CN104666543A - Traditional Chinese medicine decoction for treating hepatitis - Google Patents
Traditional Chinese medicine decoction for treating hepatitis Download PDFInfo
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- CN104666543A CN104666543A CN201310629837.8A CN201310629837A CN104666543A CN 104666543 A CN104666543 A CN 104666543A CN 201310629837 A CN201310629837 A CN 201310629837A CN 104666543 A CN104666543 A CN 104666543A
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Abstract
The invention relates to a traditional Chinese medicine decoction for treating hepatitis. The traditional Chinese medicine decoction is characterized by being prepared from the following raw materials in parts by weights: 10-35 parts of astragalus membranaceus, 10-50 parts of radix isatidis, 20-25 parts of angelica sinensis, 8-10 parts of white paeony root, 10-50 parts of selfheal, 10-50 parts of herba artemisiae scopariae, 30-50 parts of radix bupleuri, 18-50 parts of incised notopterygium, 5-10 parts of American ginseng, 10-20 parts of polygonum multiflorum, 50-60 parts of purple perilla, 20-30 parts of ganoderma lucidum, 10-15 parts of salviae miltiorrhizae, 8-12 parts of schisandra chinensis, 9-15 parts of gardenia, 20-25 parts of fried cortex phellodendri, 10-20 parts of abrus cantoniensis hance and 10-12 parts of plantain herb. The traditional Chinese medicine decoction has the efficacies of soothing the liver, tonifying the spleen and activating blood circulation, can be applied to treatment of hepatitis, and is good in clinical treatment effect and high in safety.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine decoction for the treatment of hepatitis.
Background technology
Viral hepatitis (viral heptitis) is that the common transmittable that caused by multiple hepatitis virus is sick, has that infectiousness is strong, route of transmission is complicated, popular wide general, and sickness rate is high comparatively.Main manifestations is weak, loss of appetite clinically, Nausea and vomiting, hepatomegaly and liver function injury, and some patients can have jaundice and heating.There is urticaria, arthralgia or upper airway symptoms in some patient, viral hepatitis divides A type, B-mode, the third type, fourth type and hepatitis E five kinds.Because the current removing to hepatitis virus still lacks ideal medicament, cause many conditions of patients protracteds course of disease, the life and health of serious harm extensive patients.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine decoction for the treatment of hepatitis, this Chinese medicine have that therapeutic effect is good, safety is high, soothing the liver, spleen invigorating, the effect such as to invigorate blood circulation.
Technical scheme of the present invention is: a kind of Chinese medicine decoction for the treatment of hepatitis, is characterized in that: it is made up of the raw material of following portions by weight: Radix Astragali 10-35 part, Radix Isatidis 10 ~ 50 parts, Radix Angelicae Sinensis 20 ~ 25 parts, the Radix Paeoniae Alba 8 ~ 10 parts, Spica Prunellae 10 ~ 50 parts, Herba Artemisiae Scopariae 10 ~ 50 parts, Radix Bupleuri 30 ~ 50 parts, the only 18-50 part of Qiang, Radix Panacis Quinquefolii 5-10 parts, Radix Polygoni Multiflori 10-20 part, Folium Perillae 50-60 part, Ganoderma 20 ~ 30 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Fructus Schisandrae Chinensis 8 ~ 12 parts,
gardenia9 ~ 15 parts,
cortex Phellodendri (parched)20 ~ 25 parts,
herba Abri10 ~ 20 parts and Herba Plantaginis 10 ~ 12 parts.
Described a kind of compound method for the treatment of the Chinese medicine decoction of hepatitis is: by the Radix Astragali of formula ratio, Radix Isatidis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Spica Prunellae, Herba Artemisiae Scopariae, Radix Bupleuri, Qiang solely, Radix Panacis Quinquefolii, Radix Polygoni Multiflori, Folium Perillae, Ganoderma, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis,
gardenia,
cortex Phellodendri (parched),
herba Abrisoak 30 minutes with Herba Plantaginis, decoct with water three times, first time adds 12 times of water gagings, decocts 1 hour; Second time adds 10 times of water gagings, decocts 1.5 hours; Third time adds 8 times of water gagings, decocts 0.5 hour, merges three decocting liquids, filters.
