CN104664205A - Taxus chinensis, star-of-Bethlehem and maca immunological enhancement particle and preparation method thereof - Google Patents
Taxus chinensis, star-of-Bethlehem and maca immunological enhancement particle and preparation method thereof Download PDFInfo
- Publication number
- CN104664205A CN104664205A CN201510029310.0A CN201510029310A CN104664205A CN 104664205 A CN104664205 A CN 104664205A CN 201510029310 A CN201510029310 A CN 201510029310A CN 104664205 A CN104664205 A CN 104664205A
- Authority
- CN
- China
- Prior art keywords
- extract
- particle
- bethlehem
- star
- maca
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002245 particle Substances 0.000 title claims abstract description 39
- 241001149649 Taxus wallichiana var. chinensis Species 0.000 title claims abstract description 17
- 235000000421 Lepidium meyenii Nutrition 0.000 title claims abstract description 9
- 240000000759 Lepidium meyenii Species 0.000 title claims abstract description 9
- 235000012902 lepidium meyenii Nutrition 0.000 title claims abstract description 9
- 235000016547 Ornithogalum umbellatum Nutrition 0.000 title claims abstract description 8
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 241000499865 Ornithogalum Species 0.000 title abstract description 7
- 230000001900 immune effect Effects 0.000 title abstract description 5
- 239000000284 extract Substances 0.000 claims abstract description 62
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 23
- 239000005017 polysaccharide Substances 0.000 claims abstract description 23
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims abstract description 12
- 235000013793 astaxanthin Nutrition 0.000 claims abstract description 12
- 239000001168 astaxanthin Substances 0.000 claims abstract description 12
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims abstract description 12
- 229940022405 astaxanthin Drugs 0.000 claims abstract description 12
- 230000001954 sterilising effect Effects 0.000 claims abstract description 7
- 239000011669 selenium Substances 0.000 claims description 15
- 229910052711 selenium Inorganic materials 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 12
- -1 Selenium polysaccharide Chemical class 0.000 claims description 11
- 150000004676 glycans Chemical class 0.000 claims description 11
- 239000003651 drinking water Substances 0.000 claims description 10
- 235000020188 drinking water Nutrition 0.000 claims description 10
- 235000008599 Poria cocos Nutrition 0.000 claims description 9
- WHGYBXFWUBPSRW-UHFFFAOYSA-N Cycloheptaamylose Natural products O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO WHGYBXFWUBPSRW-UHFFFAOYSA-N 0.000 claims description 8
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 8
- 244000241838 Lycium barbarum Species 0.000 claims description 6
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 6
- 238000005469 granulation Methods 0.000 claims description 6
- 230000003179 granulation Effects 0.000 claims description 6
- 235000012054 meals Nutrition 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000009083 Fructus psoraleae extract Substances 0.000 claims description 4
- 240000004670 Glycyrrhiza echinata Species 0.000 claims description 4
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 4
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 4
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 4
- 241000180649 Panax notoginseng Species 0.000 claims description 4
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 4
- 235000001188 Peltandra virginica Nutrition 0.000 claims description 4
- 229940107666 astragalus root Drugs 0.000 claims description 4
- 235000020710 ginseng extract Nutrition 0.000 claims description 4
- 229940010454 licorice Drugs 0.000 claims description 4
- 230000005415 magnetization Effects 0.000 claims description 4
- 150000001450 anions Chemical class 0.000 claims description 3
- 230000001788 irregular Effects 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 240000001382 Ornithogalum umbellatum Species 0.000 claims 1
- 244000248825 Peltandra virginica Species 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 24
- 206010028980 Neoplasm Diseases 0.000 abstract description 23
- 201000011510 cancer Diseases 0.000 abstract description 15
- 208000017667 Chronic Disease Diseases 0.000 abstract description 7
- 231100000252 nontoxic Toxicity 0.000 abstract description 4
- 230000003000 nontoxic effect Effects 0.000 abstract description 4
- 238000002560 therapeutic procedure Methods 0.000 abstract description 4
- 230000005764 inhibitory process Effects 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 235000013402 health food Nutrition 0.000 abstract description 2
- 235000019206 astragalus extract Nutrition 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 230000000378 dietary effect Effects 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 37
- 210000004027 cell Anatomy 0.000 description 18
- 239000003814 drug Substances 0.000 description 15
- 210000000952 spleen Anatomy 0.000 description 12
- 244000131316 Panax pseudoginseng Species 0.000 description 10
- 239000008280 blood Substances 0.000 description 9
- 244000197580 Poria cocos Species 0.000 description 8
- 210000004072 lung Anatomy 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 7
- 235000013305 food Nutrition 0.000 description 7
- 210000004185 liver Anatomy 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- 230000004083 survival effect Effects 0.000 description 7
- 241000282414 Homo sapiens Species 0.000 description 6
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 235000019640 taste Nutrition 0.000 description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 6
- 239000000811 xylitol Substances 0.000 description 6
- 229960002675 xylitol Drugs 0.000 description 6
- 235000010447 xylitol Nutrition 0.000 description 6
- 229920000858 Cyclodextrin Polymers 0.000 description 5
- 241000112528 Ligusticum striatum Species 0.000 description 5
- 240000000654 Ornithogalum longebracteatum Species 0.000 description 5
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 5
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 5
- 235000003140 Panax quinquefolius Nutrition 0.000 description 5
- 244000226566 Psoralea corylifolia Species 0.000 description 5
- 230000003203 everyday effect Effects 0.000 description 5
- 235000008434 ginseng Nutrition 0.000 description 5
- 230000036039 immunity Effects 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000001291 vacuum drying Methods 0.000 description 5
- 241001412627 Adenophora liliifolia Species 0.000 description 4
- 240000006509 Gynostemma pentaphyllum Species 0.000 description 4
- 235000002956 Gynostemma pentaphyllum Nutrition 0.000 description 4
