CN104666181A - Sunburn-protecting comfortable body lotion - Google Patents
Sunburn-protecting comfortable body lotion Download PDFInfo
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- CN104666181A CN104666181A CN201510065262.0A CN201510065262A CN104666181A CN 104666181 A CN104666181 A CN 104666181A CN 201510065262 A CN201510065262 A CN 201510065262A CN 104666181 A CN104666181 A CN 104666181A
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Abstract
The invention relates to the field of daily chemicals and in particular relates to sunburn-protecting comfortable body lotion. The sunburn-protecting comfortable body lotion comprises the following components in percentage by weight: 15-45 percent of tanshinone nanoemulsion, 3-15 percent of titanium dioxide, 1-5 percent of magnesium aluminum silicate, 0.1-2 percent of xanthan gum, 3-10 percent of talcum powder, 3-10 percent of propylene glycol, 2-5 percent of cetanol, 0.2-5 percent of lanolin alcohol, 0.5-2 percent of microcrystalline wax, 0.2-1 percent of polyvinylpyrrolidone and the balance of water, totaling 100 percent. The sunburn-protecting comfortable body lotion provided by the invention provides a comfortable feeling during use, is low in irritation and safe to human skin, has a broad-spectrum anti-ultraviolet radiation function, is suitable for the skin of the whole body and can achieve a sunburn-protecting effect. In addition, the body lotion can scavenge free radicals, resisting oxidation and nourishing the skin and has the effects of moisturizing and nourishing, converging, resisting aging and the like.
Description
Technical field
The present invention relates to household chemicals field, particularly the pleasant profit precursor emulsion of the anti-sunburn of one.
Background technology
Skin aging is an extremely complicated process, is namely a part for endogenic body aging, again by the impact of the multiple factors such as ectogenic optical heat radiation, life style, diet, emotion, hormonal readiness.Wherein ultraviolet radiation, has been identified as the one of the main reasons of skin aging.From molecular biology angle, ultraviolet radiation can cause two adjacent pyrimidines to be cross-linked with each other, and forms pyrimidine dimer, thus makes the three-dimensional conformation generation significant change of DNA, blocks copying and transcribing of damaged part DNA.Macroscopic view, long wave ultraviolet (UVA 320-400nm) can accelerate that melanocyte changes melanic process into by tyrosine, brings out photosensitization, multiform hot spot rash, chronic photochemical dermatitis, honor measles, lupus erythematosus, skin photomodification and phototoxic reaction.Ultraviolet B radiation (UVB 280-320nm) can make nucleic acid in skin epidermal cells or protein denaturation, and acute dermatitis occurs, and red and swollen, water scar and decortication phenomenon appear in skin, namely play erythema effect.
TANSHINONES (Tanshione) is the fat-soluble effective ingredient in salviamiltiorrhizabung, can promote that antioxidant reductase synthesizes, make catalase in blood (CAT), glutathion peroxidase (GSH-Px) vigor, in skin, SOD vigor strengthens, and improves cell clearance H
2o
2and O2
-ability, Cell protection from radical damage, and can make fibroblasts strengthen, and collagen protein synthesis increases, and slow down aging process; TANSHINONES has Ca again
2+antagonist action, can stop Ca
2+enter in cell, suppress xanthine dehydrogenase to change to xanthine oxidase, reduce free radical and produce; In addition, TANSHINONES has again slight estrogen action, is also improved effect to skin aging.
TANSHINONES poorly water-soluble, and see light, heat easily decomposes, and is subject to a definite limitation in field of household chemical such as cosmetics.By liposome technology, TANSHINONES solubility can be solved, but method for preparing lipidosome is generally complicated, and relates to organic solvent and the final problem removed.
Nano-emulsion (also known as microemulsion), the emulsion droplet of to be particle diameter be 10 ~ 100nm is dispersed in the dispersion system of colloid formed in another kind of liquid, its emulsion droplet mostly is spherical, size is more even, transparent or semitransparent, through the sub-sterilizing of heat or centrifugally layering can not be made it, usually belong to thermodynamically metastable fixed system; And submicron emulsion particle diameter is between 100 ~ 500nm, outward appearance is opaque, and in muddy or emulsus, be Heterodisperse system, thermodynamics and dynamics is all unstable.
Publication number is that the application for a patent for invention of CN102688151A discloses a kind of tanshinone microemulsion, can apply with anti-acne in flat trace cosmetics.
Publication number is that the application for a patent for invention of CN102293744A discloses a kind of Brain targeting TANSHINONES oral oil bag oil nanometer emulsion, is suitable for prevention and therapy cerebrovascular disease and central nervous system disease.
