CN104645171A - A veterinary drug for control of staphylomycosis in chicken farms and preparation thereof - Google Patents
A veterinary drug for control of staphylomycosis in chicken farms and preparation thereof Download PDFInfo
- Publication number
- CN104645171A CN104645171A CN201310581199.7A CN201310581199A CN104645171A CN 104645171 A CN104645171 A CN 104645171A CN 201310581199 A CN201310581199 A CN 201310581199A CN 104645171 A CN104645171 A CN 104645171A
- Authority
- CN
- China
- Prior art keywords
- radix
- veterinary drug
- staphylococcosis
- fructus forsythiae
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A veterinary drug for control of staphylomycosis in chicken farms is disclosed. The veterinary drug is prepared from 80-100 g of wild chrysanthemum, 50-100 g of Chinese gall, 30-50 g of honeysuckle bud and flower, 20-40 g of stemona root, 10-30 g of scutellaria baicalensis, 10-20 g of isatis root, 5-10 g of rhizoma coptidis, 5-10 g of licorice, 5-10 g of herba houttuyniae, 2-5 g of astragalus propinquus, 2-5 g of aloe, 2-5 g of herba patriniae, 2-5 g of fructus forsythiae and 2-5 g of spica prunellae. The wild chrysanthemum, the honeysuckle bud and flower, the Chinese gall, the scutellaria baicalensis and the fructus forsythiae are adopted as the main materials, and combined with other traditional Chinese medicines or antibiotics for use. The veterinary drug can effectively control a plurality of kinds of the staphylomycosis in the chicken farms, and is obvious in effects and free of side effects. Drug resistance is not liable to generate after long-term using of the veterinary drug.
Description
Technical field
The invention belongs to veterinary drug technical field, particularly a kind of veterinary drug and preparation method of preventing and treating chicken farm staphylococcosis.
Background technology
Acute or the chronic infectious disease of the one of the poultry that staphylococcosis is mainly caused by staphylococcus aureus, clinically generally show as that arthritis, tenosynovitis, callosity are swollen, omphalitis and staphylococcic septicemia etc., and there is very strong infectiousness, once morbidity, easily bring about great losses.Control generally direct employing antibiotic at present to such disease, because staphylococcus is easy to produce drug resistance to antibiotic, therefore can makes to infect easy recurrence, and have the trend increased year by year, and need not stop to research and develop new antibiotic and substitute, cost is huge.
Summary of the invention
In order to overcome the shortcoming of above-mentioned prior art, the object of the present invention is to provide a kind of veterinary drug and preparation method of preventing and treating chicken farm staphylococcosis, can suppress staphylococcus well, the various common disease of poultry caused in treatment staphylococcus has good result.
To achieve these goals, the technical solution used in the present invention is:
Prevent and treat a veterinary drug for chicken farm staphylococcosis, configured by following component and form: Flos Chrysanthemi Indici 80-100g, Galla Chinensis 50-100g, Flos Lonicerae 30-50g, Radix Stemonae 20-40g, Radix Scutellariae 10-30g, Radix Isatidis 10-20g, Rhizoma Coptidis 5-10g, Radix Glycyrrhizae 5-10g, Herba Houttuyniae 5-10g, Radix Astragali 2-5g, Aloe 2-5g, Herba Patriniae 2-5g, Fructus Forsythiae 2-5g, Spica Prunellae 2-5g.
The veterinary drug of described control chicken farm staphylococcosis is prepared with water extraction, after component feeding, add the distilled water immersion 30 minutes of the gross mass 10 times of pan feeding, intense fire boils latter 30 minutes at a simmer, then medicinal liquid is poured onto in container, adds water and decoct again once according to the method described above, twice medicinal liquid mixing, water bath with thermostatic control is heated to crude drug content 1/mL, and autoclaving is stand-by.
In the present invention, the details of each medical material is as follows:
Flos Chrysanthemi Indici: the head inflorescence of Compositae herbaceos perennial Herba Dendranthematis indici, profile is similar to Flos Chrysanthemi, wild by patana, field wing.Inhibitory action is had to staphylococcus aureus, shigella flexneri, Bacillus typhi etc.; Go ethanol extract test tube to weigh interpretation of the law, 1:5 has inhibitory action to staphylococcus aureus, Hemolytic streptococcus, escherichia coli etc.
