CN104645158A - Traditional Chinese medicine paste for treating hyperplastic scars and preparation method of traditional Chinese medicine paste - Google Patents
Traditional Chinese medicine paste for treating hyperplastic scars and preparation method of traditional Chinese medicine paste Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine paste for treating hyperplastic scars. The traditional Chinese medicine paste is prepared from the following main raw materials in parts by weight: 5-9 parts of coptis chinensis, 6-10 parts of huperzia serrata, 6-10 parts of fructus cnidii, 8-12 parts of hydnocarpus sp, 9-15 parts of folium artemisiae argyi, 6-9 parts of momordica cochinchinensis, 8-12 parts of (old) onion stem, 7-10 parts of rhizoma smilacis glabrae, 10-15 parts of platycodon grandiflorum, 8-12 parts of carrot seed, 9-15 parts of lychee seed, 6-10 parts of sophora flavescens, 0.6-1.2 parts of orange flower essential oil and 0.5-1.0 part of permanent flower essential oil. By virtue of a preparation for external application, the medicine directly acts on the scar part, so that the convex scar can be smoothened and softened; the scar can be effectively removed; and the traditional Chinese medicine paste is significant in curative effect on hyperplastic scars.
Description
Technical field
The present invention relates to traditional Chinese medicine field, especially relate to a kind of Chinese medicinal ointment and method for making for the treatment of hypertrophic cicatrix.
Background technology
Hypertrophic cicatrix is mainly in lesion depths only and the wound of corium.The pathological tissue difference of hypertrophic cicatrix and abnormal scar is only thickening of cicatrix deep collagen fiber, shows as irregular arrangement, or in great waves shape, or be wound in cord-like.Hypertrophy cicatrix shows as protuberate, and profile is irregular, is uneven, and flushing is congested, and matter is real tough, has causalgia and scratchiness.The hardening hyperemia of early stage local swelling, the epithelial cell that its organizational structure is one deck atrophy by top layer is covered, and middle level is vasodilation, and has inflammatory cell infiltration, and bottom is less collagen fiber and a large amount of connective tissue proliferations.This cicatrix exceeds skin surface, and early stage partial thickening is hardening, and capillary injection presents redness or kermesinus.This cicatrix basilar part general not with dark tissue adhesion, can promote, and contractility is less, majority can not produce severe dysfunction, but improves looks at face and the many impacts of exposure portion, therefore also often has necessity for the treatment of.Form, the size of hypertrophic cicatrix pimple are different because of the situation difference of damage: operative incision is often strip; Scratch, after injection, cause can be strand, little bulk; Hypertrophic cicatrix pimple mostly is horizontal stripe shape at anterior part of chest, and often have typical crab-like branch, someone is referred to as butterfly spot; Scald or send out survivor after burning, the area of its size thickness and damage, the degree of depth is closely related, damages darker then hypertrophic cicatrix pimple thicker; Large area infringement can cause dyskinesia because of scar contracture; Occur in joint part and can make limbs contracture, limitation of activity, even the normal work of impact and life; Hypertrophic cicatrix pimple occurs in face and can disfeature. and hypertrophic cicatrix pimple patient shows as obvious Familial Occurrence.
Cicatrix is the inevitable outcome in human body processes of wound repair, from broadly, does not have the healing of wound without cicatrix.If scar tissue is formed insufficient, damaged tissues can not get normal tension force, can cause many complication thus, the cicatrix as incision of abdominal wall healing is weak, cicatrix place can be made again to split or the outwards bulging and form abdominal hernia gradually of abdomen content under the effect of intra-abdominal pressure.On the contrary, if cicatrix is excessively formed, serious profile or major issue functionally will be caused.Its essence and characteristic are depended in the harm of cicatrix, and the fixation of secondary to deep tissue.
