CN104643071B - Health product capable of relieving fatigue - Google Patents

Health product capable of relieving fatigue Download PDF

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CN104643071B
CN104643071B CN201510059582.5A CN201510059582A CN104643071B CN 104643071 B CN104643071 B CN 104643071B CN 201510059582 A CN201510059582 A CN 201510059582A CN 104643071 B CN104643071 B CN 104643071B
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health product
fatigue
blood
kidney
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CN104643071A (en
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范颖
梁茂新
马骥
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Liaoning University of Traditional Chinese Medicine
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Liaoning University of Traditional Chinese Medicine
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/79Schisandraceae (Schisandra family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention discloses a health product capable of relieving fatigue. The healthcare product is prepared from the following traditional Chinese medicines in parts by weight: 3-15 parts of the root of kudzu vine, 3-12 parts of wolfberry fruits, 2-6 parts of fruits of Chinese magnoliavine, 1-3 parts of ginseng and 6-30 parts of astragalus membranaceus. According to the health product capable of relieving the fatigue, the selected medicines are not in paralleling with same kinds of medicines, are not in addition of the same medicine effects, and form a prescription with respect to the main etiology and pathogenesis for forming the fatigue. The schisandra chinensis is combined with the astragalus membranaceus and the ginseng in the prescription, so as to reach the effects of relieving the fatigue and improving the adaptive original shape; the root of kudzu vine is used for assisting the astragalus membranaceus in clearing yang of spleen and stomach; the wolfberry fruits are used for assisting the fruits of Chinese magnoliavine in reinforcing power for tonifying liver and kidney and boosting essence and blood; and the medication characteristics of complementing five organs and tonifying spleen and kidney are adopted, so that the health product is capable of playing a pivotal role, helping middle qi, tonifying liver and kidney and essence and blood, and fully playing a role in complementing the five organs.

Description

A kind of health product of fatigue alleviating
Technical field
The present invention relates to field of health care products, more particularly to a kind of health product of fatigue alleviating.
Background technology
Fatigability subhealth state becomes the major hidden danger for affecting the public healthy, World Health Organization (WHO)(WH0)One Global prediction investigation shows that the people of true health only accounts for 5%, and the people for having disease accounts for 20%, and 75% people is then in subhealth state. Population in subhealth state morbid state is in rising trend in many countries and regions, and Chinese adult fatigability subhealth state is about For 30%.
Fatigue refers to that " organism physiology process can not continue its function in a certain specific level as a kind of physiological phenomenon And/or can not maintain predetermined exercise intensity ".From the point of view of biochemistry angle, produce fatigue the reason for one be due to motion when The peak power of energy system output declines;Two is can not to maintain fortune due to muscle strength decline or internal organs function reduction Fatigue resistance.Fatigue occur after if cannot eliminate in time, it will gradually accumulate, ultimately result in the nerve of body, endocrine and Immune system is not normal, or even organic disease occurs, becomes the key factor of destruction human physical and mental health.
Fatigue can be divided into physiologic fatigability and pathological fatigue.Physiologic fatigability can be by resting, sleep and nutrition Dissolve by itself Deng conventional measure;And pathological fatigue is that by caused by disease, reason is more, performance is complicated, the morning and evening for going out Different, degree weight is different, primary performance or cardinal symptom of some fatigue for disease, have for minor symptom.Its recover compared with Slowly, the last symptom for disappearing mostly in disease-recovery processes, what is had even delays lifelong.So-called resisting fatigue, is exactly delay fatigue Generation or the elimination that accelerates fatigue.
At present, the chemicalses of commercially available resisting fatigue such as amphetamine, modafinil, caffeine etc. occurs in delay fatigue There is preferable effect with allaying tiredness aspect, but occur in that many untoward reaction, such as cardiovascular harmful effect, interference is slept Dormancy, abalienation, additive etc..Therefore, the health product that exploitation is a kind of safely, effectively, have no toxic side effect are needed badly and carry out fatigue alleviating, To meet the actual demand of people.
The content of the invention
It is an object of the invention to provide a kind of health product of safe and effective fatigue alleviating.
