CN104644675A - Production method of micro donkey-hide gelatin beads - Google Patents
Production method of micro donkey-hide gelatin beads Download PDFInfo
- Publication number
- CN104644675A CN104644675A CN201510038404.4A CN201510038404A CN104644675A CN 104644675 A CN104644675 A CN 104644675A CN 201510038404 A CN201510038404 A CN 201510038404A CN 104644675 A CN104644675 A CN 104644675A
- Authority
- CN
- China
- Prior art keywords
- corii asini
- colla corii
- donkey
- hide gelatin
- microgranule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention discloses a production method of micro donkey-hide gelatin beads, which comprises the following steps that: (1) a raw donkey-hide gelatin material is taken and smashed to form 10 to 100 mesh donkey-hide gelatin fine powder; (2) the donkey-hide gelatin fine powder is heated and melt to be in sheet shape and cooled, the donkey-hide gelatin sheets are cooled and solidified, and then cut into donkey-hide gelatin cubes with the particle diameters of 1-4mm, and the donkey-hide gelatin cubes are air-dried, dried or aired till the moisture content is less than 20%; and (3) clam meal is taken and heated to 150-210 DEG C by a herbal medicine roaster, the donkey-hide gelatin cubes are added after the temperature is stable, roasted, and heated to swell to form donkey-hide gelatin beads with the particle diameters of 1-3mm, the clam meal and the donkey-hide gelatin beads in the herbal medicine roaster are poured out, and subjected to a 10-mesh screen, and the finished micro donkey-hide gelatin beads are obtained. The particle diameters of the micro donkey-hide gelatin beads are much less than that of the existing donkey-hide gelatin product, so that the micro donkey-hide gelatin beads are convenient to carry and easy to take, meet market requirements, and is suitable for most people for use.
Description
Technical field
The present invention relates to Medicines and Health Product production field, particularly relate to a kind of production method of microgranule Colla Corii Asini bead.
Background technology
Colla Corii Asini be equine species donkey (
equus asinnusL.) dry skin or Cortex Dictamni through decocting, the concentrated solid gum made, there is YIN nourishing of enriching blood, moisturize the effect of hemostasis.Colla Corii Asini is colloid, and its property is grown greasy, and have denseer skin stink smell, and hinder taste, part population can produce the reaction of getting angry after taking.
Colla Corii Asini bead is the processed product after Colla Corii Asini is diced after frying (scalding) system, reduce and grow greasy property, enhance nourishing YIN and moistening the lung effect, the benefit of food and oiliness, not dry, is easy to digestion, absorbs, correct its bad smell, reduce and hinder stomach side effect, simultaneously quality is crisp, takes and does not need molten, directly take after mixing it with hot water or rapid solution take in the beverage such as decoction, milk, easy to carry.Colla Corii Asini bead, nature and flavor with return through: sweet, flat.Return lung, liver, kidney channel.Function with cure mainly: YIN nourishing of enriching blood, moisturize, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
According to " Chinese Pharmacopoeia " 2010 editions standards, the method for making of Colla Corii Asini bead is as follows: get Colla Corii Asini, softened by baking, be cut into the fourth of about 1cm, scald to Cheng Zhu according to the method for scalding (Chinese Pharmacopoeia " 2010 edition appendix II D) with Pulvis concha Mactrae, until interior without soft yolk time, take out, sieve removes Pulvis concha Mactrae, cools.Due to current Colla Corii Asini industry device and technique restriction, domestic Colla Corii Asini fourth minimum at present can cut into the square granule of 0.6cm*0.6cm, and this kind of Colla Corii Asini fourth is too large, scald the class ball-type Colla Corii Asini bead diameter made and be at least 3cm, when scalding processed or have soft yolk, or surface is charred, and often finished product Colla Corii Asini bead quality is not good, therapeutic effect is bad, simultaneously also because Colla Corii Asini bead granule is too large, be not easy to carry, it is more inconvenient to take, so cause the demand on market not vigorous, industrial volume production is few.
At present, researcher is also separately had to adopt microwave processing method to make the microgranule Colla Corii Asini bead (technical study of microwave processing Colla Corii Asini bead--" Chinese patent medicine " 05 phase in 2008, the technical study of microwave processing Colla Corii Asini bead, Cui Jinyu, Jia Tianzhu), first the method has abandoned the statutory standards of " Chinese Pharmacopoeia " 2010 editions (hereinafter referred to as " Chinese Pharmacopoeia "): production Colla Corii Asini bead must adopt " stir-frying-technology " in Chinese medicine processing method, in microwave heating process, this kind of method does not adopt " Pulvis concha Mactrae " to scald system simultaneously, this has also seriously run counter to the legal requirements in " Chinese Pharmacopoeia ".Explicitly point out in " Chinese Pharmacopoeia ", the concocting method that Manufacture of medicinal slices of TCM must specify in strict accordance with " Chinese Pharmacopoeia " is carried out, and must not adopt the diverse ways with States Pharmacopoeia specifications, otherwise, will punish according to substandard drug.The microgranule Colla Corii Asini bead adopting microwave processing method to make not only does not meet relevant national standard, and the Colla Corii Asini bead efficacy of drugs simultaneously produced reduces, and therapeutic effect is not good.
Chinese patent CN102670653A discloses a kind of Colla Corii Asini bead production method, and comprise and being heated by Pulvis concha Mactrae, deliquescing of being heated imbedded in Pulvis concha Mactrae by Colla Corii Asini, utilizes grid/cell structure pressurization Colla Corii Asini block to form reticulate pattern/eyelet, cool hardening, grind to form granule.And then by donkey-hide gelatin granule and " Pulvis concha Mactrae " in the ratio mix homogeneously of 1:3-5, be heated to 70-100 DEG C by heater, expanding through the abundant mix homogeneously of funnel becomes the Colla Corii Asini bead of 1.5-2mm.This preparation method complex process, Production conditions is harsh, and need to use a large amount of special equipment, prepare the production capacity critical constraints of product, production efficiency is lower, does not meet the national policy of development Economical Enterprises.