In the method for existing Chinese traditional treatment hypertrophic cicatrix, publication number CN103495155A(application number 201310439270.8) patent discloses a kind of pad pasting and preparation method thereof repaired for hypertrophic cicatrix, it comprises backing layer bonding successively, sticky polymer nitride layer and sealing coat, and described sticky polymer nitride layer comprises sticky polymer thing, liposome permeation enhancers and scar active component of dispelling.Publication number CN 103656103 A(application number 201310658412.X) patent discloses a kind of Chinese medicine formula for the treatment of hypertrophic cicatrix, adopt the lavandula angustifolia elite of 10 ~ 25%, the Flos Jasmini Sambac elite of 12 ~ 15%, the mentha leave of 5 ~ 15%, the Bulbus Allii of 10 ~ 15%, with distilled water allotment to 100%, boil and form.Publication number CN 103800452 A(application number 201410098699.X) the Chinese medicine composition that patent discloses a kind of Inhibiting proliferation scars and Preparation method and use, comprise the steps: that (1) takes by weight: Radix Et Rhizoma Rhei 35-45 part, Rhizoma Chuanxiong 25-35 part, Radix Notoginseng 15-25 part, Pheretima 5-15 part; (2) get Radix Et Rhizoma Rhei, pulverize, by Radix Et Rhizoma Rhei quality 6-10 petroleum ether, chloroform or ethyl acetate heating and refluxing extraction doubly 1-3 time, each 2-4 hour, extracting liquid filtering, is evaporated to the thick paste that density is 1-2g/mL; (3) Rhizoma Chuanxiong is got, pulverize, by ethanol water reflux, extract, 1-3 time that Rhizoma Chuanxiong quality 6-10 volume fraction is doubly 95%, each 2-4 hour, extracting liquid filtering, concentrating under reduced pressure removing ethanol obtains concentrated solution, concentrated solution is put into suitable concentrated solution volume 1-3 water doubly, stir, crossing and filter precipitation, is that the ratio of 1:1-2 is by filtrate petroleum ether extraction by volume; Again by volume for the filtrate after petroleum ether extraction is extracted with ethyl acetate by the ratio of 1:1-2, acetic acid ethyl acetate extract is evaporated to the thick paste that density is 1-2g/mL; (4) getting Radix Notoginseng, pulverize, is ethanol water heating and refluxing extraction 1-3 time of 65%-75% by Radix Notoginseng quality 6-10 volume fraction doubly, each 2-4 hour, and extracting liquid filtering is evaporated to the thick paste that density is 1-2g/mL; (5) get Pheretima, pulverize, by Pheretima quality 6-10 water soaking doubly reflux, extract, 1-3 time after 30 minutes, each 2-4 hour, extracting solution filtration, is concentrated into the thick paste that density is 1-2g/mL; (6) by the thick paste mix homogeneously that step (2), (3), (4) and (5) obtain, a kind of Chinese medicine composition of Inhibiting proliferation scars is obtained.
That commonly uses at present has steroid method, radioactive method, pressure application, external scar plaster method etc. multiple.Although the above two are effective, side effect is too large, is only suitable for the little cicatrix in local, cannot applies large stretch of cicatrix.Use during pressure application and oppress the position easily ulceration because of friction, patient has sense of discomfort, and prolonged application impact is attractive in appearance, and skin is uneven, and pressure is not easily even, thus affects effect.And the required time had is long, painful large, easily repeatedly, there is adverse consequences etc.And the curative effect of current most tcm therapies is also indefinite, need further lifting.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of Chinese medicinal ointment for the treatment of hypertrophic cicatrix, and all medicine compatibilities of its selected good timber, directly act on patient part, make drug molecule directly act on skin area.Another object is just to provide the preparation method of the Chinese medicinal ointment of above-mentioned treatment hypertrophic cicatrix.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a Chinese medicinal ointment for hypertrophic cicatrix, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Coptidis 5-9 part; Herba Lycopodii serrati 6-10 part; Fructus Cnidii 6-10 part; Semen Hydnocarpi 8-12 part; Folium Artemisiae Argyi 9-15 part; Semen Momordicae 6-9 part; (always) Herba Alii fistulosi stem 8-12 part; Rhizoma Smilacis Glabrae 7-10 part; Radix Platycodonis 10-15 part; Carrot seed 8-12 part; Semen Litchi 9-15 part; Radix Sophorae Flavescentis 6-10 part; Orange blossom quintessence oil 0.6-1.2 part; Permanent flower quintessence oil 0.5-1.0 part.
Treat a Chinese medicinal ointment for hypertrophic cicatrix, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Coptidis 6-8 part; Herba Lycopodii serrati 7-9 part; Fructus Cnidii 7-9 part; Semen Hydnocarpi 9-11 part; Folium Artemisiae Argyi 11-13 part; Semen Momordicae 7-8 part; (always) Herba Alii fistulosi stem 9-11 part; Rhizoma Smilacis Glabrae 8-9 part; Radix Platycodonis 11-14 part; Carrot seed 9-11 part; Semen Litchi 11-13 part; Radix Sophorae Flavescentis 7-9 part; Orange blossom quintessence oil 0.8-1.0 part; Permanent flower quintessence oil 0.6-0.9 part.
Treat a Chinese medicinal ointment for hypertrophic cicatrix, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Coptidis 7 parts; Herba Lycopodii serrati 8 parts; Fructus Cnidii 8 parts; Semen Hydnocarpi 10 parts; Folium Artemisiae Argyi 12 parts; Semen Momordicae 7.5 parts; 10 parts, (always) Herba Alii fistulosi stem; Rhizoma Smilacis Glabrae 8.5 parts; Radix Platycodonis 12 parts; Carrot seed 10 parts; Semen Litchi 12 parts; Radix Sophorae Flavescentis 8 parts; Orange blossom quintessence oil 0.9 part; Permanent flower quintessence oil 0.7 part.
