CN104605363A - Deep-sea fish collagen peptide chelate calcium capsule and preparation method thereof - Google Patents
Deep-sea fish collagen peptide chelate calcium capsule and preparation method thereof Download PDFInfo
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- CN104605363A CN104605363A CN201510088240.6A CN201510088240A CN104605363A CN 104605363 A CN104605363 A CN 104605363A CN 201510088240 A CN201510088240 A CN 201510088240A CN 104605363 A CN104605363 A CN 104605363A
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- calcium
- deep
- sea fish
- fish collagen
- collagen peptide
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 111
- 239000011575 calcium Substances 0.000 title claims abstract description 111
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 111
- 102000008186 Collagen Human genes 0.000 title claims abstract description 79
- 108010035532 Collagen Proteins 0.000 title claims abstract description 79
- 229920001436 collagen Polymers 0.000 title claims abstract description 79
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 72
- 241000251468 Actinopterygii Species 0.000 title claims abstract description 53
- 239000002775 capsule Substances 0.000 title claims abstract description 44
- 239000013522 chelant Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 36
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 36
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 35
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 35
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims abstract description 17
- 235000011613 Pinus brutia Nutrition 0.000 claims abstract description 17
- 241000018646 Pinus brutia Species 0.000 claims abstract description 17
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims abstract description 17
- 235000013734 beta-carotene Nutrition 0.000 claims abstract description 17
- 239000011648 beta-carotene Substances 0.000 claims abstract description 17
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims abstract description 17
- 229960002747 betacarotene Drugs 0.000 claims abstract description 17
- 229920001184 polypeptide Polymers 0.000 claims abstract description 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 17
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims abstract description 17
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 13
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 239000000284 extract Substances 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 17
- 238000010298 pulverizing process Methods 0.000 claims description 16
- 240000007263 Pinus koraiensis Species 0.000 claims description 12
- 235000011615 Pinus koraiensis Nutrition 0.000 claims description 12
- 229930003316 Vitamin D Natural products 0.000 claims description 12
- 238000000605 extraction Methods 0.000 claims description 12
- 235000019166 vitamin D Nutrition 0.000 claims description 12
- 239000011710 vitamin D Substances 0.000 claims description 12
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 12
- 229940046008 vitamin d Drugs 0.000 claims description 12
- 239000007787 solid Substances 0.000 claims description 11
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 238000005516 engineering process Methods 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 230000008014 freezing Effects 0.000 claims description 6
- 238000007710 freezing Methods 0.000 claims description 6
- 230000035484 reaction time Effects 0.000 claims description 6
- 238000000967 suction filtration Methods 0.000 claims description 6
- 230000008719 thickening Effects 0.000 claims description 6
- 238000002481 ethanol extraction Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims 3
- 238000007873 sieving Methods 0.000 claims 3
- 210000000988 bone and bone Anatomy 0.000 abstract description 32
- 208000001132 Osteoporosis Diseases 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 6
- 230000001502 supplementing effect Effects 0.000 abstract description 5
- 239000000654 additive Substances 0.000 abstract description 4
- 230000000996 additive effect Effects 0.000 abstract description 4
- 230000011164 ossification Effects 0.000 abstract description 3
- 210000000963 osteoblast Anatomy 0.000 abstract description 3
- 238000011161 development Methods 0.000 abstract description 2
- 238000005452 bending Methods 0.000 abstract 1
- 235000005282 vitamin D3 Nutrition 0.000 abstract 1
- 239000011647 vitamin D3 Substances 0.000 abstract 1
- 229940021056 vitamin d3 Drugs 0.000 abstract 1
- 229960005069 calcium Drugs 0.000 description 93
- 229940003871 calcium ion Drugs 0.000 description 27
- 239000000047 product Substances 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 241000270666 Testudines Species 0.000 description 7
- CADZRPOVAQTAME-UHFFFAOYSA-L calcium;hydroxy phosphate Chemical compound [Ca+2].OOP([O-])([O-])=O CADZRPOVAQTAME-UHFFFAOYSA-L 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 230000009920 chelation Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 235000001014 amino acid Nutrition 0.000 description 5
- 238000011049 filling Methods 0.000 description 5
- 238000011017 operating method Methods 0.000 description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 230000001582 osteoblastic effect Effects 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 208000010392 Bone Fractures Diseases 0.000 description 3
- 206010006956 Calcium deficiency Diseases 0.000 description 3
