CN104587019A - Medicine composition for treating climacteric functional uterine bleeding - Google Patents
Medicine composition for treating climacteric functional uterine bleeding Download PDFInfo
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- CN104587019A CN104587019A CN201510076108.3A CN201510076108A CN104587019A CN 104587019 A CN104587019 A CN 104587019A CN 201510076108 A CN201510076108 A CN 201510076108A CN 104587019 A CN104587019 A CN 104587019A
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Abstract
The invention relates to a medicine composition for treating climacteric functional uterine bleeding. The medicine composition comprises the following raw materials in parts by weight: 10 to 20 parts of platycodon grandiflorus, 10 to 20 parts of pericarpium citri reticulatae, 10 to 30 parts of immature bitter oranges and the like. According to the medicine composition, the medicines are combined, the formula is reasonable, both symptoms and root causes are treated, and good effects of regulating the endocrine and menstrual cycle, reducing the menstrual volume and improving general symptoms are achieved.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of pharmaceutical composition for the treatment of Climacteric Dysfunctional Uterine Bleeding.
Background technology
Dysfunctional uterine hemorrhage refers to neuroendocrine regulatory function not normal but not the organic focus of genitals itself or the anomalous uterine caused by general disease.The multiple climacteric women being born in 44-55 year, Menopause DUB polyphyly anovulatory anovulatory dysfunctional uterine hemorrhage, main manifestations is irregularities metrorrhagia, often cause little same degree anemia, secondary infection, mental burden is overweight, even hysterectomizes, and serious harm women's is healthy.Climacteric functional palace hemorrhage genus Chinese medicine " metrorrhagia " category, wherein kidney qi degradation, punching appoint gradually void to be its main pathogenesis.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition for the treatment of Climacteric Dysfunctional Uterine Bleeding.
In order to realize object of the present invention, the invention provides a kind of pharmaceutical composition for the treatment of Climacteric Dysfunctional Uterine Bleeding, it comprises the crude drug of following weight portion: Radix Platycodonis 10-20 part, Pericarpium Citri Reticulatae 10-20 part and Fructus Aurantii Immaturus 10-30 part.
Preferably, the pharmaceutical composition of described treatment Climacteric Dysfunctional Uterine Bleeding comprises the crude drug of following weight portion: Radix Platycodonis 15 parts, Pericarpium Citri Reticulatae 12 parts and Fructus Aurantii Immaturus 20 parts.
Preferably, the pharmaceutical composition of described treatment Climacteric Dysfunctional Uterine Bleeding also comprises the crude drug of following weight portion: Herba solani photeinocarpi 20-30 part, mountain Pericarpium Citri Reticulatae Viride 20-50 part, water hair penetrates 10-30 part, Caulis et Folium Brassicae capitatae 10-20 part, Herba Otteliae Alismoidis 10-20 part, Radix Phyllagathis fordii 10-30 part, purslane speedwell Herba 10-20 part, Parathelypteris glanduligera (Kunze) Ching 10-20 part, Herba Elsholtziae Ciliatae 10-30 part, Herba Reineckeae Carneae 1-10 part, Folium Isatidis 10-15 part, Herb Pararuelliae delavayanae 1-10 part, Fructus Ligustri Lucidi 10-20 part, Semen Plantaginis 5-10 part, Radix Oxystelmatis esculenti 1-20 part, Fructus Cnidii 1-15 part, Herba seu Radix Calanthes 1-10 part, Radix Rehmanniae 10-30 part, the sub-10-20 part of Folium Bambusae, blood aspidistra 1-10 part, Herba Thlaspis 1-10 part, Rhizoma Begoniae Fimbristipulatae 5-10 part, Fructus Evodiae 10-20 part, Folium Prinsepiae Utilis 10-20 part and Radix Glycyrrhizae 1-10 part.