The preparation method of the Chinese medicinal ointment of above-mentioned treatment hypertrophic cicatrix, step is as follows:
(1) (always) Herba Alii fistulosi stem is smashed to pieces, extraction by steam distillation 5-6 hour;
(2) pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, when moderate heat is heated to meter Mao Yan, add Fructus Cnidii, Semen Hydnocarpi, Semen Momordicae, carrot seed and Semen Litchi, stir the medical material on rice gently, moderate heat fries 20-30 minute, takes out, dry in the air cool, sieve removes rice, and medical material is ground into fine powder altogether, crosses 100-140 mesh sieve;
(3) by Rhizoma Coptidis, Herba Lycopodii serrati, Folium Artemisiae Argyi, Rhizoma Smilacis Glabrae, Radix Platycodonis and Radix Sophorae Flavescentis section, be placed in marmite, decoct twice, each decoct 30-40 minute, filter, twice filtrate merges, and is concentrated into relative density 1.20-1.40(45 DEG C) thick paste;
(4) by step (2) medicated powder join step (3) gained thick paste, mix homogeneously;
(5) extract obtained for step (1), orange blossom quintessence oil and permanent flower quintessence oil are joined in step (4) gained thick liquid, add the Borneolum Syntheticum of porphyrize, mix homogeneously, inspection, packs.
The preparation method of the Chinese medicinal ointment of above-mentioned treatment hypertrophic cicatrix, preferred scheme is: step (1) preferably extracts 5.3-5.7 hour, is more preferably extraction 5.5 hours.
The preparation method of the Chinese medicinal ointment of above-mentioned treatment hypertrophic cicatrix, preferred scheme is: step (2) preferably moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes.
The preparation method of the Chinese medicinal ointment of above-mentioned treatment hypertrophic cicatrix, preferred scheme is: step (2) is preferred crosses 110-130 mesh sieve, is more preferably 120 mesh sieves.
The preparation method of the Chinese medicinal ointment of above-mentioned treatment hypertrophic cicatrix, preferred scheme is: step (3) is preferably concentrated into relative density 1.25-1.35(45 DEG C) thick paste, be more preferably and be concentrated into relative density 1.30(45 DEG C) thick paste.
The preparation method of the Chinese medicinal ointment of above-mentioned treatment hypertrophic cicatrix, preferred scheme is: the consumption of the preferred Borneolum Syntheticum of step (5) is the 5%-7% of thick liquid quality, and the consumption being more preferably Borneolum Syntheticum is 6% of thick liquid quality.
using method: cleaned at cicatrix place and dry, will spread on cicatrix place outside this product, smearing thickness is 0.5 mm, and external application every day once, 7 days is a course for the treatment of.
Beneficial effect of the present invention is mainly reflected in:
1, the present invention is based on the principle of Chinese traditional treatment hypertrophic cicatrix, protruding cicatrix can be made smooth, softening, effectively desalinate cicatrix, evident in efficacy to hypertrophic cicatrix.
2, the medical material selected is more common, cheap and easy to operate, and painful few, the numerous common people can afford.
3, adopt the mode of external application, by the local penetration of medicine, be applied directly to skin area, more effectively eliminate cicatrix more fast.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1treat a Chinese medicinal ointment for hypertrophic cicatrix, take off and state primary raw material and be prepared from (getting 30g for every part): Rhizoma Coptidis 5 parts; Herba Lycopodii serrati 6 parts; Fructus Cnidii 6 parts; Semen Hydnocarpi 8 parts; Folium Artemisiae Argyi 9 parts; Semen Momordicae 6 parts; 8 parts, (always) Herba Alii fistulosi stem; Rhizoma Smilacis Glabrae 7 parts; Radix Platycodonis 10 parts; Carrot seed 8 parts; Semen Litchi 9 parts; Radix Sophorae Flavescentis 6 parts; Orange blossom quintessence oil 0.6 part; Permanent flower quintessence oil 0.5 part.
A kind of Chinese medicinal ointment preparation process for the treatment of hypertrophic cicatrix is as follows:
(1) (always) Herba Alii fistulosi stem is smashed to pieces, extraction by steam distillation 5 hours;
(2) pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, when moderate heat is heated to meter Mao Yan, add Fructus Cnidii, Semen Hydnocarpi, Semen Momordicae, carrot seed and Semen Litchi, stir the medical material on rice gently, moderate heat fries 20 minutes, takes out, dry in the air cool, sieve removes rice, and medical material is ground into fine powder altogether, crosses 100 mesh sieves;
(3) by Rhizoma Coptidis, Herba Lycopodii serrati, Folium Artemisiae Argyi, Rhizoma Smilacis Glabrae, Radix Platycodonis and Radix Sophorae Flavescentis section, be placed in marmite, decoct twice, each to decoct 30 minutes, filter, twice filtrate merges, and is concentrated into relative density 1.20(45 DEG C) thick paste;
(4) by step (2) medicated powder join step (3) gained thick paste, mix homogeneously;
(5) extract obtained for step (1), orange blossom quintessence oil and permanent flower quintessence oil are joined in step (4) gained thick liquid, add the Borneolum Syntheticum of porphyrize, mix homogeneously, inspection, packs.