Galla Chinensis: all have significantly antibacterial or bactericidal action to staphylococcus aureus, streptococcus, streptococcus pneumoniae and typhoid fever, paratyphoid fever, dysentery, anthrax, diphtheria, bacillus pyocyaneus etc.Galla Chinensis is still containing other antibiotic effective ingredients except tannic acid, and be mainly distributed in skin zone, the decoct of the Galla Chinensis heart is without antibacterial action.Galla Chinensis decoct has inhibitory action to the influenza PR8 strain of influenza virus type A virus being inoculated in Embryo Gallus domesticus, may with wherein contained tannic acid is relevant.All inhibitory action is had to bacillus pyocyaneus, dysentery bacterium, Bacillus proteus, escherichia coli, Bacillus typhi, bacillus enteritidis, anthrax bacillus, diphtheria corynebacterium, staphylococcus aureus, group B streptococcus and streptococcus pneumoniae, its bacteriostasis is not the acidity due to tannic acid, but has consolidation because of it to albumen; The Galla Chinensis liquid proposed after tannin through ether still has antibacterial action.
Flos Lonicerae: property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out the cards such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.
Radix Scutellariae: heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Inflammation-inhibiting model oozes out swelling, capillary permeability increases; Suppress rat assist agent arthritis.
Fructus Forsythiae: have another name called Hemerocallis citrina Baroni bar, Fructus Forsythiae, green grass or young crops stick up, fall to sticking up, Huang Qidan etc., the pharmacological action such as have antibacterial, heart tonifying, diuresis, town to tell, there is antibacterial action, Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc. can be suppressed.
The present invention with Flos Chrysanthemi Indici, Flos Lonicerae, Galla Chinensis, Radix Scutellariae and Fructus Forsythiae for main material, with all the other drug matching, or use with antibiotic compatibility, possesses good bacteriostasis, effectively can prevent and treat the multiple staphylococcosis in chicken farm, successful has no side effect, and life-time service not easily develops immunity to drugs.
Detailed description of the invention
Embodiments of the present invention are described in detail below in conjunction with embodiment.
Embodiment 1
Prevent and treat a veterinary drug for chicken farm staphylococcosis, configured by following component and form: Flos Chrysanthemi Indici 80g, Galla Chinensis 50g, Flos Lonicerae 30g, Radix Stemonae 20g, Radix Scutellariae 10g, Radix Isatidis 10g, Rhizoma Coptidis 5g, Radix Glycyrrhizae 5g, Herba Houttuyniae 5g, Radix Astragali 5g, Aloe 2g, Herba Patriniae 5g, Fructus Forsythiae 5g, Spica Prunellae 2g.
Embodiment 2
Prevent and treat a veterinary drug for chicken farm staphylococcosis, configured by following component and form: Flos Chrysanthemi Indici 100g, Galla Chinensis 100g, Flos Lonicerae 50g, Radix Stemonae 40g, Radix Scutellariae 10g, Radix Isatidis 10g, Rhizoma Coptidis 10g, Radix Glycyrrhizae 10g, Herba Houttuyniae 10g, Radix Astragali 5g, Aloe 5g, Herba Patriniae 5g, Fructus Forsythiae 5g, Spica Prunellae 5g.
Embodiment 3
Prevent and treat a veterinary drug for chicken farm staphylococcosis, configured by following component and form: Flos Chrysanthemi Indici 9g, Galla Chinensis 6g, Flos Lonicerae 40g, Radix Stemonae 30g, Radix Scutellariae 20g, Radix Isatidis 20g, Rhizoma Coptidis 0.6g, Radix Glycyrrhizae 0.6g, Herba Houttuyniae 0.6g, Radix Astragali 2g, Aloe 2g, Herba Patriniae 2g, Fructus Forsythiae 2g, Spica Prunellae 5g.
Wherein, embodiment of the present invention 1-3 can be prepared with water extraction, after component feeding, with distilled water immersion 30 minutes, intense fire boiled latter 30 minutes at a simmer, is then poured onto in container by medicinal liquid, add water and decoct again once according to the method described above, twice medicinal liquid mixing, water bath with thermostatic control is heated to crude drug content 1g/mL, and autoclaving is stand-by.During use, medicament is admixed in feedstuff, in every kilogram of feed, admix about 1L medicinal liquid.
The ingredients of the embodiment of the present invention two is utilized to carry out antibacterial tests.
