CN104622960A - 复方丹参浓缩丸及其制备方法 - Google Patents
复方丹参浓缩丸及其制备方法 Download PDFInfo
- Publication number
- CN104622960A CN104622960A CN201510035049.5A CN201510035049A CN104622960A CN 104622960 A CN104622960 A CN 104622960A CN 201510035049 A CN201510035049 A CN 201510035049A CN 104622960 A CN104622960 A CN 104622960A
- Authority
- CN
- China
- Prior art keywords
- salviae miltiorrhizae
- pill
- concentrated
- order
- filtrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006187 pill Substances 0.000 title claims abstract description 36
- 150000001875 compounds Chemical class 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 18
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 16
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims abstract description 6
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract description 6
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- 238000010992 reflux Methods 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 11
- 239000012567 medical material Substances 0.000 claims description 11
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 9
- 241000180649 Panax notoginseng Species 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000011230 binding agent Substances 0.000 claims description 4
- 239000007888 film coating Substances 0.000 claims description 4
- 238000009501 film coating Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 7
- 238000004090 dissolution Methods 0.000 abstract description 6
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract description 4
- 239000008187 granular material Substances 0.000 abstract description 4
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract description 3
- 239000002775 capsule Substances 0.000 abstract description 3
- 239000003826 tablet Substances 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 238000000227 grinding Methods 0.000 abstract description 2
- 241001072909 Salvia Species 0.000 abstract 3
- 235000017276 Salvia Nutrition 0.000 abstract 3
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 2
- 229940116229 borneol Drugs 0.000 abstract 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 2
- 239000008899 fufang danshen Substances 0.000 description 10
- 229940079593 drug Drugs 0.000 description 8
- 238000004891 communication Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 239000002245 particle Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000010298 pulverizing process Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000013459 approach Methods 0.000 description 2
- 229940126678 chinese medicines Drugs 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- SNKFFCBZYFGCQN-UHFFFAOYSA-N 2-[3-[3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyloxy]-3-(3,4-dihydroxyphenyl)propanoic acid Chemical compound C=1C=C(O)C=2OC(C=3C=C(O)C(O)=CC=3)C(C(=O)OC(CC=3C=C(O)C(O)=CC=3)C(O)=O)C=2C=1C=CC(=O)OC(C(=O)O)CC1=CC=C(O)C(O)=C1 SNKFFCBZYFGCQN-UHFFFAOYSA-N 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 239000003390 Chinese drug Substances 0.000 description 1
- SNKFFCBZYFGCQN-VWUOOIFGSA-N Lithospermic acid B Natural products C([C@H](C(=O)O)OC(=O)\C=C\C=1C=2[C@H](C(=O)O[C@H](CC=3C=C(O)C(O)=CC=3)C(O)=O)[C@H](OC=2C(O)=CC=1)C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 SNKFFCBZYFGCQN-VWUOOIFGSA-N 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000007905 drug manufacturing Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000001970 hydrokinetic effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- STCJJTBMWHMRCD-UHFFFAOYSA-N salvianolic acid B Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=O)C=Cc2cc(O)c(O)c3OC(C(C(=O)OC(Cc4ccc(O)c(O)c4)C(=O)O)c23)c5ccc(O)c(O)c5 STCJJTBMWHMRCD-UHFFFAOYSA-N 0.000 description 1
- 238000005549 size reduction Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510035049.5A CN104622960B (zh) | 2015-01-23 | 2015-01-23 | 复方丹参浓缩丸及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510035049.5A CN104622960B (zh) | 2015-01-23 | 2015-01-23 | 复方丹参浓缩丸及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104622960A true CN104622960A (zh) | 2015-05-20 |
CN104622960B CN104622960B (zh) | 2016-05-18 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201510035049.5A Active CN104622960B (zh) | 2015-01-23 | 2015-01-23 | 复方丹参浓缩丸及其制备方法 |
Country Status (1)
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CN (1) | CN104622960B (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109394832A (zh) * | 2018-10-29 | 2019-03-01 | 华玉海 | 一种治疗心脑血管病的复方滴丸及其制备方法 |
CN109745290A (zh) * | 2017-11-03 | 2019-05-14 | 庄香久 | 一种中药剂型-微粉中药微丸或小丸及其制作方法 |
CN112402488A (zh) * | 2020-12-17 | 2021-02-26 | 爱民药业集团股份有限公司 | 一种复方丹参浓缩丸及其制备方法 |
CN113350264A (zh) * | 2021-06-18 | 2021-09-07 | 周宇 | 一种复方丹参口服制剂及其制备工艺 |
CN115429827A (zh) * | 2022-09-14 | 2022-12-06 | 爱民药业集团股份有限公司 | 一种复方丹参浓缩丸的制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1939404A (zh) * | 2006-09-30 | 2007-04-04 | 海口康力元制药有限公司 | 一种复方丹参液体胶囊及其制备方法 |
-
2015
- 2015-01-23 CN CN201510035049.5A patent/CN104622960B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1939404A (zh) * | 2006-09-30 | 2007-04-04 | 海口康力元制药有限公司 | 一种复方丹参液体胶囊及其制备方法 |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109745290A (zh) * | 2017-11-03 | 2019-05-14 | 庄香久 | 一种中药剂型-微粉中药微丸或小丸及其制作方法 |
CN109394832A (zh) * | 2018-10-29 | 2019-03-01 | 华玉海 | 一种治疗心脑血管病的复方滴丸及其制备方法 |
CN112402488A (zh) * | 2020-12-17 | 2021-02-26 | 爱民药业集团股份有限公司 | 一种复方丹参浓缩丸及其制备方法 |
CN113350264A (zh) * | 2021-06-18 | 2021-09-07 | 周宇 | 一种复方丹参口服制剂及其制备工艺 |
CN115429827A (zh) * | 2022-09-14 | 2022-12-06 | 爱民药业集团股份有限公司 | 一种复方丹参浓缩丸的制备方法 |
CN115429827B (zh) * | 2022-09-14 | 2023-05-05 | 爱民药业集团股份有限公司 | 一种复方丹参浓缩丸的制备方法 |
Also Published As
Publication number | Publication date |
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CN104622960B (zh) | 2016-05-18 |
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Denomination of invention: Compound salviae miltiorrhizae condensed pill and preparation method thereof Effective date of registration: 20170519 Granted publication date: 20160518 Pledgee: Henan machinery and equipment investment Refco Group Ltd Pledgor: AIMIN PHARMACEUTICAL GROUP LIMITED BY SHARE LTD. Registration number: 2017990000426 |
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