CN104587199A - traditional Chinese medicine composition for treating chronic subdural hematoma, as well as preparation method thereof - Google Patents
traditional Chinese medicine composition for treating chronic subdural hematoma, as well as preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating chronic subdural hematoma, as well as a preparation method thereof, and aims at further disclosing the preparation method of the composition. The traditional Chinese medicine composition is prepared from the following active pharmaceutical ingredients in parts by weight: 100-220 parts of fructus liquidambaris, 100-210 parts of rhizoma bletillae, 20-100 parts of carapax trionycis, 60-160 parts of poria, 60-160 parts of carapax trionycis, 60-160 parts of radix stellariae, 60-120 parts of radix cynanchi atrati, 30-120 parts of radix rehmanniae recens, 30-120 parts of fructus gardeniae, 30-120 parts of pericarpium citri reticulatae, 20-100 parts of fructus citri sarcodactylis, 10-80 parts of radix paeoniae alba, 10-80 parts of semen litchi, 10-80 parts of rhizoma pinelliae preparatum, 10-80 parts of chlorite schist, 10-80 parts of concha margaritifera, 10-80 parts of fructus schisandrae chinensis, 30-90 parts of fructus mume, 30-90 parts of fructus chebulae and 30-160 parts of radix glycyrrhizae. According to the traditional Chinese medicine composition, conventional excipients can be added to prepare clinically acceptable tablets and capsules according to the conventional technology.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, specifically, relate to a kind of Chinese medicine composition for the treatment of chronic subdural hematoma and preparation method thereof.
Background technology
Chronic subdural hematoma refers to that intracranial hemorrhage liquid occurs symptom in more than three weeks after accumulating in cerebral dura mater cavity of resorption, wound.The current source of bleeding for hematoma and pathogeny there is no unified understanding.Its incidence rate accounts for 10% of intracranial hematoma, and hematoma often betides volume top temporo hemisphere convex surface, and hematocele amount can reach 100-300 milliliter.Face art performance based on increased intracranial pressure, have a headache comparatively outstanding, partly have the mental symptoms such as dementia, indifferent and intellectual retardation, minority can have office's source property brain symptom such as hemiplegia, aphasia drawn game source property epilepsy.
Chronic subdural hematoma adopts bore flushing drain or operation of opening cranium excision usually, has the problem that hematoma recurs.Effective Therapeutic Method that chronic subdural hematoma is relatively generally acknowledged at present is boring external drainage art ", but operation also has the complication such as intracranial infection, brain tissue impairment, intracranial hemorrhage, hematoma inadequate drainage, hematoma recurrence, tensive pneumocrania, cerebrospinal leak, the outbreak of insane carbuncle, hemiplegia increase the weight of.And this disease is common in old people, patient age is large, has other organ diseases or chronic senile disease in various degree, also may there is brain atrophy in various degree, therefore, poor to the toleration of operative treatment, and exist in art because stress also may cause the risk of some other disease.
Primary disease shows as chronic process, as critical in time diagnosis and treatment, the state of an illness or with complications.
Current western medicine effect is undesirable, and Chinese medicine is of extensive knowledge and profound scholarship, by prescription compatibility, also just starts, there is no the medicine that curative effect is determined in the research for the treatment of chronic subdural hematoma treatment.
Summary of the invention
The object of the invention is to openly a kind of Chinese medicine composition for the treatment of chronic subdural hematoma, the present invention also aims to the preparation method of open said composition.
A kind of Chinese medicine composition for the treatment of chronic subdural hematoma involved in the present invention, it is mainly by crude drug Fructus Liquidambaris, Pseudobulbus Bletillae (Rhizoma Bletillae), Carapax Trionycis, Poria, Cortex Lycii, Radix Stellariae, Radix Cynanchi Atrati, Radix Rehmanniae, SHANZHIZI, Pericarpium Citri Reticulatae, Fructus Citri Sarcodactylis, the Radix Paeoniae Alba, Semen Litchi, the Rhizoma Pinelliae, Lapis Micae Aureus, Concha Margaritifera, Fructus Schisandrae Chinensis, Fructus Mume, Fructus Chebulae, Radix Glycyrrhizae Preparata.