At present, TANSHINONES mainly uses in field of medicaments, fewer about the application example of TANSHINONES in cosmetic field.The chemical composition of Radix Salviae Miltiorrhizae is numerous, and especially red sage root water soluble ingredient has the extensively pharmacological action of complexity, as Radix Salviae Miltiorrhizae enzyme acid B has natural anti-oxidation concurrently, anti-inflammation, improves microcirculation, defying age, anti-acne and enhancing metabolism.But due to the complexity of effective component in red sage and the complexity of each composition mechanism of action, people are also incomplete for the Application and Development of the various composition of Radix Salviae Miltiorrhizae, application in beauty and skin care is also comparatively rare at present, and these all await the further further investigation of people.
Publication number is that the application for a patent for invention of CN104135993A discloses a kind of fast light sunscreen composition comprising opacifier stabilizing agent, and it preferably extracts from natural material, guarantees the long-term efficacy of the UV-A Organic sunscreens wherein used simultaneously.
Publication number is that the application for a patent for invention of 103550104A discloses a kind of anti-senile preparation and cosmetics, discloses the application of TANSHINONES in anti-senile preparation.
Summary of the invention
The object of this invention is to provide a kind of sunscreen product, in particular, provide the pleasant profit precursor emulsion of a kind of anti-sunburn, described anti-sunburn pleasant profit precursor emulsion belongs to anti-sunburn cosmetics.
To achieve the object of the present invention, the technical scheme that concrete employing is following: a kind of anti-sunburn cosmetics, its raw material percentage composition by weight, comprises the tanshinone nano breast of 5 ~ 50% and the ultraviolet scattering diluent of 1 ~ 30%; Described tanshinone nano Ruzhong, the weight percentage of TANSHINONES is 0.05 ~ 5%.
Preferably, its raw material percentage composition by weight, comprises the tanshinone nano breast of 15 ~ 45% and the ultraviolet scattering diluent of 3 ~ 20%; Described tanshinone nano Ruzhong, the weight percentage of TANSHINONES is 0.1 ~ 1%.
As the preferred forms of tanshinone nano breast, described tanshinone nano breast by weight, comprises 1 part of TANSHINONES, 1.5 parts of phospholipid, 15 parts of caprylic/capric triglyceride, 0.5 part of polyglycerol monooleate, 1 part of Tween 80,1 part of Labraso, 73 parts of glycerol, 7 parts of water.
Further, the preparation method of described tanshinone nano breast comprises the following steps:
(1) by phospholipid, caprylic/capric triglyceride, polyglycerol monooleate, Tween 80, Labraso mixing, high speed shear, without the visible solid content of naked eyes to system;
(2) TANSHINONES joined in step (1) products therefrom, the system that is stirred to is limpid transparent;
(3) join in step (2) products therefrom by glycerol, water, high speed shear, after obtaining colostrum, high pressure homogenizer process, obtains tanshinone nano breast.
Concrete, described ultraviolet scattering diluent is selected from one or more in titanium dioxide, zinc oxide, ferrum oxide, ferrous oxide, cerium oxide germanium, Magnesiumaluminumsilicate, Muscovitum, Kaolin, Pulvis Talci or calcium carbonate.
The present invention is not containing ultraviolet absorber; have the advantages that safety is high; the mechanism of action of the present invention eliminates interior free yl by TANSHINONES, and by the physical action of ultraviolet scattering diluent to ultraviolet reflection and scattering, protection skin exempts from the injury that ultraviolet radiation causes.In addition, the present invention, using nano-emulsion as TANSHINONES carrier, strengthens the stability of TANSHINONES thus, and by it and ultraviolet scattering diluent efficient combination.
The anti-sunburn cosmetics that the present invention is above-mentioned, also comprise and utilize the conventional matrix composition of cosmetics to become the pleasant profit precursor emulsion of anti-sunburn or suntan lotion.
The pleasant profit precursor emulsion of the first anti-sunburn of the present invention, percentage composition by weight, shown in it is composed as follows:
Preferably, percentage composition by weight, it is composed as follows:
The preparation method of this anti-sunburn pleasant profit precursor emulsion can select any-mode of the prior art, preferably adopts following preparation method: after component C being heated to 75 DEG C, after waxy substance is melted, B component is added when being cooled to 45 DEG C, grind, 0.6mm grinding bead, 1300rpm grinds 10min.D material is heated to 50 DEG C, adds under 150rpm condition in B, C mixture, add component A after being cooled to room temperature, homogenizing, to obtain final product.