- 239000009636 Huang Qi Substances 0.000 description 4
- 244000241872 Lycium chinense Species 0.000 description 4
- 235000015468 Lycium chinense Nutrition 0.000 description 4
- 230000001093 anti-cancer Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 229930012538 Paclitaxel Natural products 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 229960001592 paclitaxel Drugs 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 3
- 231100000820 toxicity test Toxicity 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 208000005623 Carcinogenesis Diseases 0.000 description 2
- 244000050510 Cunninghamia lanceolata Species 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 244000046052 Phaseolus vulgaris Species 0.000 description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 208000037842 advanced-stage tumor Diseases 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 230000036952 cancer formation Effects 0.000 description 2
- 231100000504 carcinogenesis Toxicity 0.000 description 2
- 239000000287 crude extract Substances 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- 238000001784 detoxification Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 235000013373 food additive Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- 230000007365 immunoregulation Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 231100001083 no cytotoxicity Toxicity 0.000 description 2
- 230000001473 noxious effect Effects 0.000 description 2
- 238000011275 oncology therapy Methods 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000002636 symptomatic treatment Methods 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 2
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 229910001369 Brass Inorganic materials 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 229930187712 Caudaside Natural products 0.000 description 1
- 241000050051 Chelone glabra Species 0.000 description 1
- 241000206575 Chondrus crispus Species 0.000 description 1
- 208000031404 Chromosome Aberrations Diseases 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 description 1
- 231100000111 LD50 Toxicity 0.000 description 1
- 231100000911 LD50 test Toxicity 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 description 1
- 206010027336 Menstruation delayed Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 241001116500 Taxus Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 229940009456 adriamycin Drugs 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000001147 anti-toxic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000010951 brass Chemical class 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 125000001895 carotenoid group Chemical group 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 231100000005 chromosome aberration Toxicity 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 231100000085 chronic toxic effect Toxicity 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229930004069 diterpene Natural products 0.000 description 1
- 125000000567 diterpene group Chemical group 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 125000004383 glucosinolate group Chemical group 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 210000003016 hypothalamus Anatomy 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000002434 immunopotentiative effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 201000002313 intestinal cancer Diseases 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 230000003397 luteinic effect Effects 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 230000000527 lymphocytic effect Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 231100000668 minimum lethal dose Toxicity 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000036457 multidrug resistance Effects 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000001114 myogenic effect Effects 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- WCNLCIJMFAJCPX-UHFFFAOYSA-N pethidine hydrochloride Chemical group Cl.C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 WCNLCIJMFAJCPX-UHFFFAOYSA-N 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 229910052701 rubidium Inorganic materials 0.000 description 1
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- BUGBHKTXTAQXES-DBXDQKISSA-N selenium-70 Chemical compound [70Se] BUGBHKTXTAQXES-DBXDQKISSA-N 0.000 description 1
- 150000003346 selenoethers Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 206010055031 vascular neoplasm Diseases 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a taxus chinensis, star-of-Bethlehem and maca immunological enhancement particle and a preparation method thereof. The particle is prepared by combining, granulating, sterilizing and magnetizing 20 edible and medicinal dual-use substances such as a taxus chinensis non-toxic extract, a star-of-Bethlehem extract, a black maca extract, an astaxanthin extract, an astragalus extract and organic se-polysaccharide. The taxus chinensis, star-of-Bethlehem and maca immunological enhancement particle disclosed by the invention is used for treating twenty kinds of middle and advanced stage of cancer patients, remarkable in effect of assisting inhibition on cancers in a dietary therapy manner as a functional health food, and also good for recovery of other various chronic diseases.
Description
Technical field
The present invention relates to a kind of immunopotentiating agent in functional health-care food technical field, is the functional health-care food of a kind of auxiliary for treating cancer, various chronic disease.
Background technology
In recent years, the functional food of various cancer therapy drug, inhibition cancer cell growth is a lot, although all each have their own characteristic, but really can play anticancer adjuvant, regulate body immunologic balance, anti-cell is oxidized, and the Immune enhancement functional health-care food of T suppression cell variation canceration is also rare.
Summary of the invention
The object of the invention is the tumour for many various middle and advanced stages and various patients with chronic diseases, the red brave agate Immune enhancement particle functionality health food of a kind of immunological regulation, anti-cell oxidation, benefiting qi and nourishing blood, the canceration of suppression mutant is provided.
The invention provides a kind of material combination of red brave agate Immune enhancement particle.
The invention provides a kind of preparation method of red brave agate Immune enhancement particle.
The invention provides a kind of toxicity test of red brave agate Immune enhancement particle.
The invention provides a kind of oral experimental example of red brave agate Immune enhancement particle.