- 230000002742 anti-folding effect Effects 0.000 description 3
- 159000000007 calcium salts Chemical class 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 210000004051 gastric juice Anatomy 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- 206010065687 Bone loss Diseases 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000037182 bone density Effects 0.000 description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 2
- 239000001527 calcium lactate Substances 0.000 description 2
- 229960002401 calcium lactate Drugs 0.000 description 2
- 235000011086 calcium lactate Nutrition 0.000 description 2
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 2
- 235000005487 catechin Nutrition 0.000 description 2
- 229950001002 cianidanol Drugs 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 235000006408 oxalic acid Nutrition 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- VZRRCQOUNSHSGB-UHFFFAOYSA-N 4-hydroxy-4,6,6-trimethylbicyclo[3.1.1]heptan-3-one Chemical compound C1C2C(C)(C)C1CC(=O)C2(O)C VZRRCQOUNSHSGB-UHFFFAOYSA-N 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 102000012286 Chitinases Human genes 0.000 description 1
- 108010022172 Chitinases Proteins 0.000 description 1
- 108010010256 Dietary Proteins Proteins 0.000 description 1
- 102000015781 Dietary Proteins Human genes 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- JPIJQSOTBSSVTP-STHAYSLISA-N L-threonic acid Chemical compound OC[C@H](O)[C@@H](O)C(O)=O JPIJQSOTBSSVTP-STHAYSLISA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 238000012356 Product development Methods 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000003262 anti-osteoporosis Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
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- 210000002805 bone matrix Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 102000014823 calbindin Human genes 0.000 description 1
- 108060001061 calbindin Proteins 0.000 description 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
- 239000001639 calcium acetate Substances 0.000 description 1
- 229960005147 calcium acetate Drugs 0.000 description 1
- 235000011092 calcium acetate Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- 229960004256 calcium citrate Drugs 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000004227 calcium gluconate Substances 0.000 description 1
- 229960004494 calcium gluconate Drugs 0.000 description 1
- 235000013927 calcium gluconate Nutrition 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- QXDMQSPYEZFLGF-UHFFFAOYSA-L calcium oxalate Chemical compound [Ca+2].[O-]C(=O)C([O-])=O QXDMQSPYEZFLGF-UHFFFAOYSA-L 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- -1 compound amino acid Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229920002770 condensed tannin Polymers 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000021245 dietary protein Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000013538 functional additive Substances 0.000 description 1
- 239000007863 gel particle Substances 0.000 description 1
- WPEXVRDUEAJUGY-UHFFFAOYSA-B hexacalcium;(2,3,4,5,6-pentaphosphonatooxycyclohexyl) phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OC1C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C1OP([O-])([O-])=O WPEXVRDUEAJUGY-UHFFFAOYSA-B 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229940056902 l- threonic acid Drugs 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000002188 osteogenic effect Effects 0.000 description 1
- 230000001009 osteoporotic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 150000007965 phenolic acids Chemical class 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 235000018192 pine bark supplement Nutrition 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
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- 229940106796 pycnogenol Drugs 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 230000009919 sequestration Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
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- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a deep-sea fish collagen peptide chelate calcium capsule and a preparation method thereof. The capsule is prepared from the following components in mass percentage: 80-85% of deep-sea fish collagen peptide and calcium ion chelate, 0.003-0.006% of beta-carotene, 0.0002-0.00045% of vitamin D3, 4.5-9% of pine polyphenol and the balance of collagen polypeptide. According to the invention, pine polyphenol is used as an additive to not only meet the calcium supplementing demand of patients with osteoporosis, but also strengthen the osteogenesis function of the patients by increasing osteoblast amount through supplementing collagen to strengthen bone bending toughness. Therefore, the deep-sea fish collagen peptide chelate calcium capsule has an irreplaceable curative effect to osteoporosis and considerable development prospect.
Description
Technical field
The present invention relates to a kind of compound strong bone gel particle capsule and preparation method thereof.
Background technology
Bone is made up of jointly organic principle and inorganic constituents, and its organic principle is mainly ossein, bone matrix and citric acid; Its inorganic constituents is a small amount of fluorine and magnesium etc. of calcium, phosphorus.The density of bone mainly sees the number of calcic in calcium salt crystallization in bone.
