CN104623639A - 白介素22二聚体在制备治疗胰腺炎药物中的应用 - Google Patents

白介素22二聚体在制备治疗胰腺炎药物中的应用 Download PDF

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Publication number
CN104623639A
CN104623639A CN201310549648.XA CN201310549648A CN104623639A CN 104623639 A CN104623639 A CN 104623639A CN 201310549648 A CN201310549648 A CN 201310549648A CN 104623639 A CN104623639 A CN 104623639A
Authority
CN
China
Prior art keywords
dimer
pancreatitis
monomer
interleukin
serum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201310549648.XA
Other languages
English (en)
Chinese (zh)
Inventor
严孝强
黄诚
武栋栋
汤凯扬
黄予良
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Generon Shanghai Corp Ltd
Original Assignee
Generon Shanghai Corp Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Generon Shanghai Corp Ltd filed Critical Generon Shanghai Corp Ltd
Priority to CN201310549648.XA priority Critical patent/CN104623639A/zh
Priority to HK16111864.2A priority patent/HK1223556B/zh
Priority to CA2929637A priority patent/CA2929637C/en
Priority to CN201480061188.9A priority patent/CN105705160B/zh
Priority to AU2014346051A priority patent/AU2014346051B2/en
Priority to PCT/CN2014/090519 priority patent/WO2015067198A1/en
Priority to ES14860161T priority patent/ES2794082T3/es
Priority to US15/034,857 priority patent/US20160271221A1/en
Priority to EP14860161.0A priority patent/EP3065765B1/en
Priority to JP2016550931A priority patent/JP6825181B2/ja
Publication of CN104623639A publication Critical patent/CN104623639A/zh
Priority to JP2019129934A priority patent/JP2019206548A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201310549648.XA 2013-11-07 2013-11-07 白介素22二聚体在制备治疗胰腺炎药物中的应用 Pending CN104623639A (zh)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CN201310549648.XA CN104623639A (zh) 2013-11-07 2013-11-07 白介素22二聚体在制备治疗胰腺炎药物中的应用
PCT/CN2014/090519 WO2015067198A1 (en) 2013-11-07 2014-11-06 Use of il-22 dimers in manufacture of medicaments for treating pancreatitis
CA2929637A CA2929637C (en) 2013-11-07 2014-11-06 USE OF IL-22 DIMERS IN THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF PANCREATITIS
CN201480061188.9A CN105705160B (zh) 2013-11-07 2014-11-06 Il-22二聚体在制备用于治疗胰腺炎的药物中的用途
AU2014346051A AU2014346051B2 (en) 2013-11-07 2014-11-06 Use of IL-22 dimers in manufacture of medicaments for treating pancreatitis
HK16111864.2A HK1223556B (zh) 2013-11-07 2014-11-06 Il-22二聚体在制备用於治疗胰腺炎的药物中的用途
ES14860161T ES2794082T3 (es) 2013-11-07 2014-11-06 Uso de dímeros de IL-22 en la fabricación de medicamentos para tratar la pancreatitis
US15/034,857 US20160271221A1 (en) 2013-11-07 2014-11-06 Use of il-22 dimers in manufacture of medicaments for treating pancreatitis
EP14860161.0A EP3065765B1 (en) 2013-11-07 2014-11-06 Use of il-22 dimers in manufacture of medicaments for treating pancreatitis
JP2016550931A JP6825181B2 (ja) 2013-11-07 2014-11-06 膵炎を治療するための薬剤の製造におけるｉｌ−２２二量体の使用
JP2019129934A JP2019206548A (ja) 2013-11-07 2019-07-12 膵炎を治療するための薬剤の製造におけるｉｌ−２２二量体の使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310549648.XA CN104623639A (zh) 2013-11-07 2013-11-07 白介素22二聚体在制备治疗胰腺炎药物中的应用

Publications (1)

Publication Number Publication Date
CN104623639A true CN104623639A (zh) 2015-05-20

Family

ID=53040916

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201310549648.XA Pending CN104623639A (zh) 2013-11-07 2013-11-07 白介素22二聚体在制备治疗胰腺炎药物中的应用
CN201480061188.9A Active CN105705160B (zh) 2013-11-07 2014-11-06 Il-22二聚体在制备用于治疗胰腺炎的药物中的用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201480061188.9A Active CN105705160B (zh) 2013-11-07 2014-11-06 Il-22二聚体在制备用于治疗胰腺炎的药物中的用途

