CN104602653B - 层流液滴发生器装置以及使用方法 - Google Patents

层流液滴发生器装置以及使用方法 Download PDF

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Publication number
CN104602653B
CN104602653B CN201380034596.0A CN201380034596A CN104602653B CN 104602653 B CN104602653 B CN 104602653B CN 201380034596 A CN201380034596 A CN 201380034596A CN 104602653 B CN104602653 B CN 104602653B
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CN
China
Prior art keywords
fluid
injector
plate
generator plate
opening
Prior art date
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Active
Application number
CN201380034596.0A
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English (en)
Chinese (zh)
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CN104602653A (zh
Inventor
J·R·维尔克森
I·林奇
L·T·格米纳里奥
C·E·亨特
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Corinthian Ophthalmic Inc
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Corinthian Ophthalmic Inc
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Publication date
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0638—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
    • B05B17/0646—Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/02—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, or having an outlet of particular shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/14—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with multiple outlet openings; with strainers in or outside the outlet opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/28—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with integral means for shielding the discharged liquid or other fluent material, e.g. to limit area of spray; with integral means for catching drips or collecting surplus liquid or other fluent material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/50—Arrangements for cleaning; Arrangements for preventing deposits, drying-out or blockage; Arrangements for detecting improper discharge caused by the presence of foreign matter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0653—Details
    • B05B17/0661—Transducer materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0653—Details
    • B05B17/0669—Excitation frequencies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/0012—Apparatus for achieving spraying before discharge from the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B1/00—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
    • B06B1/02—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
    • B06B1/06—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
    • B06B1/0644—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction using a single piezoelectric element
    • B06B1/0651—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction using a single piezoelectric element of circular shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02M—SUPPLYING COMBUSTION ENGINES IN GENERAL WITH COMBUSTIBLE MIXTURES OR CONSTITUENTS THEREOF
    • F02M61/00—Fuel-injectors not provided for in groups F02M39/00 - F02M57/00 or F02M67/00
    • F02M61/16—Details not provided for in, or of interest apart from, the apparatus of groups F02M61/02 - F02M61/14
    • F02M61/18—Injection nozzles, e.g. having valve seats; Details of valve member seated ends, not otherwise provided for
    • F02M61/1853—Orifice plates

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Nozzles (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Reciprocating Pumps (AREA)
  • Coating Apparatus (AREA)
  • Micromachines (AREA)
  • Particle Formation And Scattering Control In Inkjet Printers (AREA)
CN201380034596.0A 2012-05-14 2013-05-14 层流液滴发生器装置以及使用方法 Active CN104602653B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261646721P 2012-05-14 2012-05-14
US61/646,721 2012-05-14
US201261722600P 2012-11-05 2012-11-05
US61/722,600 2012-11-05
PCT/US2013/040927 WO2013173321A1 (en) 2012-05-14 2013-05-14 Laminar flow droplet generator device and methods of use

Publications (2)

Publication Number Publication Date
CN104602653A CN104602653A (zh) 2015-05-06
CN104602653B true CN104602653B (zh) 2018-02-16

Family

ID=48700690

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380034596.0A Active CN104602653B (zh) 2012-05-14 2013-05-14 层流液滴发生器装置以及使用方法

Country Status (14)