Up to now, the product of replenishing the calcium is divided three classes: a class is inorganic calcium, is also called first generation calcium supplementing product, as calcium carbonate, calcium phosphate and calcium oxide, or comes from the animal shell bone through machining.Molecular calcium and must consume enzyme relevant in human body and do carrier by vitamin and could be absorbed by the hydrochloric acid in gastric juice of people, even if molecular calcium is dissociated into calcium ion, owing to lacking compatibility, also difficulty is combined with calbindin, the shortcoming that absorptivity is low so the calcium of molecular state exists, calcium content is low.Equations of The Second Kind is calcium of organic acid, i.e. the agent of second generation calcium, as calcium gluconate, calcium lactate, calcium citrate, calcium acetate etc.The calcium of the second type is the calcium that can be dissociated into ionic state, although they are easy to be dissociated into calcium ion, but calcium ion easily combines with the acidic materials such as the oxalic acid in hydrochloric acid in gastric juice and food, phytic acid and forms calcium oxalate, phytic acid calcium etc. and precipitate and the absorption that hinders calcium in stomach, after calcium ion enters small intestine, also be easily combined with hydroxyl and form calcium hydroxide precipitation and calcium can not be absorbed, so the absorptivity of ionized calcium is also lower.The effective rate of utilization of molecular calcium is generally only 2-5%, and calcium gluconae, calcium lactate etc. can be dissociated into the calcium product of ionic state, and its effective rate of utilization generally also only has about 10-15%.Therefore the agent of second generation calcium also exists the defect that calcium content is low and bioavilability is not high.The calcium of the third type is the calcium that huge legendary turtle closes form existence, and as Aminoacid sequestration calcium, compound amino acid chelating calcium, l threonic acid, it is the direction of Developing.Chelating calcium is entrenched in the middle of amino acid by calcium constituent, directly to be absorbed by intestinal mucosa, can not be destroyed by hydrochloric acid in gastric juice and alkalescence, also plant acid in food, oxalic acid impact can not be subject to, realize real high-selenium corn, in numerous calcium supplementing products, there is the new direction that bioactive huge legendary turtle mould assembly amino acid calcium product represents calcium supplementing product development.
Calcium is the important measures for the treatment of and prevention of osteoporosis, and calcium is the important component part of bone, and bone is the metabolic pool of calcium, for maintaining the stable of blood calcium, therefore, replenishing the calcium and can prevent bone loss, reduce the generation of the elderly's bone loss and fracture.Calcium can increase bone calcium amount, suppresses thyroid function, improves the negative balance absorbed between bon e formation, prevents and treats osteoporosis and fracture.But common mode of replenishing the calcium only increases bone density, can only increase the calmness of bone calcium salt, makes bone hardness increase, but the toughness of the anti-folding of bone can not be increased, bone still very crisp, lacks enough rupture strengths, namely toughness, such bone, even if not calcium deficiency, still easily fractures, so, simple calcium supplementary treatment osteoporosis, prevention fracture is difficult to prove effective.
Collagen accounts for the 70-80% of bone weight, in bone, it is the vigorous mixture of calcium hydroxy phosphate, and it and calcium hydroxy phosphate together constitute the main body of bone, lacks the bone of collagen, just can not be called bone, it is the heap of calcium hydroxy phosphate molecule and particle; Must containing sufficient and carry out the collagen of eubolism in healthy bone.But collagen synthesis is slow, is difficult to be supplemented.Old collagen is constantly degraded, decompose, make a variation, aging, structure change etc. causes its effect of suddenly closing calcium hydroxy phosphate can be worse and worse, quantity is fewer and feweri, effectively by all calcium hydroxy phosphate molecules all, be suddenly fixed up by certain accumulation mode and structure altogether and by calcium hydroxy phosphate uniformly, at this moment can not will there is osteoporosis.Calcium hydroxy phosphate enters blood plasma, causes blood calcium concentration too high, just has calcium and discharges, thus cause calcium deficiency.At this moment, the best method of replenishing the calcium often is exactly, supplements the collagen combining calcium in time.Collagen can effectively adsorb calcareous, makes doped calcium in bone, instead of is deposited on other position and forms calculus, makes to replenish the calcium safer, the calcium of absorption is stored in bone.