To realize the above-mentioned purpose of the present invention, the present invention provides a kind of health product of fatigue alleviating, is by following weight portion Several Chinese medicine compositions:Radix Puerariae 3-15 parts, Fructus Lycii 3-12 parts, Fructus Schisandrae Chinensis 2-6 parts, Radix Ginseng 1-3 parts, Radix Astragali 6-30 parts.
The present invention also provides a kind of preparation technology of the health product of fatigue alleviating, and concrete technology is as follows.
(1)Extract:Above-mentioned medical material is taken by formula, coarse powder is ground into, by solvent of water three extractions are carried out.First time dosing The water of 10 times of amounts of material, extracts 2 hours;Second plus the water of 8 times of amounts of medical material, extract 1.5 hours;6 times of amounts of third time plus medical material Water, extracts 1 hour;Merge three extracting solution, be condensed into dry extract, be concentrated into proportion 1.3.
(2)Prepare:Radix Ginseng is used as medicine for former powder in formula, and mixes with the dry extract of other 4 taste medicines concentrations in side, in proportion Icing Sugar is added, the Icing Sugar is 1 with the weight ratio of concentration thick paste:4, moistening is made with 75% ethanol, soft material processed is carried out with 12 mesh sieves Granulation, 65 DEG C of drying, with 10 mesh and 60 mesh sieves granulate is carried out, and is obtained final product.
In the prescription of the present invention.
With Fructus Schisandrae Chinensis as monarch drug,《Sheng Nong's herbal classic》Point out that Fructus Schisandrae Chinensis sour in the mouth is warm in nature, be used with QI invigorating qi-restoratives, can treat Impairment caused by overstrain weakness and emaciation.《Mingyi Bielu》Then think that it can lead foster the five internal organs;The famous doctor Zhang Jiegu clouds of Jin and Yuan dynasty:Fructus Schisandrae Chinensis, big benefit five Visceral-qi.Eastern Han Dynasty's holy doctor Zhang Zhongjing once pointed out that Fructus Schisandrae Chinensis can be controlled " consumptive disease with deficient symptoms ".
Radix Ginseng, the Radix Astragali are ministerial drug, and Radix Ginseng strongly invigorating primordial QI, the Radix Astragali is the length of QI invigorating, and two medicines are shared with significant resisting fatigue Effect.The Tang Dynasty, famous medical scholar's Sun Simiao was pointed out:May informal dress Fructus Schisandrae Chinensis, with tonifying five ZANG-organses gas.Meet between the moon in summer, the last month of summer, be stranded Weary powerless, depletion of QI, with the Radix Astragali, ginseng compatibility, is made one spirit and is added with dynamic, and two sufficient biceps are gushed out.《Must be with book on Chinese herbal medicine》Assistant ginseng, stilbene, Control summer tired.Two medicines assist monarch drug to strengthen the work(of QI invigorating qi-restoratives.Fructus Schisandrae Chinensis are help others ginseng, and to receive the lung gold of dissipation, then golden gas is hard Solidifying, water source deep pool is thorough, and natural lung is sufficient and kidney is also sufficient.
Radix Puerariae, Fructus Lycii are adjuvant drug,《This Jing meets original》Think that Radix Puerariae rises category sun, the gas of clear sun in stomach can be inspired, assist Radix Ginseng, the Radix Astragali strengthen the effect of tonification gastric qi;《Book on Chinese herbal medicine covers bamboo fish trap》Point out Fructus Lycii with " resistance to cold and summer-heat is lengthened the life.Add the solid marrow of essence, strong bone is strong The work(of muscle ", mends impairment caused by overstrain especially.
Upper five kinds of Chinese medicine is shared, tonification liver heart spleen and lung kidney the five internal organs, again can Qi and Yijing, fatigue alleviating.This experimentation shows, This side has the effect of obvious fatigue alleviating.
Modern society's life operating pressure causes greatly psychology to be constrained, and up to orderly and clearly, in addition modern's depression of liver-QI stays up late for a long time, Excessive thinking, dark gas consumption blood consumes sad god, secretly consumes essence and blood, causes the sub-health states such as fatigue, hypomnesis.Western medicine is recognized For subhealth state is the intermediateness between health and disease.Without corresponding record in TCM Document, but tired conduct Common symptom in tcm clinical practice, be commonly described as in Chinese medical book " tired ", " exhausted ", " weary ", " asthenia ", " slack ", " tired ", " powerless ", " weak ", " inability to raise the limbs " etc..