The primary raw material that the invention provides a kind of red brave agate Immune enhancement particle is:
Chinese yew, Ornithogalum caudatum, agate coffee, astaxanthin, the Radix Astragali, ginseng, raw Radix Glycyrrhizae, rhizoma atractylodis macrocephalae, Poria cocos, gynostemma pentaphylla, the root of straight ladybell, dried orange peel, pseudo-ginseng, the fruit of Chinese wolfberry, red date, Organic Selenium polysaccharide, Ligusticum wallichii, Psoralea corylifolia, xylitol, cycloheptaamylose, magnetized drinking water.
The effect of each raw material of the present invention:
1, Chinese yew: by alcohol immersion, filtration, temperature 75 DEG C of distillations in dynamic circulation, utilize oil water separator, the Chinese yew noxious material included " beans China fir essential oil " is separated, and then through cryogenic freezing vacuum drying, the taxus nontoxic extract crude product obtained, by Physical detoxification, remove the noxious material beans China fir essential oil of more than 96%, through repeatedly LD50 test, do not measure because of poisoning and lethal dose, its security is close to ginseng.The withdrawal ratio of Chinese yew CE is 50: 1, and namely 50kg dry product complete stool extracts 1kg crude product, and include the compounds such as the taxol of polysaccharide, flavonoids, Diterpenes and picotrace, content of taxol is at 3 μ g/ kilogram crude extracts.
Chinese yew is the botanical anticancer medicine that world medical circle is generally acknowledged, it has the not depolymerization of locking cancer cell, destroys DNA living chain, to making cancer cell atrophy, suicide, apoptosis, death.Chinese yew can also suppress the function of human variation's cell carcinogenesis simultaneously.Show through the experiment of repeatedly animals and human beings, the cell DNA that makes a variation can be suppressed active, mutant cell is turned over a new leaf, simultaneously to normal cell no cytotoxicity.Therefore, adopt the nontoxic extract of Chinese yew, utilize and in red brave agate Immune enhancement particle, carry out T suppression cell canceration have good benefit.And safely, have no side effect.
2, Ornithogalum caudatum: be a kind of flowers that the seventies in last century, China cultivated from Africa introduction, includes the medicine-food two-purpose materials such as brave eye blue or green saponin(e, polysaccharide, flavonoids, amino acid, mineral matter.Caudaside has good active anticancer, and to normal cell no cytotoxicity, polysaccharide, brass compounds have lifting immunity, excites the lymphocytic immune vigor of T, improves body immunity to entirety, and the effect of cancer-resisting aspect is given prominence to.Therefore, the present invention adopt be 50: 1 Ornithogalum caudatum's crude extract.
3, agate coffee: be the black agate coffee adopting the areas such as Lijiang, yunnan to introduce cultivation.Agate coffee mainly contains white, yellow, purple and black four kinds, color is more deeply felt and is shown that quality is better, chemical composition in the dry root of black agate coffee: protein content 14%, carbohydrate accounts for 59%, the crude fibre of 8.5%, include the mineral matters such as abundant zinc, iron, titanium, rubidium, potassium, sodium, copper, magnesium, strontium, phosphorus, iodine, selenium, and containing vitamin C, B1, B2, B6, A, E, B12, B5, fat is not high, but mostly wherein be unrighted acid, the content of linoleic acid plus linolenic acid reaches more than 53%.Active skull cap components comprises alkaloid, glucosinolate, flavonoids, the compound such as polysaccharide and macamide, especially agate coffee alkene and macamide, regulate the hormonal active principle of human body, but agate coffee self is not containing hormone, alkaloid contained by it will directly act on hypothalamus, hormone secretion speed is accelerated, by regulating adrenal gland, thyroid gland, pancreas, testis, the functions such as ovary carry out the hormone level in balanced body, thus kidney power can be promoted, cell self-repairing capability, the allomeric function of body is made to reach the state of balance, there is antifatigue, immunity moderation systemic-function, anti-cell is oxidized, anti-leukocythemia, promote fecundity, the effect that ovulation rate and elimination climacteric obstacle etc. are magical.The present invention adopt be 30: 1 black Maca extract.
4, astaxanthin: the similar beta carotene of its chemical constitution, also be the one of carotenoid group, natural astaxanthin is that the mankind find the antioxidant that nature is the strongest up to now, and its antioxidation activity, considerably beyond 1000 times of existing antioxidant VE, is 10 times of natural beta-carotin, it is 17 times of grapestone, luteinic 200 times, 150 times of OPC, 60 times of Q10,200 times of Tea Polyphenols are also 7 times of lycopene.Astaxanthin significantly can affect the immunologic function of people, when there being antigen to exist, obviously can promoting that splenocyte produces the ability of antibody, strengthening TB lymphocyte, the immunocompetence of NK cell and Mφ macrophage, stimulating the generation of immunoglobulin (Ig) in body.Specific humoral immune reaction can be strengthened, there is the possibility of important immunoregulation effect and prevention cell carcinogenesis.Therefore, the present invention adopt be 4: 1 astaxanthin extract.
5, the Radix Astragali: there is tonifying Qi and lifting yang, benefit defends the effect of solid table, detoxification myogenic, inducing diuresis for removing edema, acts on various middle and advanced stage cancer and suffers from and various chronic disease qi-blood deficiency, have good benefiting action, what the present invention adopted is 50: 1 extract.
6, ginseng: have reinforce vital energy, reinforce the spleen to benefit the lung, promote the production of body fluid to quench thirst, calming the nerves increases the effect of intelligence, to all because of vigour fictitious pole, deficiency of spleen-QI, qi-blood deficiencyly waits disease to have higher tune to mend effect.