Country Link
US (1) US9463486B2 (https=)
EP (1) EP2849692A1 (https=)
JP (2) JP2015519952A (https=)
KR (1) KR102168906B1 (https=)
CN (1) CN104602653B (https=)
AU (1) AU2013262986A1 (https=)
BR (1) BR112014028342A2 (https=)
CA (1) CA2873276A1 (https=)
EA (1) EA201492096A1 (https=)
IL (1) IL235707A0 (https=)
IN (1) IN2014DN10521A (https=)
MX (1) MX2014013853A (https=)
SG (1) SG11201407428YA (https=)
WO (1) WO2013173321A1 (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010150629A1 (ja) * 2009-06-22 2010-12-29 パナソニック電工株式会社 弾性表面波を用いる霧または微細気泡の発生方法および霧または微細気泡発生装置
JP6329130B2 (ja) 2012-04-10 2018-05-30 アイノビア，インコーポレイティド 噴霧エジェクタ機構、電荷分離及び制御可能な液滴電荷を提供する装置、並びに低投与量の点眼
EP2838669B1 (en) 2012-04-20 2018-01-03 Eyenovia, Inc. Spray ejector device and methods of use
EA201492094A1 (ru) 2012-05-15 2015-04-30 Айновиа, Инк. Эжекторные устройства, способы, возбудители и схемы для них
PT3099362T (pt) 2014-01-31 2018-12-04 Eye Go As Dispositivo para aplicar um fluido oftálmico
WO2016172712A2 (en) 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
JP2016104474A (ja) * 2014-08-22 2016-06-09 有限会社情報科学研究所 共鳴発泡と真空キャビテーションによるウルトラファインバブル製造方法及びウルトラファインバブル水製造装置。
HK1248570A1 (zh) 2015-05-29 2018-10-19 西德奈克西斯公司 D2o稳定化的药物制剂
KR20160141249A (ko) * 2015-05-29 2016-12-08 세메스 주식회사 노즐, 이를 포함하는 기판 처리 장치 및 기판 처리 방법
GB2549720A (en) * 2016-04-25 2017-11-01 Jetronica Ltd Industrial printhead
EP3452150B1 (en) 2016-05-03 2024-01-17 Pneuma Respiratory, Inc. Droplet delivery device for delivery of fluids to the pulmonary system
WO2017192774A1 (en) 2016-05-03 2017-11-09 Pneuma Respiratory, Inc. Methods for the systemic delivery of therapeutic agents to the pulmonary system using a droplet delivery device
EP4624054A3 (en) 2016-05-03 2025-11-19 Pneuma Respiratory, Inc. Methods for generating and delivering droplets to the pulmonary system using a droplet delivery device
WO2017192773A1 (en) * 2016-05-03 2017-11-09 Pneuma Respiratory, Inc. Methods for treatment of pulmonary lung diseases with improved therapeutic efficacy and improved dose efficiency
WO2017192782A1 (en) 2016-05-03 2017-11-09 Pneuma Respiratory, Inc. Systems and methods comprising a droplet delivery device and a breathing assist device for therapeutic treatment
EP3320884A1 (en) * 2016-11-15 2018-05-16 Yu-Kang Huang Eye nebulizer
EP3338842A1 (en) * 2016-12-22 2018-06-27 Bernhard Schulz Nebulizer for laminar flow inhalation of an aerosol
WO2018213834A1 (en) 2017-05-19 2018-11-22 Pneuma Respiratory, Inc. Dry powder delivery device and methods of use
JP7227163B2 (ja) 2017-06-10 2023-02-21 アイノビア，インコーポレイティド 流体を取扱い、目に流体を送出するための方法および装置
CN111526914A (zh) 2017-10-04 2020-08-11 精呼吸股份有限公司 电子呼吸致动式直线型液滴输送装置及其使用方法
EP4344719B1 (en) 2017-10-17 2025-12-31 Pneuma Respiratory, Inc. NASAL MEDICATION ADMINISTRATION DEVICE
CN109674576B (zh) * 2017-10-19 2024-02-27 深圳市启明医药科技有限公司 流体供应单元及微液滴喷射驱动装置、发生装置
JP2021502178A (ja) 2017-11-08 2021-01-28 ニューマ・リスパイラトリー・インコーポレイテッド 小容積アンプルを有して呼吸により電気的に作動するインライン液滴送達装置および使用方法
AU2018371787A1 (en) 2017-11-21 2020-11-05 Sydnexis, Inc. Ophthalmic composition and delivery device thereof
WO2021119513A1 (en) * 2019-12-11 2021-06-17 Eyenovia, Inc. Systems and devices for delivering fluids to the eye and methods of use
WO2021191160A1 (en) * 2020-03-24 2021-09-30 Stamford Devices Limited A vibrating aperture plate nebulizer
EP4164625A1 (en) 2020-06-10 2023-04-19 Ocular Science, Inc. Compositions and uses in method for post-operative ocular care
NL2026282B1 (en) * 2020-08-17 2022-04-14 Medspray B V Spray device
US11793945B2 (en) 2021-06-22 2023-10-24 Pneuma Respiratory, Inc. Droplet delivery device with push ejection
US12420296B2 (en) * 2021-10-06 2025-09-23 Ford Motor Company Ultrasonic atomizer for applying a coating to a substrate with electrostatic charge to prevent droplet coalescence during atomization
US20230120997A1 (en) 2021-10-18 2023-04-20 Ocular Science, Inc. Compositions and methods for myopia control and orthokeratology lenses treatment
JP2023064254A (ja) * 2021-10-26 2023-05-11 セイコーエプソン株式会社 開口面積の決定方法及び液滴噴射装置
US12419979B2 (en) 2021-12-03 2025-09-23 Eyenovia, Inc. Pulsed ultraviolet in-line sterilization system for primary drug containers
CN119768202A (zh) 2022-07-18 2025-04-04 精呼吸股份有限公司 小步长高分辨率气溶胶生成系统及方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5024355A (en) * 1988-12-20 1991-06-18 Societe Technique de Pulverisation--STEP Device for dispensing a liquid or a cream in small-volume drops, and an associated dispensing assembly
US20030116642A1 (en) * 2001-10-29 2003-06-26 Williams Roger O. Apparatus and method for droplet steering
CN1854503A (zh) * 2005-04-18 2006-11-01 株式会社电装 具有喷嘴孔的喷射阀
US20090212133A1 (en) * 2008-01-25 2009-08-27 Collins Jr James F Ophthalmic fluid delivery device and method of operation
WO2012009706A1 (en) * 2010-07-15 2012-01-19 Corinthian Ophthalmic, Inc. Drop generating device