Using method: cleaned at cicatrix place and dry, will spread on cicatrix place outside this product, smearing thickness is 0.5 mm, and external application every day once, 7 days is a course for the treatment of.
model case onerhizoma Zingiberis Recens XX, man, 26 years old, people from Huancui District, In Shandong Weihai.20 years old that year, grown a lot of comedos with it, especially on face cheek limit, shoulder, back, Mr. Jiang always squeezes with hands and does small pox, and the time has been grown, and the place behind squeezed lane leaves a lot of cicatrix.After make a return journey and just to know after examination in hospital and oneself belong to cicatrix body constitution, the cicatrix produced is difficult to recovery from illness, so select to have an injection treatment, effect well at that time, the skin of result irriate creates hypertrophic cicatrix, and present trace trace just there will be pain and pruritus at improper diet or when having a rest bad.
Use the Chinese medicinal ointment of embodiment 1 gained treatment hypertrophic cicatrix, about 1 course for the treatment of of medication, the obvious deliquescing of cicatrix, the color of cicatrix is also thin out a lot.After continuing 2 courses for the treatment of of use, the transference cure of pain pruritus, cicatrix is cancellation, just also has light vestige.Follow up a case by regular visits to after half a year and learn and fully recover, do not recur, period has no adverse reaction.
embodiment 2treat a Chinese medicinal ointment for hypertrophic cicatrix, take off and state primary raw material and be prepared from (getting 20g for every part): Rhizoma Coptidis 9 parts; Herba Lycopodii serrati 10 parts; Fructus Cnidii 10 parts; Semen Hydnocarpi 12 parts; Folium Artemisiae Argyi 15 parts; Semen Momordicae 9 parts; 12 parts, (always) Herba Alii fistulosi stem; Rhizoma Smilacis Glabrae 10 parts; Radix Platycodonis 15 parts; Carrot seed 12 parts; Semen Litchi 15 parts; Radix Sophorae Flavescentis 10 parts; Orange blossom quintessence oil 1.2 parts; Permanent flower quintessence oil 1.0 parts.
A kind of preparation process for the treatment of the Chinese medicinal ointment of hypertrophic cicatrix is as follows:
(1) (always) Herba Alii fistulosi stem is smashed to pieces, extraction by steam distillation 6 hours;
(2) pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, when moderate heat is heated to meter Mao Yan, add Fructus Cnidii, Semen Hydnocarpi, Semen Momordicae, carrot seed and Semen Litchi, stir the medical material on rice gently, moderate heat fries 30 minutes, takes out, dry in the air cool, sieve removes rice, and medical material is ground into fine powder altogether, crosses 140 mesh sieves;
(3) by Rhizoma Coptidis, Herba Lycopodii serrati, Folium Artemisiae Argyi, Rhizoma Smilacis Glabrae, Radix Platycodonis and Radix Sophorae Flavescentis section, be placed in marmite, decoct twice, each to decoct 40 minutes, filter, twice filtrate merges, and is concentrated into relative density 1.40(45 DEG C) thick paste;
(4) by step (2) medicated powder join step (3) gained thick paste, mix homogeneously;
(5) extract obtained for step (1), orange blossom quintessence oil and permanent flower quintessence oil are joined in step (4) gained thick liquid, add the Borneolum Syntheticum of porphyrize, mix homogeneously, inspection, packs.
Using method: cleaned at cicatrix place and dry, will spread on cicatrix place outside this product, smearing thickness is 0.5 mm, and external application every day once, 7 days is a course for the treatment of.
model case twostone XX, female, 38 years old, Qingdao of Shandong province Pingdu City people.Testedly before 9 years find ovarian cyst, so carried out ovarian tumor resection operation, perform the operation very successful.But postoperative wound develops into hypertrophic cicatrix, scarring areas pruritus, pain.
Use the Chinese medicinal ointment of the embodiment of the present invention 2 gained treatment hypertrophic cicatrix, after 2 courses for the treatment of, cicatrix has flattened smooth a lot, and effect is very good.See this curative effect, after continuing 2 courses for the treatment of of use, sense of discomfort disappears, and skin area flattens smooth, and the symptom of pruritus pain disappears substantially.1 year visit is learnt, hypertrophic cicatrix is without recurrence sign, and symptom disappears completely.
embodiment 3treat a Chinese medicinal ointment for hypertrophic cicatrix, take off and state primary raw material and be prepared from (getting 50g for every part): Rhizoma Coptidis 6 parts; Herba Lycopodii serrati 7 parts; Fructus Cnidii 7 parts; Semen Hydnocarpi 9 parts; Folium Artemisiae Argyi 11 parts; Semen Momordicae 7 parts; 9 parts, (always) Herba Alii fistulosi stem; Rhizoma Smilacis Glabrae 8 parts; Radix Platycodonis 11 parts; Carrot seed 9 parts; Semen Litchi 11 parts; Radix Sophorae Flavescentis 7 parts; Orange blossom quintessence oil 0.8 part; Permanent flower quintessence oil 0.6 part.