7, raw Radix Glycyrrhizae: taste is sweet, property is put down, enter the heart, lung, spleen, stomach warp.Have and invigorate the spleen and benefit qi, moisten the lung and relieve the cough, relieving spasm to stop pain and relax the effect of the property of medicine, therefore, what the present invention adopted is 50: 1 extract.
8, rhizoma atractylodis macrocephalae: bitter, sweet, warm in nature.Enter spleen, stomach warp.Have air making-up and spleen enlivening, eliminating dampness Li Shui, the effect of main tonifying spleen sun, weakness of the spleen and the stomach to various chronic disease, poor appetite symptom has good regulating action, what the present invention adopted is 50: 1 extract.
9, Poria cocos: taste is sweet, light, property is put down.There is clearing damp and promoting diuresis, invigorating the spleen bowl spares, the effect of antitoxic heart-soothing and sedative.Containing pachyman in Poria cocos.Pachymic acids etc., have slow and lasting diuresis, can promote the discharge of sodium, potassium, also have calm and hypoglycemic effect.The present invention adopt be 50: 1 extract.
10, dried orange peel: there is regulating qi-flowing for strengthening spleen, in tune, eliminating dampness, the effect of reducing phlegm.The present invention adopt be 50: 1 extract.
11, the root of straight ladybell: taste is sweet, slightly warm in nature, has clearing lung and nourishing yin, the effect of reinforcing stomach reg fluid, the present invention adopt be 50: 1 extract.
12, gynostemma pentaphylla: be the abundantest product of current plant medicine-food two-purpose nutriment, there is step-down, lipopenicillinase, hypoglycemic, anti arteriosclerosis, inhibition thrombosis, calms the nerves and nourishs one's nature, and delays senility, improve mental activity, improve cerebral function, immunity moderation systemic-function, cancer inhibitting and killing cell, strengthen the activity of blood of human body medium size lymphocyte, develop immunitypty.Eliminate the poisonous side effect of medicine of steroids, anti-inflammatory, the anti-function such as swollen, what the present invention adopted is 50: 1 extract.
13, pseudo-ginseng: taste is sweet, warm in nature, enters liver, stomach warp, has removing blood stasis and hemostasis, the effect of analgesic therapy of invigorating blood circulation.To qi-blood deficiency, the patient of cancer district pain and bleeding has good regulating action, and what the present invention adopted is the full powder of pseudo-ginseng.
14, the fruit of Chinese wolfberry: taste is sweet, property is flat, enters liver, lung channel, has nourishing liver and kidney, the effect of develop immunitypty, and especially Lycium barbarum polysaccharides tonifies the liver and kidney especially, the nutrient source of immunity moderation balance, therefore, the present invention adopt to be content be 40% Lycium barbarum polysaccharides.
15, red date: taste is sweet, warm in nature, enters spleen, stomach warp, has tonifying middle-Jiao and Qi, nourishing blood and tranquilization, relaxes the effect of the property of medicine, what the present invention adopted is 50: 1 extract.
16, Ligusticum wallichii, Psoralea corylifolia: share not only blood-activating and qi-promoting, wind-expelling pain-stopping, tonify the kidney and support yang, more importantly can suppress mdr cell high expressed, tumor multidrug-resistance is the one of the main reasons of doctor trained in Western medicine chemotherapy failure, the potential mechanism of reason to be the high expressed of P-glycoprotein be MDR, the Ligusticum wallichii contained in the present invention, Psoralea corylifolia skim the cream off milk can completely reversing tumor cell to the tumor drug resistance bacterial strain of the medicines such as adriamycin, vincristin, taxol.The high expressed of P=glycoprotein can be resisted, Germicidal efficacy is after 48 hours, and its mdr cell P-P-glycoprotein expression disappears completely, this to long-term prescription cause the tumor patient of drug resistance and many chronics useful, therefore, the present invention adopt be 50: 1 extract.
17, Organic Selenium polysaccharide: employing be selenide of carragheen, organic selenium content 2%, polyoses content 50%.Organic Selenium polysaccharide has anti-cell oxidation, and its selenoenzyme can make MDA free radical effectively be removed.Blocking-up vascular tumor is formed, and prevents metastases and growth, due to the immunoregulation effect of polysaccharide, facilitates immunocyte release inhibiting factor in body and better detoxifies, toxin expelling, has significant complementary rehabilitative action to tumour and various chronic disease.
18, cycloheptaamylose: be adopt in commercially available food additives, a kind of a kind of cycloheptaamylose powder that can play thickness and eliminate overall raw material astringent taste, bitter taste effect, makes granular product, and granulation after adopting cyclodextrine to dilute, quality is better.
19, xylitol: be a kind of not sugary food additives, the red brave agate Immune enhancement particle mouthfeel of adding xylitol is good, greatly can alleviate bitter taste.
20, magnetized drinking water: be ordinary tap water by 4600 Gauss's water magnetizing apptss through later, form the micromolecular water with Magnetic Memory, granulation is sprayed with magnetized drinking water dilution cyclodextrine, can make each material in raw material all with thoughts magnetic and the peculiar smell that can also eliminate in raw material, frequent drinking magnetized water and the food taken with Magnetic Memory are benefited to health.