Monarch drug Fructus Liquidambaris inducing diuresis to remove edema, ministerial drug Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, Carapax Trionycis nourishing kidney yin, Poria spleen reinforcing stomach reinforcing, Cortex Lycii, Radix Stellariae, Radix Cynanchi Atrati clearind deficient heat, Radix Rehmanniae, SHANZHIZI removing heat from blood, Pericarpium Citri Reticulatae, Fructus Citri Sarcodactylis regulating functional activities of vital QI are adjuvant drug altogether, the Radix Paeoniae Alba, Semen Litchi liver-smoothing, qi-regulating, Rhizoma Pinelliae Preparatum is dispelled the expectorant of venation, Lapis Micae Aureus, Concha Margaritifera suppressing liver-YANG, Fructus Schisandrae Chinensis, Fructus Mume, Fructus Chebulae restrain astringent or styptic treatment for spontaneous sweating altogether for making medicine, Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription just share entirely, and all medicines share and play inducing diuresis to remove edema altogether, the effect of the dredging collateral that eliminates the phlegm.
The present invention is used for clinical common Patients with Chronic Subdural Hematoma, and disease sees dizziness, headache, limbs are weak, drowsiness, red tongue is red lacks tongue, and deficient pulse is micro-.
The consumption of Chinese medicine composition of the present invention and Chinese medicinal components thereof is also through inventor and gropes in a large number to sum up and draw.
Described a kind of treat the Chinese medicine composition of chronic subdural hematoma composition and weight portion be: Fructus Liquidambaris 100-220 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 100-210 parts, Carapax Trionycis 20-100 parts, 60-160 parts, Poria, Cortex Lycii 60-160 parts, Radix Stellariae 60-160 parts, Radix Cynanchi Atrati 60-120 parts, Radix Rehmanniae 30-120 parts, SHANZHIZI 30-120 parts, Pericarpium Citri Reticulatae 30-120 parts, Fructus Citri Sarcodactylis 20-100 parts, the Radix Paeoniae Alba 10-80 parts, Semen Litchi 10-80 parts, Rhizoma Pinelliae Preparatum 10-80 parts, Lapis Micae Aureus 10-80 parts, Concha Margaritifera 10-80 parts, Fructus Schisandrae Chinensis 10-80 parts, Fructus Mume 30-90 parts, Fructus Chebulae 30-90 parts, 30-160 parts, Radix Glycyrrhizae.
Described a kind of treat the Chinese medicine composition of chronic subdural hematoma further composition and weight portion be: Fructus Liquidambaris 100-220 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 100-210 parts, Carapax Trionycis 20-100 parts, 60-160 parts, Poria, Cortex Lycii 60-160 parts, Radix Stellariae 60-160 parts, Radix Cynanchi Atrati 60-120 parts, Radix Rehmanniae 30-120 parts, SHANZHIZI 30-120 parts, Pericarpium Citri Reticulatae 30-120 parts, Fructus Citri Sarcodactylis 20-100 parts, the Radix Paeoniae Alba 10-80 parts, Semen Litchi 10-80 parts, Rhizoma Pinelliae Preparatum 10-80 parts, Lapis Micae Aureus 10-80 parts, Concha Margaritifera 10-80 parts, Fructus Schisandrae Chinensis 10-80 parts, Fructus Mume 30-90 parts, Fructus Chebulae 30-90 parts, 30-160 parts, Radix Glycyrrhizae.