Advantage of the present invention is: Chinese medicine of the present invention can be applicable to treat hepatitis, particularly chronic hepatitis B, has effect of soothing liver and strengthening spleen, " Fuzheng Huoxue.Chinese medicine of the present invention selects Radix Bupleuri to be that monarch's dispersing the stagnated live-QI to relieve the stagnation of QI is with suitable liver property, minister is with Ganoderma lucidum (Leyss. Ex Fr.) Karst., and invigorating middle warmer strengthening the spleen is with ridging, and get the meaning of " seeing the disease of liver; tonifying the spleen in the ban; knowing the liver disease will be transmitted into the spleen ", Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling is helped mutually with Radix Bupleuri, gas one blood, QI and blood is adjusted smooth, in addition " simply, merit is with four things for Radix Salviae Miltiorrhizae ", nourishing blood and promoting blood circulation; Assistant is with Fructus Schisandrae Chinensis, and the five tastes are known all, and acid is salty is main, sour to enter liver, YIN nourishing nourishing the liver, suitable walk kidney, replenishing the kidney(water)to nourish the liver(wood), Liver and kidney yi and Kui are derived from the same origin, essence and blood provides mutually, 5, one loose one receives mutually with Radix Bupleuri, pungent with loose strange gas, acid, to hold back liver kidney tonifying, is opposed each other and yet also complement each other, and has both made irritability adjust smooth, has made again essence and blood abundant;
herba Abribitter in the mouth, cold in nature, return liver, gallbladder meridian; Function: soothing liver and strengthening spleen; The Chinese angelica blood supplementing effect of invigorating blood circulation; All medicines share, giving consideration to both the incidental and fundamental, eliminating evil and just do not hinder, righting and do not love heresy, gather the merit of soothing liver and strengthening spleen " Fuzheng Huoxue altogether.
Detailed description of the invention
Can the present invention be further illustrated below by the specific embodiment provided, but not as a limitation of the invention.
embodiment 1
A kind of preparation method for the treatment of the Chinese medicine decoction of hepatitis comprises the steps:
By Radix Astragali 10g, Radix Isatidis 10g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 8g, Spica Prunellae 10g, Herba Artemisiae Scopariae 10g, Radix Bupleuri 30g, the only 18g of Qiang, Radix Panacis Quinquefolii 5g, Radix Polygoni Multiflori 10g, Folium Perillae 50g, Ganoderma 20g, Radix Salviae Miltiorrhizae 10g, Fructus Schisandrae Chinensis 8g,
gardenia9g,
cortex Phellodendri (parched)20g,
herba Abri10g and Herba Plantaginis 10g soaks 30 minutes, decocts with water three times, and first time adds 12 times of water gagings, decocts 1 hour; Second time adds 10 times of water gagings, decocts 1.5 hours; Third time adds 8 times of water gagings, decocts 0.5 hour, merges three decocting liquids, filters.
Chinese medicine decoction of the present invention, 3 times on the oral one, serveing on 4 weeks was 1 course for the treatment of.
embodiment 2
Substantially identical with embodiment 1, difference is: treatment hepatitis Chinese medicine decoction be made up of the raw material of following weight: Radix Astragali 35g, Radix Isatidis 50g, Radix Angelicae Sinensis 25g, Radix Paeoniae Alba 10g, Spica Prunellae 50g, Herba Artemisiae Scopariae 50g, Radix Bupleuri 50g, the only 50g of Qiang, Radix Panacis Quinquefolii 10g, Radix Polygoni Multiflori 20 g, Folium Perillae 60g, Ganoderma 30g, Radix Salviae Miltiorrhizae 15g, Fructus Schisandrae Chinensis 12g,
gardenia15g,
cortex Phellodendri (parched)25g,
herba Abri20g and Herba Plantaginis 12g.
embodiment 3
Substantially identical with embodiment 1, difference is: treatment hepatitis Chinese medicine decoction be made up of the raw material of following portions by weight: Radix Astragali 25g, Radix Isatidis 20g, Radix Angelicae Sinensis 23g, Radix Paeoniae Alba 9g, Spica Prunellae 20g, Herba Artemisiae Scopariae 20g, Radix Bupleuri 35g, the only 20g of Qiang, Radix Panacis Quinquefolii 8g, Radix Polygoni Multiflori 15g, Folium Perillae 55g, Ganoderma 25g, Radix Salviae Miltiorrhizae 12g, Fructus Schisandrae Chinensis 10g,
gardenia10g,
cortex Phellodendri (parched)22g,
herba Abri15g and Herba Plantaginis 11g.