The each material combination of a kind of red brave agate Immune enhancement particle of the present invention, scientific and reasonable, serve Immune enhancement, anti-cell oxidation, suppress mutant canceration, stop cancer cell multiplication and transfer to have significant effect.
The preparation method of a kind of red brave agate Immune enhancement particle of the present invention:
1, prescription metering:
Chinese yew extract 90g, extract of star of bethlehem 120g, black Maca extract 120g, astaxanthin extract 120g, Astragalus Root P.E 100g, ginseng extract 70g, raw licorice 60g, Rhizoma Atractylodis Macrocephalae (parched) extract 90g, tuckahoe extracts 90g, Herb Gynostemmae Pentaphylli extract 100g, Radix Adenophorae (Radix Glehniae) extract 60g, dried orange peel extracts 90g, Radix Notoginseng powder 110g, Lycium barbarum polysaccharides 100g, red date extract 90g, Rhizoma Chuanxiong extract 90g, Fructus Psoraleae extract 90g, Organic Selenium polysaccharide 1000mg, xylosic alcohol powder 130g, cycloheptaamylose powder 30g, magnetized drinking water 540ml.
2, preparation method:
(1) by Chinese yew, Ornithogalum caudatum, black agate coffee, astaxanthin, the Radix Astragali, ginseng, raw Radix Glycyrrhizae, rhizoma atractylodis macrocephalae, Poria cocos, gynostemma pentaphylla, the root of straight ladybell, dried orange peel, pseudo-ginseng, the fruit of Chinese wolfberry, red date, Ligusticum wallichii, Psoralea corylifolia, xylitol.All put into stainless steel motor hybrids, after being fully mixed 10 minutes, putting into electronic comminutor, stand-by.
(2) magnetized drinking water 540ml is got, add Organic Selenium polysaccharide 1000mg, indirect 85 DEG C, to stir evenly and after fully dissolving, add cyclodextrine 30g again, being stirred well to liquid is after scattered paste shape, injects in watering can, be sprayed directly in mixed raw meal, limit spray limit granulation, when raw meal is irregular particle shape, progressively takes out, sabot, thickness is 1.5cm is good, then sends in vacuum drying chamber, under the isoperibol of 65 DEG C, vacuum drying 4 hours, until moisture lower than less than 4% time take out cooling:
(3) sent in anion air sterilization tank by the particle after cooling, sterilizing after 30 minutes, then puts into automatic granule bottle placer material container, under aseptic environment, filling with the dosage of every pouch 6g, vacuum seal.
(4) then, delivered to by conveyer belt and to be equipped with in the gauss magnetic field of-N.S pole 5,000 one and to pass by form and carry out magnetization treatment, with the loading amount of every box 30 pouch, mounted box is cased, and namely becomes a kind of red brave agate Immune enhancement particle functionality health products.
Cycloheptaamylose in the present invention is a kind of food solubilizer of circulus, flavouring; stabilizing agent; remove the peculiar smell in food, the shelf life of food can be extended, more importantly can protect that some raw material nutriments are anti-oxidant, anti-light, heat resistanceheat resistant, the function such as volatilization prevention and immobilization.
Organic Selenium polysaccharide in the present invention, Se content is 2%, adds 1000mg, and press the gauge of 10mg for each person every day, the day magnitude of recruitment of Organic Selenium is 200 μ g.
Particle in the present invention, pass by after formation magnetization treatment through 5000 gauss magnetic fields one, hard particle and each nutriment will by strong magnetic Irradiations, formed slot-shaped, after oral, easy decomposition and absorption, each nutriment is remembered with magnetic strength simultaneously, the almost identical frequency that shakes is had with human body cell, to become silted up malicious rubbish by scavenger-cell film, cell membrane can be impelled to produce the malicious antibody that becomes silted up at short notice, use magnetized drinking water granulation, again by granulated magnetic, the Function and operation of red brave agate Immune enhancement particle will be promoted.
A kind of red brave agate Immune enhancement particle of the present invention and preparation method thereof is production standard by everyone oral dose of 100 days, the in-built 6g of every pouch, every day 3 times, every day 18g dose.Every pouch includes Chinese yew extract 0.3g, extract of star of bethlehem 0.4g, black Maca extract 0.4g, astaxanthin extract 0.4g, Astragalus Root P.E 0.33g, ginseng extract 0.23g, raw licorice 0.2g, Rhizoma Atractylodis Macrocephalae (parched) extract 0.3g, tuckahoe extracts 0.3g, Herb Gynostemmae Pentaphylli extract 0.33g, Radix Adenophorae (Radix Glehniae) extract 0.2g, dried orange peel extracts 0.3g, Radix Notoginseng powder 0.37g, Lycium barbarum polysaccharides 0.33g, red date extract 0.3g, Rhizoma Chuanxiong extract 0.3g, Fructus Psoraleae extract 0.3g, Organic Selenium polysaccharide 3.3mg (containing selenium 70 μ g), xylitol 0.43g, cycloheptaamylose 0.1g, add up to: 6g/ bag.
The toxicity test of a kind of red brave agate Immune enhancement particle of the present invention:
(1) toxicity test:
Red brave agate Immune enhancement particle, Mouse oral administration does not measure median lethal dose, maximal tolerance dose reaches 20g/kg, (2 monthly ages) dead mouse is had no in one week, the nontoxic level in true border, test illustrates its minimum lethal dose LDm > 20g/kg, and this dosage is the Coming-of-Age Day 66.6 times of consumption of a 60kg body weight.