Our Fructus Schisandrae Chinensis are monarch drug, and Compatibility with Radix Astragali, Radix Ginseng then strengthen the effect of fatigue alleviating, improve the effect for adapting to former state, Radix Puerariae helps Radix Astragali hair growth promoting taste positive clearly, and Fructus Lycii assists Fructus Schisandrae Chinensis to strengthen the power of invigorating the liver and kidney benefiting essence-blood.
Beneficial effects of the present invention compared with prior art.
The present invention provide fatigue alleviating health product, selected medicine neither similar medicine it is arranged side by side, nor identical medicine The addition of effect, but the Etiological pathogenesis formed for fatigue carries out using drugs to form a prescription.The five internal organs are adopted in side and is mended, with spleen reinforcing kidney Based on Medicinal Trait, can both assume personal Central Region, help middle gas, again can liver and kidney tonifying essence and blood, give full play to the effect of " the five internal organs are simultaneously mended ".
Specific embodiment
The present invention is further described with reference to specific embodiment.
Embodiment 1.
The present embodiment 1 provides a kind of health product of fatigue alleviating, is made up of the Chinese medicine of following parts by weight:Radix Puerariae 15 Part, 12 parts of Fructus Lycii, 2 parts of Fructus Schisandrae Chinensis, 3 parts of Radix Ginseng, 9 parts of the Radix Astragali.
The present invention also provides a kind of preparation technology of the health product of fatigue alleviating, and concrete technology is as follows.
(1)Extract:Above-mentioned medical material is taken by formula, coarse powder is ground into, by solvent of water three extractions are carried out.First time dosing The water of 10 times of amounts of material, extracts 2 hours;Second plus the water of 8 times of amounts of medical material, extract 1.5 hours;6 times of amounts of third time plus medical material Water, extracts 1 hour.Merge three extracting solution, be condensed into dry extract, be concentrated into proportion 1.3, thick paste weight 1097g.
(2)Prepare:Radix Ginseng is used as medicine for former powder in formula, and mixes with the dry extract of other 6 taste medicines concentrations in side, in proportion Icing Sugar is added, the Icing Sugar is 1 with the weight ratio of concentration thick paste:4, moistening is made with 75% ethanol, soft material processed is carried out with 12 mesh sieves Granulation, 65 DEG C of drying, with 10 mesh and 60 mesh sieves granulate is carried out.
To further illustrate beneficial effects of the present invention, the test case in clinical practice report presented below.
1st, experiment material.
1.1 animal:Kunming mouse, male mice body weight 18-22 gram, the long-living Bioisystech Co., Ltd in Liaoning provides, Credit number:SCXK (the Liao Dynasty) 2013-0009.The long-living Bioisystech Co., Ltd in SD rats Liaoning provides, credit number:SCXK (the Liao Dynasty) 2010-0001.
1.2 medicine:Test medicine(The health product of the present embodiment 1), solvent for use is distilled water, takes gavage mode to be administered, Gastric infusion volume 0.2ml/10g.Ke Laoke positive groups(Ke Laoke, Shenyang Yongda Pharmaceutical Co., Ltd., lot number 20131212, 2.25g for each person every day);Ten simply SHENQI PIAN the positive group(Ten SHENQI PIAN simply, Jilin Pharmacy stock Co., Ltd, lot number 20131212,100ml for each person every day).
1.3 reagent:Blood urea nitrogen(BUN)Testing cassete(Bioengineering Research Institute, lot number 20150518 are built up in Nanjing), liver/flesh Glycogen testing cassete(Lot number 20141123), lactic acid(LD, lot number 20140920)Testing cassete(Survey serum, tissue etc.), it is Nanjing Build up Bioengineering Research Institute.
1.4 instrument:Animal balance, electronic balance, centrifuge, high speed disperser, boiling water bath, agitator, Plasma lactate instrument, 721 spectrophotometers, swimming trunk(50cm×50cm×40cm), sheet lead, timer, hemoglobin pipet, sample injector, pipette, Test tube, tool plug test tube.
2nd, experimental technique.
