IN2015DN01445A - - Google Patents

Info

Publication number
IN2015DN01445A
IN2015DN01445A IN1445DEN2015A IN2015DN01445A IN 2015DN01445 A IN2015DN01445 A IN 2015DN01445A IN 1445DEN2015 A IN1445DEN2015 A IN 1445DEN2015A IN 2015DN01445 A IN2015DN01445 A IN 2015DN01445A
Authority
IN
India
Prior art keywords
formula
compound
different
same
alkyl group
Prior art date
Application number
Inventor
De Ben Lange
Dennis Heemskerk
Henricus Leonardus Marie Elsenberg
Original Assignee
Dsm Sinochem Pharm Nl Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Sinochem Pharm Nl Bv filed Critical Dsm Sinochem Pharm Nl Bv
Publication of IN2015DN01445A publication Critical patent/IN2015DN01445A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention provides a process for the production of a compound of formula (I), said process comprising reacting a compound of formula (II) with a compound of formula (III) wherein Rl and R2 may be the same or different and are selected from H; a C1-C6 alkyl which may be straight or branched, substituted or unsubstituted; or Rl and R2 together represent an alkylidene group of the formula CRaRb wherein Ra and Rb may be the same or different and are selected from an alkyl group having between 1 and 6 atoms, and wherein R3 represents a C1-C6 alkyl group, wherein the reaction is carried out at reduced pressure. This may advantageously allow for lower reaction temperatures and/or may result in a higher yield. Also, a phase separation step may be omitted.
IN1445DEN2015 2012-09-17 2013-09-12 IN2015DN01445A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12184688 2012-09-17
PCT/EP2013/068887 WO2014041059A1 (en) 2012-09-17 2013-09-12 Process to produce atorvastatin intermediates

Publications (1)

Publication Number Publication Date
IN2015DN01445A true IN2015DN01445A (en) 2015-07-03

Family

ID=46881005

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1445DEN2015 IN2015DN01445A (en) 2012-09-17 2013-09-12

Country Status (7)

Country Link
US (1) US20150251998A1 (en)
EP (1) EP2895460A1 (en)
CN (1) CN104619684A (en)
IL (1) IL237329A0 (en)
IN (1) IN2015DN01445A (en)
MX (1) MX2015003312A (en)
WO (1) WO2014041059A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109232354A (en) * 2018-10-09 2019-01-18 河南师范大学 A kind of preparation method of high purity atorvastatin calcium raw material drug
CN109232353A (en) * 2018-10-09 2019-01-18 河南师范大学 A kind of preparation method of Atorvastatin calcium condensation product

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1793815A4 (en) * 2004-09-30 2010-12-29 Reddys Lab Ltd Dr Amorphous atorvastatin calcium
JP2008533128A (en) 2005-03-14 2008-08-21 ファイザー・サイエンス・アンド・テクノロジー・アイルランド・リミテッド Preparation of atorvastatin intermediate using Paal-Knorr condensation
SI2614057T1 (en) * 2010-09-09 2016-03-31 Dsm Sinochem Pharmaceuticals Netherlands B.V. Salts of 7-amino-3,5-dihydroxyheptanoic acid esters

Also Published As

Publication number Publication date
EP2895460A1 (en) 2015-07-22
CN104619684A (en) 2015-05-13
MX2015003312A (en) 2015-07-14
WO2014041059A1 (en) 2014-03-20
US20150251998A1 (en) 2015-09-10
IL237329A0 (en) 2015-04-30

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