Described a kind of treat the Chinese medicine composition of chronic subdural hematoma preferred composition and weight portion be: Fructus Liquidambaris 220 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 200 parts, Carapax Trionycis 100 parts, 120 parts, Poria, Cortex Lycii 150 parts, Radix Stellariae 80 parts, Radix Cynanchi Atrati 80 parts, Radix Rehmanniae 100 parts, SHANZHIZI 100 parts, Pericarpium Citri Reticulatae 100 parts, Fructus Citri Sarcodactylis 80 parts, the Radix Paeoniae Alba 50 parts, Semen Litchi 50 parts, Rhizoma Pinelliae Preparatum 50 parts, Lapis Micae Aureus 50 parts, Concha Margaritifera 50 parts, Fructus Schisandrae Chinensis 80 parts, Fructus Mume 60 parts, Fructus Chebulae 30 parts, 120 parts, Radix Glycyrrhizae.
Described a kind of treat the Chinese medicine composition of chronic subdural hematoma preferred composition and weight portion be: Fructus Liquidambaris 200 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 180 parts, Carapax Trionycis 80 parts, 100 parts, Poria, Cortex Lycii 100 parts, Radix Stellariae 90 parts, Radix Cynanchi Atrati 80 parts, Radix Rehmanniae 100 parts, SHANZHIZI 60 parts, Pericarpium Citri Reticulatae 60 parts, Fructus Citri Sarcodactylis 60 parts, the Radix Paeoniae Alba 50 parts, Semen Litchi 40 parts, Rhizoma Pinelliae Preparatum 80 parts, Lapis Micae Aureus 50 parts, Concha Margaritifera 50 parts, Fructus Schisandrae Chinensis 70 parts, Fructus Mume 70 parts, Fructus Chebulae 80 parts, 100 parts, Radix Glycyrrhizae.
Described a kind of treat the Chinese medicine composition of chronic subdural hematoma preferred composition and weight portion be: Fructus Liquidambaris 180 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 160 parts, Carapax Trionycis 20 parts, 90 parts, Poria, Cortex Lycii 80 parts, Radix Stellariae 80 parts, Radix Cynanchi Atrati 90 parts, Radix Rehmanniae 120 parts, SHANZHIZI 100 parts, Pericarpium Citri Reticulatae 100 parts, Fructus Citri Sarcodactylis 80 parts, the Radix Paeoniae Alba 60 parts, Semen Litchi 60 parts, Rhizoma Pinelliae Preparatum 60 parts, Lapis Micae Aureus 60 parts, Concha Margaritifera 50 parts, Fructus Schisandrae Chinensis 40 parts, Fructus Mume 50 parts, Fructus Chebulae 50 parts, 90 parts, Radix Glycyrrhizae.
In a word, the present invention forms monarch, minister, help, make various, and compatibility is rigorous, complements each other, play altogether all medicines share play inducing diuresis to remove edema altogether, the effect of the dredging collateral that eliminates the phlegm.
Medicine of the present invention can add customary adjuvant, conveniently technique, makes clinical acceptable tablet, capsule etc.
The tablet of the preparation of medicine of the present invention or the method for capsule comprise the steps:
Carapax Trionycis, more than Poria two tastes are ground into fine powder, sieve, all the other 18 taste decoctings, concentrated, 50% precipitate with ethanol, and after filtration, filtrate concentrates, the two mixing, and granule processed is dry, encapsulated or tabletting.
The preparation method of medicine of the present invention preferably includes following steps: Carapax Trionycis, and more than Poria two tastes are ground into fine powder, sieve.All the other 18 taste decoctings 2 times, each 30 minutes, concentrated, 50% precipitate with ethanol, after filtration, filtrate concentrates, spraying dry, mixing, and granule processed is dry, makes capsule or tablet.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
1, prescription:
Fructus Liquidambaris 220g, Pseudobulbus Bletillae (Rhizoma Bletillae) 200g, Carapax Trionycis 100g, Poria 120g, Cortex Lycii 150g, Radix Stellariae 80g, Radix Cynanchi Atrati 80g, Radix Rehmanniae 100g, SHANZHIZI 100g, Pericarpium Citri Reticulatae 100g, Fructus Citri Sarcodactylis 80g, Radix Paeoniae Alba 50g, Semen Litchi 50g, Rhizoma Pinelliae Preparatum 50g, Lapis Micae Aureus 50g, Concha Margaritifera 50g, Fructus Schisandrae Chinensis 80g, Fructus Mume 60g, Fructus Chebulae 30g, Radix Glycyrrhizae 120g.