Preferably, the pharmaceutical composition of described treatment Climacteric Dysfunctional Uterine Bleeding also comprises the crude drug of following weight portion: Herba solani photeinocarpi 25 parts, 30 parts, mountain Pericarpium Citri Reticulatae Viride, water hair penetrates 20 parts, Caulis et Folium Brassicae capitatae 15 parts, Herba Otteliae Alismoidis 15 parts, Radix Phyllagathis fordii 20 parts, purslane speedwell Herba 12 parts, Parathelypteris glanduligera (Kunze) Ching 15 parts, Herba Elsholtziae Ciliatae 20 parts, Herba Reineckeae Carneae 9 parts, Folium Isatidis 12 parts, Herb Pararuelliae delavayanae 8 parts, Fructus Ligustri Lucidi 15 parts, Semen Plantaginis 8 parts, Radix Oxystelmatis esculenti 10 parts, Fructus Cnidii 10 parts, Herba seu Radix Calanthes 7 parts, 20 parts, the Radix Rehmanniae, Folium Bambusae 15 parts, blood aspidistra 7 parts, Herba Thlaspis 7 parts, Rhizoma Begoniae Fimbristipulatae 8 parts, Fructus Evodiae 18 parts, Folium Prinsepiae Utilis 12 parts and 9 parts, Radix Glycyrrhizae.
Preferably, described pharmaceutical composition can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or lotion.
The present invention also provides the purposes of compositions in the medicine of preparation treatment Climacteric Dysfunctional Uterine Bleeding, and described compositions comprises the crude drug of following weight portion: Radix Platycodonis 10-20 part, Pericarpium Citri Reticulatae 10-20 part and Fructus Aurantii Immaturus 10-30 part.
Preferably, described compositions comprises the crude drug of following weight portion: Radix Platycodonis 15 parts, Pericarpium Citri Reticulatae 12 parts and Fructus Aurantii Immaturus 20 parts.
Preferably, described compositions also comprises the crude drug of following weight portion: Herba solani photeinocarpi 20-30 part, mountain Pericarpium Citri Reticulatae Viride 20-50 part, water hair penetrates 10-30 part, Caulis et Folium Brassicae capitatae 10-20 part, Herba Otteliae Alismoidis 10-20 part, Radix Phyllagathis fordii 10-30 part, purslane speedwell Herba 10-20 part, Parathelypteris glanduligera (Kunze) Ching 10-20 part, Herba Elsholtziae Ciliatae 10-30 part, Herba Reineckeae Carneae 1-10 part, Folium Isatidis 10-15 part, Herb Pararuelliae delavayanae 1-10 part, Fructus Ligustri Lucidi 10-20 part, Semen Plantaginis 5-10 part, Radix Oxystelmatis esculenti 1-20 part, Fructus Cnidii 1-15 part, Herba seu Radix Calanthes 1-10 part, Radix Rehmanniae 10-30 part, the sub-10-20 part of Folium Bambusae, blood aspidistra 1-10 part, Herba Thlaspis 1-10 part, Rhizoma Begoniae Fimbristipulatae 5-10 part, Fructus Evodiae 10-20 part, Folium Prinsepiae Utilis 10-20 part and Radix Glycyrrhizae 1-10 part.
Preferably, described compositions also comprises the crude drug of following weight portion: Herba solani photeinocarpi 25 parts, 30 parts, mountain Pericarpium Citri Reticulatae Viride, water hair penetrate 20 parts, Caulis et Folium Brassicae capitatae 15 parts, Herba Otteliae Alismoidis 15 parts, Radix Phyllagathis fordii 20 parts, purslane speedwell Herba 12 parts, Parathelypteris glanduligera (Kunze) Ching 15 parts, Herba Elsholtziae Ciliatae 20 parts, Herba Reineckeae Carneae 9 parts, Folium Isatidis 12 parts, Herb Pararuelliae delavayanae 8 parts, Fructus Ligustri Lucidi 15 parts, Semen Plantaginis 8 parts, Radix Oxystelmatis esculenti 10 parts, Fructus Cnidii 10 parts, Herba seu Radix Calanthes 7 parts, 20 parts, the Radix Rehmanniae, Folium Bambusae 15 parts, blood aspidistra 7 parts of, Herba Thlaspiss 7 parts, Rhizoma Begoniae Fimbristipulatae 8 parts, Fructus Evodiae 18 parts, Folium Prinsepiae Utilis 12 parts and 9 parts, Radix Glycyrrhizae.
Preferably, described medicine can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or lotion.