Under the prerequisite meeting the regulations such as national relevant laws and regulations, produce microgranule Colla Corii Asini bead, improve the quality of products, production efficiency is improved while guarantee pharmaceutical effectiveness, realize industrialized mass, for consumer provides medication convenient, break through the problem needing solution in the existing Colla Corii Asini production technology in market badly.
Summary of the invention
The object of the invention is to overcome Colla Corii Asini bead granule in prior art huge, lack the deficiency of efficiently feasible microgranule Colla Corii Asini bead production method, a kind of production method of microgranule Colla Corii Asini bead is provided.
In order to realize foregoing invention object, the invention provides following technical scheme:
A production method for microgranule Colla Corii Asini bead, comprises the following steps:
(1) get Colla Corii Asini raw material pulverizing and make 10-100 object donkey-hide gelatin fine powder, preferred 20-100, more preferably 40-100 order, most preferably 60-100 order.
(2) by this donkey-hide gelatin fine powder heating and melting slabbing, cooling, after Colla Corii Asini cooled and solidified, cut into the Colla Corii Asini fourth that particle diameter is 1-4 millimeter, preferable particle size is 1-3 millimeter, and most preferably particle diameter is 1.5-2 millimeter, by air-dry for this Colla Corii Asini fourth, dry or airing, to moisture lower than 20%, preferred moisture is low to moderate 15%-18%.
(3) get Pulvis concha Mactrae medicine roasting machine and be heated to 150-210 DEG C, preferred 170-210 DEG C, more preferably 170-190 DEG C, most preferably 180 DEG C, after preferably waiting for Pulvis concha Mactrae temperature stabilization, add Colla Corii Asini fourth, parch makes Colla Corii Asini fourth expanded by heating become particle diameter to be 2-16 millimeter, during the Colla Corii Asini bead of preferred 1-3 millimeter, pour out Pulvis concha Mactrae wherein and Colla Corii Asini bead, cross 10 mesh sieves, screen out the impurity such as unreacted Pulvis concha Mactrae and tiny Colla Corii Asini powder, both obtain finished particle Colla Corii Asini bead.
The inventive method by Colla Corii Asini successively through precomminution process, melt in flakes, dice, the processing step such as parch, the degree of purity of effective guarantee Colla Corii Asini and the uniformity, when Colla Corii Asini final sum stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE makes microgranule Colla Corii Asini bead time, Colla Corii Asini due to degree of purity and the uniformity splendid, very thin and uniform Pulvis concha Mactrae adhesive layer can be formed on surface, be beneficial to people to take, excellent taste.
Because preparation technology of the present invention have employed the heating process of stagewise, control more accurate for processing temperature and process time, greatly reduce the different condition of fried production of burning in production to occur, improve the quality of microgranule Colla Corii Asini bead, reduce integrated cost, there is outstanding economic worth and environment protection significance.
Further, in step (1), described Colla Corii Asini raw material be the dry skin of equine species donkey or Cortex Dictamni through decocting, the concentrated solid gum made.Colla Corii Asini raw material selected by the present invention is the raw material that the crude drug company with authentication code buys, and guarantees the quality of microgranule Colla Corii Asini finished product.
Further, in step (1), Colla Corii Asini raw material is crushed to order number through two steps.Be first 5-30 order coarse powder by pulverizer or crusher in crushing, be preferably 10-30 order coarse powder, then this coarse powder carried out fragmentation with pulverizer or disintegrating machine again, make 60-100 object donkey-hide gelatin fine powder.Particularly preferably, Colla Corii Asini coarse powder is 10 objects.Colla Corii Asini raw material is carried out in two steps be crushed to corresponding frequency, improve the degree of accuracy of crushing process greatly, reduce the energy caused because of Colla Corii Asini raw material size difference in crushing process and waste, reduce production cost, improve the cost performance of microgranule Colla Corii Asini.
Further, in step (2), donkey-hide gelatin fine powder is put into steaming plate, adopt Steam Heating to melt, obtain lamellar Colla Corii Asini.Preferably, donkey-hide gelatin fine powder is layered in steaming plate, puts into steam box or steamer, and adopt temperature to be that 100-105 DEG C of steam steams, Colla Corii Asini powder is melted, and steaming time is 15-60 minute, is preferably 15-30 minute, block in flakes to donkey-hide gelatin fine powder fusing.Steam-energy makes Colla Corii Asini surface be heated evenly, and temperature constant, and Colla Corii Asini surface is not easily charred, and can be good at the quality ensureing finished product Colla Corii Asini bead.Preferably, pave when donkey-hide gelatin fine powder loads steaming plate, keep donkey-hide gelatin fine powder thickness to be 1-4 millimeter, be preferably 1-2 millimeter.Steam Heating is melted Colla Corii Asini and is had the uniform feature of hygral equilibrium, and Colla Corii Asini there will not be local temperature superelevation, also can not destroy the drug effect quality of Colla Corii Asini.Steam Heating of controlling well melts Colla Corii Asini steaming time, while the thawing fully realizing donkey-hide gelatin fine powder, does not increase the energy consumption steamed of Colla Corii Asini, and ensures the abundant efficiency utilization rate of Colla Corii Asini.