A kind of Chinese medicinal ointment preparation process for the treatment of hypertrophic cicatrix is as follows:
(1) (always) Herba Alii fistulosi stem is smashed to pieces, extraction by steam distillation 5.3 hours;
(2) pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, when moderate heat is heated to meter Mao Yan, add Fructus Cnidii, Semen Hydnocarpi, Semen Momordicae, carrot seed and Semen Litchi, stir the medical material on rice gently, moderate heat fries 25 minutes, takes out, dry in the air cool, sieve removes rice, and medical material is ground into fine powder altogether, crosses 120 mesh sieves;
(3) by Rhizoma Coptidis, Herba Lycopodii serrati, Folium Artemisiae Argyi, Rhizoma Smilacis Glabrae, Radix Platycodonis and Radix Sophorae Flavescentis section, be placed in marmite, decoct twice, each to decoct 35 minutes, filter, twice filtrate merges, and is concentrated into relative density 1.25(45 DEG C) thick paste;
(4) by step (2) medicated powder join step (3) gained thick paste, mix homogeneously;
(5) extract obtained for step (1), orange blossom quintessence oil and permanent flower quintessence oil are joined in step (4) gained thick liquid, add the Borneolum Syntheticum of porphyrize, mix homogeneously, inspection, packs.
Using method: cleaned at cicatrix place and dry, will spread on cicatrix place outside this product, smearing thickness is 0.5 mm, and external application every day once, 7 days is a course for the treatment of.
embodiment 4treat a Chinese medicinal ointment for hypertrophic cicatrix, take off and state primary raw material and be prepared from (getting 20g for every part): Rhizoma Coptidis 8 parts; Herba Lycopodii serrati 9 parts; Fructus Cnidii 9 parts; Semen Hydnocarpi 11 parts; Folium Artemisiae Argyi 13 parts; Semen Momordicae 8 parts; 11 parts, (always) Herba Alii fistulosi stem; Rhizoma Smilacis Glabrae 9 parts; Radix Platycodonis 14 parts; Carrot seed 11 parts; Semen Litchi 13 parts; Radix Sophorae Flavescentis 9 parts; Orange blossom quintessence oil 1.0 parts; Permanent flower quintessence oil 0.9 part.
A kind of Chinese medicinal ointment preparation process for the treatment of hypertrophic cicatrix is as follows:
(1) (always) Herba Alii fistulosi stem is smashed to pieces, extraction by steam distillation 5.7 hours;
(2) pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, when moderate heat is heated to meter Mao Yan, add Fructus Cnidii, Semen Hydnocarpi, Semen Momordicae, carrot seed and Semen Litchi, stir the medical material on rice gently, moderate heat fries 27 minutes, takes out, dry in the air cool, sieve removes rice, and medical material is ground into fine powder altogether, crosses 130 mesh sieves;
(3) by Rhizoma Coptidis, Herba Lycopodii serrati, Folium Artemisiae Argyi, Rhizoma Smilacis Glabrae, Radix Platycodonis and Radix Sophorae Flavescentis section, be placed in marmite, decoct twice, each to decoct 37 minutes, filter, twice filtrate merges, and is concentrated into relative density 1.35(45 DEG C) thick paste;
(4) by step (2) medicated powder join step (3) gained thick paste, mix homogeneously;
(5) extract obtained for step (1), orange blossom quintessence oil and permanent flower quintessence oil are joined in step (4) gained thick liquid, add the Borneolum Syntheticum of porphyrize, mix homogeneously, inspection, packs.
Using method: cleaned by sore place and dry, directly this product is affixed on affected part, often pastes and uses 10-20 hour, and within every two days, using one to paste, 7 days is a course for the treatment of.
model case threeyellow XX, man, 21 years old, Accessories during Binzhou, Shandong Province from Bincheng District.Before 2 years, having there is a lot of small pox in Mr. Huang, there is no positive effect after smearing some medicines on the face, and skin also becomes more coarse, and pore increases.After the hospital that makes a return journey done acupuncture, but post-stimulatory skin is left many soft little meatballs, hard, some colors or even purple, sometimes can itch, can ache.Examination in hospital is gone to be diagnosed as proliferative cicatrix.Used cicatrix enemy to stick afterwards, and when being finished rear cleaning, all can think that deliquescing had flattened at every turn, but if need not, again can be hardening, then occur disturbing sample pain.
After using 2 courses for the treatment of of Chinese medicinal ointment of embodiment 4 gained treatment hypertrophic cicatrix, the symptom of pruritus pain obviously alleviates, and cicatrix obviously reduces.After continuing 2 courses for the treatment of of use, cicatrix disappears substantially, for preventing again recurring, continuing use and consolidating 1 course for the treatment of.Later stage visits and learns and fully recover, and has no adverse reaction during medication.
embodiment 5treat a Chinese medicinal ointment for hypertrophic cicatrix, take off and state primary raw material and be prepared from (getting 10g for every part): Rhizoma Coptidis 7 parts; Herba Lycopodii serrati 8 parts; Fructus Cnidii 8 parts; Semen Hydnocarpi 10 parts; Folium Artemisiae Argyi 12 parts; Semen Momordicae 7.5 parts; 10 parts, (always) Herba Alii fistulosi stem; Rhizoma Smilacis Glabrae 8.5 parts; Radix Platycodonis 12 parts; Carrot seed 10 parts; Semen Litchi 12 parts; Radix Sophorae Flavescentis 8 parts; Orange blossom quintessence oil 0.9 part; Permanent flower quintessence oil 0.7 part.