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU553251B2 (en) 1981-10-15 1986-07-10 Matsushita Electric Industrial Co., Ltd. Arrangement for ejecting liquid
DE69206824C5 (de) * 1991-12-04 2009-07-09 The Technology Partnership PLC, Melbourn, Royston Vorrichtung und verfahren zur erzeugung von fluessigkeitstroepfchen
WO1993020949A1 (fr) * 1992-04-09 1993-10-28 Omron Corporation Atomiseur a ultrasons, inhalateur a ultrasons et procede de commande de ceux-ci
US5607410A (en) 1993-02-16 1997-03-04 Branch; John D. Vision directed eye wash
KR100326679B1 (ko) 1993-12-09 2002-07-03 지. 애비슨 액체스프레이장치및방법
GB9405952D0 (en) 1994-03-25 1994-05-11 Zeneca Ltd Aqueous ophthalmic sprays
US6011062A (en) 1994-12-22 2000-01-04 Alcon Laboratories, Inc. Storage-stable prostaglandin compositions
US20020085067A1 (en) 2000-12-29 2002-07-04 Robert Palifka Ink jet printing module
ATE261743T1 (de) 2000-12-29 2004-04-15 Instrumentarium Corp Flüssigkeitsausstossvorrichtung mit magnetisch betätigbares ventil
US6758837B2 (en) 2001-02-08 2004-07-06 Pharmacia Ab Liquid delivery device and method of use thereof
US6550472B2 (en) 2001-03-16 2003-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids using flow directors
FR2832987B1 (fr) 2001-12-04 2004-07-09 Valois Sa Distributeur de produit fluide
AU2002230267A1 (en) * 2002-02-11 2003-09-04 Sara Lee/De N.V. Liquid spray-head, apparatus comprising a liquid spray-head and container therefore
US7427115B2 (en) 2002-03-28 2008-09-23 Xerox Corporation Fluid ejector including a drop size symbol, a method of disposing a drop size symbol in a fluid ejector, and an image forming device including a marking fluid ejector with a drop size symbol
US20040039355A1 (en) 2002-08-26 2004-02-26 Gonzalez Jose M. Fluid dispensing devices and methods
US20070211212A1 (en) 2002-09-26 2007-09-13 Percy Bennwik Eye state sensor
US7074827B2 (en) 2002-10-24 2006-07-11 Sucampo Ag (Usa) Inc. Method for treating ocular hypertension and glaucoma
ATE501766T1 (de) 2003-05-20 2011-04-15 James F Collins Ophthalmisches arzneimittelabgabesystem
US8545463B2 (en) 2003-05-20 2013-10-01 Optimyst Systems Inc. Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device
US20100222752A1 (en) 2003-05-20 2010-09-02 Collins Jr James F Ophthalmic fluid delivery system
FR2862009B1 (fr) 2003-11-07 2007-01-05 Valois Sas Tete de pulverisation de produit fluide et pompe de distribution comportant une telle tete.
WO2006006963A2 (en) 2004-04-02 2006-01-19 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Aerosol delivery systems and methods
TWI268179B (en) * 2005-04-12 2006-12-11 Ind Tech Res Inst Improved structure of atomizing nozzle the plate can be vibrated by the vibrator element to compress the fluid, so that the fluid is jet from the perforations in form of tiny particle