Further, in step (2), after Colla Corii Asini heating and melting slabbing, airing is cooled to the not sticky steaming plate of Colla Corii Asini surface solidification.Preferably, during airing cooling, ambient temperature is no more than 30 DEG C, is preferably 10-24 DEG C, as 18 DEG C.The object of Colla Corii Asini heating and melting slabbing cuts into fourth in order to next step, controls the Colla Corii Asini thickness steamed well, can ensure that Colla Corii Asini is at the particle diameter cutting the Colla Corii Asini fourth obtained, and improves the size uniformity of microgranule Colla Corii Asini product.And in airing process, should ensure that the Colla Corii Asini after melting is cooled to solid-state fast, prevent because the Colla Corii Asini supercool Colla Corii Asini be full of cracks caused fast again, combined selection is no more than the temperature of 30 DEG C, and preferably controlled cooling model temperature is 10-24 DEG C.The preferred airing time is 24-120 hour, preferred 48-96 hour.Be cooled to Colla Corii Asini to solidify completely, Colla Corii Asini block and steaming plate peeled off, making molding Colla Corii Asini block for cutting Colla Corii Asini fourth.Control the chilling temperature of airing more auxiliary corresponding airing time well, make that the Colla Corii Asini of thawing is slowly stable to be cooled to solid-state, be conducive to improving the yield rate of gained solid E-gelatin sheet in the process cutting into fourth.
Further, in step (3), Pulvis concha Mactrae is that shell disintegrating machine or pulverizer fragmentation are made Pulvis concha Mactrae coarse powder, Pulvis concha Mactrae coarse powder is 600-900 DEG C of calcining, in the Pulvis concha Mactrae of high-temperature calcination, the impurity volatilization of impurity totally, remaining Pulvis concha Mactrae material quality is excellent, is more suitable for the preparation needs of microgranule Colla Corii Asini bead, is preferably 700-800 DEG C of calcining.The calcine time is 15-60 minute, calcine after 15-60 minute, impurity in Pulvis concha Mactrae coarse powder volatilizees totally substantially, on the basis ensureing Pulvis concha Mactrae quality, control Pulvis concha Mactrae calcination time and reduce energy consumption, be preferably 30-60 minute, again pulverize, cross 40-100 mesh sieve, preferred 60-100 mesh sieve, be the Pulvis concha Mactrae adjuvant or Pulvis concha Mactrae raw material of preparing microgranule Colla Corii Asini.
Preferably, the raw material preparing Pulvis concha Mactrae is the shell of Veneridae animal Conch Meretricis seu Cyclinae, Concha Meretricis Seu Cyclinae.
Further, in step (3), the usage ratio of Pulvis concha Mactrae and Colla Corii Asini fourth is 100:0.1-10, and preferred 100:1-5, is more preferably 100:1-2.First Pulvis concha Mactrae is heated to 170-190 DEG C, then adds Colla Corii Asini fourth, parch 1-10 minute, treat that Colla Corii Asini fourth expanded by heating becomes particle diameter to be the Colla Corii Asini bead of 1-3 millimeter, then close medicine roasting machine, pour out adjuvant Pulvis concha Mactrae wherein and finished particle Colla Corii Asini bead.
compared with prior art, beneficial effect of the present invention:
(1) microgranule Colla Corii Asini bead particle diameter of the present invention is much smaller than existing Colla Corii Asini product, easy to carry, is easy to take, accords with the demands of the market, and is applicable to most of crowd and takes.
(2) microgranule Colla Corii Asini bead of the present invention is not containing soft yolk, and surface is without being charred, and yields is high, and meets relevant national standard requirement completely, and efficacy of drugs is good.
(3) microgranule Colla Corii Asini bead production method of the present invention, production efficiency is high, and cost is low, and product has the market competitiveness, can greatly reduce the economic pressures that Colla Corii Asini product is taken by consumer.
Detailed description of the invention
A kind of microgranule Colla Corii Asini bead, adopts following steps to produce and makes:
S1: adopt pulverizer or disintegrating machine to carry out fragmentation Colla Corii Asini raw material, make 5-15 object Colla Corii Asini coarse powder;
S2: the Colla Corii Asini coarse powder made by step S1 adopts pulverizer or disintegrating machine to carry out fragmentation again, makes 60-100 object donkey-hide gelatin fine powder;
S3: donkey-hide gelatin fine powder being loaded steaming plate and evenly pave, is highly 1-2 millimeter;
S4: the steaming plate of dress donkey-hide gelatin fine powder is put into steam box or steamer, and adopt temperature to be that 100-105 degree Celsius of steam steams, Colla Corii Asini powder is melted, and steaming time is 5-25 minute, block in flakes to donkey-hide gelatin fine powder fusing; ; Employing steams mode, and to carry out colloidal sol process to Colla Corii Asini be because steam-energy makes Colla Corii Asini surface be heated evenly, and temperature constant, Colla Corii Asini surface is not easily charred, and can be good at the quality ensureing finished product Colla Corii Asini bead.
S5: steaming plate is taken out, employing temperature is that the condition of less than 18 degrees Celsius carries out airing cooling, until the sticky steaming plate of Colla Corii Asini block surface solidification, then Colla Corii Asini block and steaming plate is peeled off, makes molding Colla Corii Asini block;
S6: adopt medicine cutter molding Colla Corii Asini block to be cut into the square Colla Corii Asini fourth that length is 1-2 millimeter, and adopt the condition of less than 30 degrees Celsius to carry out air-dry, natural airing or oven drying at low temperature, time is 48-96 hour, when Colla Corii Asini fourth moisture is at 15-18%, carry out rewinding.
S7: 100 portions of adjuvant Pulvis concha Mactrae are loaded medicine roasting machine, setting medicine roasting machine temperature is between 170-190 degree Celsius, when temperature stabilization is at 180 degrees Celsius, 1 part of Colla Corii Asini fourth is also added medicine roasting machine and parch 1 minute, treat that Colla Corii Asini expanded by heating becomes particle diameter to be the Colla Corii Asini bead of 1-3 millimeter, then close medicine roasting machine, pour out adjuvant Pulvis concha Mactrae wherein and Colla Corii Asini bead.
S8: adopt 10 mesh sieves to carry out sieving separating the adjuvant Pulvis concha Mactrae poured out and Colla Corii Asini bead, obtain finished particle Colla Corii Asini bead.
