CN104645315A - 达到所需胶质生长因子2血浆水平的方法 - Google Patents

达到所需胶质生长因子2血浆水平的方法 Download PDF

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Publication number
CN104645315A
CN104645315A CN201410709391.4A CN201410709391A CN104645315A CN 104645315 A CN104645315 A CN 104645315A CN 201410709391 A CN201410709391 A CN 201410709391A CN 104645315 A CN104645315 A CN 104645315A
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China
Prior art keywords
ggf2
myelin
myelination
patient
cultures
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Pending
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CN201410709391.4A
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English (en)
Chinese (zh)
Inventor
H·金
A·O·卡加诺
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Acorda Therapeutics Inc
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Acorda Therapeutics Inc
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Publication of CN104645315A publication Critical patent/CN104645315A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/285—Demyelinating diseases; Multipel sclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CN201410709391.4A 2008-02-29 2009-03-02 达到所需胶质生长因子2血浆水平的方法 Pending CN104645315A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6758908P 2008-02-29 2008-02-29
US61/067,589 2008-02-29

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200980114836.1A Division CN102026651B (zh) 2008-02-29 2009-03-02 达到所需胶质生长因子2血浆水平的方法

Publications (1)

Publication Number Publication Date
CN104645315A true CN104645315A (zh) 2015-05-27

Family

ID=41016663

Family Applications (2)

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CN201410709391.4A Pending CN104645315A (zh) 2008-02-29 2009-03-02 达到所需胶质生长因子2血浆水平的方法
CN200980114836.1A Expired - Fee Related CN102026651B (zh) 2008-02-29 2009-03-02 达到所需胶质生长因子2血浆水平的方法

Family Applications After (1)

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CN200980114836.1A Expired - Fee Related CN102026651B (zh) 2008-02-29 2009-03-02 达到所需胶质生长因子2血浆水平的方法

Country Status (11)

Country Link
US (5) US8410050B2 (https=)
EP (3) EP3120863B1 (https=)
JP (2) JP5697455B2 (https=)
CN (2) CN104645315A (https=)
AU (1) AU2009217606B2 (https=)
BR (1) BRPI0908271A2 (https=)
CA (1) CA2717193C (https=)
ES (2) ES2613177T3 (https=)
PL (2) PL3120863T3 (https=)
RU (3) RU2530650C2 (https=)
WO (1) WO2009108390A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3120863T3 (pl) 2008-02-29 2021-02-22 Acorda Therapeutics, Inc. Kompozycje do osiągnięcia pożądanych poziomów glejowego czynnika wzrostu 2 w osoczu
CN102159236A (zh) 2008-07-17 2011-08-17 阿索尔达治疗公司 用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂
EP2328606B1 (en) 2008-08-15 2016-10-05 Acorda Therapeutics, Inc. Compositions and methods for treatment during non-acute periods following cns neurological injury
WO2011047183A2 (en) 2009-10-14 2011-04-21 Acorda Therapeutics, Inc. Use of a neuregulin to treat peripheral nerve injury
CN103118698A (zh) * 2010-05-28 2013-05-22 意识-Nrg公司 神经调节素同种型，神经调节素多肽和其使用
WO2012021818A2 (en) * 2010-08-13 2012-02-16 Georgetown University Ggf2 and methods of use
AU2013237896B2 (en) * 2012-03-30 2017-11-02 Acorda Therapeutics, Inc. Use of neuregulin to treat peripheral nerve injury
JP7064197B2 (ja) * 2016-09-23 2022-05-10 国立大学法人大阪大学 シュワン細胞分化促進剤及び末梢神経再生促進剤
CN108653274B (zh) * 2017-04-01 2022-09-16 鲁南制药集团股份有限公司 牛蒡子苷元在制备治疗骨髓损伤药物中的用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135456B1 (en) 1991-04-10 2006-11-14 Acorda Therapeutics, Inc. Glial mitogenic factors, their preparation and use
US5716930A (en) 1991-04-10 1998-02-10 Ludwig Institute For Cancer Research Glial growth factors
US5530109A (en) 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
US7319019B1 (en) 1991-04-10 2008-01-15 Acorda Therapeutics, Inc. Glial mitogenic factors lacking an N-terminal signal sequence
US7037888B1 (en) 1992-04-03 2006-05-02 Acorda Therapeutics, Inc. Methods for treating muscle diseases and disorders
GB9217316D0 (en) * 1992-08-14 1992-09-30 Ludwig Inst Cancer Res Schwann cell mitogenic factor,its preparation and use
US5912326A (en) 1995-09-08 1999-06-15 President And Fellows Of Harvard College Cerebellum-derived growth factors
AU3003701A (en) 1999-11-19 2001-05-30 Axxima Pharmaceuticals Ag Inhibitors of helicobacter pylori induced gastrointestinal diseases
US20030232761A1 (en) 2002-03-28 2003-12-18 Hinke Simon A. Novel analogues of glucose-dependent insulinotropic polypeptide
WO2004110359A2 (en) * 2003-05-16 2004-12-23 Acorda Therapeutics, Inc. Fusion proteins for the treatment of cns
US20080213817A1 (en) * 2004-02-19 2008-09-04 Michael Karin Enhancement of Th2-Dependent and Inflammatory Response
JP2008528697A (ja) 2005-02-02 2008-07-31 ネクサスファーマ・インコーポレイテッド 癌の病因に関連するウィルス感染症を治療するためのアミン誘導体含有組成物および方法
US7776817B2 (en) 2005-09-02 2010-08-17 Morehouse School Of Medicine Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue and as regulators of neuronal stem cell migration
US20080003013A1 (en) * 2006-06-30 2008-01-03 Static Control Components, Inc. Cartridge split rail clip
PL3120863T3 (pl) 2008-02-29 2021-02-22 Acorda Therapeutics, Inc. Kompozycje do osiągnięcia pożądanych poziomów glejowego czynnika wzrostu 2 w osoczu
CN102834498B (zh) 2010-04-01 2014-04-30 宝洁公司 织物软化剂
WO2012021818A2 (en) 2010-08-13 2012-02-16 Georgetown University Ggf2 and methods of use