2. method for making:
Carapax Trionycis, more than Poria two tastes are ground into fine powder, sieve, all the other 18 taste decoctings 2 times, each 30 minutes, concentrated, 50% precipitate with ethanol, and after filtration, filtrate concentrates, spraying dry, mixing, and granule processed is dry, makes 1000 tablets.
Embodiment 2
1, prescription:
Fructus Liquidambaris 200g, Pseudobulbus Bletillae (Rhizoma Bletillae) 180g, Carapax Trionycis 80g, Poria 100g, Cortex Lycii 100g, Radix Stellariae 90g, Radix Cynanchi Atrati 80g, Radix Rehmanniae 100g, SHANZHIZI 60g, Pericarpium Citri Reticulatae 60g, Fructus Citri Sarcodactylis 60g, Radix Paeoniae Alba 50g, Semen Litchi 40g, Rhizoma Pinelliae Preparatum 80g, Lapis Micae Aureus 50g, Concha Margaritifera 50g, Fructus Schisandrae Chinensis 70g, Fructus Mume 70g, Fructus Chebulae 80g, Radix Glycyrrhizae 100g.
2. method for making:
Carapax Trionycis, more than Poria two tastes are ground into fine powder, sieve, all the other 18 taste decoctings 2 times, each 30 minutes, concentrated, 50% precipitate with ethanol, and after filtration, filtrate concentrates, spraying dry, mixing, and granule processed is dry, makes 1000 capsules.
Embodiment 3
1, prescription:
Fructus Liquidambaris 180g, Pseudobulbus Bletillae (Rhizoma Bletillae) 160g, Carapax Trionycis 20g, Poria 90g, Cortex Lycii 80g, Radix Stellariae 80g, Radix Cynanchi Atrati 90g, Radix Rehmanniae 120g, SHANZHIZI 100g, Pericarpium Citri Reticulatae 100g, Fructus Citri Sarcodactylis 80g, Radix Paeoniae Alba 60g, Semen Litchi 60g, Rhizoma Pinelliae Preparatum 60g, Lapis Micae Aureus 60g, Concha Margaritifera 50g, Fructus Schisandrae Chinensis 40g, Fructus Mume 50g, Fructus Chebulae 50g, Radix Glycyrrhizae 90g.
2, technique:
Carapax Trionycis, more than Poria two tastes are ground into fine powder, sieve, all the other 18 taste decoctings 2 times, each 30 minutes, concentrated, 50% precipitate with ethanol, and after filtration, filtrate concentrates, spraying dry, mixing, and granule processed is dry, makes 1000 tablets.
Embodiment 4 clinical experiment: clearing brain tablet is to the clinical observation for the treatment of chronic subdural hematoma
[test drug]
Test medicine: clearing brain tablet: 0.30g/ grain, is obtained by embodiment 1, is made into the suspension of required concentration with front distilled water.
[MethodsThe cases enrolled]
Clinical data
1.1 physical data Stochastic choice in-patients are totally 40 examples, are divided into treatment by Chinese herbs group 20 example and western medicine group 20 example according to random packet principle.
The standard that 1.2 diagnostic criterias are formulated according to " neurosurgery " the 1st edition of Wang Zhongcheng academician chief editor in 1998: draft with reference to " nervous system disease Differential Diagnosis ".1. primary symptom: headache, dizziness, tinnitus, forgetful.2. secondary disease: bradykinesia, faculty of understanding go down, irritated, vomiting, insomnia and dreamful sleep or hemiplegia, tic of the limbs etc.3. head trauma medical history is had.4. cerebral CT or nuclear magnetic resonance check are shown in one-sided or bilateral subdural hematoma.All cases gets rid of blood system and hepatorenal disease, makes a definite diagnosis, combines symptom or head trauma history when being admitted to hospital and, more than 3 weeks, be willing to the patient of cooperation associated treatment through head CT/MR scanning.Quantity of hematoma with 1/2 π of Sachs J, L, S, slice formulae discovery.