In the manufacturing process of microgranule Colla Corii Asini bead of the present invention, the Colla Corii Asini raw material of step S1 be the dry skin of equine species donkey or Cortex Dictamni through decocting, the concentrated solid gum made.
In the manufacturing process of microgranule Colla Corii Asini bead of the present invention, the manufacture method of the adjuvant Pulvis concha Mactrae of step S7 comprises:
S701: by Pulvis concha Mactrae raw material shell disintegrating machine or pulverizer fragmentation, make Pulvis concha Mactrae coarse powder;
S702: Pulvis concha Mactrae coarse powder is carried out calcine with forging medicine stove, and calcine temperature is 700-800 degree Celsius, and the calcine time is 15-30 minute;
S703: again pulverized by the Pulvis concha Mactrae coarse powder after calcine, then sieve, obtains 60-100 object adjuvant Pulvis concha Mactrae.
Preferred as one, in the manufacturing process of microgranule Colla Corii Asini bead of the present invention, the Pulvis concha Mactrae raw material shell of step S701 is the shell of Veneridae animal Conch Meretricis seu Cyclinae, Concha Meretricis Seu Cyclinae.
Preferred as one, in the manufacturing process of microgranule Colla Corii Asini bead of the present invention, the Colla Corii Asini coarse powder described in step S1 is 10 orders.
A production method for microgranule Colla Corii Asini bead, comprises the steps:
S1: adopt pulverizer or disintegrating machine to carry out fragmentation Colla Corii Asini raw material, make 5-15 object Colla Corii Asini coarse powder;
S2: the Colla Corii Asini coarse powder made by step S1 adopts pulverizer or disintegrating machine to carry out fragmentation again, makes 60-100 object donkey-hide gelatin fine powder;
S3: donkey-hide gelatin fine powder being loaded steaming plate and evenly pave, is highly 1-2 millimeter;
S4: the steaming plate of dress donkey-hide gelatin fine powder is put into steam box or steamer, and adopt temperature to be that 100-105 degree Celsius of steam steams, Colla Corii Asini powder is melted, and steaming time is 5-25 minute, block in flakes to donkey-hide gelatin fine powder fusing; Employing steams mode, and to carry out colloidal sol process to Colla Corii Asini be because steam-energy makes Colla Corii Asini surface be heated evenly, and temperature constant, Colla Corii Asini surface is not easily charred, and can be good at the quality ensureing finished product Colla Corii Asini bead.
S5: steaming plate is taken out, employing temperature is that the condition of less than 18 degrees Celsius carries out airing cooling, until the sticky steaming plate of Colla Corii Asini block surface solidification, then Colla Corii Asini block and steaming plate is peeled off, makes molding Colla Corii Asini block;
S6: adopt medicine cutter molding Colla Corii Asini block to be cut into the square Colla Corii Asini fourth that length is 1-2 millimeter, and adopt the condition of less than 30 degrees Celsius to carry out air-dry, natural airing or oven drying at low temperature, time is 48-96 hour, when Colla Corii Asini fourth moisture is at 15-18%, carry out rewinding.
S7: 100 portions of adjuvant Pulvis concha Mactrae are loaded medicine roasting machine, setting medicine roasting machine temperature is between 170-190 degree Celsius, when temperature stabilization is at 180 degrees Celsius, 1 part of Colla Corii Asini fourth is also added medicine roasting machine and parch 1 minute, treat that Colla Corii Asini expanded by heating becomes particle diameter to be the Colla Corii Asini bead of 1-3 millimeter, then close medicine roasting machine, pour out adjuvant Pulvis concha Mactrae wherein and Colla Corii Asini bead.
S8: adopt 10 mesh sieves to carry out sieving separating the adjuvant Pulvis concha Mactrae poured out and Colla Corii Asini bead, obtain finished particle Colla Corii Asini bead.
The Colla Corii Asini raw material of the inventive method step S1 be the dry skin of equine species donkey or Cortex Dictamni through decocting, the concentrated solid gum made.
The manufacture method of the adjuvant Pulvis concha Mactrae of the inventive method step S7 comprises:
S701: by Pulvis concha Mactrae raw material shell disintegrating machine or pulverizer fragmentation, make Pulvis concha Mactrae coarse powder;
S702: Pulvis concha Mactrae coarse powder is carried out calcine with forging medicine stove, and calcine temperature is 700-800 degree Celsius, and the calcine time is 15-30 minute;
S703: again pulverized by the Pulvis concha Mactrae coarse powder after calcine, then sieve, obtains 60-100 object adjuvant Pulvis concha Mactrae.
Preferred as one, the Pulvis concha Mactrae raw material shell of the inventive method step S701 is the shell of Veneridae animal Conch Meretricis seu Cyclinae, Concha Meretricis Seu Cyclinae.
Preferred as one, the Colla Corii Asini coarse powder described in the inventive method step S1 is 10 orders.
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.Percentage ratio not specified in the present invention is all weight percentage, and " wt% " of the present invention refers in particular to percentage by weight.
embodiment 1
Get Colla Corii Asini raw material powder 50kg, brokenly make 60 object donkey-hide gelatin fine powder, by this donkey-hide gelatin fine powder heating and melting slabbing, natural cooling is frozen into Colla Corii Asini.This Colla Corii Asini is cut into the Colla Corii Asini fourth that particle diameter is 2-4 millimeter, air-dry to moisture lower than 20%.Get Pulvis concha Mactrae 40kg, be heated to 190 DEG C, after temperature stabilization with medicine roasting machine, add above-mentioned Colla Corii Asini fourth 0.5kg, when parch makes Colla Corii Asini fourth expanded by heating become particle diameter to be the Colla Corii Asini bead of 1-3 millimeter, pour out Pulvis concha Mactrae wherein and Colla Corii Asini bead, cross 10 mesh sieves, obtain finished particle Colla Corii Asini bead.Donkey-hide gelatin granule outward appearance is good, and without being charred a little, texture is outstanding, through adjusting the grid electricity fee cost about 180 yuan often producing 0.5kg microgranule Colla Corii Asini bead.