Prevention and therapy osteoporosis can not be dealt with problems completely by simple supplement calcium, and the high-absorbility of calcium must assist higher doped calcium and higher utilization rate just can tackle the problem at its root.Enough calcium intakes and corresponding collagen are the essential condition of skeletonization, indispensable, prevent one of osteoporotic key element, ossein and calcium can increase bone density fully effectively, strengthen elasticity and the toughness of bone, thus set up and recover good, normal sclerotin, effectively could prevent osteoporosis.Recent study shows, if do not have enough collagens, calcium salt just cannot deposit, and bone will become fragile gradually, and loose, toughness weakens, and easily fractures.Therefore, supplement sufficient collagen and just can make bone health.
Summary of the invention
The object of this invention is to provide a kind of deep-sea fish collagen peptide chelating calcium capsule and preparation method thereof, overcome the shortcoming of inorganic calcium and organic calcium, the absorption of body to calcium can be increased significantly, nontoxic, have no side effect, without deposition, do not damage digestive system; Do not affect the absorption of other trace element and vitamins and other nutritious components; Not easily molten mistake in water, chemistry and biochemical stability all good.Because this product uses loose polyphenol as additive, this just not only can solve the problem that sufferers of osteoporosis face needs supplementary calcium, can also be solved it and need replenishing collagen and the toughness that increases the anti-folding of bone, osteoblastic quantity is increased and then plays stronger osteogenesis function.Therefore this product has irreplaceable effect in anti-osteoporosis curative effect, and development prospect is considerable.
The object of the invention is to be achieved through the following technical solutions:
A kind of deep-sea fish collagen peptide chelating calcium capsule, by percentage to the quality, comprises following component:
Deep-sea fish collagen peptide and calcium ion chelate: 80 ~ 85%;
Beta carotene: 0.003 ~ 0.006%;
Vitamin D
3: 0.0002 ~ 0.00045%;
Pine polyphenol: 4.5 ~ 9%;
Collagen polypeptide: surplus.
A preparation method for above-mentioned deep-sea fish collagen peptide chelating calcium capsule, comprises following operating procedure:
One, deep-sea fish collagen small peptide and calcium ion are carried out chelating: choose the deep-sea fish collagen small peptide of molecular weight between 500 ~ 1000 dalton, with CaCl
2as calcium source, controlling peptide calcium mass ratio is 1.5:1 ~ 2.5:1, and pH is between 0.65 ~ 0.85 in reaction, and the reaction time is 20 ~ 40 min; After extracting chelate products product with 75 ~ 95% ethanol (ethanolic solution of water content 5 ~ 25%), utilize Vacuum Freezing & Drying Technology to remove moisture, cross 200 eye mesh screens after pulverizing and obtain pressed powder.
Two, loose polyphenol is prepared: cones of Pinus koraiensis crosses 60 eye mesh screens after pulverizing, with 50 ~ 70% ethanol (ethanolic solution of water content 30 ~ 50%), cones of Pinus koraiensis powder is extracted, extraction time is 12 ~ 24 hours, then ultrasonic assistant extracts 1 ~ 3 time, ultrasonic power is 200 ~ 500W, and ultrasonic assistant extraction time is 30 min ~ 60 min.Gained extract is concentrated, makes its volume concentration be 20 ~ 30% of original volume, thickening temperature 35 ~ 55 DEG C.Concentrate is centrifugal, suction filtration, to remove solid content, then through vacuum freeze drying removing moisture, is crossed 200 eye mesh screens and is obtained solid powdery pine polyphenol after pulverizing.
Three, raw material is added in proportion: by collagen polypeptide and calcium ion chelate, loose polyphenol, beta carotene, vitamin D
3mixing;
Four, capsule is prepared: in being incapsulated by capsule filling machine by the raw material after mixing, make its weight be 500 ~ 550mg.
The present invention has the following advantages:
1, the present invention adopts deep-sea fish collagen small peptide and calcium ion to carry out chelating, belongs to the agent of third generation calcium.In addition, containing loose polyphenol in the present invention, this just not only can solve the problem that sufferers of osteoporosis face needs supplementary calcium, and can also solve it needs replenishing collagen and the toughness that increases the anti-folding of bone, osteoblastic quantity is increased and then plays stronger osteogenesis function.