2, treatment and observational technique:
Matched group patient gives to use dehydrant, and 20% mannitol 250mL q12h iv-drip, use Glycerin Fructose 250mL qd ivdrip after 2 weeks instead, treatments period should carry out under close observation.
3, efficacy evaluation:
Draft according to " clinical disease diagnosis is according to curing improvement standard ".
Recovery from illness: clinical symptom disappearance, cerebral CT/M R checks and shows that subdural hematoma absorbs 100%; Effective: clinical symptom disappearance, cerebral CT/M R checks and shows that subdural hematoma absorbs 50% ~ 99%; Effective: clinical symptoms takes a turn for the better, cerebral CT/M R checks and shows that subdural hematoma absorbs 30% ~ 49%; Invalid: clinical symptoms is without improvement, and cerebral CT/M R checks and shows that subdural hematoma absorbs 0% ~ 29%; Increase the weight of/recur: clinical symptoms increases the weight of or increases the weight of once again after taking a turn for the better, after cerebral CT/M R checks and shows that subdural hematoma absorbs, occur that high density signal and volume increase.
4, statistical analysis:
Adopt SPSS13.0 to carry out data analysis, enumeration data adopts chi-square criterion.
5, the results are shown in Table 1:
Table 1 is to the Comparison of therapeutic table (n=20) for the treatment of chronic subdural hematoma
As seen from Table 1, treatment group and matched group comparitive study are in table 1, and treatment group is compared with matched group, and two groups are compared and have significant difference (P<0.05).
Claims (7)
1. treat the Chinese medicine composition of chronic subdural hematoma for one kind, it is characterized in that: composition and the weight portion of making the crude drug of this medicine are: Fructus Liquidambaris 100-220 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 100-210 parts, Carapax Trionycis 20-100 parts, 60-160 parts, Poria, Cortex Lycii 60-160 parts, Radix Stellariae 60-160 parts, Radix Cynanchi Atrati 60-120 parts, Radix Rehmanniae 30-120 parts, SHANZHIZI 30-120 parts, Pericarpium Citri Reticulatae 30-120 parts, Fructus Citri Sarcodactylis 20-100 parts, the Radix Paeoniae Alba 10-80 parts, Semen Litchi 10-80 parts, Rhizoma Pinelliae Preparatum 10-80 parts, Lapis Micae Aureus 10-80 parts, Concha Margaritifera 10-80 parts, Fructus Schisandrae Chinensis 10-80 parts, Fructus Mume 30-90 parts, Fructus Chebulae 30-90 parts, 30-160 parts, Radix Glycyrrhizae.
2. a kind of Chinese medicine composition for the treatment of chronic subdural hematoma according to claim 1, it is characterized in that: composition and the weight portion of making the crude drug of this medicine are: Fructus Liquidambaris 100-220 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 100-210 parts, Carapax Trionycis 20-100 parts, 60-160 parts, Poria, Cortex Lycii 60-160 parts, Radix Stellariae 60-160 parts, Radix Cynanchi Atrati 60-120 parts, Radix Rehmanniae 30-120 parts, SHANZHIZI 30-120 parts, Pericarpium Citri Reticulatae 30-120 parts, Fructus Citri Sarcodactylis 20-100 parts, the Radix Paeoniae Alba 10-80 parts, Semen Litchi 10-80 parts, Rhizoma Pinelliae Preparatum 10-80 parts, Lapis Micae Aureus 10-80 parts, Concha Margaritifera 10-80 parts, Fructus Schisandrae Chinensis 10-80 parts, Fructus Mume 30-90 parts, Fructus Chebulae 30-90 parts, 30-160 parts, Radix Glycyrrhizae.
