CN104619702B - Ccr2的稠合环戊基拮抗剂 - Google Patents

Ccr2的稠合环戊基拮抗剂 Download PDF

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Publication number
CN104619702B
CN104619702B CN201380029978.4A CN201380029978A CN104619702B CN 104619702 B CN104619702 B CN 104619702B CN 201380029978 A CN201380029978 A CN 201380029978A CN 104619702 B CN104619702 B CN 104619702B
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compound
pyran
formula
salt
disease
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CN104619702A (zh
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S.布拉努姆
N.E.法兹
F-A.康
M.雷曼
R.K.鲁斯塞尔
Z.隋
C.A.特勒哈
M.P.温特斯
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Janssen Pharmaceutica NV
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CN201380029978.4A 2012-04-06 2013-04-05 Ccr2的稠合环戊基拮抗剂 Expired - Fee Related CN104619702B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261621138P 2012-04-06 2012-04-06
US61/621138 2012-04-06
PCT/US2013/035396 WO2013152269A1 (en) 2012-04-06 2013-04-05 Fused cyclopentyl antagonists of ccr2

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CN104619702A CN104619702A (zh) 2015-05-13
CN104619702B true CN104619702B (zh) 2017-09-15

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US (2) US8822460B2 (https=)
EP (1) EP2834234B1 (https=)
JP (2) JP6110474B2 (https=)
CN (1) CN104619702B (https=)
AU (1) AU2013243353B2 (https=)
CA (1) CA2869647A1 (https=)
ES (1) ES2648175T3 (https=)
HK (1) HK1210150A1 (https=)
WO (1) WO2013152269A1 (https=)

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AU2013290418B2 (en) * 2012-07-19 2017-08-03 Chaozhong Cai Octahydro-cyclopentapyrrolyl antagonists of CCR2
ES2764840T3 (es) 2015-01-28 2020-06-04 Univ Bordeaux Uso de plerixafor para tratar y/o prevenir exacerbaciones agudas de la enfermedad pulmonar obstructiva crónica
ES2904252T3 (es) * 2015-05-21 2022-04-04 Chemocentryx Inc Moduladores de CCR2
CN106366091A (zh) * 2016-08-24 2017-02-01 河北艾林国际贸易有限公司 海南霉素及其衍生物的用途及其海南霉素衍生物和制备方法
CN118267479A (zh) 2017-09-25 2024-07-02 凯莫森特里克斯股份有限公司 使用趋化因子受体2(ccr2)拮抗剂和pd-1/pd-l1抑制剂的联合治疗
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
IL275898B2 (en) 2018-01-08 2025-05-01 Chemocentryx Inc Methods for treating solid tumors with CCR2 antagonists
EP3833762A4 (en) 2018-08-09 2022-09-28 Verseau Therapeutics, Inc. Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof
CN110028469B (zh) * 2019-04-28 2022-08-09 南京药石科技股份有限公司 一种非阿片类镇痛药的关键中间体的制备方法及应用
TW202300150A (zh) 2021-03-18 2023-01-01 美商薛定諤公司 環狀化合物及其使用方法

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