2, deep-sea fish collagen peptide chelating calcium capsule of the present invention and various treatment before this and to alleviate the kind of osteoporosis different, the important composition of its one of containing is the loose polyphenol (having another name called pycnogenol) that can promote Calcium-ion absorption and utilization.Its Main Ingredients and Appearance contained be phenolic acid, flavones, OPC, also containing catechin and catechin-derived thing, be internationally recognized excellent nutrition and functional additive.Rising direct acting in skeleton-forming process is Gegenbaur's cell, and Gegenbaur's cell can utilize calcareous and collagen to form new bone.In unit bone volume, contained osteoblastic how much decide can fully utilize calcium and collagen in body and become the speed of bone amount unit interval expert, also namely generates the speed of new bone speed.Pine polyphenol can stimulate the Gegenbaur's cell in bone, makes its fast breeding, osteoblastic quantity is increased and then plays stronger osteogenic action.Recent study finds, loose polyphenol can improve thighbone density; Reduce the level of eight hydroxyl di-deoxynucleosides and calcium in urine; On a cellular level can by increasing osteoblast activity, being suppressed to the aspects such as apoptosis of bone cells and playing a role; The activity of human osteoblast cell's alkaline phosphatase can be increased, and do not produce obvious cytotoxicity.Further, loose polyphenol can also combine vitamin A (beta carotene) and vitamin D (vitamin D in the present invention
3) under the calcium ion of abundance and the existence of collagen, generate bone fast.
3, deep-sea fish collagen peptide chelating calcium capsule of the present invention is easy to take, and daily 4 both can have been supplemented whole calcium and vitamin A, D needed for human body every day, were adapted to the needs of replenishing the calcium of different calcium deficiency crowd.
4, the low interference of homeostasis.Deep-sea fish collagen peptide and calcium ion is adopted to carry out chelating and effectively can resist the inorganic salts generating indissoluble with other ion using loose polyphenol as the calcium capsule of additive, alleviate the antagonism Competition between mineral matter, splendid with various nutriment (comprising vitamin), antibiotic compatibility, there is synergy.
5, Purificatiou is high.The absorption of calcium carries out huge legendary turtle conjunction with aminoacid protein before intestinal absorption place or digestion, and the calcium capsule absorptivity of closing using loose polyphenol as additive huge legendary turtle is about 3-8 times of inorganic calcium.
6, absorb soon.Because the calcium capsule closed through loose polyphenol huge legendary turtle is a kind of existence form closest to natural salt, under body environment condition, dissolubility is good, calcium capsule about 30-45% faster than the absorbed speed of inorganic calcium.
7, immunity is strong.The calcium capsule closed through loose polyphenol huge legendary turtle is conducive to absorbing because being similar to the natural form of enzyme, more easily be attached among the biological component of self by body by the form after absorbing, the resurrection of human chitinase can be strengthened thus and produce and intensify, promoting protein and utilization that is fatty and vitamin.
8, trophism is strong.Calcium capsule through loose polyphenol huge legendary turtle conjunction can increase the dietary protein origin of body.
Detailed description of the invention
Below in conjunction with accompanying drawing, technical scheme of the present invention is further described; but be not limited thereto; everyly technical solution of the present invention modified or equivalent to replace, and not departing from the spirit and scope of technical solution of the present invention, all should be encompassed in protection scope of the present invention.
Detailed description of the invention one: the preparation method that present embodiments provide for a kind of deep-sea fish collagen peptide chelating calcium capsule, comprises following operating procedure:
The first, choose the deep-sea fish collagen small peptide of molecular weight between 500 ~ 1000 dalton, with CaCl
2as calcium source, peptide calcium mass ratio is between 1.5:1 ~ 2.5:1; PH is between 0.65 ~ 0.85 in reaction; Reaction time is 20 ~ 40 min; After ethanol (ethanolic solution of water content 5 ~ 25%) with 75 ~ 95% extracts chelate products product, utilize Vacuum Freezing & Drying Technology to remove moisture, cross 200 eye mesh screens after pulverizing and obtain pressed powder.
With infrared spectrophotometer detect products obtained therefrom whether with calcium ion chelating, its method is: the infared spectrum of chelate and collagen carries out contrasting its waveform direction and there occurs movement, 2100cm
-1the peak position at place almost disappears completely.3073cm
-1the acid amides B absworption peak at place moves to high wave number direction, and is in 1650cm
-1amide I band absworption peak move to lower wave number direction.
Namely the mensuration of product chelation percent adopt EDTA compleximetry: chelation percent (%)=(total amount of the content/calcium of Chelating state calcium) × 100%=(CV
1/ CV
0) × 100%=(V
1/ V
0) × 100%.