embodiment 2
Get the dry skin of equine species donkey or Cortex Dictamni through decocting, the concentrated solid gum made, obtain Colla Corii Asini raw material 50kg.By Colla Corii Asini raw material disintegrating machine, 10 object Colla Corii Asini coarse powder are made in fragmentation, are then again pulverized by this Colla Corii Asini coarse powder pulverizer and obtain 100 object donkey-hide gelatin fine powder.Donkey-hide gelatin fine powder is put into steaming plate, paves into 1-3 millimeter thin layer, adopt Steam Heating to melt, vapor (steam) temperature 100-105 DEG C, donkey-hide gelatin fine powder fusing is in flakes block, to be melted completely after, take out steaming plate, natural cooling obtains lamellar Colla Corii Asini (Colla Corii Asini).This Colla Corii Asini is cut into the Colla Corii Asini fourth that particle diameter is 1-3 millimeter, air-dry to moisture lower than 18%.Get Pulvis concha Mactrae 50kg, be heated to 180 DEG C, after temperature stabilization with medicine roasting machine, add above-mentioned Colla Corii Asini fourth 0.5kg, when parch makes Colla Corii Asini fourth expanded by heating become particle diameter to be the Colla Corii Asini bead of 1-3 millimeter, pour out Pulvis concha Mactrae wherein and Colla Corii Asini bead, cross 10 mesh sieves, obtain finished particle Colla Corii Asini bead.Donkey-hide gelatin granule outward appearance is good, and without being charred a little, texture is outstanding, through adjusting the grid electricity fee cost about 340 yuan often producing 1kg microgranule Colla Corii Asini bead.
embodiment 3
Get Colla Corii Asini raw material powder 50kg, brokenly make 80 object donkey-hide gelatin fine powder, this donkey-hide gelatin fine powder is put into steaming plate, is laid into thickness 1-4 millimeter thin layer, adopt 120 DEG C of Steam Heating to be melted into lamellar, then natural cooling is frozen into Colla Corii Asini.This Colla Corii Asini is cut into the Colla Corii Asini fourth that particle diameter is 2-3 millimeter, air-dry to moisture lower than 15%.20-60 order Pulvis concha Mactrae coarse powder is made in the shell pulverizer fragmentation of getting Veneridae animal Conch Meretricis seu Cyclinae, by this Pulvis concha Mactrae coarse powder 800 DEG C of calcine 15 minutes, again pulverizes, and crosses 100 mesh sieves, obtains Pulvis concha Mactrae raw material.Get above-mentioned Pulvis concha Mactrae 50kg, be heated to 170 DEG C, after temperature stabilization with medicine roasting machine, add above-mentioned Colla Corii Asini fourth 0.5kg, when parch makes Colla Corii Asini fourth expanded by heating become particle diameter to be the Colla Corii Asini bead of 1-3 millimeter, pour out Pulvis concha Mactrae wherein and Colla Corii Asini bead, Pulvis concha Mactrae is reclaimed in screening, obtains finished particle Colla Corii Asini bead.Donkey-hide gelatin granule outward appearance is good, and without being charred a little, texture is outstanding, and through adjusting the grid electricity fee cost about 160 yuan often producing 0.5kg microgranule Colla Corii Asini bead, the method is best.
embodiment 4
Get Colla Corii Asini raw material powder 50kg, brokenly make 80 object donkey-hide gelatin fine powder, this donkey-hide gelatin fine powder is put into steaming plate, is laid into thickness 1-4 millimeter thin layer, adopt 120 DEG C of Steam Heating to be melted into lamellar, be then frozen into Colla Corii Asini with the cold wind blast-cold of less than 18 DEG C.This Colla Corii Asini is cut into the Colla Corii Asini fourth of particle diameter 1-3 millimeter, dry to moisture lower than 15%.Get the shell of Veneridae animal Concha Meretricis Seu Cyclinae, make 40-80 order Pulvis concha Mactrae coarse powder with pulverizer fragmentation, by this Pulvis concha Mactrae coarse powder 700 DEG C of calcine 30 minutes, again pulverize, cross 80 mesh sieves, obtain Pulvis concha Mactrae raw material.Get above-mentioned Pulvis concha Mactrae 50kg, be heated to 180 DEG C, after temperature stabilization with medicine roasting machine, add above-mentioned Colla Corii Asini fourth 0.05kg, when parch makes Colla Corii Asini fourth expanded by heating become particle diameter to be the Colla Corii Asini bead of 1-2 millimeter, pour out Pulvis concha Mactrae wherein and Colla Corii Asini bead, cross 10 mesh sieves, obtain finished particle Colla Corii Asini bead.Donkey-hide gelatin granule outward appearance is good, and without being charred a little, texture is outstanding, often calculates the grid electricity fee cost about 520 yuan producing 1kg microgranule Colla Corii Asini bead through core.