2.1 packets and dose design:6 groups of test point:Blank control group, the health product low dose group of the present embodiment 1(2g/ kg), middle dose group(4g/kg), high dose group(8g/kg), Ke Laoke positive groups(Mice 0.09g/kg is equivalent to Ke Laoke liquid 16.7ml/kg, rat 0.045g/kg are equivalent to the ml/kg of Ke Laoke liquid 8.35), ten simply SHENQI PIAN the positive group(Mice 0.6g/ Kg, rat 0.3g/kg)Adopt gavage(ig)Mode, 1 time/d, continuous 30d.
2.2 Loaned swimming test:Last is given after the health product 30min of the present embodiment 1, puts mice in swimming trunk went swimming, The depth of water about 30cm, 25 DEG C ± 0.5 DEG C of water temperature, the sheet lead of the body weight of rat-tail root load 5%.Record mice starts to death from swimming Time, as mice swimming time(min).
2.3 serum urea nitrogen determinations:Diacetyl monoxime method.Male adult rat, last gives the health product of the present embodiment 1 After 30min, in the water went swimming 90min that temperature is 30 DEG C.Peace and quiet 60min dials eyeball blood sampling, 0.5ml after motion.In 4 DEG C of standings After 3h, 5000r/min centrifugation 30min take serum and operate by kit specification, press examination and calculate serum urea nitrogen content:Urine Plain nitrogen=A specimen/A standard × 20.0(mg/dl).
2.4 hepatic glycogen are determined:Anthrone method.Male rat, last to 30min after sample, in the water tank middle reaches that temperature is 30 DEG C Swimming 90min, peace and quiet 60min puts to death after motion, takes liver and is blotted with filter paper Jing after normal saline rinsing, accurately weighs liver 200mg, adds 4ml 5%TCA(Trichloroacetic acid), 1min is homogenized, homogenate is poured into centrifuge tube, with 3000r/min centrifugations 15min, supernatant is transferred in another test tube.4ml TCA are added in precipitation, then 15min is centrifuged after being homogenized 1 minute, taken Supernatant, the supernatant of centrifugation merges with first time, fully mixes.With anthrone method after 620nm wavelength colorimetric determinations, as the following formula Calculate hepatic glycogen content:Hepatic glycogen(Mg/100g livers)=DU/DS×0.5V/G×100×0.9.Wherein, DU:Sample cell extinction Degree;V:Extracting liquid volume;DS:Standard pipe absorbance;G:Hepatic tissue grams;0.5:Glucose in 0.5ml glucose standards Content;0.9:Glucose is converted into into the coefficient of glycogen.
2.5 Plasma lactate:Male rat, last is added in 40ul rupture of membranes liquid to each blood sampling 20ul after sample 30min, and vibration is equal It is even;Then 4% is born a heavy burden(Body weight), stop after the water went swimming 10min that temperature is 30 DEG C, take a blood sample immediately 20ul, disposes 30min, Take a blood sample again 20ul, and in adding 40ul rupture of membranes liquid, shaken well is determined with Plasma lactate instrument.After the motion of blood lactase acid elevation amplitude The blood lactase acid value sampled immediately deducts the blood lactase acid value before motion and represents, the blood sampled immediately after the motion of blood lactate removal amplitude Lactate deducts the blood lactase acid value of 30min after motion and represents.
2.6 statistical disposition:All data compare between two groups and adopt independent samples t-test by SPSS17.0 software processes, data Represented using mean ± standard deviation, withP< 0.05 represents there is significant difference.
3 results.
3.1 are grouped at random according to Mouse Weight, and at the end of experiment, the weight ratio of each group mice is compared with difference is not notable, i.e. sample Product are on the body weight increase of mice without impact.Concrete outcome is shown in Table 1.
Table 1:Impact of the test medicine to Mouse Weight(Mean ± standard deviation).
Group Dosage g/kg Number of cases/only Original body mass/g At the end of body weight/g
Blank control group - 14 18.92 ±0.20 37.94±3.97
Ke Laoke positive groups 0.09 14 18.86 ±0.53 39.95±4.84
Ten simply SHENQI PIAN the positive group 0.6 14 18.87 ±0.42 37.39±6.21
Health product high dose group 16 14 19.14±0.68 38.24±5.07
Health product middle dose group 8 14 18.89 ±0.65 37.95 ±6.42
Health product low dose group 4 14 18.90 ±0.63 38.23±4.89
Note:Compared with blank control group, *P< 0.05, * *P< 0.01, * * *P< 0.001.