Wherein, C: standard EDTA solution concentration, mol/L; V
1: titration chelating calcium consumes EDTA liquor capacity, mL; V
0: the total amount of titration calcium consumes EDTA liquor capacity, mL.
Choosing chelation percent is after the deep-sea fish collagen polypeptide calcium ion chelate vacuum freeze drying of 40 ~ 60%, is crushed into powder, continues to employ after crossing 60 mesh sieves.
The second, cones of Pinus koraiensis crosses 60 eye mesh screens after pulverizing, and the ethanol (ethanolic solution of water content 30 ~ 50%) with 50 ~ 70% extracts cones of Pinus koraiensis powder, 12 ~ 24 hours extraction times.Then ultrasonic assistant extracts 1 ~ 3 time, and ultrasonic power is 200 ~ 500W, and ultrasonic assistant extraction time is 30 ~ 60 min.Gained extract is concentrated, makes its volume concentration be 20 ~ 30% of original volume, thickening temperature 35 ~ 55 DEG C.Concentrate is centrifugal, suction filtration, to remove solid content, then through vacuum freeze drying removing moisture, is crossed 200 eye mesh screens and is obtained solid powdery pine polyphenol after pulverizing.
3rd, by with the deep-sea fish albumen small peptide of calcium ion chelating, loose polyphenol, beta carotene and vitamin D
3mix according to following mass percent: deep-sea fish collagen peptide and calcium ion chelate content 80 ~ 85%; Content beta-carotene 0.003 ~ 0.006%; Vitamin D
3content 0.0002 ~ 0.00045%; Pine polyphenol content 4.5 ~ 9%; Surplus is collagen polypeptide.
4th, make its weight be 500 ~ 550mg in being incapsulated by capsule filling machine by the raw material after mixing.
Detailed description of the invention two: the preparation method that present embodiments provide for a kind of deep-sea fish collagen peptide chelating calcium capsule, comprises following operating procedure:
The first step, chooses the deep-sea fish collagen small peptide of molecular weight between 500 ~ 1000 dalton, with CaCl
2as calcium source, peptide calcium mass ratio is 1.5:1; Reaction pH 0.65; Reaction time is 20min; After the ethanol extraction chelate products product of 95%, utilize Vacuum Freezing & Drying Technology to remove moisture, cross 200 eye mesh screens after pulverizing and obtain pressed powder.With infrared spectrophotometer detect products obtained therefrom whether with calcium ion chelating.Choosing chelation percent is after the deep-sea fish collagen polypeptide calcium ion chelate vacuum freeze drying of 40 ~ 60%, is crushed into powder, continues to employ after crossing 60 mesh sieves.
Second step, cones of Pinus koraiensis crosses 60 eye mesh screens after pulverizing, and the ethanol (ethanolic solution of water content 50%) with 50% extracts cones of Pinus koraiensis powder, 12 hours extraction times.Then ultrasonic assistant extracts 3 times, and ultrasonic power is 500W, and ultrasonic assistant extraction time is 60 min.Gained extract is concentrated, makes its volume concentration be 20% of original volume, thickening temperature 55 DEG C.Concentrate is centrifugal, suction filtration, to remove solid content, then through vacuum freeze drying removing moisture, is crossed 200 eye mesh screens and is obtained solid powdery pine polyphenol after pulverizing.
3rd step, by with the deep-sea fish albumen small peptide of calcium ion chelating, loose polyphenol, beta carotene and vitamin D
3mix according to following mass percent: deep-sea fish collagen peptide and calcium ion chelate content 85%; Content beta-carotene 0.003%; Vitamin D
3content 0.0002%; Pine polyphenol content 9%; Surplus is collagen polypeptide.
4th step, makes its weight be 550mg in being incapsulated by the raw material after mixing by capsule filling machine.
Detailed description of the invention three: the preparation method that present embodiments provide for a kind of deep-sea fish collagen peptide chelating calcium capsule, comprises following operating procedure:
The first step, chooses the deep-sea fish collagen small peptide of molecular weight between 500 ~ 1000 dalton, with CaCl
2as calcium source, peptide calcium mass ratio is 2.5:1; Reaction pH 0.85; Reaction time is 40min; After the ethanol extraction chelate products product of 75%, utilize Vacuum Freezing & Drying Technology to remove moisture, cross 200 eye mesh screens after pulverizing and obtain pressed powder.With infrared spectrophotometer detect products obtained therefrom whether with calcium ion chelating.Choosing chelation percent is after the deep-sea fish collagen polypeptide calcium ion chelate vacuum freeze drying of 40 ~ 60%, is crushed into powder, continues to employ after crossing 60 mesh sieves.
