CN106728148A - It is a kind of to treat medicine of omphalitis and preparation method thereof - Google Patents

It is a kind of to treat medicine of omphalitis and preparation method thereof Download PDF

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Publication number
CN106728148A
CN106728148A CN201710125775.5A CN201710125775A CN106728148A CN 106728148 A CN106728148 A CN 106728148A CN 201710125775 A CN201710125775 A CN 201710125775A CN 106728148 A CN106728148 A CN 106728148A
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grams
medicine
madder
coptis
borneol
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CN201710125775.5A
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Chinese (zh)
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董新芳
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

Medicine of omphalitis and preparation method thereof is treated the invention discloses a kind of, it is mainly and is prepared from according to a certain weight ratio by the coptis, borneol, madder, the root of three-nerved spicebush, medicine of the present invention has purging intense heat eliminating dampness, cooling blood and hemostasis, Stasis through, clearing heat and detoxicating function, for treating omphalitis instant effect, good effect, does not recur.

Description

It is a kind of to treat medicine of omphalitis and preparation method thereof
Technical field
Medicine of omphalitis and preparation method thereof is treated the present invention relates to a kind of, belongs to the field of Chinese medicines.
Technical background
Omphalitis is the bacterial infection of navel stump.The traditional Chinese medical science is then considered because spleen kidney deficiency is weak, caused by damp-heat accumulation.Due to west Medicine treatment omphalitis side effect is big, therefore people have great demand to the Chinese medicine of effectively treatment omphalitis, up to now, also Without discovery on relevant report of the invention.
The content of the invention
The present inventor have found effectively treatment omphalitis finally according to the checking repeatedly of research and the clinical test of theory of traditional Chinese medical science Medicine, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine composition of effective treatment omphalitis.
Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.
Medicine of the present invention is to select the coptis, madder, the root of three-nerved spicebush, Radix Glycyrrhizae, rhizome of cyrtomium, borneol to be combined preparation, by these medicines Thing is combined and causes that each efficacy of drugs produces synergy such that it is able to effectively treat omphalitis.Wherein from the coptis because its property Bitter, trembles with fear, and enters the heart, liver, stomach, large intestine channel, there is purging intense heat, and eliminating dampness, removing toxic substances, the function of desinsection, row heat toxin, typhoid fever when controlling, heat contains the heart Tired, feeling of fullness is vomitted inverse, bacillary dysentery, and heat rushes down stomachache, pulmonary tuberculosis, is told, is defeated in battle, lower blood, is quenched one's thirst, infantile malnutrition due to digestive disturbances or intestinalparasites, roundworm disease, pertussis, abscess of throat, Pinkeye, aphtha, skin sore, eczema, the burning hot wound of soup.From madder because its is bitter in taste, tremble with fear, there is cooling blood and hemostasis, dissolving stasis are led to The function of warp, controls haematemesis, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, traumatism and bleeding, stasis blocking Amenorrhea, joint pain, tumbling and swelling.From the root of three-nerved spicebush because Its nature and flavor is pungent, temperature, enters spleen, lung, kidney, bladder warp, there is pleasant, opens strongly fragrant, cold dispelling, the function of analgesic, controls circulation of vital energy in the wrong direction chest and abdomen swelling and pain, place food Discontented, food, cold hernia, tinea pedis, frequent urination are told in gastric disorder causing nausea.From Radix Glycyrrhizae because its property sweet taste, enters spleen, stomach, lung channel, have with Emergency, moistening lung, removing toxic substances, the function of coordinating the drug actions of a prescription processs, deficiency of food weakness of the spleen and the stomach with controlling, loose stool of suffering from abdominal pain, overstrain heating, consumptive lung disease cough, Palpitaition, shies carbuncle, raw with controlling abscess of throat, peptic ulcer, ulcer sores, antidote poison and poisons by food.From rhizome of cyrtomium because Its is bitter in taste, cool, enter liver, stomach, kills ascarid, silk ribbon, pinworm, and heat-clearing is detoxified, and cool blood, the function of hemostasis controls anemopyretic cold, wet Hot ecchymosis, spits blood, bleeding from five sense organs or subcutaneous tissue, hematochezia, bloody flux, metrorrhagia, under band.It is cool from borneol because its nature and flavor is arduous, enter the heart, lung Through, there are logical all keys, stagnated fire is dissipated, screen improving eyesight is gone, the function of swelling and pain relieving controls apoplexy lockjaw, and pyreticosis coma , Jing Epilepsy phlegm fans are gas-tight Deafness, larynx numbness, aphtha, tympanitis, carbuncle swells, hemorrhoid, conjunctivitis, enterobiasis.