In the present invention, Herba solani photeinocarpi, mountain Pericarpium Citri Reticulatae Viride, water hair are penetrated as monarch drug; Radix Platycodonis, Caulis et Folium Brassicae capitatae, Herba Otteliae Alismoidis, Radix Phyllagathis fordii, purslane speedwell Herba, Parathelypteris glanduligera (Kunze) Ching, Herba Elsholtziae Ciliatae are ministerial drug; Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Herba Reineckeae Carneae, Folium Isatidis, Herb Pararuelliae delavayanae, Fructus Ligustri Lucidi, Semen Plantaginis, Radix Oxystelmatis esculenti, Fructus Cnidii, Herba seu Radix Calanthes, the Radix Rehmanniae, Folium Bambusae, blood aspidistra, Herba Thlaspis, Rhizoma Begoniae Fimbristipulatae, Fructus Evodiae, Folium Prinsepiae Utilis are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, plays the effect making medicine in the compositions of the present invention.
All medicines are harmonious in the present invention, reasonable recipe, giving consideration to both the incidental and fundamental, endocrine regulation, adjustment menstrual cycle, reduce through blood volume, improve General Symptoms, treating both the principal and secondary aspects of a disease and obtain good effect.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment lotion of the present invention
Take Radix Platycodonis 150 grams, Pericarpium Citri Reticulatae 120 grams, Fructus Aurantii Immaturus 200 grams, Herba solani photeinocarpi 250 grams, 300 grams, mountain Pericarpium Citri Reticulatae Viride, water hair penetrates 200 grams, Caulis et Folium Brassicae capitatae 150 grams, Herba Otteliae Alismoidis 150 grams, Radix Phyllagathis fordii 200 grams, purslane speedwell Herba 120 grams, Parathelypteris glanduligera (Kunze) Ching 150 grams, Herba Elsholtziae Ciliatae 200 grams, Herba Reineckeae Carneae 90 grams, Folium Isatidis 120 grams, Herb Pararuelliae delavayanae 80 grams, Fructus Ligustri Lucidi 150 grams, Semen Plantaginis 80 grams, Radix Oxystelmatis esculenti 100 grams, Fructus Cnidii 100 grams, Herba seu Radix Calanthes 70 grams, 200 grams, the Radix Rehmanniae, Folium Bambusae 150 grams, blood aspidistra 70 grams, Herba Thlaspis 70 grams, Rhizoma Begoniae Fimbristipulatae 80 grams, Fructus Evodiae 180 grams, Folium Prinsepiae Utilis 120 grams and 90 grams, Radix Glycyrrhizae, add 20 liters, water, heating 5 hours under the condition of backflow, filter, obtain filtering residue 1 and filtrate 1, 10 liters, water is added in filtering residue 1, heating 3 hours under the condition of backflow, filter, obtain filtering residue 2 and filtrate 2, merging filtrate 1 and filtrate 2, obtain.
Experimental example
According to new Chinese medicine guideline of clinical investigations (Ministry of Health of the People's Republic of China. new Chinese medicine guideline of clinical investigations [M]. Beijing: People's Health Publisher, 133:236-238) diagnostic criteria carries out.Choose patient 45 example, the age be 42-51 year; Clinical manifestation is the confusion of the menstrual cycle, and the time of passing through was more than more than 15 days, or the several months continuously endlessly, also has the menolipsis several months sudden and violent lower more than or not to the utmost dripping suddenly again, often has anemia in various degree.Auxiliary examination: gynecologial examination and B ultrasonic or the equal ametria of MR and adnexa occupying lesion, without internal medicine disease in the blood system, hepatic and renal function Non Apparent Abnormality, has the therapist such as oral contraceptive or estrogen in getting rid of 3 months, and confirms without intrauterine device.
The lotion using embodiment to prepare is treated, every day 3 times, and each use 200 milliliters cleans vagina 1 minute, continuously treatment 20 days.
Efficacy determination
With reference to the standard envisages of new Chinese medicine guideline of clinical investigations.Recovery from illness: after hemorrhage control, continuous 3 menstrual cycle menstrual period, all normal through amount, subjective symptoms disappears, or blood only after menopause.Effective: after Bleeding control, menstrual cycle, normal through measuring, but menstrual period are still longer (more than 7d, below 10d), and subjective symptoms disappears substantially.Effective: menstrual cycle, menstrual period part subjective symptoms effectively improved, through amount reduce.Invalid: above every all without improvement.
Therapeutic outcome
Through treatment, find that 45 routine patients are after hemorrhage control, all continuous 3 menstrual cycle menstrual period, all normal through amount, subjective symptoms disappears, and all meets the standard of recovery from illness.