Second step, cones of Pinus koraiensis crosses 60 eye mesh screens after pulverizing, and the ethanol (ethanolic solution of water content 25%) with 75% extracts cones of Pinus koraiensis powder, 24 hours extraction times.Then ultrasonic assistant extracts 3 times, and ultrasonic power is 300W, and ultrasonic assistant extraction time is 30 min.Gained extract is concentrated, makes its volume concentration be 20% of original volume, thickening temperature 55 DEG C.Concentrate is centrifugal, suction filtration, to remove solid content, then through vacuum freeze drying removing moisture, is crossed 200 eye mesh screens and is obtained solid powdery pine polyphenol after pulverizing.
3rd step, by with the deep-sea fish albumen small peptide of calcium ion chelating, loose polyphenol, beta carotene and vitamin D
3mix according to following mass percent: deep-sea fish collagen peptide and calcium ion chelate content 80%; Content beta-carotene 0.006%; Vitamin D
3content 0.00045%; Pine polyphenol content 4.5%; Surplus is collagen polypeptide.
4th step, makes its weight be 500mg in being incapsulated by the raw material after mixing by capsule filling machine.
Detailed description of the invention four: the preparation method that present embodiments provide for a kind of deep-sea fish collagen peptide chelating calcium capsule, comprises following operating procedure:
The first step, chooses the deep-sea fish collagen small peptide of molecular weight between 500 ~ 1000 dalton, with CaCl
2as calcium source, peptide calcium mass ratio is 2:1; Reaction pH 0.75; Reaction time is 30min; After the ethanol extraction chelate products product of 85%, utilize Vacuum Freezing & Drying Technology to remove moisture, cross 200 eye mesh screens after pulverizing and obtain pressed powder.With infrared spectrophotometer detect products obtained therefrom whether with calcium ion chelating.Choosing chelation percent is after the deep-sea fish collagen polypeptide calcium ion chelate vacuum freeze drying of 40 ~ 60%, is crushed into powder, continues to employ after crossing 60 mesh sieves.
Second step, cones of Pinus koraiensis crosses 60 eye mesh screens after pulverizing, and the ethanol (ethanolic solution of water content 35%) with 65% extracts cones of Pinus koraiensis powder, 18 hours extraction times.Then ultrasonic assistant extracts 3 times, and ultrasonic power is 400W, and ultrasonic assistant extraction time is 40 min.Gained extract is concentrated, makes its volume concentration be 25% of original volume, thickening temperature 55 DEG C.Concentrate is centrifugal, suction filtration, to remove solid content, then through vacuum freeze drying removing moisture, is crossed 200 eye mesh screens and is obtained solid powdery pine polyphenol after pulverizing.
3rd step, by with the deep-sea fish albumen small peptide of calcium ion chelating, loose polyphenol, beta carotene and vitamin D
3mix according to following mass percent: deep-sea fish collagen peptide and calcium ion chelate content 82%; Content beta-carotene 0.0045%; Vitamin D
3content 0.00032%; Pine polyphenol content 6.7%; Surplus is collagen polypeptide.
4th step, makes its weight be 525mg in being incapsulated by the raw material after mixing by capsule filling machine.
Claims (10)
1. a deep-sea fish collagen peptide chelating calcium capsule, is characterized in that by percentage to the quality, and described capsule is made up of following component:
Deep-sea fish collagen peptide and calcium ion chelate: 80 ~ 85%;
Beta carotene: 0.003 ~ 0.006%;
Vitamin D
3: 0.0002 ~ 0.00045%;
Pine polyphenol: 4.5 ~ 9%;
Collagen polypeptide: surplus.
2. deep-sea fish collagen peptide chelating calcium capsule according to claim 1, it is characterized in that by percentage to the quality, described capsule is made up of following component:
Deep-sea fish collagen peptide and calcium ion chelate: 85%;
Beta carotene: 0.003%;
Vitamin D
3: 0.0002%;
Pine polyphenol: 9%;
Collagen polypeptide: surplus.
3. deep-sea fish collagen peptide chelating calcium capsule according to claim 1, it is characterized in that by percentage to the quality, described capsule is made up of following component:
Deep-sea fish collagen peptide and calcium ion chelate: 80%;
Beta carotene: 0.006%;
Vitamin D
3: 0.00045%;
Pine polyphenol: 4.5%;
Collagen polypeptide: surplus.