1, staphylococcus aureus and White staphylococcus is cultivated
Staphylococcus aureus is separated the leg from suffering from arthritic chicken, and White staphylococcus is separated the liver region from the chicken suffering from pneumonopathy, and cultivate 22 hours in culture medium before using, and wash away lawn with normal saline, dilution is the bacteria suspension of 1 × 1010CFU/mL.
2, process of the test
Draw two kinds of ingredients and be coated on slat chain conveyor primary surface respectively, make a call to 4 holes in the equidistant symmetry of slat chain conveyor primary surface, choose the culture medium in hole, by dull and stereotyped back cover.
Get sterilizing test tubes 6, often pipe adds sterilizing broth bouillon 1mL, then in the first pipe, adds the embodiment of the present invention two ingredients 1mL, mix homogeneously, then takes out 1mL and puts into the second pipe, and the rest may be inferred to the 6th pipe, and the 1mL finally taken out from the 6th pipe abandons.Concentration in 6 test tubes is respectively 1.00g/mL, 0.75/mL, 0.50g/mL, 0.25g/mL, 0.10g/mL, 0.05g/mL.
Draw each concentration of two kinds of ingredients, drip respectively in hole, culture plate base is put into 37 DEG C of incubators and cultivate 22h, often kind of each concentration of ingredients repeats 3 times, use vernier caliper measurement antibacterial circle diameter, ingredients same concentration of the same race gets the meansigma methods of its antibacterial circle diameter, obtains the fungistatic effect to strains tested under variable concentrations.Antibacterial circle diameter > 20mm is extremely quick, is Gao Min between 15 ~ 20mm, quick between 10 ~ 15mm being, antibacterial circle diameter < 10mm is hypoallergenic, is drug resistance without inhibition zone.
Result is as table 1 and table 2:
Table 1, to the fungistatic effect of staphylococcus aureus
Table 2, the staphylococcic fungistatic effect of dialogue
Test determination, embodiment two ingredients shows as extremely quick at more than concentration 0.25g/mL to staphylococcus aureus, 0.05g/mL and 0.01g/mL all shows as Gao Min.
Two schemes of the present invention all has good fungistatic effect to staphylococcus aureus and White staphylococcus, for further checking, carry out clinical experiment, choose disease chicken in experiment and be all diagnosed as staphylococcosis, various disease all chooses 100 examples, cures and improvement standard reference industry standard.Embodiment two admixes in feedstuff by medicament, and admix 1L medicinal liquid in every kilogram of feed, take 15 continuously, experimental data is as table 3:
| Arthritis | Tenosynovitis | Omphalitis | Septicemia | |
| Cure | 90 | 88 | 89 | 91 |
| Take a turn for the better | 95 | 93 | 92 | 94 |
Therefore, the arthritis that the present invention causes staphylococcus, tenosynovitis, callosity swell, omphalitis and septicemia etc. all have good prevention effect, and drug effect is gentle simultaneously, is adapted to life-time service.
Claims (3)
1. prevent and treat a veterinary drug for chicken farm staphylococcosis, it is characterized in that, configured by following component and form: Flos Chrysanthemi Indici 80-100g, Galla Chinensis 50-100g, Flos Lonicerae 30-50g, Radix Stemonae 20-40g, Radix Scutellariae 10-30g, Radix Isatidis 10-20g, Rhizoma Coptidis 5-10g, Radix Glycyrrhizae 5-10g, Herba Houttuyniae 5-10g, Radix Astragali 2-5g, Aloe 2-5g, Herba Patriniae 2-5g, Fructus Forsythiae 2-5g, Spica Prunellae 2-5g.
2. prevent and treat the veterinary drug of chicken farm staphylococcosis according to claim 1, it is characterized in that, configured by following component and form: Flos Chrysanthemi Indici 100g, Galla Chinensis 100g, Flos Lonicerae 50g, Radix Stemonae 40g, Radix Scutellariae 10g, Radix Isatidis 10g, Rhizoma Coptidis 10g, Radix Glycyrrhizae 10g, Herba Houttuyniae 10g, Radix Astragali 5g, Aloe 5g, Herba Patriniae 5g, Fructus Forsythiae 5g, Spica Prunellae 5g.