Untoward reaction and toxic and side effects supervision
By detect patient blood pressure, pulse, whether there is Nausea and vomiting, dizzy clinical symptoms judges untoward reaction.Find that the systolic pressure of all patients is between 90-140mmHg, diastolic pressure is between 60-90mmHg, and pulse is 60-100 beat/min, and blood pressure and pulse all within normal range, and does not occur Nausea and vomiting, dizzy clinical symptoms.This illustrates that pharmaceutical composition of the present invention does not have obvious untoward reaction, and then proves that medicine does not have obvious toxic and side effects for human body.
Claims (10)
1. treat a pharmaceutical composition for Climacteric Dysfunctional Uterine Bleeding, it is characterized in that, it comprises the crude drug of following weight portion: Radix Platycodonis 10-20 part, Pericarpium Citri Reticulatae 10-20 part and Fructus Aurantii Immaturus 10-30 part.
2. the pharmaceutical composition for the treatment of Climacteric Dysfunctional Uterine Bleeding according to claim 1, is characterized in that, it comprises the crude drug of following weight portion: Radix Platycodonis 15 parts, Pericarpium Citri Reticulatae 12 parts and Fructus Aurantii Immaturus 20 parts.
3. the pharmaceutical composition for the treatment of Climacteric Dysfunctional Uterine Bleeding according to claim 2, it is characterized in that, it also comprises the crude drug of following weight portion: Herba solani photeinocarpi 20-30 part, mountain Pericarpium Citri Reticulatae Viride 20-50 part, water hair penetrates 10-30 part, Caulis et Folium Brassicae capitatae 10-20 part, Herba Otteliae Alismoidis 10-20 part, Radix Phyllagathis fordii 10-30 part, purslane speedwell Herba 10-20 part, Parathelypteris glanduligera (Kunze) Ching 10-20 part, Herba Elsholtziae Ciliatae 10-30 part, Herba Reineckeae Carneae 1-10 part, Folium Isatidis 10-15 part, Herb Pararuelliae delavayanae 1-10 part, Fructus Ligustri Lucidi 10-20 part, Semen Plantaginis 5-10 part, Radix Oxystelmatis esculenti 1-20 part, Fructus Cnidii 1-15 part, Herba seu Radix Calanthes 1-10 part, Radix Rehmanniae 10-30 part, the sub-10-20 part of Folium Bambusae, blood aspidistra 1-10 part, Herba Thlaspis 1-10 part, Rhizoma Begoniae Fimbristipulatae 5-10 part, Fructus Evodiae 10-20 part, Folium Prinsepiae Utilis 10-20 part and Radix Glycyrrhizae 1-10 part.
4. the pharmaceutical composition for the treatment of Climacteric Dysfunctional Uterine Bleeding according to claim 3, it is characterized in that, it also comprises the crude drug of following weight portion: Herba solani photeinocarpi 25 parts, 30 parts, mountain Pericarpium Citri Reticulatae Viride, water hair penetrates 20 parts, Caulis et Folium Brassicae capitatae 15 parts, Herba Otteliae Alismoidis 15 parts, Radix Phyllagathis fordii 20 parts, purslane speedwell Herba 12 parts, Parathelypteris glanduligera (Kunze) Ching 15 parts, Herba Elsholtziae Ciliatae 20 parts, Herba Reineckeae Carneae 9 parts, Folium Isatidis 12 parts, Herb Pararuelliae delavayanae 8 parts, Fructus Ligustri Lucidi 15 parts, Semen Plantaginis 8 parts, Radix Oxystelmatis esculenti 10 parts, Fructus Cnidii 10 parts, Herba seu Radix Calanthes 7 parts, 20 parts, the Radix Rehmanniae, Folium Bambusae 15 parts, blood aspidistra 7 parts, Herba Thlaspis 7 parts, Rhizoma Begoniae Fimbristipulatae 8 parts, Fructus Evodiae 18 parts, Folium Prinsepiae Utilis 12 parts and 9 parts, Radix Glycyrrhizae.
5. the pharmaceutical composition for the treatment of Climacteric Dysfunctional Uterine Bleeding according to claim 4, is characterized in that, described pharmaceutical composition can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or lotion.
6. the purposes of compositions in the medicine of preparation treatment Climacteric Dysfunctional Uterine Bleeding, it is characterized in that, described compositions comprises the crude drug of following weight portion: Radix Platycodonis 10-20 part, Pericarpium Citri Reticulatae 10-20 part and Fructus Aurantii Immaturus 10-30 part.