The pleasant profit precursor emulsion of the anti-sunburn of the second of the present invention, percentage composition by weight, shown in it is composed as follows:
Preferably, percentage composition by weight, it is composed as follows:
The preparation method of this anti-sunburn pleasant profit precursor emulsion can select any-mode of the prior art, the preparation method that preferred employing is following: after component C is heated to 70 DEG C, after waxy substance is melted, B, D component is added when being cooled to 50 DEG C, 300rpm stirs 10min, add component A after being cooled to room temperature, homogenizing, to obtain final product.
The present invention with tanshinone nano breast and ultraviolet scattering diluent for functional components, assistant is with adjuvant, learn from other's strong points to offset one's weaknesses, obtain two kinds of pleasant profit precursor emulsions of the good anti-sunburn of effect, anti-sunburn provided by the invention pleasant profit precursor emulsion gives pleasant sensation when using, excitatory low, to human body skin safety, there is the ultra-violet radiation resisting function of wide spectrum, be applicable to whole body skin, effect of anti-sunburn can be played, in addition can scavenging free radicals, antioxidation and skin nutrition, there is moisturizing, tighten up, anti-ageing effect of waiting for a long time.
Suntan lotion of the present invention, by weight percentage composition, shown in it is composed as follows:
Preferably, percentage composition by weight, it is composed as follows:
The preparation method of this suntan lotion can select any-mode of the prior art, preferably adopts following preparation method: B component is heated to 80 DEG C, after waxy substance is melted, add B component when being cooled to 40 DEG C, 250rpm stirs 10min, adds component A after being cooled to room temperature, homogenizing, to obtain final product.
The present invention for functional components with tanshinone nano breast and ultraviolet scattering diluent, helps with adjuvant, learns from other's strong points to offset one's weaknesses, and grope summary in a large number through inventor and draw the detailed consumption of each component, obtain the good suntan lotion of effect.
Detailed description of the invention
Be described in detail embodiment of the present invention below in conjunction with embodiment, the following example only for illustration of the present invention, and should not be considered as limiting scope of the present invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercial acquisition.
Embodiment 1: tanshinone nano breast
Constituent | Weight (g) |
TANSHINONES | 1 |
Soybean phospholipid | 1.5 |
Caprylic/capric triglyceride | 15 |
Polyglycerol monooleate | 0.5 |
Tween 80 | 1 |
Labraso | 1 |
Glycerol | 73 |
Water | 7 |
The preparation method of this nano-emulsion is as follows:
1) by recipe quantity, by soybean phospholipid, caprylic/capric triglyceride, polyglycerol monooleate, Tween 80, Labraso mixing, high speed shear under 8000rpm condition, without the visible solid content of naked eyes to system;
2) TANSHINONES is joined step 1) product, under 200rpm condition, the system that is stirred to is limpid transparent;
3) glycerol, water are joined step 2) product, high speed shear under 10000rpm condition, after obtaining colostrum, high pressure homogenizer process, pressure 2000bar used, circulates 10 times, obtains tanshinone nano breast.
Embodiment 2: the pleasant profit precursor emulsion of anti-sunburn
The preparation method of this anti-sunburn pleasant profit precursor emulsion is as follows:
After component C being heated to 75 DEG C, after waxy substance is melted, add B component when being cooled to 45 DEG C, grind, 0.6mm grinding bead, 1300rpm grinds 10min.D material is heated to 50 DEG C, adds under 150rpm condition in B, C mixture, add component A after being cooled to room temperature, homogenizing, to obtain final product.
Embodiment 3: the pleasant profit precursor emulsion of anti-sunburn
The preparation method of this anti-sunburn pleasant profit precursor emulsion is as follows:
After component C being heated to 70 DEG C, after waxy substance is melted, add B, D component when being cooled to 50 DEG C, 300rpm stirs 10min, adds component A, homogenizing, to obtain final product after being cooled to room temperature.
Embodiment 4: suntan lotion
The preparation method of this suntan lotion is as follows:
B component is heated to 80 DEG C, after waxy substance is melted, add B component when being cooled to 40 DEG C, 250rpm stirs 10min, adds component A, homogenizing, to obtain final product after being cooled to room temperature.
Embodiment 5-6
Embodiment 5-6 and embodiment 2 are distinguished and are only that the content of component is different, specific as follows:
Embodiment 7-8
From the difference of embodiment 3, embodiment 7-8 is only that the content of component is different, specific as follows:
Embodiment 9-10
From the difference of embodiment 4, embodiment 9-10 is only that the content of component is different, specific as follows:
Experimental example 1: sensitization is tested
Experimental technique: choose 12 Cavia porcelluss of body weight between 350 ~ 450g, be divided into A, B two groups at random.