embodiment 5
Get Colla Corii Asini raw material powder 50kg, brokenly make 80 object donkey-hide gelatin fine powder, this donkey-hide gelatin fine powder is put into steaming plate, is laid into thickness 1-4 millimeter thin layer, adopt 120 DEG C of Steam Heating to be melted into lamellar, then natural cooling is frozen into Colla Corii Asini.This Colla Corii Asini is cut into the Colla Corii Asini fourth of particle diameter 1-4 millimeter, airing 165 hours, to moisture lower than 15%.20-60 order Pulvis concha Mactrae coarse powder is made in the shell pulverizer fragmentation of getting Veneridae animal Conch Meretricis seu Cyclinae, by this Pulvis concha Mactrae coarse powder 800 DEG C of calcine 15 minutes, again pulverizes, and crosses 100 mesh sieves, obtains Pulvis concha Mactrae raw material.Get above-mentioned Pulvis concha Mactrae 50kg, be heated to 170 DEG C, after temperature stabilization with medicine roasting machine, add above-mentioned Colla Corii Asini fourth 0.5kg, when parch makes Colla Corii Asini fourth expanded by heating become particle diameter to be the Colla Corii Asini bead of 1-2 millimeter, pour out Pulvis concha Mactrae wherein and Colla Corii Asini bead, Pulvis concha Mactrae is reclaimed in screening, obtains finished particle Colla Corii Asini bead.Production cycle is long, and donkey-hide gelatin granule outward appearance is good, and without being charred a little, texture is outstanding, through adjusting the grid electricity fee cost about 145 yuan often producing 0.5kg microgranule Colla Corii Asini bead.
embodiment 6
Get Colla Corii Asini raw material powder 50kg, brokenly make 80 object donkey-hide gelatin fine powder, this donkey-hide gelatin fine powder is put into steaming plate, is laid into thickness 1-4 millimeter thin layer, adopt 120 DEG C of Steam Heating to be melted into lamellar, then natural cooling is frozen into Colla Corii Asini.This Colla Corii Asini is cut into the Colla Corii Asini fourth of particle diameter 1.5-2 millimeter, airing 146 hours, to moisture lower than 15%.20-60 order Pulvis concha Mactrae coarse powder is made in the shell pulverizer fragmentation of getting Veneridae animal Conch Meretricis seu Cyclinae, by this Pulvis concha Mactrae coarse powder 800 DEG C of calcine 15 minutes, again pulverizes, and crosses 100 mesh sieves, obtains Pulvis concha Mactrae raw material.Get above-mentioned Pulvis concha Mactrae 50kg, be heated to 170 DEG C, after temperature stabilization with medicine roasting machine, add above-mentioned Colla Corii Asini fourth 0.1kg, when parch makes Colla Corii Asini fourth expanded by heating become particle diameter to be the Colla Corii Asini bead of 1-2 millimeter, pour out Pulvis concha Mactrae wherein and Colla Corii Asini bead, Pulvis concha Mactrae is reclaimed in screening, obtains finished particle Colla Corii Asini bead.Production cycle is long, and donkey-hide gelatin granule outward appearance is good, and without being charred a little, texture is outstanding, through adjusting the grid electricity fee cost about 155 yuan often producing 0.5kg microgranule Colla Corii Asini bead.
In Colla Corii Asini bead production method of the present invention: estimated by volume of production 50kg/ days, pulverize, steam, cut medicine, drying (air-dry), scald the operation production cycle processed be respectively 1,1,1,4,1 day, need 16 people altogether, screening, 2 days production cycles of packaging, need 11 people altogether, working time every day is 8 hours, always needs labor hour to want for 216 man-hours, and dry (air-dry) needs 96 hours.
evaluation test one
Interview Colla Corii Asini bead buyer 26 people at random in pharmacy, the microgranule Colla Corii Asini bead embodiment of the present invention prepared also please it evaluate to it, and 20 people represent that microgranule Colla Corii Asini bead outward appearance is good, best in quality, and be ready to try out, separately there are 6 people to represent first contacts microgranule Colla Corii Asini bead, but are ready to try out.Trial employment period, sooner or later respectively take microgranule Colla Corii Asini bead 2 for each person every day, take continuously after 1 month and follow up a case by regular visits to, wherein 24 people represent that QI and blood is lived profit more, and skin becomes and more compacts, and separately have 2 expression healths to improve, complexion is better.
comparative example 1
Adopt the Colla Corii Asini bead production method that Chinese patent CN102670653A discloses, trial production 10kg microgranule Colla Corii Asini bead.Temporarily transfer equipment 10 altogether, be worth about 200,000 yuan, produce about 280 hours consuming time, produce grid electricity fee cost about 7200 yuan, donkey-hide gelatin granule diameter is about 2-5 millimeter, and fluctuation is comparatively large, and outward appearance is general, and comparatively coarse, texture is poor, has and is obviously charred a little.
comparative example 2
Prepare Colla Corii Asini bead method by prior art and prepare 5kg Colla Corii Asini bead, produce 160 hours consuming time, production process is difficult to Mass Control, produce grid electricity fee cost 3580 yuan, donkey-hide gelatin granule outward appearance is general, mean diameter 8-14mm, comparatively coarse, texture is poor, and the inside has major part to have obvious soft yolk, also has part to be obviously charred a little, Colla Corii Asini bead buyer 26 people is interviewed at random in pharmacy, only 5 people represent outward appearance still can, all the other 2 people represent that outward appearance is general, separately has 19 people to represent Colla Corii Asini bead bad.
Claims (10)
1. a production method for microgranule Colla Corii Asini bead, comprises the following steps:
(1) get Colla Corii Asini raw material and be ground into 10-100 object donkey-hide gelatin fine powder;
(2) by donkey-hide gelatin fine powder heating and melting slabbing, cooling, after Colla Corii Asini cooled and solidified, cut into the Colla Corii Asini fourth that particle diameter is 1-4 millimeter, by air-dry for Colla Corii Asini fourth, dry or airing, to moisture lower than 20%;
(3) get Pulvis concha Mactrae medicine roasting machine and be heated to 170-190 DEG C, add Colla Corii Asini fourth, when parch makes Colla Corii Asini fourth expanded by heating become particle diameter to be the Colla Corii Asini bead of 2-16 millimeter, pour out Pulvis concha Mactrae wherein and Colla Corii Asini bead, cross 10 eye mesh screens, both obtain finished particle Colla Corii Asini bead.
2. the production method of microgranule Colla Corii Asini bead according to claim 1, is characterized in that, in step (1), described Colla Corii Asini raw material be the dry skin of equine species donkey or Cortex Dictamni through decocting, the concentrated solid gum made.