7. purposes according to claim 6, is characterized in that, described compositions comprises the crude drug of following weight portion: Radix Platycodonis 15 parts, Pericarpium Citri Reticulatae 12 parts and Fructus Aurantii Immaturus 20 parts.
8. purposes according to claim 7, it is characterized in that, described compositions also comprises the crude drug of following weight portion: Herba solani photeinocarpi 20-30 part, mountain Pericarpium Citri Reticulatae Viride 20-50 part, water hair penetrates 10-30 part, Caulis et Folium Brassicae capitatae 10-20 part, Herba Otteliae Alismoidis 10-20 part, Radix Phyllagathis fordii 10-30 part, purslane speedwell Herba 10-20 part, Parathelypteris glanduligera (Kunze) Ching 10-20 part, Herba Elsholtziae Ciliatae 10-30 part, Herba Reineckeae Carneae 1-10 part, Folium Isatidis 10-15 part, Herb Pararuelliae delavayanae 1-10 part, Fructus Ligustri Lucidi 10-20 part, Semen Plantaginis 5-10 part, Radix Oxystelmatis esculenti 1-20 part, Fructus Cnidii 1-15 part, Herba seu Radix Calanthes 1-10 part, Radix Rehmanniae 10-30 part, the sub-10-20 part of Folium Bambusae, blood aspidistra 1-10 part, Herba Thlaspis 1-10 part, Rhizoma Begoniae Fimbristipulatae 5-10 part, Fructus Evodiae 10-20 part, Folium Prinsepiae Utilis 10-20 part and Radix Glycyrrhizae 1-10 part.
9. purposes according to claim 8, it is characterized in that, described compositions also comprises the crude drug of following weight portion: Herba solani photeinocarpi 25 parts, 30 parts, mountain Pericarpium Citri Reticulatae Viride, water hair penetrates 20 parts, Caulis et Folium Brassicae capitatae 15 parts, Herba Otteliae Alismoidis 15 parts, Radix Phyllagathis fordii 20 parts, purslane speedwell Herba 12 parts, Parathelypteris glanduligera (Kunze) Ching 15 parts, Herba Elsholtziae Ciliatae 20 parts, Herba Reineckeae Carneae 9 parts, Folium Isatidis 12 parts, Herb Pararuelliae delavayanae 8 parts, Fructus Ligustri Lucidi 15 parts, Semen Plantaginis 8 parts, Radix Oxystelmatis esculenti 10 parts, Fructus Cnidii 10 parts, Herba seu Radix Calanthes 7 parts, 20 parts, the Radix Rehmanniae, Folium Bambusae 15 parts, blood aspidistra 7 parts, Herba Thlaspis 7 parts, Rhizoma Begoniae Fimbristipulatae 8 parts, Fructus Evodiae 18 parts, Folium Prinsepiae Utilis 12 parts and 9 parts, Radix Glycyrrhizae.
10. purposes according to claim 9, is characterized in that, described medicine can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or lotion.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510076108.3A CN104587019A (en) | 2015-02-13 | 2015-02-13 | Medicine composition for treating climacteric functional uterine bleeding |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510076108.3A CN104587019A (en) | 2015-02-13 | 2015-02-13 | Medicine composition for treating climacteric functional uterine bleeding |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103330809A (en) * | 2013-07-23 | 2013-10-02 | 黄淑娟 | Traditional Chinese medicine composition for curing functional uterine bleeding |
| CN103933269A (en) * | 2014-04-28 | 2014-07-23 | 刘芳 | Traditional Chinese medicine for treating metrorrhagia disease |
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2015
- 2015-02-13 CN CN201510076108.3A patent/CN104587019A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103330809A (en) * | 2013-07-23 | 2013-10-02 | 黄淑娟 | Traditional Chinese medicine composition for curing functional uterine bleeding |
| CN103933269A (en) * | 2014-04-28 | 2014-07-23 | 刘芳 | Traditional Chinese medicine for treating metrorrhagia disease |
Non-Patent Citations (2)
| Title |
|---|
| 刘兰芳主编: "《当代妇科名医名方》", 30 November 2009, 金盾出版社 * |
| 刘玉成编著: "《赐嗣 不孕症诊疗理论与实践》", 31 August 2007, 军事医学科学出版社 * |
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Application publication date: 20150506 |