In order to show the therapeutic effect of medicine of the present invention, invention has been animal experiment.In test, medicine of the present invention used is the decoction adopting embodiment 1 obtained, and 3 times on the oral one, serveing on 4 weeks was 1 course for the treatment of.Show that the present invention can resist the hepatic necrosis caused by the lipid peroxidation of CCl4 effectively, significantly can block the hepatic injury of D-GalN induced murine chronic, reduce D-GalN, LPS induced damage primary rat hepatocyte significantly.The mediated damage of blocks cellular factor pair hepatocyte effectively.The present invention can alleviate liver tissue injury, alanine aminotransferase (ALT) and Aspartic Acid transferring enzyme (AST) activity in remarkable suppression immunological liver injury, raise liver homogenate NO level simultaneously, make it to be tending towards normal, in hepatic tissue, TNF shows strong positive, Fn shows the weak positive, and Kupffer cellular mast hypertrophy, endotheliocyte is activated.Endotoxic removing in energy acceleration bodies of the present invention, the process stablized liver plasma membrane, stop TNF and Fn participation hepatic injury.The present invention significantly can reduce AST, ALT, ALP, MAO(P<0.01 in rats with liver cirrhosis serum).The long term toxicity test result of acute toxicity testing of the present invention and 6 months does not find overt toxicity effect.
For further illustrating the beneficial effect of medicine decoction of the present invention, adopt the clinical observation test of the medicine decoction treatment hepatitis patient of the embodiment of the present invention 1.
Adopt random, Double-blind double-dummy test method, select age 18-65 year sex case 100 example, treatment group and matched group is divided into be respectively 50 examples at random, Chinese medical discrimination is that stagnation of liver-QI with deficiency of the spleen is held concurrently syndrome of blood stasis, Western medicine diagnose meets chronic hepatitis B, has all carried out routine blood test, routine urinalysis, just routine, liver function, renal function, B ultrasonic and Electrocardioscopy have liver dysfunction (ALT >=2-5 times of normal value) before and after two groups of patient.The treatment group medicine of the embodiment of the present invention 1, matched group is used
guanule contg. ' Jigucao granule, every day of the present invention 3 times; Matched group every day 3 times, once a bag; All serveing on 4 weeks was 1 course for the treatment of.
Effective: the one or more declines in enzyme, ALT, AST, GGT.
Table 1 embodiment of the present invention treatment effectiveness comparison after 4 weeks
Clinical test results shows: the therapeutic effect of the embodiment of the present invention 1 is better than
guanule contg. ' Jigucao granule.The Chinese medicine of the embodiment of the present invention 1 is not shown in untoward reaction.Doing identical animal experiment and clinical observation by embodiment 2 and 3, to test its effect consistent with embodiment 1.
Claims (2)
1. treat a Chinese medicine decoction for hepatitis, it is characterized in that: it is made up of the raw material of following portions by weight: Radix Astragali 10-35 part, Radix Isatidis 10 ~ 50 parts, Radix Angelicae Sinensis 20 ~ 25 parts, the Radix Paeoniae Alba 8 ~ 10 parts, Spica Prunellae 10 ~ 50 parts, Herba Artemisiae Scopariae 10 ~ 50 parts, Radix Bupleuri 30 ~ 50 parts, the only 18-50 part of Qiang, Radix Panacis Quinquefolii 5-10 parts, Radix Polygoni Multiflori 10-20 part, Folium Perillae 50-60 part, Ganoderma 20 ~ 30 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Fructus Schisandrae Chinensis 8 ~ 12 parts, Gardenia 9 ~ 15 parts, Cortex Phellodendri (parched) 20 ~ 25 parts, Herba Abri 10 ~ 20 parts and Herba Plantaginis 10 ~ 12 parts.
2. a kind of Chinese medicine decoction for the treatment of hepatitis according to claim 1, it is characterized in that: its compound method is: by the Radix Astragali of formula ratio, Radix Isatidis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Spica Prunellae, Herba Artemisiae Scopariae, Radix Bupleuri, Qiang solely, Radix Panacis Quinquefolii, Radix Polygoni Multiflori, Folium Perillae, Ganoderma, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Gardenia, Cortex Phellodendri (parched), Herba Abri and Herba Plantaginis soak 30 minutes, decoct with water three times, first time adds 12 times of water gagings, decocts 1 hour; Second time adds 10 times of water gagings, decocts 1.5 hours; Third time adds 8 times of water gagings, decocts 0.5 hour, merges three decocting liquids, filters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310629837.8A CN104666543A (en) | 2013-12-02 | 2013-12-02 | Traditional Chinese medicine decoction for treating hepatitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310629837.8A CN104666543A (en) | 2013-12-02 | 2013-12-02 | Traditional Chinese medicine decoction for treating hepatitis |
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| Publication Number | Publication Date |
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| CN104666543A true CN104666543A (en) | 2015-06-03 |
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| CN201310629837.8A Withdrawn CN104666543A (en) | 2013-12-02 | 2013-12-02 | Traditional Chinese medicine decoction for treating hepatitis |
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| CN (1) | CN104666543A (en) |
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2013
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Application publication date: 20150603 |