheliocyte is activated.Endotoxic removing in energy acceleration bodies of the present invention, the process stablized liver plasma membrane, stop TNF and Fn participation hepatic injury.The present invention significantly can reduce AST, ALT, ALP, MAO(P<0.01 in rats with liver cirrhosis serum).The long term toxicity test result of acute toxicity testing of the present invention and 6 months does not find overt toxicity effect.

For further illustrating the beneficial effect of medicine of the present invention, adopt the clinical observation test of the Drug therapy hepatitis patient of the embodiment of the present invention 1.

Adopt random, Double-blind double-dummy test method, select age 18-65 year sex case 240 example, treatment group and matched group is divided into be respectively 120 examples at random, Chinese medical discrimination is that stagnation of liver-QI with deficiency of the spleen is held concurrently syndrome of blood stasis, Western medicine diagnose meets chronic hepatitis B, has all carried out routine blood test, routine urinalysis, just routine, liver function, renal function, B ultrasonic and Electrocardioscopy have liver dysfunction (ALT >=2-5 times of normal value) before and after two groups of patient.The treatment group medicine of the embodiment of the present invention 1, matched group is used guanule contg. ' Jigucao granule, every day of the present invention 3 times, each 5; Matched group every day 3 times, once a bag; All serveing on 4 weeks was 1 course for the treatment of.

Effective: the one or more declines in enzyme, ALT, AST, GGT.

Table 1 embodiment of the present invention treatment effectiveness comparison after 4 weeks

Clinical test results shows: the therapeutic effect of the embodiment of the present invention 1 is better than guanule contg. ' Jigucao granule.The Chinese medicine of the embodiment of the present invention 1 is not shown in untoward reaction.Doing identical animal experiment and clinical observation by embodiment 2 and 3, to test its effect consistent with embodiment 1.

Claims (2)

1. treat a Chinese medicine for hepatitis, it is characterized in that: it is made up of the raw material of following portions by weight: Radix Isatidis 10 ~ 50 parts, Radix Angelicae Sinensis 20 ~ 25 parts, the Radix Paeoniae Alba 8 ~ 10 parts, Spica Prunellae 10 ~ 50 parts, Herba Artemisiae Scopariae 10 ~ 50 parts, Radix Bupleuri 30 ~ 50 parts, Ganoderma 20 ~ 30 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Fructus Schisandrae Chinensis 8 ~ 12 parts, Gardenia 9 ~ 15 parts, Cortex Phellodendri (parched) 20 ~ 25 parts, Radix Gentianae 30 ~ 50 parts, Herba Abri 10 ~ 20 parts, Radix Et Rhizoma Rhei 30 ~ 50 parts, Herba Plantaginis 10 ~ 12 parts and Rhizoma Polygoni Cuspidati 8 ~ 12 parts.

2. a kind of Chinese medicine for the treatment of hepatitis according to claim 1, is characterized in that: its preparation method comprises the steps:

1), raw material is taken by following portions by weight:

Radix Isatidis 10 ~ 50 parts, Radix Angelicae Sinensis 20 ~ 25 parts, the Radix Paeoniae Alba 8 ~ 10 parts, Spica Prunellae 10 ~ 50 parts, Herba Artemisiae Scopariae 10 ~ 50 parts, Radix Bupleuri 30 ~ 50 parts, Ganoderma 20 ~ 30 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Fructus Schisandrae Chinensis 8 ~ 12 parts, Gardenia 9 ~ 15 parts, Cortex Phellodendri (parched) 20 ~ 25 parts, Radix Gentianae 30 ~ 50 parts, Herba Abri 10 ~ 20 parts, Radix Et Rhizoma Rhei 30 ~ 50 parts, Herba Plantaginis 10 ~ 12 parts and Rhizoma Polygoni Cuspidati 8 ~ 12 parts;

2), by the Radix Isatidis of above-mentioned weight portion, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Spica Prunellae, Herba Artemisiae Scopariae, Radix Bupleuri, Ganoderma, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis 150 object fine powders were broken into, and mix homogeneously, for subsequent use;

3), the Gardenia of above-mentioned weight portion, Cortex Phellodendri (parched), Radix Gentianae, Herba Abri, Radix Et Rhizoma Rhei, Herba Plantaginis and Rhizoma Polygoni Cuspidati were broken into 100 object coarse powder, and by after its mix homogeneously, adding is 85% ethanol of its weight 8-12 times amount, heating-up temperature 65 DEG C, reflux, extract, 1-3 time, each extraction 0.5-2 hour, filter, merging filtrate, reclaims ethanol, and is concentrated in 60 DEG C the thick paste that relative density is 1.36-1.38;

4), by step 2) after the thick paste that obtains of the fine powder that mixes, step 3) stirs, adding is 85% ethanol of its weight 2 times amount, heating-up temperature 65 DEG C, reflux, extract, 1-3 time, each extraction 0.5 hour, filters, merging filtrate, reclaim ethanol, and be concentrated in 60 DEG C the thick paste that relative density is 1.36-1.38;

5), by the thick paste of step 4) gained dry, pulverize into 150 object fine powders.