Also Published As

Publication number Publication date
EP2262527B1 (en) 2016-08-03
US9744215B2 (en) 2017-08-29
US9272015B2 (en) 2016-03-01
WO2009108390A2 (en) 2009-09-03
BRPI0908271A2 (pt) 2017-06-13
PL2262527T3 (pl) 2017-07-31
EP3120863B1 (en) 2020-05-06
PL2262527T4 (pl) 2017-07-31
EP2262527A2 (en) 2010-12-22
US20130345131A1 (en) 2013-12-26
WO2009108390A3 (en) 2010-11-18
PL3120863T3 (pl) 2021-02-22
JP5964920B2 (ja) 2016-08-03
RU2014131265A (ru) 2016-02-20
ES2613177T3 (es) 2017-05-23
EP3120863A1 (en) 2017-01-25
JP5697455B2 (ja) 2015-04-08
US20210060128A1 (en) 2021-03-04
US8410050B2 (en) 2013-04-02
JP2015042656A (ja) 2015-03-05
RU2019110452A (ru) 2020-10-09
CA2717193C (en) 2022-08-16
ES2811127T3 (es) 2021-03-10
EP3750551A1 (en) 2020-12-16
US20160367634A1 (en) 2016-12-22
AU2009217606B2 (en) 2015-03-05
CN102026651A (zh) 2011-04-20
JP2011513310A (ja) 2011-04-28
AU2009217606A1 (en) 2009-09-03
CA2717193A1 (en) 2009-09-03
US20100029559A1 (en) 2010-02-04
US20180055909A1 (en) 2018-03-01
CN102026651B (zh) 2015-06-03
RU2530650C2 (ru) 2014-10-10
US10675331B2 (en) 2020-06-09
RU2687097C2 (ru) 2019-05-07
RU2010139906A (ru) 2012-04-10

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Application publication date: 20150527

RJ01 Rejection of invention patent application after publication