A kind of Chinese medicinal ointment preparation process for the treatment of hypertrophic cicatrix is as follows:
(1) (always) Herba Alii fistulosi stem is smashed to pieces, extraction by steam distillation 5.5 hours;
(2) pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, when moderate heat is heated to meter Mao Yan, add Fructus Cnidii, Semen Hydnocarpi, Semen Momordicae, carrot seed and Semen Litchi, stir the medical material on rice gently, moderate heat fries 25 minutes, takes out, dry in the air cool, sieve removes rice, and medical material is ground into fine powder altogether, crosses 120 mesh sieves;
(3) by Rhizoma Coptidis, Herba Lycopodii serrati, Folium Artemisiae Argyi, Rhizoma Smilacis Glabrae, Radix Platycodonis and Radix Sophorae Flavescentis section, be placed in marmite, decoct twice, each to decoct 35 minutes, filter, twice filtrate merges, and is concentrated into relative density 1.30(45 DEG C) thick paste;
(4) by step (2) medicated powder join step (3) gained thick paste, mix homogeneously;
(5) extract obtained for step (1), orange blossom quintessence oil and permanent flower quintessence oil are joined in step (4) gained thick liquid, add the Borneolum Syntheticum of porphyrize, mix homogeneously, inspection, packs.
Using method: cleaned at cicatrix place and dry, will spread on cicatrix place outside this product, smearing thickness is 0.5 mm, and external application every day once, 7 days is a course for the treatment of.
The pharmacological effect of each crude drug is respectively:
Rhizoma Coptidis: bitter in the mouth, cold in nature.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.For the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall.There is heat clearing and damp drying, effect of eliminating fire and detoxication.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.
Herba Lycopodii serrati: bitter in the mouth, pungent, micro-sweet, property is put down.Return lung, large intestine, liver, kidney channel.For the herb of Huperziaceae plants of Huperzia snake-stone stone China fir.Herba Lycopodii serrati grass is containing alkaloid: lycopodine, [4aR-(4a.alpha.,5.alpha.,10b.alpha.,12R .), serrate clubmoss herb alkali, lycodoline, excellent lycoclavanin alkali, the peaceful alkali of Herba Lycopodii serrati, its peaceful alkali of Herba Lycopodii serrati, and its Buddhist nun of Herba Lycopodii serrati determines alkali, lycoclavine alkali etc.Have dissipating blood stasis hemostasis, effect of removing damp-heat, detumescence, for traumatic injury, over-strained hemoptysis, hematuria, hemorrhoid hematochezia, tympanites, leucorrhea, venom, ulcer does not close up for a long time, burn and scald.
Fructus Cnidii: acrid in the mouth, hardship, warm in nature.Return kidney channel.For the dry mature fruit of samphire cnidium monnieri.There is warming the kidney to invigorate YANG, dampness, dispel the wind, effect of parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.
Semen Hydnocarpi: acrid in the mouth, hot in nature.Enter lung, Liver Channel.Another name is Semen Hydnocarpi, meter Kang Qie, tail add wood, leprosy.For the mature seed of Semen Hydnocarpi section plant Semen Hydnocarpi.There is dispeiling pathogenic wind and removing dampness, effect of detoxicating and killing parasites.For dispeiling pathogenic wind and removing dampness, detoxicating and killing parasites, leprosy, scabies, syphilitic skin lesion etc.
Folium Artemisiae Argyi: acrid in the mouth, hardship, warm in nature, slightly poisonous.Return liver,spleen,kidney warp.For the dried leaves of feverfew Chinese mugwort.There is dispersing cold for relieving pain, effect of warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, official is cold infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage, external treatment skin pruritus.The routine fashion of Folium Artemisiae Argyi (charcoal) is: get clean Folium Artemisiae Argyi, is placed in pot, fries to 6 seventy percent with high heat, and spray clear water is a little, and go out most Mars, and slightly fry, taking-up cools completely.
Semen Momordicae: bitter in the mouth, micro-sweet, cool in nature, poisonous.Return liver, spleen, stomach warp.For the dry mature seed of cucurbitaceous plant Semen Momordicae.Have mass dissipating and swelling eliminating, counteracting toxic substances treats effect of skin ulcer.For sore swollen toxin, acute mastitis, scrofula, anal fistula, chronic eczema, tinea alba.
(always) Herba Alii fistulosi stem: acrid in the mouth, warm in nature.Attach to the lung and stomach meridians.For Liliaceae allium Herba Alii fistulosi, with bulb or all herbal medicine.Have and deliver, activate yang, effect of removing toxic substances.For the headache of typhoid fever cold and heat, YIN-cold is suffered from abdominal pain, malnutrition due to parasitic infestation internal resistance, constipation and anuresis, dysentery, carbuncle.