3. the production method of microgranule Colla Corii Asini bead according to claim 1, it is characterized in that, in step (1), Colla Corii Asini raw material is crushed to order number through two steps; Be first 10-30 order coarse powder by crusher in crushing, then this coarse powder pulverized with pulverizer again, make 60-100 object donkey-hide gelatin fine powder.
4. the production method of microgranule Colla Corii Asini bead according to claim 1, is characterized in that, in step (2), donkey-hide gelatin fine powder is put into steaming plate, adopts Steam Heating to melt, obtains lamellar Colla Corii Asini.
5. the production method of microgranule Colla Corii Asini bead according to claim 1, is characterized in that, in step (2), after Colla Corii Asini heating and melting slabbing, airing is cooled to the sticky steaming plate of Colla Corii Asini surface solidification.
6. the production method of microgranule Colla Corii Asini bead according to claim 5, is characterized in that, during the cooling of airing Colla Corii Asini, ambient temperature is no more than 30 DEG C.
7. the production method of microgranule Colla Corii Asini bead according to claim 1, it is characterized in that, in step (3), Pulvis concha Mactrae is that shell disintegrating machine or pulverizer fragmentation are made Pulvis concha Mactrae coarse powder, Pulvis concha Mactrae coarse powder 600-900 DEG C of calcine 30-60 minute, again pulverize, cross 40-100 mesh sieve, be the Pulvis concha Mactrae adjuvant preparing microgranule Colla Corii Asini.
8. the production method of microgranule Colla Corii Asini bead according to claim 1, it is characterized in that, the raw material preparing Pulvis concha Mactrae is the shell of Veneridae animal Conch Meretricis seu Cyclinae or Concha Meretricis Seu Cyclinae.
9. the production method of microgranule Colla Corii Asini bead according to claim 1, it is characterized in that, in step (3), the usage ratio of Pulvis concha Mactrae and Colla Corii Asini fourth is 100:0.1-10.
10. the production method of microgranule Colla Corii Asini bead according to claim 9, it is characterized in that, the usage ratio of Pulvis concha Mactrae and Colla Corii Asini fourth is 100:1-5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510038404.4A CN104644675B (en) | 2014-02-26 | 2015-01-26 | A kind of production method of particulate Colla Corii Asini bead |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410067456 | 2014-02-26 | ||
| CN201410067456X | 2014-02-26 | ||
| CN201510038404.4A CN104644675B (en) | 2014-02-26 | 2015-01-26 | A kind of production method of particulate Colla Corii Asini bead |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104644675A true CN104644675A (en) | 2015-05-27 |
| CN104644675B CN104644675B (en) | 2018-05-01 |
Family
ID=53236645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510038404.4A Active CN104644675B (en) | 2014-02-26 | 2015-01-26 | A kind of production method of particulate Colla Corii Asini bead |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104644675B (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108185415A (en) * | 2018-01-11 | 2018-06-22 | 刘言周 | A kind of preparation method of the glue bead containing volatile materials |
| CN108244511A (en) * | 2018-01-11 | 2018-07-06 | 刘言周 | A kind of preparation method of glue bead |
| CN108578234A (en) * | 2018-04-19 | 2018-09-28 | 四川御致药业有限公司 | A kind of Colla Corii Asini bead bulking equipment and technique |
| CN108618965A (en) * | 2018-04-19 | 2018-10-09 | 四川御致药业有限公司 | A kind of rotating electromagnetic heated type Colla Corii Asini bead bulking equipment and Colla Corii Asini bead bulking process |
| CN110448573A (en) * | 2019-07-18 | 2019-11-15 | 山东东阿国胶堂阿胶药业有限公司 | A kind of Colla Corii Asini bead processing unit (plant) and Colla Corii Asini bead processing technology is processed using the device |
| CN111011837A (en) * | 2019-12-02 | 2020-04-17 | 东阿阿胶股份有限公司 | Donkey-hide gelatin product composition, donkey-hide gelatin bead product and preparation method thereof |
| CN111972588A (en) * | 2020-09-10 | 2020-11-24 | 上海中医药大学附属曙光医院 | Red date and donkey-hide gelatin solid beverage and preparation method thereof |
| CN112772756A (en) * | 2021-01-27 | 2021-05-11 | 辽宁中医药大学 | Donkey-hide gelatin chocolate bean and preparation method thereof |
| CN112956533A (en) * | 2021-03-24 | 2021-06-15 | 重庆海王生物工程有限公司 | Donkey-hide gelatin milk tea and preparation process thereof |
| CN113368136A (en) * | 2021-05-11 | 2021-09-10 | 东阿阿胶股份有限公司 | Automatic retrieve donkey-hide gelatin pearl of clam powder and concoct device |
| CN113632915A (en) * | 2021-08-10 | 2021-11-12 | 安徽盛安堂药业有限公司 | Stir-frying process for donkey-hide gelatin beads |
| CN114224918A (en) * | 2021-12-20 | 2022-03-25 | 广东一方制药有限公司 | Donkey-hide gelatin bead decoction pieces, donkey-hide gelatin bead extract, donkey-hide gelatin bead traditional Chinese medicine formula granules and preparation method thereof |
| CN116135045A (en) * | 2023-03-30 | 2023-05-19 | 北京晨益药业有限公司 | Processing technology of donkey-hide gelatin beads |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670653A (en) * | 2012-05-14 | 2012-09-19 | 陈道恒 | Donkey-hide gelatin balls and preparation method thereof |
| CN103372028A (en) * | 2012-04-23 | 2013-10-30 | 由国峰 | Rotary preparation method of colla corii asini |
-
2015