Slow poison test:
The rat of 3 first quarter moons and the male dogs at 1 age gavage the red brave agate Immune enhancement particle of higher than clinical dosage 100 times respectively, every day 1 time, continuous 6 months, the each dosage group of result is grown, routine blood test, blood biochemical and the heart, liver, lung inspection all have no significant effect, histopathological examination shows no obvious abnormalities, and illustrates not have chronic toxic effect.
Other:
The red brave agate Immune enhancement particle of Mouse oral, institute tests, micronucleus test, Chromosome Aberration Test, and result is feminine gender, detects respectively with eucaryon and prokaryotic, shows that red brave agate Immune enhancement particle does not obviously show mutagenesis.
The invention provides a kind of oral experimental example of red brave agate Immune enhancement particle:
1, upper cancer of the esophagus: Liu XX, man, 42 years old, people from suburb, Horqin, Tongliao, Inner Mongolia city, suffered from cancer of the esophagus Post operation and leave hospital for 4 months in September, 2011, and recur again after 3 first quarter moons of leaving hospital, cancer metastasis is to organs such as lymph, lung, stomaches.Take traditional Chinese and western medicine cancer therapy drug, do not feel any better in 1 month, cancer district hurt like hell, injects Sauteralgyl every day to maintain, under the support of symptomatic treatment traditional Chinese and western medicine medicine, through taking the red brave agate Immune enhancement particle of the present invention after 3 days, symptom takes a turn for the better to some extent, pain relief after 10 days, appetite increases to some extent, coordinate after medicine is used in conjunction 3 months, doctor's inspection tumour and cancer cell all disappear, after take separately again the present invention and within 4 months, consolidate rehabilitation and within more than 3 years, have no recurrence so far.
2, lesser curvature cancer:
Lee XX, man, 72 years old, Fuxin City suburb, Liaoning Province peasant, in February, 2012, initial survey was lesser curvature cancer, take and namely tell, phlegm prolongs as gushed, just dry, complexion ash is stagnant, become thin, drink like a fish at ordinary times, lest operation, within 1 month, do not feel any better in conjunction with the treatment of being in of traditional Chinese and western medicine medicine, the pain increased in cancer district, appetite is successively decreased, body is weary unable, Body weight loss, through in conjunction with the red brave agate Immune enhancement particle of oral the present invention after 1 week, self-induction symptom alleviates, be used in conjunction 2 months, rehabilitation is more than half, following the service cured inspection after 5 months, tumour all disappears, return to the front level of disease, after serve on again 10 months and consolidated, so far within more than 1 year, recurrence is had no.
3, malignant lymphoma:
King XX, female, 46 years old, Chifeng bank clerk, in March, 2012, initial survey was swell thing 40 days in neck side, originally as soybean grain size, long as large in walnut after 1 month, and spread to surrounding, after the excision of city's hospital surgical, recur again after 4 months, spread again to supraclavicular fossa, concavo-convex as rock, hardly not move, lump 6 below right side of neck and Xiache point, greatly as almond joins together, add externally-used pain-relieving do not imitate for 1 month through taking Western medicine, the state of an illness progressively worsens, the red brave agate Immune enhancement particle of the present invention is taken after 1 week through coordinating, symptom alleviates to some extent, serve on 3 months, knurl body all disappears, after again following the service within 6 months, returned to level before disease, so far within more than 2 years, recurrence is had no.
4, Korea Spro X, man, 63 years old, retired worker, suffers from type-II diabetes for many years, at present by Chinese medicine hypoglycemic medicine with in conjunction with nutritious food, the methods such as insulin injection maintain, fasting blood-glucose still at 10.3mmol/L, glucose in urine " ++ ", blood pressure 165-90/ millimetres of mercury, serve on 4 months, looks into fasting blood-glucose 6.1mmol/L, glucose in urine " ± " blood pressure 130-90/ millimetres of mercury, return to normal level, after following the service 5 months again, within 2 years, have no recurrence so far.
5, Guo XX, female, 61 years old, the sub-town peasant in small city, Ningcheng County, Chifeng City, weak and sickly, as hypertension 175-100 millimetres of mercury, slight rheumatism, cervical vertebra is uncomfortable, has prominent features, often catches a cold, body is weary unable, poor sleep, through singly taking the red brave agate Immune enhancement particle of the present invention after 1 month, symptom reduces by half, take period without once catching a cold, and sleep quality makes moderate progress, after being used in conjunction 4 months, symptomatology is eliminated, blood pressure has returned to the normal level of 90-130 millimetres of mercury, cervical vertebra sense of discomfort disappears, and self-induction is full of physical strength, and energy is pure.
6, suffer from through the various middle and advanced stage cancer of nearly 160 many cases more than 6 years and taking, it is efficient reaches 99%, by coordinating other medicines symptomatic treatment, simultaneously auxiliary take red brave agate Immune enhancement particle anticancer after more than 5 years survival rate 127 people, account for 79.3%, 4 years survival rate 19 people, account for 11.8%, within 3 years, survival rate 8 people accounts for 5%, 2 years survival rate 3 people, account for 1.8%, 1 year survival rate 2 people, account for 1.2%, invalid 1 people, account for 0.6%, these data show, to be suited the medicine to the illness combined treatment by oral red brave agate Immune enhancement particle and traditional Chinese and western medicine, to lung cancer, liver cancer, cancer of the stomach, cancer of the esophagus, the survival rate that the cancers such as intestinal cancer are suffered from is comparatively high than the national conventional therapy level survival rate of more than 5 years 33.9%, because many people are near late period when accepting treatment, so, Immune enhancement therapy of the present invention is effective, also be feasible.