Rhizoma Smilacis Glabrae: sweet in the mouth, light, property is put down.Return liver, stomach, spleen channel.For Liliaceae perennial evergreen climbs shape shrub, part of being used as medicine only selects its dried rhizome.There is removing toxic substances, dehumidifying, the effect in sharp joint.For controlling syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, furuncle, carbuncle, scrofula, syphilis and the limbs contracture caused by mercurialism, bones and muscles pain.
Radix Platycodonis: bitter in the mouth, pungent, property is put down.Return lung meridian.For the dry root of Campanulaceae Radix Platycodonis.There is lung qi dispersing, sore-throat relieving, eliminate the phlegm, effect of evacuation of pus.For cough with copious phlegm, uncomfortable in chest smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Carrot seed: sweet in the mouth, pungent, property is put down.Return lung, spleen, stomach warp.Containing multivitamin and mineral, lignin, nicotinic acid, protein, fat, also containing calcium, phosphorus, ferrum etc.Containing carotene in carrot seed, be very easily absorbed by the body.In 8 seed amino acids that human body needs, Radix Dauci Sativae contains 5 kinds more than, especially the highest with lysine content.For preventing hepatitis, liver cirrhosis, promote muscle power, strengthening vision, treatment menoxenia, treats anemia, has bad physiques, appetite stimulator, promotes hemopoietic and can change congestion, useful body of gland system, conditioning body in refuse hoard, diuresis, pre-menstrual syndrome of releiving, treatment spondylitis.
Semen Litchi: sweet in the mouth, micro-hardship, warm in nature.Return liver, kidney channel.For the dry mature seed of sapindaceous plant Fructus Litchi.There is promoting QI to circulate and dispersing the agglomeration of the pathogens, effect of cold-dispelling pain-relieving.For colic of cold type stomachache, painful and swollen testis.
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature.GUIXIN, liver, stomach, large intestine, urinary bladder channel.For the dry root of leguminous plant Radix Sophorae Flavescentis.There is heat clearing and damp drying, parasite killing, effect of diuresis.For hematodiarrhoea, have blood in stool. jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
Orange blossom quintessence oil: purchased from Ya Qi industry (Shanghai) Co., Ltd..Spend middle extraction from a kind of bigarabe plant.Main chemical compositions australene, camphene, nopinene, α-terpinene, nerol, neryl acetate, farnesol, acid esters and indole.There is effect of whitening, moisturizing, crease-resistant, light speckle.Strengthen cell viability, help cell regeneration, increase skin elasticity; Whitening, moisturizing, light speckle, nourish crease-resistant, recovers tender and lovely.
Permanent flower quintessence oil: purchased from Ya Qi industry (Shanghai) Co., Ltd..Be from the flower of permanent flower, leaf, stem, root or fruit, refined the volatile flavor of extraction by steam distillation, squeezing and pressing method, cold-maceration or solvent extraction method.There is antiinflammatory, spasmolytic, antiviral, convergence, sterilization, function of gallbladder promoting, diuresis, soft skin, reduce phlegm, promote the effects such as cell regeneration, antifungal, sharp liver, calmness, sharp spleen.Can blood stasis removing, antiinflammatory antiallergic, wound cicatrix etc.
test example: in order to verify the curative effect of the Chinese medicinal ointment (embodiment 5) of gained of the present invention treatment hypertrophic cicatrix: in June, 2008, in JIUYUE ,-2010 did contrast test.
General data: screen 250 routine patients in Duo Suo hospital, wherein women 162 example, male 88 example, max age 56 years old, minimal ages 10 years old.Be divided into experimental group and matched group two groups (wherein experimental group has 150 people, and matched group has 100 people) at random.
Diagnostic criteria: 1, protuberate, profile is irregular, is uneven, and flushing is congested, and matter is real tough.2, there are causalgia and scratchiness, notably can cause surperficial ulceration because scratching.3, cicatrix is apparently higher than four sides normal skin, and partial thickening is hardening.4, in early days, scar surface takes on a red color, flushing or purplish red, and itching with pain is cardinal symptom.
Usage and dosage: experimental group uses gained of the present invention to treat the Chinese medicinal ointment of hypertrophic cicatrix, and using method is: cleaned at cicatrix place and dry, will spread on cicatrix place outside this product, smearing thickness is 0.5 mm, and external application every day once, 7 days is a course for the treatment of.Matched group uses other Therapeutic Method (as used cicatrix enemy, Shu Hen etc.).
Curative effect situation criterion: (1) cures: no conscious sympton (comprise and disturb sample pain etc.), outstanding cicatrix cancellation, color and luster and normal skin close; Effective: conscious sufferings symptom obviously alleviates, and cicatrix thickness obviously alleviates, color and luster improves; Invalid: sufferings symptom is without alleviating, and cicatrix thickness is without improvement and even some increases, and hyperemia is still obvious.