The impact of 3.2 swimmings with a load attached to the body experiment.
Compare with blank control group, the mice trip of the basic, normal, high dosage group of the health product of the present embodiment 1 and the positive groups of Ke Laoke The swimming time is obviously prolonged, significant difference;Ten simply the positive group swimming time of SHENQI PIAN also have prolongation, but there was no significant difference. Show that the fatigue alleviating health product of the present embodiment 1 can improve the mice burden swimming time.The results are shown in Table 2.
Table 2:Impact of the test medicine to the mice burden swimming time(Mean ± standard deviation).
Group Dosage g/kg Number of cases/only Swimming time/min
Blank control group - 20 112.50±38.62
Ke Laoke positive groups 0.09 20 251.95±51.43***
Ten simply SHENQI PIAN the positive group 0.6 20 140.05±58.35
Health product high dose group 16 17 218.12±72.14***
Health product middle dose group 8 12 194.82±45.86***
Health product low dose group 4 20 217.45±40.90***
Note:Compared with blank control group, *P< 0.05, * *P< 0.01.
3.3 serum urea nitrogen determinations.
Compare with blank control group, the health product middle dose group of the present embodiment 1, ten simply the positive group of SHENQI PIAN can significantly drop Blood urea nitrogen is generated after harmonic motion;The health product high dose group of the present embodiment 1 also has obvious reduction to act on, but there was no significant difference. Concrete outcome is shown in Table 3.
Table 3:Impact of the test medicine to serum urea nitrogen during rat motor(Mean ± standard deviation).
Group Dosage g/kg Number of cases/only Serum urea nitrogen mmol/L
Blank control group - 12 8.33±6.40
Ke Laoke positive groups 0.045 10 7.69±2.29
Ten simply SHENQI PIAN the positive group 0.3 10 4.14±1.86**
Health product high dose group 8 12 6.38±1.75
Health product middle dose group 4 10 4.87±0.79*
Health product low dose group 2 10 8.51±2.23
Note:Compared with blank control group, *P< 0.05, * *P< 0.01.
3.4 hepatic glycogen are determined.
Compare with blank control group, each dosage group group hepatic glycogen is reduced, inconsistent with expected resultss, analysis reason is probably Detection glycogen preparation sample time is slightly longer, causes glycogenolysis.
Table 4:Impact of the test medicine to rats'liver glycogen use amount(Mean ± standard deviation).
Group Dosage g/kg Number of cases/only Hepatic glycogen mg/g
Blank control group - 16 18.47±10.85
Ke Laoke positive groups 0.045 16 11.62±7.11*
Ten simply SHENQI PIAN the positive group 0.3 16 16.86±9.93
Health product high dose group 1) 8 16 9.97±5.76*
Health product middle dose group 2) 4 16 16.08±6.69
Health product low dose group 3) 2 16 8.94±6.77*
Note:Compared with blank control group, * P < 0.05.
3.5 Plasma lactate.
Compare with blank control group, the health product low dose group of the present embodiment 1, middle dose group effect are not substantially or without effect; The health product high dose group of the present embodiment 1 and Ke Laoke positive groups, the ten blood lactate removal amplitudes that simply the SHENQI PIAN positive is organized are bright It is aobvious to increase;Show that the health product of the present embodiment 1 can promote the elimination of blood lactase acid after motion.Concrete outcome is shown in Table 5.
Table 5:Impact of the test medicine to blood lactate removal amplitude after rat motor(Mean ± standard deviation).
Group Dosage g/kg Number of cases/only Blood lactase acid mmol/L
Blank control group - 12 5.65±2.07
Ke Laoke positive groups 0.045 12 10.48±1.72*
Ten simply SHENQI PIAN the positive group 0.3 12 8.37±1.51*
Health product high dose group 1) 8 12 8.75±2.97*
Health product middle dose group 2) 4 12 7.98±2.25*
Health product low dose group 3) 2 12 6.90±1.29▲1)
Note:Compared with blank control group, * P < 0.05;Compared with model group,P < 0.05;Each health product group is compared ,1)2)3)P < 0.05.