US7828232B2 (en) * 2005-04-18 2010-11-09 Denso Corporation Injection valve having nozzle hole
CN101479046B (zh) 2006-09-01 2012-06-27 株式会社神户制钢所 加速喷嘴及喷射喷嘴装置
US8376525B2 (en) 2006-09-08 2013-02-19 Canon Kabushiki Kaisha Liquid discharge head and method of manufacturing the same
US7891580B2 (en) 2008-04-30 2011-02-22 S.C. Johnson & Son, Inc. High volume atomizer for common consumer spray products
FR2934128B1 (fr) 2008-07-24 2012-12-14 Oreal Tete de diffusion melangeuse.
US20100211408A1 (en) 2009-02-17 2010-08-19 Carl Hyunsuk Park Systems and methods for generating medical diagnoses
CN102711880B (zh) 2010-01-11 2015-11-25 皇家飞利浦电子股份有限公司 用于气雾剂产生器械的磁力联接
US8205971B2 (en) 2010-01-19 2012-06-26 Xerox Corporation Electrically grounded inkjet ejector and method for making an electrically grounded inkjet ejector
TW201132414A (en) 2010-03-24 2011-10-01 Micro Base Technology Corp Atomizing assembly
JP5585768B2 (ja) 2010-04-14 2014-09-10 セイコーエプソン株式会社 液体噴射ヘッド、液体噴射装置および圧電素子
JP2011235202A (ja) * 2010-05-01 2011-11-24 Optnics Precision Co Ltd 霧化装置
WO2012009696A2 (en) 2010-07-15 2012-01-19 Corinthian Ophthalmic, Inc. Ophthalmic drug delivery
JP2013531548A (ja) 2010-07-15 2013-08-08 コリンシアン オフサルミック，インコーポレイティド 遠隔治療及び遠隔モニタリングを実施する方法及びシステム
DE102011013192A1 (de) 2011-03-05 2012-09-06 Dietmar Przytulla Palettenbehälter
US20130172830A1 (en) 2011-12-12 2013-07-04 Corinthian Ophthalmic, Inc. Ejector mechanism, ejector device, and methods of use
WO2013105096A1 (en) 2012-01-12 2013-07-18 Scentcom Ltd An ultrasonic micro valve array unit for production of mist
JP6329130B2 (ja) 2012-04-10 2018-05-30 アイノビア，インコーポレイティド 噴霧エジェクタ機構、電荷分離及び制御可能な液滴電荷を提供する装置、並びに低投与量の点眼
EP2838669B1 (en) 2012-04-20 2018-01-03 Eyenovia, Inc. Spray ejector device and methods of use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5024355A (en) * 1988-12-20 1991-06-18 Societe Technique de Pulverisation--STEP Device for dispensing a liquid or a cream in small-volume drops, and an associated dispensing assembly
US20030116642A1 (en) * 2001-10-29 2003-06-26 Williams Roger O. Apparatus and method for droplet steering
CN1854503A (zh) * 2005-04-18 2006-11-01 株式会社电装 具有喷嘴孔的喷射阀
US20090212133A1 (en) * 2008-01-25 2009-08-27 Collins Jr James F Ophthalmic fluid delivery device and method of operation
WO2012009706A1 (en) * 2010-07-15 2012-01-19 Corinthian Ophthalmic, Inc. Drop generating device

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IL235707A0 (en) 2015-01-29
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HK1210006A1 (en) 2016-04-15
US20130334335A1 (en) 2013-12-19
JP3219060U (ja) 2018-11-29
AU2013262986A1 (en) 2015-01-22
KR102168906B1 (ko) 2020-10-22
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