Use 5 courses for the treatment of of Drug therapy, observe latter 1 month for the treatment of.Adopt the matched group of other treatment mode and use gained of the present invention to treat the Comparison of therapeutic of the experimental group of the Chinese medicinal ointment of hypertrophic cicatrix, result is as shown in table 1:
Table 1
therapeutic effect: use gained of the present invention to treat healing 102 people of the Chinese medicinal ointment of hypertrophic cicatrix, cure rate is up to 68%, and effective 45 people, obvious effective rate 30%, invalid 3 people, effective percentage reaches 98%.And using healing 40 people of other Therapeutic Method, cure rate only reaches 40%, effective 45 people, and invalid number is but up to 15 people, and inefficiency reaches 15%, effective percentage only 85%.Can find out: the successful using gained of the present invention to treat the Chinese medicinal ointment of hypertrophic cicatrix is better than using the effect of other therapeutic modality.And just can fully recover after generally using 3-5 the course for the treatment of, use little recurrence of the present invention is learnt in visiting of postmenstruation, substantially once can cure, bring Gospel to extensive patients, alleviate the misery of patient.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat a Chinese medicinal ointment for hypertrophic cicatrix, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Coptidis 5-9 part; Herba Lycopodii serrati 6-10 part; Fructus Cnidii 6-10 part; Semen Hydnocarpi 8-12 part; Folium Artemisiae Argyi 9-15 part; Semen Momordicae 6-9 part; (always) Herba Alii fistulosi stem 8-12 part; Rhizoma Smilacis Glabrae 7-10 part; Radix Platycodonis 10-15 part; Carrot seed 8-12 part; Semen Litchi 9-15 part; Radix Sophorae Flavescentis 6-10 part; Orange blossom quintessence oil 0.6-1.2 part; Permanent flower quintessence oil 0.5-1.0 part.
2. Chinese medicinal ointment according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Coptidis 6-8 part; Herba Lycopodii serrati 7-9 part; Fructus Cnidii 7-9 part; Semen Hydnocarpi 9-11 part; Folium Artemisiae Argyi 11-13 part; Semen Momordicae 7-8 part; (always) Herba Alii fistulosi stem 9-11 part; Rhizoma Smilacis Glabrae 8-9 part; Radix Platycodonis 11-14 part; Carrot seed 9-11 part; Semen Litchi 11-13 part; Radix Sophorae Flavescentis 7-9 part; Orange blossom quintessence oil 0.8-1.0 part; Permanent flower quintessence oil 0.6-0.9 part.
3. Chinese medicinal ointment according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Coptidis 7 parts; Herba Lycopodii serrati 8 parts; Fructus Cnidii 8 parts; Semen Hydnocarpi 10 parts; Folium Artemisiae Argyi 12 parts; Semen Momordicae 7.5 parts; 10 parts, (always) Herba Alii fistulosi stem; Rhizoma Smilacis Glabrae 8.5 parts; Radix Platycodonis 12 parts; Carrot seed 10 parts; Semen Litchi 12 parts; Radix Sophorae Flavescentis 8 parts; Orange blossom quintessence oil 0.9 part; Permanent flower quintessence oil 0.7 part.
4., according to the preparation method of the arbitrary described Chinese medicinal ointment of claim 1-3, it is characterized in that, step is as follows:
(1) (always) Herba Alii fistulosi stem is smashed to pieces, extraction by steam distillation 5-6 hour;
(2) pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, when moderate heat is heated to meter Mao Yan, add Fructus Cnidii, Semen Hydnocarpi, Semen Momordicae, carrot seed and Semen Litchi, stir the medical material on rice gently, moderate heat fries 20-30 minute, takes out, dry in the air cool, sieve removes rice, and medical material is ground into fine powder altogether, crosses 100-140 mesh sieve;
(3) by Rhizoma Coptidis, Herba Lycopodii serrati, Folium Artemisiae Argyi, Rhizoma Smilacis Glabrae, Radix Platycodonis and Radix Sophorae Flavescentis section, be placed in marmite, decoct twice, each decoct 30-40 minute, filter, twice filtrate merges, and is concentrated into relative density 1.20-1.40(45 DEG C) thick paste;
(4) by step (2) medicated powder join step (3) gained thick paste, mix homogeneously;
(5) extract obtained for step (1), orange blossom quintessence oil and permanent flower quintessence oil are joined in step (4) gained thick liquid, add the Borneolum Syntheticum of porphyrize, mix homogeneously, inspection, packs.
5. preparation method according to claim 4, is characterized in that: step (1) preferably extracts 5.3-5.7 hour, is more preferably extraction 5.5 hours.
6. preparation method according to claim 4, is characterized in that: step (2) preferably moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes.
7. preparation method according to claim 4, is characterized in that: step (2) is preferred crosses 110-130 mesh sieve, is more preferably 120 mesh sieves.
8. preparation method according to claim 4, is characterized in that: step (3) is preferably concentrated into the thick paste of relative density 1.25-1.35, is more preferably the thick paste being concentrated into relative density 1.30.
9. preparation method according to claim 4, is characterized in that: the consumption of the preferred Borneolum Syntheticum of step (5) is the 5%-7% of thick liquid quality, and the consumption being more preferably Borneolum Syntheticum is 6% of thick liquid quality.
10. the application of the Chinese medicinal ointment as described in as arbitrary in claim 1-3 when the medicine for the preparation for the treatment of hypertrophic cicatrix.
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