7, through the nearly 6 years various chronic diseases of 300 many cases and part sub-health population men and women, oral red brave agate Immune enhancement particle, the overwhelming majority obtains rehabilitation all, proves that red brave agate Immune enhancement therapy is effective.
The red brave agate Immune enhancement particle of the present invention, nourishing qi and blood, anti-cell is oxidized, and antiviral, anti-inflammatory, protects the liver invigorating the spleen, develop immunitypty, suppresses the cell of variation to turn cancer, cancer-resisting.Serve the heart, liver, spleen, lung, the large internal organs of kidney 5 with the dietotherapy effect of mending the people having the same aspiration and interest.
In a kind of red brave agate Immune enhancement particle of the present invention and preparation method thereof description, be only the corresponding description to content of the present invention, not by the restriction of the scope of the invention, the personnel in art can operate.Scope of the present invention is to define in claims.
By a kind of for the present invention red brave agate Immune enhancement particle and preparation method thereof, be described further again with specific embodiment form down.
Detailed description of the invention
Embodiment 1: prescription measures:
Chinese yew extract 90g, extract of star of bethlehem 120g, black Maca extract 120g, astaxanthin extract 120g, Astragalus Root P.E 100g, ginseng extract 70g, raw licorice 60g, Rhizoma Atractylodis Macrocephalae (parched) extract 90g, tuckahoe extracts 90g, Herb Gynostemmae Pentaphylli extract 100g, Radix Adenophorae (Radix Glehniae) extract 60g, dried orange peel extracts 90g, Radix Notoginseng powder 110g, Lycium barbarum polysaccharides 100g, red date extract 90g, Rhizoma Chuanxiong extract 90g, Fructus Psoraleae extract 90g, Organic Selenium polysaccharide 1000mg, xylosic alcohol powder 130g, B-cyclodextrine powder 30g, magnetized drinking water 540ml.
Embodiment 2: preparation method:
(1) by Chinese yew, Ornithogalum caudatum, black agate coffee, astaxanthin, the Radix Astragali, ginseng, raw Radix Glycyrrhizae, rhizoma atractylodis macrocephalae, Poria cocos, gynostemma pentaphylla, the root of straight ladybell, dried orange peel, pseudo-ginseng, the fruit of Chinese wolfberry, red date, Ligusticum wallichii, Psoralea corylifolia, xylitol.All put into stainless steel motor hybrids, after being fully mixed 10 minutes, putting into electronic comminutor, stand-by.
(2) magnetized drinking water 540ml is got, add Organic Selenium polysaccharide 1000mg, indirect 85 DEG C, to stir evenly and after fully dissolving, add cyclodextrine 30g again, being stirred well to liquid is after scattered paste shape, injects in watering can, be sprayed directly in mixed raw meal, limit spray limit granulation, when raw meal is irregular particle shape, progressively takes out, sabot, thickness is 1.5cm is good, then sends in vacuum drying chamber, under the isoperibol of 65 DEG C, vacuum drying 4 hours, until moisture lower than less than 4% time take out cooling;
(3) sent in anion air sterilization tank by the particle after cooling, sterilizing after 30 minutes, then puts into automatic granule bottle placer material container, under aseptic environment, filling with the dosage of every pouch 6g, vacuum seal.
(4) then, delivered to by conveyer belt and to be equipped with in the gauss magnetic field of-N.S pole 5,000 one and to pass by form and carry out magnetization treatment, with the loading amount of every box 30 pouch, mounted box is cased.
Claims (4)
1. Chinese yew extract 90g, extract of star of bethlehem 120g, black Maca extract 120g, astaxanthin extract 120g, Astragalus Root P.E 100g, ginseng extract 70g, raw licorice 60g, Rhizoma Atractylodis Macrocephalae (parched) extract 90g, tuckahoe extracts 90g, Herb Gynostemmae Pentaphylli extract 100g, Radix Adenophorae (Radix Glehniae) extract 60g, dried orange peel extracts 90g, Radix Notoginseng powder 110g, Lycium barbarum polysaccharides 100g, red date extract 90g, Rhizoma Chuanxiong extract 90g, Fructus Psoraleae extract 90g, Organic Selenium polysaccharide 1000mg, xylosic alcohol powder 130g, cycloheptaamylose powder 30g, magnetized drinking water 540ml.
2. get magnetized drinking water 540ml, add Organic Selenium polysaccharide 1000mg, indirect 85 DEG C, stirs evenly and after fully dissolving, then adds cycloheptaamylose 30g, being stirred well to liquid is after scattered paste shape, in injection watering can, be sprayed directly in mixed raw meal, limit spray limit granulation, when raw meal is irregular particle shape, progressively take out.
3. the particle after cooling is sent in anion air sterilization tank, sterilizing 30 minutes.