Specific embodiment
The drug dose of instant component is also that inventor summarizes what is drawn by largely groping, and the consumption of each component is following heavy All there is preferable curative effect in the range of amount：
10-20 grams of the coptis, 1-5 grams of borneol, 3-7 grams of madder, 4-8 grams of the root of three-nerved spicebush, 3-7 grams of Radix Glycyrrhizae, 5-15 grams of rhizome of cyrtomium.
Preferably：
15 grams of the coptis, 3 grams of borneol, 5 grams of madder, 6 grams of the root of three-nerved spicebush, 5 grams of Radix Glycyrrhizae, 10 grams of rhizome of cyrtomium.The preparation method of medicine of the present invention is such as Under
First, get the raw materials ready
1st, the coptis：Impurity is picked, silt particle is cleaned, run through, cut into slices, dried in the shade；
2nd, borneol：Original is used as medicine；
3rd, madder：Impurity is removed, is cleaned, run through, cut sheet or section, dried, weed out chip；
4th, the root of three-nerved spicebush：Impurity is picked, size bar is separated, is noted changing water according to season with bubble thoroughly, prevent smelly, pulled out cut in time Piece, weeds out grey bits；
5th, Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant it is saturating when, pull out, run through, cut into slices, airing；
6th, rhizome of cyrtomium：Slightly soaked with clear water, taken out, each watering sooner or later once, is softened, and is cut into slices, and is dried.
2nd, prepare
1st, the coptis that will cook, madder, the root of three-nerved spicebush, Radix Glycyrrhizae, rhizome of cyrtomium are put into decocting container and add water to cook secondary, add water for the first time 8 times of amounts, decoct 1.5 hours, add water for the second time 6 times and measure decoction 1 hour, merge decoction liquor twice, filter to get filtrate；
2nd, filtrate is condensed into the medicinal extract that proportion is 1.35, plus 90%-95% ethanol carries out alcohol precipitation, reclaims ethanol and concentrates, in 45- Dried at 50 DEG C, dry extract is obtained；
3rd, dry extract and borneol are ground to the powder altogether, is bottled stand-by.
Coptis purging intense heat in prescription, eliminating dampness, removing toxic substances, desinsection is monarch drug in a prescription；Madder cooling blood and hemostasis, Stasis through；Borneol has logical all Key, dissipates stagnated fire, goes screen improving eyesight, the function of swelling and pain relieving, and the two is ministerial drug, and three taste medicines play purging intense heat jointly, and eliminating dampness, cool blood is stopped Blood, Stasis through dissipates the effect of stagnated fire, treatment omphalitis effect comprehensively, and with purging intense heat eliminating dampness, cooling blood and hemostasis, based on Stasis through Can effect a permanent cure, Radix Glycyrrhizae has detoxifies with middle emergency, moistening lung, and coordinating the drug actions of a prescription function is adjutant, and rhizome of cyrtomium kills ascarid, silk ribbon, pinworm, heat-clearing, solution Poison, cool blood is stopped blooding to make medicine, and all medicines are to take stopgap measures with being left.
Medicine of the present invention has a purging intense heat eliminating dampness, cooling blood and hemostasis, Stasis through, clearing heat and detoxicating function, for treating omphalitis, Short treating period, instant effect, non-relapse after healing.
The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples include this hair The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention：
West Germany rabbit 30 is taken, rabbit belly hair removing is first exposed skin by male and female dual-purpose, body weight 2.0-2.5kg, then will The medicinal powder for mixing up is applied at rabbit belly baring skin, is then twined with gauze and tied up, daily coating 1 time, continuous coating 5 days, often Its observation administration reaction, as a result shows that rabbit activity, diet are normal, and medicine is without bad toxic and side effect.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1st, physical data
Accept omphalitis out-patient totally 16 for medical treatment.
2nd, diagnostic criteria
The symptom of omphalitis is umbilical region pain, hyperemia, oedema, often there is the slurries sexual secretion with stink, empyema in severe patient omphalos With heating.
3rd, treatment method
From above-mentioned medicinal powder, used to patient, cleaning goes to be spread on umbilical region in right amount behind affected part, is covered with antiseptic gauze, uses bandage bag Prick and fix, it is daily to change once, it is continuous to use 10 days.
4th, efficacy assessment standard
It is effective：Omphalitis symptom disappears, and constitution recovers normal, recovery from illness；
Take a turn for the better：Patient affected part pain, hyperemia, oedema, the phenomenon for stink slurries sexual secretion occur mitigate, and omphalitis symptom is substantially good Turn, constitution is progressively recovered；
It is invalid：Improvement standard person is not reached.
5th, treatment results（See the table below）
In above-mentioned treatment, with drug therapy omphalitis patient 16 of the present invention, as a result effective 13, obvious effective rate is 81.25%, good Turn 2, improvement rate is 12.5%, and invalid 1, total effective rate is 93.75%.