The sample that A group selects embodiment 2 to prepare.
B group is control sample, according to embodiment 2, changes tanshinone nano breast the OctMet of Isodose into, all the other components and preparation method constant.In test, guinea pig back is shaved hair, respectively about 0.2 gram of sample, reference substance are smeared to 1cm × 1cm region.Observe after 18h and smear cosmetics area skin situation, result is as shown in table 1.
Guinea pig back change of skin after cosmetics smeared by table 1
Quantity | No change | Erythema, infiltration or pimple | Edematous erythema, pimple | Remarkable redness, companion's bulla |
Embodiment 2 | 5 | 1 | 0 | 0 |
Reference substance | 0 | 3 | 3 | 0 |
As shown in Table 1, after ultraviolet absorber (OctMet) is changed to tanshinone nano breast, the sensitization of corresponding cosmetics significantly declines.
Experimental example 2: sun-proof result is tested
Test method: the pertinent regulations detected with reference to spf value in " cosmetics health specification " (version in 2002).30 healthy volunteers are chosen, each 15 of men and women in test, IV type skin (namely seldom tan severely, but easily tanned skin quality), unglazed allergies.30 volunteers are divided into 3 groups, often organize 10 people.
Trial target is sample 1-3 and reference substance 1-6, as follows respectively:
Sample 1-3: using the product prepared by embodiment 2-4 as sample 1-3.
Reference substance 1-3: respectively according to embodiment 2-4, removes tanshinone nano breast wherein, appropriate section with water polishing, all the other prescriptions and preparation method constant.
Reference substance 4: according to embodiment 2, changes the tanshinone microemulsion mentioned in the identical CN102688151A of active component (i.e. TANSHINONES) into by tanshinone nano breast wherein, all the other components and preparation method constant.
Reference substance 5: according to embodiment 2, tanshinone nano breast is wherein changed into mention in the identical CN102293744A of active component (i.e. TANSHINONES) tanshinone nano breast, all the other components and preparation method constant.
Reference substance 6: according to embodiment 2, changes wherein tanshinone nano breast into active component identical commercially available TANSHINONES, all the other components and preparation method constant.
Experimental result is in table 2:
The different sample spf value of table 2
Can be seen by table 2, add the sunscreen product of the application's tanshinone nano breast, its spf value, compared with reference substance 1-6, improves.
Experimental example 3:MTT activity test
Take the logarithm the human epidermal cell HEK-n of trophophase, according to 1 × 10
5the concentration of cells/mL inoculates 96 orifice plates, every pore volume 200 μ L, after normal cultivation 24h, in protection group cell culture fluid, adds trial target respectively, after 5min, adopts 1mM H respectively
2o
2carry out oxidative damage process 6h.After oxidative damage process terminates, take out 96 well culture plates, abandon supernatant, after carefully rushing 2-3 time with PBS, then add the fresh medium of 200 μ L containing 0.5mg/mL MTT, continue at 37 DEG C, 5%CO
24h is cultivated under condition.After cultivation terminates, discard MTT solution, every hole adds 100 μ LDMSO, vibration mixing, and survey each hole absorbance (A490) that wavelength is 490nm, calculate cell survival rate, trial target is identical with experimental example 2, the results are shown in Table 3.
Table 3 MTT activity test
From result table 3, compared with reference substance 1-6, the sun care preparations containing the application's tanshinone nano breast greatly can improve cell viability.
Experimental example 4: heat-resisting, cold-resistant experiment
Heat-resisting (40 ± 1 DEG C, 24 hours) experiment is carried out to the cosmetics of embodiment 2-4, without oil-water separation after recovery room temperature, not muddy.
To resist cold (-15 ± 1 DEG C, 24 hours) experiment to the cosmetics of embodiment 2-4, recover after room temperature, system is normal, without turbid phenomenon.
Through cold-resistant heat-resistant experiment, every organoleptic indicator of embodiment 2-4 product, physical and chemical index, sanitary index all meet corresponding national standard.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1. anti-sunburn cosmetics, is characterized in that: its raw material percentage composition by weight, comprise the tanshinone nano breast of 5 ~ 50% and the ultraviolet scattering diluent of 1 ~ 30%; Described tanshinone nano Ruzhong, the weight percentage of TANSHINONES is 0.05 ~ 5%.
2. anti-sunburn cosmetics according to claim 1, is characterized in that: its raw material percentage composition by weight, comprise the tanshinone nano breast of 15 ~ 45% and the ultraviolet scattering diluent of 3 ~ 20%; Described tanshinone nano Ruzhong, the weight percentage of TANSHINONES is 0.1 ~ 1%.