4th, conclusion:Test result indicate that there is the health product of the present embodiment 1 anti-fatigue health-caring to act on.
5th, model case.
Case 1:Cui, female, 45 years old, civil servant.Feel fatigue and weak often over one year, faint low voice, spontaneous perspiration, food is received not It is good, accidental abdominal distention, two is just uncomfortable, when send out oral ulcer, dreaming often and waking easily, sore waist and aching in the waist and the back, hands and feet being not warm etc., pale tongue with white fur, thready pulse It is weak.Doctor trained in Western medicine is examined as " fatigue syndrome ".After the oral health product four weeks of the present embodiment 1, patient's weak sense mitigates, and spontaneous perspiration stops, drinks Food is gradually good, and remaining symptom has improvement in various degree.After taking three months, above-mentioned symptom disappears substantially.
Case 2:Certain is shut out, man, 56 years old, government bodies cadre.Increase suddenly because of working strength within nearly one month, sense from head to foot without Power, easily tired, absent minded, vexed, tinnitus, visual deterioration, foreign body sensation in the throat, palm is tacky.Red tongue, stringy and thready pulse. The system parenchyma such as absent cardiovascular, endocrine sexually transmitted disease (STD) becomes.The trouble is " sub-health state ".Give the health product of the present embodiment 1 oral, while Take a good rest.1 health product of the present embodiment are taken after one week, that is, is felt above-mentioned symptom and is clearly better, following the service one week, above-mentioned performance is basic Disappear.
Case 3:Poplar, female, 37 years old.Puerperal day and night looks after baby, does not have enough sleep, and occurs constipation today, 2-3 day a line, Neck shoulder stiffness, the vexed discomfort of stomach, shortness of breath and palpitation, dark and dim eyesight when standing up, get up in the morning unplessantness displeasure, sighing frequently, pale tongue with white fur, arteries and veins It is weak.Jing is looked into, without organic disease.The smooth feelings will of patient is advised, diet is adjusted, is rested, while giving the health product of the present embodiment 1 oral more.Clothes After with two weeks of the invention, take a favorable turn above-mentioned symptom more, still feel shoulder and carry on the back stiff, following the service January, above-mentioned performance disappears substantially.
Embodiment 2.
The present embodiment 2 provides a kind of health product of fatigue alleviating, is made up of the Chinese medicine of following parts by weight:Radix Puerariae 10 Part, 8 parts of Fructus Lycii, 3 parts of Fructus Schisandrae Chinensis, 2.5 parts of Radix Ginseng, 11 parts of the Radix Astragali.
Embodiment 3.
The present embodiment 3 provides a kind of health product of fatigue alleviating, is made up of the Chinese medicine of following parts by weight:Radix Puerariae 8 Part, 5 parts of Fructus Lycii, 4 parts of Fructus Schisandrae Chinensis, 1.5 parts of Radix Ginseng, 9 parts of the Radix Astragali.

Claims (4)

1. a kind of health product of fatigue alleviating, it is characterised in that be made up of the Chinese medicine of following parts by weight:Radix Puerariae 3-15 Part, Fructus Lycii 3-12 parts, Fructus Schisandrae Chinensis 2-6 parts, Radix Ginseng 1-3 parts, Radix Astragali 6-30 parts.
2. health product of fatigue alleviating as claimed in claim 1, it is characterised in that be made up of the Chinese medicine of following parts by weight 's:15 parts of Radix Puerariae, 12 parts of Fructus Lycii, 2 parts of Fructus Schisandrae Chinensis, 3 parts of Radix Ginseng, 9 parts of the Radix Astragali.
3. health product of fatigue alleviating as claimed in claim 1, it is characterised in that be made up of the Chinese medicine of following parts by weight 's:10 parts of Radix Puerariae, 8 parts of Fructus Lycii, 3 parts of Fructus Schisandrae Chinensis, 2.5 parts of Radix Ginseng, 11 parts of the Radix Astragali.
4. health product of fatigue alleviating as claimed in claim 1, it is characterised in that be made up of the Chinese medicine of following parts by weight 's:8 parts of Radix Puerariae, 5 parts of Fructus Lycii, 4 parts of Fructus Schisandrae Chinensis, 1.5 parts of Radix Ginseng, 9 parts of the Radix Astragali.
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