Country Status (8)

Country Link
US (1) US20160271221A1 (enExample)
EP (1) EP3065765B1 (enExample)
JP (2) JP6825181B2 (enExample)
CN (2) CN104623639A (enExample)
AU (1) AU2014346051B2 (enExample)
CA (1) CA2929637C (enExample)
ES (1) ES2794082T3 (enExample)
WO (1) WO2015067198A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106146668A (zh) * 2015-04-01 2016-11-23 中国人民解放军第二军医大学 长效白细胞介素22的制备方法及其用途
CN108137667A (zh) * 2015-07-16 2018-06-08 菲洛根有限公司 Il22免疫缀合物

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101361968B (zh) 2007-08-06 2011-08-03 健能隆医药技术（上海）有限公司 白介素-22在治疗脂肪肝中的应用
CN104623637A (zh) 2013-11-07 2015-05-20 健能隆医药技术（上海）有限公司 Il-22二聚体在制备静脉注射药物中的应用
WO2016201007A1 (en) * 2015-06-08 2016-12-15 New York University Stabilized minimal coiled-coil mimetics
CN109328069B (zh) 2016-04-15 2023-09-01 亿一生物医药开发(上海)有限公司 Il-22在治疗坏死性小肠结肠炎中的用途
JP7560445B2 (ja) 2018-09-10 2024-10-02 コールド スプリング ハーバー ラボラトリー 膵炎を処置するための方法
CN110302363B (zh) * 2019-07-04 2020-10-09 北京大学第三医院（北京大学第三临床医学院） Il-22作为制备治疗pcos药物的应用及药物制剂
EP4106794A4 (en) * 2020-02-19 2024-03-20 Evive Biotechnology (Shanghai) Ltd METHOD FOR TREATING TRANSPLANT AND HOST DISEASE

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Publication number Priority date Publication date Assignee Title
JPH08503950A (ja) 1992-12-02 1996-04-30 アルカーメス・コントロールド・セラピユーテイクス・インコーポレーテツド 徐放性成長ホルモン含有マイクロスフェア
CA2196184C (en) 1994-09-09 2009-06-09 Yasutaka Igari Sustained release preparation containing metal salt of a peptide
EP0831787B1 (en) 1995-06-07 2001-08-22 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of human growth hormone
ZA965368B (en) 1995-07-14 1997-01-14 Novo Nordisk As A pharmaceutical formulation
US6274710B1 (en) 1998-10-26 2001-08-14 Ludwig Institute For Cancer Research Antibodies which specifically bind T Cell inducible factors (TIFs)
US7597876B2 (en) * 2007-01-11 2009-10-06 Immunomedics, Inc. Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
CN100515491C (zh) * 2005-01-04 2009-07-22 健能隆医药技术（上海）有限公司 白介素-22的医药用途
CN102380091A (zh) * 2010-08-31 2012-03-21 健能隆医药技术（上海）有限公司 白介素-22在治疗病毒性肝炎中的应用
US8690554B2 (en) * 2011-07-15 2014-04-08 Xylem Ip Holdings Llc Diaphragm pump using duckbill and other types of valves
US10160793B2 (en) * 2013-03-15 2018-12-25 Genentech, Inc. Methods of treating inflammatory bowel disease using IL-22 Fc fusion proteins

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106146668A (zh) * 2015-04-01 2016-11-23 中国人民解放军第二军医大学 长效白细胞介素22的制备方法及其用途
CN108137667A (zh) * 2015-07-16 2018-06-08 菲洛根有限公司 Il22免疫缀合物

Also Published As

Publication number Publication date
HK1223556A1 (zh) 2017-08-04
CA2929637C (en) 2025-02-11
JP2019206548A (ja) 2019-12-05
CN105705160A (zh) 2016-06-22
CN105705160B (zh) 2020-02-07
JP6825181B2 (ja) 2021-02-03
WO2015067198A1 (en) 2015-05-14
EP3065765A4 (en) 2017-08-02
AU2014346051A1 (en) 2016-05-26
JP2016536357A (ja) 2016-11-24
EP3065765A1 (en) 2016-09-14
ES2794082T3 (es) 2020-11-17
US20160271221A1 (en) 2016-09-22
CA2929637A1 (en) 2015-05-14
AU2014346051B2 (en) 2020-02-27
EP3065765B1 (en) 2020-04-08

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Application publication date: 20150520