Claims (3)

1. a kind of medicine for treating omphalitis, it is characterised in that：It is made up of the bulk drug in following weight range：
10-20 grams of the coptis, 1-5 grams of borneol, 3-7 grams of madder, 4-8 grams of the root of three-nerved spicebush, 3-7 grams of Radix Glycyrrhizae, 5-15 grams of rhizome of cyrtomium.
2. medicine according to claim 1, wherein the consumption of each bulk drug is：
15 grams of the coptis, 3 grams of borneol, 5 grams of madder, 6 grams of the root of three-nerved spicebush, 5 grams of Radix Glycyrrhizae, 10 grams of rhizome of cyrtomium.
3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：
（One）Get the raw materials ready
（1）The coptis：Impurity is picked, silt particle is cleaned, run through, cut into slices, dried in the shade；
（2）Borneol：Original is used as medicine；
（3）Madder：Impurity is removed, is cleaned, run through, cut sheet or section, dried, weed out chip；
（4）The root of three-nerved spicebush：Impurity is picked, size bar is separated, is noted changing water according to season with bubble thoroughly, prevent smelly, pulled out cut in time Piece, weeds out grey bits；
（5）Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant it is saturating when, pull out, run through, cut into slices, airing；
（6）Rhizome of cyrtomium：Slightly soaked with clear water, taken out, each watering sooner or later once, is softened, and is cut into slices, and is dried；
（Two）Prepare
（1）The coptis that to cook, madder, the root of three-nerved spicebush, Radix Glycyrrhizae, rhizome of cyrtomium be put into decocting container add water to cook it is secondary, for the first time plus 8 times of amounts of water, decoct 1.5 hours, add water for the second time 6 times and measure decoction 1 hour, merge decoction liquor twice, filter to get filtrate；
（2）Filtrate is condensed into the medicinal extract that proportion is 1.35, plus 90%-95% ethanol carries out alcohol precipitation, reclaims ethanol and concentrates, Dried at 45-50 DEG C, dry extract is obtained；
（3）Dry extract and borneol are ground to the powder altogether and is obtained final product.
CN201710125775.5A 2017-03-05 2017-03-05 It is a kind of to treat medicine of omphalitis and preparation method thereof Withdrawn CN106728148A (en)

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CN201710125775.5A CN106728148A (en) 2017-03-05 2017-03-05 It is a kind of to treat medicine of omphalitis and preparation method thereof

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1679718A (en) * 2005-02-01 2005-10-12 郝玉文 Multifunctional external-applied ointment and production thereof
CN104645171A (en) * 2013-11-16 2015-05-27 西安交大京盛科技发展有限公司 A veterinary drug for control of staphylomycosis in chicken farms and preparation thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1679718A (en) * 2005-02-01 2005-10-12 郝玉文 Multifunctional external-applied ointment and production thereof
CN104645171A (en) * 2013-11-16 2015-05-27 西安交大京盛科技发展有限公司 A veterinary drug for control of staphylomycosis in chicken farms and preparation thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李政敏: "冰硼香矾散外用治疗婴幼儿脐炎", 《山东中医杂志》 *

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