3. anti-sunburn cosmetics according to claim 1 and 2, it is characterized in that: described tanshinone nano breast, comprise 1 part of TANSHINONES by weight, 1.5 parts of phospholipid, 15 parts of caprylic/capric triglyceride, 0.5 part of polyglycerol monooleate, 1 part of Tween 80,1 part of Labraso, 73 parts of glycerol, 7 parts of water.
4. anti-sunburn cosmetics according to claim 3, is characterized in that, the preparation method of described tanshinone nano breast comprises the following steps:
(1) by phospholipid, caprylic/capric triglyceride, polyglycerol monooleate, Tween 80, Labraso mixing, high speed shear, without the visible solid content of naked eyes to system;
(2) TANSHINONES joined in step (1) products therefrom, the system that is stirred to is limpid transparent;
(3) join in step (2) products therefrom by glycerol, water, high speed shear, after obtaining colostrum, through high pressure homogenize process, obtains tanshinone nano breast.
5. anti-sunburn cosmetics according to claim 1, it is characterized in that, described ultraviolet scattering diluent is selected from one or more in titanium dioxide, zinc oxide, ferrum oxide, ferrous oxide, cerium oxide germanium, Magnesiumaluminumsilicate, Muscovitum, Kaolin, Pulvis Talci or calcium carbonate.
6. the anti-sunburn cosmetics according to any one of claim 1-5, is characterized in that: described anti-sunburn cosmetics are the pleasant profit precursor emulsion of anti-sunburn or suntan lotion.
7. anti-sunburn cosmetics according to claim 6, is characterized in that, the pleasant profit precursor emulsion of described anti-sunburn percentage composition by weight, consists of the following composition: the tanshinone nano breast of 15 ~ 45%, the titanium dioxide of 3 ~ 15%, the C of 3 ~ 10%
16alkyl dimethicone, the annular dimethyl polysiloxane of 3 ~ 10%, the octyl stearate of 5 ~ 15%, the castor oil hydrogenated of 0.1 ~ 2%, the microwax of 0.5 ~ 2%, the Jojoba oil of 1 ~ 5%, the sodium chloride of 0.2 ~ 1%, water complements to 100%.
8. anti-sunburn cosmetics according to claim 7, is characterized in that, the pleasant profit precursor emulsion of described anti-sunburn percentage composition by weight, consists of the following composition: the tanshinone nano breast of 15%, the titanium dioxide of 7%, the C of 8%
16alkyl dimethicone, the annular dimethyl polysiloxane of 7%, the octyl stearate of 12%, the castor oil hydrogenated of 0.5%, the microwax of 1%, the Jojoba oil of 2%, the sodium chloride of 0.5%, water complements to 100%.
9. anti-sunburn cosmetics according to claim 6, is characterized in that, the pleasant profit precursor emulsion of described anti-sunburn percentage composition by weight, consist of the following composition: the tanshinone nano breast of 15 ~ 45%, the titanium dioxide of 3 ~ 15%, the Magnesiumaluminumsilicate of 1 ~ 5%, the HANSHENGJIAO of 0.1 ~ 2%, the Pulvis Talci of 3 ~ 10%, the propylene glycol of 3 ~ 10%, the hexadecanol of 2 ~ 5%, the lanolin alcohol of 0.2 ~ 5%, the microwax of 0.5 ~ 2%, the polyvinylpyrrolidone of 0.2 ~ 1%, water complements to 100%.
10. anti-sunburn cosmetics according to claim 6, is characterized in that, described suntan lotion percentage composition by weight, consist of the following composition: the tanshinone nano breast of 15 ~ 45%, the propylene glycol of 2 ~ 5%, the Tween 80 of 0.1 ~ 2%, the titanium dioxide of 3 ~ 15%, the microwax of 5 ~ 15%, the Cera Flava of 0.2 ~ 5%, the vaseline of 3 ~ 10%, the lanoline of 3 ~ 10%, the Squalene of 20 ~ 40%, the olein of 2 ~ 10%, the adipic acid C of 2 ~ 10%
16alkane ester, purified water complements to 100%.
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Cited By (1)
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CN106726751A (en) * | 2016-12-10 | 2017-05-31 | 钦州学院 | A kind of carrot profit body breast and preparation method thereof |
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CN101849890A (en) * | 2010-05-18 | 2010-10-06 | 董萍 | Synchronous repair and sunscreen composite nano emulsion for skin injury from ultraviolet A radiation and ultraviolet B radiation and method for preparing same |
CN104135993A (en) * | 2012-01-26 | 2014-11-05 | 荷兰联合利华有限公司 | A photostable sunscreen composition |
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