3. prepare the preparation method of preventing and treating the veterinary drug of chicken farm staphylococcosis described in claim 1, it is characterized in that: prepare with water extraction, after component feeding, add the distilled water immersion 30 minutes of the gross mass 10 times of pan feeding, intense fire boils latter 30 minutes at a simmer, is then poured onto in container by medicinal liquid, add water and decoct again once according to the method described above, twice medicinal liquid mixing, water bath with thermostatic control is heated to crude drug content 1/mL, and autoclaving is stand-by.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310581199.7A CN104645171A (en) | 2013-11-16 | 2013-11-16 | A veterinary drug for control of staphylomycosis in chicken farms and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310581199.7A CN104645171A (en) | 2013-11-16 | 2013-11-16 | A veterinary drug for control of staphylomycosis in chicken farms and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104645171A true CN104645171A (en) | 2015-05-27 |
Family
ID=53237140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310581199.7A Pending CN104645171A (en) | 2013-11-16 | 2013-11-16 | A veterinary drug for control of staphylomycosis in chicken farms and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104645171A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106106567A (en) * | 2016-06-16 | 2016-11-16 | 山东省实验动物中心 | A kind of disinfection solution being applicable to hen house |
| CN106728148A (en) * | 2017-03-05 | 2017-05-31 | 董新芳 | It is a kind of to treat medicine of omphalitis and preparation method thereof |
-
2013
- 2013-11-16 CN CN201310581199.7A patent/CN104645171A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106106567A (en) * | 2016-06-16 | 2016-11-16 | 山东省实验动物中心 | A kind of disinfection solution being applicable to hen house |
| CN106728148A (en) * | 2017-03-05 | 2017-05-31 | 董新芳 | It is a kind of to treat medicine of omphalitis and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106900781A (en) | Antibacterial bacteriostatic liquid prepared by a kind of vegetable Chinese herbal medicine | |
| CN105284957A (en) | Chinese herbal medicine preparation for disinfection of henhouses | |
| CN107382474A (en) | A kind of production method of Traditional Chinese medicine fertilizer | |
| CN104208294B (en) | It is a kind of to be used to treat Chinese medicine composition of piglet yellow-white dysentery and preparation method thereof | |
| CN101023805A (en) | Ginger, onion tea and preparing method | |
| CN104644755A (en) | Medicine for preventing chicken staphylococcus disease by traditional Chinese medicine extracts product and antibiotic and preparation method thereof | |
| CN104645171A (en) | A veterinary drug for control of staphylomycosis in chicken farms and preparation thereof | |
| CN106177221B (en) | Traditional Chinese medicine composition for treating porcine colibacillosis diarrhea and preparation method thereof | |
| CN102872307A (en) | Traditional Chinese medicine oral liquid for preventing and treating virus diseases of poultry and method for preparing traditional Chinese medicine oral liquid | |
| CN107320758A (en) | A kind of efficient air purifying preparation for removing livestock and poultry cultivation environmental bacteria | |
| CN108524725B (en) | Chlorine dioxide solution for oral administration | |
| CN104771745A (en) | Traditional Chinese medicine composition for treating diarrhea, preparation method and application thereof | |
| CN106389717A (en) | Piglet drug-resistant colibacillosis treating traditional Chinese medicine composition | |
| CN104524555A (en) | Traditional Chinese medicinal oral liquid for enhancing livestock and poultry immunity and preparation method of oral liquid | |
| CN104306492A (en) | Drug with anti-bacterial and synergistically anti-bacterial activity, and preparation method and application thereof | |
| CN111588801B (en) | Traditional Chinese medicine dispersible granule for preventing livestock and poultry epidemic diseases and preparation method thereof | |
| CN105831392B (en) | Pig feed additive and feed thereof | |
| CN104840591B (en) | A kind of Chinese medicine composition for having effects that to prevent ewcastle disease | |
| CN102988933B (en) | A kind of Chinese medicine composition for the treatment of evil poison heap soil or fertilizer over and around the roots pulmonary type pneumonia | |
| CN109432287B (en) | Traditional Chinese medicine oral liquid for preventing and treating excessive heat syndrome of poultry qi system and preparation method thereof | |
| CN103071029A (en) | Demodicid mite treatment agent and preparation method thereof | |
| CN105687315A (en) | Traditional Chinese medicine perfusion agent preventing and treating dairy cow mastitis and preparation method thereof | |
| CN104784621A (en) | Traditional Chinese medicine composition for treating diarrhea, and preparation method and application thereof | |
| CN110404006A (en) | A kind of pharmaceutical composition for treating chicken necrotizing enterocolitis | |
| CN103263521B (en) | Bacterial infectious disease prevention and treatment traditional Chinese veterinary medicine and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150527 |
|
| WD01 | Invention patent application deemed withdrawn after publication |