3. a kind of Chinese medicine composition for the treatment of chronic subdural hematoma according to claim 2, is characterized in that: composition and the weight portion of making the crude drug of this medicine are: Fructus Liquidambaris 220 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 200 parts, Carapax Trionycis 100 parts, 120 parts, Poria, Cortex Lycii 150 parts, Radix Stellariae 80 parts, Radix Cynanchi Atrati 80 parts, Radix Rehmanniae 100 parts, SHANZHIZI 100 parts, Pericarpium Citri Reticulatae 100 parts, Fructus Citri Sarcodactylis 80 parts, the Radix Paeoniae Alba 50 parts, Semen Litchi 50 parts, Rhizoma Pinelliae Preparatum 50 parts, Lapis Micae Aureus 50 parts, Concha Margaritifera 50 parts, Fructus Schisandrae Chinensis 80 parts, Fructus Mume 60 parts, Fructus Chebulae 30 parts, 120 parts, Radix Glycyrrhizae.
4. a kind of Chinese medicine composition for the treatment of chronic subdural hematoma according to claim 2, is characterized in that: composition and the weight portion of making the crude drug of this medicine are: Fructus Liquidambaris 200 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 180 parts, Carapax Trionycis 80 parts, 100 parts, Poria, Cortex Lycii 100 parts, Radix Stellariae 90 parts, Radix Cynanchi Atrati 80 parts, Radix Rehmanniae 100 parts, SHANZHIZI 60 parts, Pericarpium Citri Reticulatae 60 parts, Fructus Citri Sarcodactylis 60 parts, the Radix Paeoniae Alba 50 parts, Semen Litchi 40 parts, Rhizoma Pinelliae Preparatum 80 parts, Lapis Micae Aureus 50 parts, Concha Margaritifera 50 parts, Fructus Schisandrae Chinensis 70 parts, Fructus Mume 70 parts, Fructus Chebulae 80 parts, 100 parts, Radix Glycyrrhizae.
5. a kind of Chinese medicine composition for the treatment of chronic subdural hematoma according to claim 2, is characterized in that: composition and the weight portion of making the crude drug of this medicine are: Fructus Liquidambaris 180 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 160 parts, Carapax Trionycis 20 parts, 90 parts, Poria, Cortex Lycii 80 parts, Radix Stellariae 80 parts, Radix Cynanchi Atrati 90 parts, Radix Rehmanniae 120 parts, SHANZHIZI 100 parts, Pericarpium Citri Reticulatae 100 parts, Fructus Citri Sarcodactylis 80 parts, the Radix Paeoniae Alba 60 parts, Semen Litchi 60 parts, Rhizoma Pinelliae Preparatum 60 parts, Lapis Micae Aureus 60 parts, Concha Margaritifera 50 parts, Fructus Schisandrae Chinensis 40 parts, Fructus Mume 50 parts, Fructus Chebulae 50 parts, 90 parts, Radix Glycyrrhizae.
6. the preparation method of the Chinese medicine composition as described in as arbitrary in claim 1-5, it is characterized in that: Carapax Trionycis, more than Poria two tastes are ground into fine powder, sieve, all the other 18 taste decoctings, concentrated, 50% precipitate with ethanol, after filtration, filtrate concentrates, the two mixing, granule processed, dry, encapsulated or tabletting.
7. the preparation method of Chinese medicine composition as claimed in claim 6, it is characterized in that: Carapax Trionycis, more than Poria two tastes are ground into fine powder, sieve, all the other 18 taste decoctings 2 times, each 30 minutes, concentrated, 50% precipitate with ethanol, after filtration, filtrate concentrates, spraying dry, mixing, granule processed, drying, makes capsule or tablet.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105943639A (en) * | 2016-06-16 | 2016-09-21 | 张连纲 | Traditional Chinese medicine composition assisting in treating chronic subdural hematoma |
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