4. delivered to by conveyer belt and to be equipped with in the gauss magnetic field of-N.S pole 5,000 one and to pass by form and carry out magnetization treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510029310.0A CN104664205A (en) | 2015-01-22 | 2015-01-22 | Taxus chinensis, star-of-Bethlehem and maca immunological enhancement particle and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510029310.0A CN104664205A (en) | 2015-01-22 | 2015-01-22 | Taxus chinensis, star-of-Bethlehem and maca immunological enhancement particle and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104664205A true CN104664205A (en) | 2015-06-03 |
Family
ID=53300210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510029310.0A Pending CN104664205A (en) | 2015-01-22 | 2015-01-22 | Taxus chinensis, star-of-Bethlehem and maca immunological enhancement particle and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104664205A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106723054A (en) * | 2016-11-15 | 2017-05-31 | 林树芳 | A kind of GL-PP peptide oral liquid and preparation method |
| CN107212413A (en) * | 2017-07-18 | 2017-09-29 | 云南核度生物产业发展有限公司 | A kind of maca rose piece and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1195481A (en) * | 1997-10-27 | 1998-10-14 | 高国勤 | Method for preparing magnetized drink and food |
| CN1279892A (en) * | 1999-07-13 | 2001-01-17 | 泰山科学技术研究院 | Magnetized food for auxiliary curing of diabetes |
| CN101773625A (en) * | 2010-03-03 | 2010-07-14 | 南京中医药大学 | Anticancerogen, preparation method and application thereof |
| CN102580065A (en) * | 2012-02-13 | 2012-07-18 | 林树芳 | Ornithogalum caudatum saponin OSW-1 oral anticancer preparation and preparation method thereof |
| CN103300421A (en) * | 2013-06-05 | 2013-09-18 | 林树芳 | Medicated food for adjuvant therapy on cancer |
-
2015
- 2015-01-22 CN CN201510029310.0A patent/CN104664205A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1195481A (en) * | 1997-10-27 | 1998-10-14 | 高国勤 | Method for preparing magnetized drink and food |
| CN1279892A (en) * | 1999-07-13 | 2001-01-17 | 泰山科学技术研究院 | Magnetized food for auxiliary curing of diabetes |
| CN101773625A (en) * | 2010-03-03 | 2010-07-14 | 南京中医药大学 | Anticancerogen, preparation method and application thereof |
| CN102580065A (en) * | 2012-02-13 | 2012-07-18 | 林树芳 | Ornithogalum caudatum saponin OSW-1 oral anticancer preparation and preparation method thereof |
| CN103300421A (en) * | 2013-06-05 | 2013-09-18 | 林树芳 | Medicated food for adjuvant therapy on cancer |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106723054A (en) * | 2016-11-15 | 2017-05-31 | 林树芳 | A kind of GL-PP peptide oral liquid and preparation method |
| CN107212413A (en) * | 2017-07-18 | 2017-09-29 | 云南核度生物产业发展有限公司 | A kind of maca rose piece and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104041645A (en) | Weight reducing and spirit raising coffee and making method thereof | |
| CN105265990A (en) | Herba dendrodii officinalis compound health-care enzyme drink and preparation method thereof | |
| CN104856009A (en) | An eucommia ulmoides staminate flower health-care product | |
| CN104489516A (en) | Health-preserving porridge capable of improving postoperative immune function of cancer paint and preparation method for health-preserving porridge | |
| CN102210820A (en) | Chinese medicinal composition for treating leukemia | |
| CN102488038B (en) | Traditional Chinese medicine health tea and its preparation method | |
| CN101926942A (en) | Glucose-lowering health care medicinal tea and preparation method thereof | |
| CN104687193A (en) | Fructo-oligosaccharide beverage and preparation method thereof | |
| CN104664205A (en) | Taxus chinensis, star-of-Bethlehem and maca immunological enhancement particle and preparation method thereof | |
| CN109105587A (en) | The tea bag and preparation method thereof of effect is relieved fatigue with strengthen immunity | |
| CN111227225A (en) | Natural health food for preventing tumor | |
| TW202330006A (en) | Composition for preventing, improving or alleviating symptoms relating to qi deficiency and/or blood deficiency | |
| CN103798435A (en) | Fingered citron folium mori and wolfberry tea and preparation method thereof | |
| CN104587126B (en) | A kind of traditional Chinese powder medicine for treating stomach trouble | |
| CN114177261A (en) | Chinese herbal medicine formula for preventing and treating chronic diseases and resisting cancer and protecting health | |
| CN112807415A (en) | Spleen and stomach warming and tonifying middle-jiao tea and preparation method thereof | |
| CN112494614A (en) | Chinese medicinal formula for preventing and treating cancer by using combination of pawpaw and various medicines | |
| CN107468938A (en) | A kind of formula of asparagus tea and preparation method thereof | |
| CN108186937A (en) | A kind of aloetic anti-acne drug and preparation method thereof | |
| KR20060030575A (en) | Pharmaceutical composition comprising the complex crude drug extract for preventing and treating hyperthyroidism | |
| CN104082733A (en) | Instant food for conditioning bone cancer | |
| CN105961677A (en) | Healthcare tea with effect of lubricating the intestines to relieve constipation and preparation method thereof | |
| CN104082732A (en) | Instant food for regulating melanin tumours | |
| CN103599163B (en) | A kind of pharmaceutical composition with antitumaous effect | |
| CN104082734A (en) | Instant food for regulating pancreatic cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150603 |
|
| WD01 | Invention patent application deemed withdrawn after publication |