- 2015-01-26 CN CN201510038404.4A patent/CN104644675B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103372028A (en) * | 2012-04-23 | 2013-10-30 | 由国峰 | Rotary preparation method of colla corii asini |
| CN102670653A (en) * | 2012-05-14 | 2012-09-19 | 陈道恒 | Donkey-hide gelatin balls and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 国家药典委员会: "《中华人民共和国药典 2010年版 一部》", 31 January 2010, 中国医药科技出版社 * |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108244511A (en) * | 2018-01-11 | 2018-07-06 | 刘言周 | A kind of preparation method of glue bead |
| CN108185415A (en) * | 2018-01-11 | 2018-06-22 | 刘言周 | A kind of preparation method of the glue bead containing volatile materials |
| CN108244511B (en) * | 2018-01-11 | 2021-09-03 | 刘言周 | Preparation method of rubber beads |
| CN108578234A (en) * | 2018-04-19 | 2018-09-28 | 四川御致药业有限公司 | A kind of Colla Corii Asini bead bulking equipment and technique |
| CN108618965A (en) * | 2018-04-19 | 2018-10-09 | 四川御致药业有限公司 | A kind of rotating electromagnetic heated type Colla Corii Asini bead bulking equipment and Colla Corii Asini bead bulking process |
| CN110448573A (en) * | 2019-07-18 | 2019-11-15 | 山东东阿国胶堂阿胶药业有限公司 | A kind of Colla Corii Asini bead processing unit (plant) and Colla Corii Asini bead processing technology is processed using the device |
| CN111011837B (en) * | 2019-12-02 | 2023-04-28 | 东阿阿胶股份有限公司 | Donkey-hide gelatin product composition, donkey-hide gelatin bead product and preparation method thereof |
| CN111011837A (en) * | 2019-12-02 | 2020-04-17 | 东阿阿胶股份有限公司 | Donkey-hide gelatin product composition, donkey-hide gelatin bead product and preparation method thereof |
| CN111972588A (en) * | 2020-09-10 | 2020-11-24 | 上海中医药大学附属曙光医院 | Red date and donkey-hide gelatin solid beverage and preparation method thereof |
| CN111972588B (en) * | 2020-09-10 | 2023-09-19 | 上海中医药大学附属曙光医院 | Red date donkey-hide gelatin solid beverage and preparation method thereof |
| CN112772756A (en) * | 2021-01-27 | 2021-05-11 | 辽宁中医药大学 | Donkey-hide gelatin chocolate bean and preparation method thereof |
| CN112956533A (en) * | 2021-03-24 | 2021-06-15 | 重庆海王生物工程有限公司 | Donkey-hide gelatin milk tea and preparation process thereof |
| CN113368136B (en) * | 2021-05-11 | 2023-04-07 | 东阿阿胶股份有限公司 | Automatic retrieve donkey-hide gelatin pearl of clam powder and concoct device |
| CN113368136A (en) * | 2021-05-11 | 2021-09-10 | 东阿阿胶股份有限公司 | Automatic retrieve donkey-hide gelatin pearl of clam powder and concoct device |
| CN113632915A (en) * | 2021-08-10 | 2021-11-12 | 安徽盛安堂药业有限公司 | Stir-frying process for donkey-hide gelatin beads |
| CN114224918A (en) * | 2021-12-20 | 2022-03-25 | 广东一方制药有限公司 | Donkey-hide gelatin bead decoction pieces, donkey-hide gelatin bead extract, donkey-hide gelatin bead traditional Chinese medicine formula granules and preparation method thereof |
| CN116135045A (en) * | 2023-03-30 | 2023-05-19 | 北京晨益药业有限公司 | Processing technology of donkey-hide gelatin beads |
| CN116135045B (en) * | 2023-03-30 | 2024-04-26 | 北京晨益药业有限公司 | Processing technology of donkey-hide gelatin beads |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104644675B (en) | 2018-05-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104644675A (en) | Production method of micro donkey-hide gelatin beads | |
| CN102670653B (en) | Donkey-hide gelatin balls and preparation method thereof | |
| CN103519257B (en) | Cashew energy bar and preparation method thereof | |
| CN103005000A (en) | Method for preparing vegetable beef food | |
| CN107019761A (en) | A kind of instant stem of noble dendrobium fine grained and preparation method thereof | |
| CN107495159A (en) | A kind of ultramicronising phyllostachys pracecox shoot dietary fiber ham sausage and preparation method thereof | |
| KR20130027318A (en) | Dough for the shell of walnut cake, the preparation thereof, and the preparation method of the walnut cake using the same | |
| CN103494124A (en) | Green bean cake | |
| CN102309414A (en) | Dry-process granulation method of kuntai capsule | |
| KR101406213B1 (en) | Preparation Method for Lump Tea Using Tea Powder And Lump Tea By That Method | |
| CN101720802A (en) | Method for preparing seafood cakes | |
| CN102461688A (en) | Brown rice tea and preparation method | |
| CN104705644B (en) | Potato nutritional rice and its manufacture method | |
| CN103109933B (en) | Processing technology of walnut milk tablets | |
| CN101856443A (en) | Method for preparing Chinese patent medicament arisaema cum bile | |
| CN104706681A (en) | Preparation method of river sand serving as auxiliary material for traditional Chinese medicine processing | |
| CN104431093A (en) | Instant highland barley tea and preparation method thereof | |
| CN103976305A (en) | Method for preparing instant water chestnut powder | |
| CN107242450A (en) | Suitable sugared rice resistant starch paddy vegetable vermicelli of one kind and preparation method thereof | |
| TW201141388A (en) | Manufacturing method and processing device of shrimp cake | |
| CN105192778A (en) | Walnut cake and preparation method thereof | |
| CN104642699A (en) | Method for making qi and yang tonifying and health maintenance pressed candies | |
| CN103355677A (en) | Heat-clearing jelly and preparation method thereof | |
| JP6682362B2 (en) | Dried grated konjac thin film piece and method for producing the same | |
| CN102687787B (en) | Processing technology of whistle bubble gum |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |