CN104619684A - 生产阿托伐他汀中间体的方法 - Google Patents

生产阿托伐他汀中间体的方法 Download PDF

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Publication number
CN104619684A
CN104619684A CN201380047912.8A CN201380047912A CN104619684A CN 104619684 A CN104619684 A CN 104619684A CN 201380047912 A CN201380047912 A CN 201380047912A CN 104619684 A CN104619684 A CN 104619684A
Authority
CN
China
Prior art keywords
compound
reaction
structural formula
methyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380047912.8A
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English (en)
Chinese (zh)
Inventor
本·蓝格·德
丹尼斯·海姆斯柯克
亨利克斯·利昂杜斯·玛丽·艾森伯格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centrient Pharmaceuticals Netherlands BV
Original Assignee
DSM Sinochem Pharmaceuticals Netherlands BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM Sinochem Pharmaceuticals Netherlands BV filed Critical DSM Sinochem Pharmaceuticals Netherlands BV
Publication of CN104619684A publication Critical patent/CN104619684A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201380047912.8A 2012-09-17 2013-09-12 生产阿托伐他汀中间体的方法 Pending CN104619684A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12184688 2012-09-17
EP12184688.5 2012-09-17
PCT/EP2013/068887 WO2014041059A1 (en) 2012-09-17 2013-09-12 Process to produce atorvastatin intermediates

Publications (1)

Publication Number Publication Date
CN104619684A true CN104619684A (zh) 2015-05-13

Family

ID=46881005

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380047912.8A Pending CN104619684A (zh) 2012-09-17 2013-09-12 生产阿托伐他汀中间体的方法

Country Status (7)

Country Link
US (1) US20150251998A1 (https=)
EP (1) EP2895460A1 (https=)
CN (1) CN104619684A (https=)
IL (1) IL237329A0 (https=)
IN (1) IN2015DN01445A (https=)
MX (1) MX2015003312A (https=)
WO (1) WO2014041059A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109232354A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种高纯度阿托伐他汀钙原料药的制备方法
CN109232353A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种阿托伐他汀钙缩合物的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006039441A2 (en) * 2004-09-30 2006-04-13 Dr. Reddy's Laboratories Ltd. Amorphous atorvastatin calcium
WO2006097909A1 (en) * 2005-03-14 2006-09-21 Pfizer Science And Technology Ireland Limited Preparation of an atorvastatin intermediate using a paal-knorr condensation
WO2012032035A1 (en) * 2010-09-09 2012-03-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Salts of 7-amino-3,5-dihydroxyheptanoic acid esters

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006039441A2 (en) * 2004-09-30 2006-04-13 Dr. Reddy's Laboratories Ltd. Amorphous atorvastatin calcium
WO2006097909A1 (en) * 2005-03-14 2006-09-21 Pfizer Science And Technology Ireland Limited Preparation of an atorvastatin intermediate using a paal-knorr condensation
WO2012032035A1 (en) * 2010-09-09 2012-03-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Salts of 7-amino-3,5-dihydroxyheptanoic acid esters

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VENKATARAMAN AMARNATH等: "Intermediates in the Paal-Knorr Synthesis of Pyrroles", 《J. ORG. CHEM.》, vol. 56, no. 24, 1 November 1991 (1991-11-01), XP055001659, DOI: doi:10.1021/jo00024a040 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109232354A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种高纯度阿托伐他汀钙原料药的制备方法
CN109232353A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种阿托伐他汀钙缩合物的制备方法

Also Published As

Publication number Publication date
EP2895460A1 (en) 2015-07-22
IL237329A0 (en) 2015-04-30
MX2015003312A (es) 2015-07-14
US20150251998A1 (en) 2015-09-10
WO2014041059A1 (en) 2014-03-20
IN2015DN01445A (https=) 2015-07-03

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Legal Events

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PB01 Publication
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SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150513