4. deep-sea fish collagen peptide chelating calcium capsule according to claim 1, it is characterized in that by percentage to the quality, described capsule is made up of following component:
Deep-sea fish collagen peptide and calcium ion chelate: 82%;
Beta carotene: 0.0045%;
Vitamin D
3: 0.00032%;
Pine polyphenol: 6.7%;
Collagen polypeptide: surplus.
5. a preparation method for the deep-sea fish collagen peptide chelating calcium capsule described in the arbitrary claim of claim 1-4, is characterized in that described method step is as follows:
One, with CaCl
2as calcium source, deep-sea fish collagen small peptide and calcium ion are carried out chelating, controlling peptide calcium mass ratio is 1.5 ~ 2.5:1, and pH is between 0.65 ~ 0.85 in reaction, and the reaction time is 20 ~ 40 min; After 75 ~ 95% ethanol extraction chelate products products, utilize Vacuum Freezing & Drying Technology to remove moisture, grinding and sieving net obtains collagen polypeptide and calcium ion chelate pressed powder;
Two, loose polyphenol is prepared: cones of Pinus koraiensis grinding and sieving net, extract cones of Pinus koraiensis powder with 50 ~ 70% ethanol, extraction time is 12 ~ 24 hours, and then ultrasonic assistant extracts 1 ~ 3 time, ultrasonic power is 200 ~ 500W, and ultrasonic assistant extraction time is 30 min ~ 60 min; Concentrated by gained extract, make its volume concentration be 20 ~ 30% of original volume, thickening temperature is 35 ~ 55 DEG C; Concentrate is centrifugal, suction filtration is to remove solid content, and then through vacuum freeze drying removing moisture, grinding and sieving obtains loose polyphenol pressed powder;
Three, raw material is added in proportion: by collagen polypeptide and calcium ion chelate, loose polyphenol, beta carotene, vitamin D
3mixing;
Four, capsule is prepared: incapsulated by the raw material after mixing, obtain deep-sea fish collagen peptide chelating calcium capsule.
6. the preparation method of deep-sea fish collagen peptide chelating calcium capsule according to claim 5, is characterized in that in described step one, and the molecular weight of deep-sea fish collagen small peptide is 500 ~ 1000 dalton.
7. the preparation method of deep-sea fish collagen peptide chelating calcium capsule according to claim 5, it is characterized in that in described step one, concentration of alcohol is 75 ~ 95%.
8. the preparation method of deep-sea fish collagen peptide chelating calcium capsule according to claim 5, it is characterized in that in described step 2, concentration of alcohol is 50 ~ 70%.
9. the preparation method of deep-sea fish collagen peptide chelating calcium capsule according to claim 5, is characterized in that in described step one and two, crosses 200 eye mesh screens after pulverizing.
10. the preparation method of deep-sea fish collagen peptide chelating calcium capsule according to claim 5, is characterized in that in described step 4, and the weight of deep-sea fish collagen peptide chelating calcium capsule is 500 ~ 550mg.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114938847A (en) * | 2022-05-24 | 2022-08-26 | 江南大学 | Processing method of high-quality instant fish gelatin and instant fish gelatin |
| CN115463111A (en) * | 2022-06-10 | 2022-12-13 | 汕头大学 | Composite material with three-layer core-shell structure, preparation method thereof and calcium supplement preparation |
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| CN102871121A (en) * | 2012-10-10 | 2013-01-16 | 中国食品发酵工业研究院 | Preparation method of oceanic ossein peptide calcium chelate biological calcium supplement |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114938847A (en) * | 2022-05-24 | 2022-08-26 | 江南大学 | Processing method of high-quality instant fish gelatin and instant fish gelatin |
| CN114938847B (en) * | 2022-05-24 | 2024-03-22 | 江南大学 | Processing method of high-quality instant fish gelatin and instant fish gelatin |
| CN115463111A (en) * | 2022-06-10 | 2022-12-13 | 汕头大学 | Composite material with three-layer core-shell structure, preparation method thereof and calcium supplement preparation |
| CN115463111B (en) * | 2022-06-10 | 2023-09-12 | 汕头大学 | Composite material with three-layer core-shell structure, preparation method thereof and calcium supplementing preparation |
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Application publication date: 20150513 |