CN104586949A - Preparation method of substance capable of relieving hypersensitive response and inflammatory response - Google Patents
Preparation method of substance capable of relieving hypersensitive response and inflammatory response Download PDFInfo
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- CN104586949A CN104586949A CN201410831612.5A CN201410831612A CN104586949A CN 104586949 A CN104586949 A CN 104586949A CN 201410831612 A CN201410831612 A CN 201410831612A CN 104586949 A CN104586949 A CN 104586949A
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Abstract
The invention discloses a preparation method of a substance capable of relieving hypersensitive response and inflammatory response. The preparation method of the substance capable of relieving the hypersensitive response and inflammatory response comprises the following steps: putting gorgon euryale seeds and purified water into a container according to a ratio, and stirring for 30-60 minutes; taking out the mixture obtained after mixing, filtering by virtue of a sieving basket which is provided with sieve openings with the diameter or maximum edge length less than 2mm, and collecting a filtered solution; then putting the gorgon euryale seeds left in the sieving basket and purified water into the container according to a mass ratio of (1:0.5)-(1:5), stirring for 30-60 minutes, further collecting the filtered solution, repeating the processes, and collecting the filtered solution for N times until the gorgon euryale seeds show gorgon euryale seed kernels, namely semen euryales; and finally, mixing all the filtered solutions, and adding vitamin C, so that the substance capable of relieving the hypersensitive response and inflammatory response is obtained. The preparation method of the substance capable of relieving the hypersensitive response and inflammatory response has the advantages that active ingredients in shells of the gorgon euryale seeds can be fully released, and the problem that produced heat is too high as grinding is carried out for a long time is solved, so that the preparation method disclosed by the invention can be applied to preparation of the substance capable of relieving the hypersensitive response and inflammatory response.
Description
Technical field
The invention belongs to biological technical field, be specifically related to a kind of preparation method alleviating the material of allergy and inflammatory reaction.
Background technology
Gorgon euryale, thorniness, belongs to Nymphaeceae Gorgon euryale and belongs to annual large-scale aquatic herbaceous plant.Kernel after Gorgon euryale seed removes kind of shell (about 1.5mm) is called Semen Euryales, and it not only has spleen reinforcing of drying, kidney tonifying mends essence, beneficial blood is allayed excitement effect, and has and make people clear-headed and clear-sighted, improves the multiple nutrients functions such as antioxidant ability of organism.Over the past thousands of years, people are considered as precious health food Semen Euryales always.
In recent years, along with market increasing sharply to the demand of Semen Euryales, Semen Euryales processing enterprise gets more and more, and has spread all over the national multiple province in Jiangsu, Anhui, Shandong, Henan, Guangdong etc.At present, Semen Euryales seed has become a kind of good merchantable brand of generally acknowledged energy nourishing and fit keeping function, but the function of Gorgon euryale kind shell is developed seldom, and therefore, Semen Euryales processing enterprise is rubbish depending on Gorgon euryale kind shell, arbitrarily stacks, abandons.This not only causes environmental pollution, or a kind of wasting of resources.Gorgon euryale seed whole body is all precious in fact, and the kernel (Semen Euryales) of Gorgon euryale seed is good health product, and the kind shell of Gorgon euryale seed is also a treasured.The content that the present invention is correlated with presses down the correlational study of scorching, antiallergic aspect around Gorgon euryale kind shell and launches.
The present invention not only works out the New function of Gorgon euryale kind shell, turns waste into wealth, and have developed one and have and alleviate allergy and inflammatory reaction substances preparation method.This invention produces the disposed waste of Semen Euryales for raw material with food enterprise, and preparation method simply, is easily grasped, the low production cost of finished product, therefore, this invention has good social benefit, environmental benefit and economic benefit, has potentiality and the prospect of powerful merchandized handling.
Summary of the invention
The object of the present invention is to provide a kind of preparation method alleviating the material of allergy and inflammatory reaction, to make the effective ingredient in Gorgon euryale seed hull fully be discharged, and avoiding because once grinding the problem causing heat production too high for a long time.
In order to solve above technical problem, the present invention relates to and determine to prepare the short-cut method in Gorgon euryale kind shell with alleviation allergy and inflammatory reaction material; Determine to utilize the material prepared in Gorgon euryale kind shell to alleviate allergy and inflammatory reaction biological activity.Concrete technical scheme is as follows:
Alleviate a preparation method for the material of allergy and inflammatory reaction, it is characterized in that: repeatedly grind to grind when replacing a vice-minister when utilizing few, specifically comprise the following steps:
Step one: the container preparing an opening, longitudinally puts into container, not bottom contacting container by stirring rod;
Step 2: Gorgon euryale seed and pure water are put into described container in the ratio of 1:1 ~ 1:5;
Step 3: utilize described stirring rod to stir 30 ~ 60 minutes to obtain mixture;
Step 4: take out the described mixture in container, filters with the sieve basket that sieve size is below 2mm, collects 1 filtered solution;
Step 5: using the Gorgon euryale seed stayed in sieve basket as the Gorgon euryale seed in step 2, repeats step 2, till Gorgon euryale seed shows Gorgon euryale kernel and Semen Euryales to step 4 common N time; In repetitive process, correspondence is collected 2 times respectively, 3 times ... N+1 filtered solution;
Step 6: merge 1 time to N+1 filtered solution, and under centrifugal speed is 12000 rpm conditions after centrifugal 10 minutes, add antioxidant, namely obtain the material of described alleviation allergy and inflammatory reaction effect.
Described antioxidant is vitamin C.
Described stirring rod is " rich " type driven stirring rod, and to make Gorgon euryale seed under the abundant stirring of driven stirring rod, upper, middle and lower-ranking is ground fully in a reservoir.
Described container is the earthen container of wide-mouth, to make Gorgon euryale seed achieve mutual grinding between Gorgon euryale seed under the stirring of " rich " type stirring rod, and makes to achieve grinding between Gorgon euryale seed and earthen container inwall.
the present invention has beneficial effect.gorgon euryale kind shell is a kind of garbage of Semen Euryales manufacturing enterprise, and at present, these discarded Gorgon euryale kind shells do not obtain Appropriate application, can only be taken as rubbish and arbitrarily abandon, cause environmental pollution and the wasting of resources.The present invention prepares a kind of method with alleviation allergy and inflammatory reaction material from Gorgon euryale kind shell, repeatedly grind to grind when replacing a vice-minister when utilizing few, this can not only make the effective ingredient in Gorgon euryale seed hull fully be discharged, and avoids the problem of once grinding for a long time and causing heat production too high.The present invention has many beneficial effects, and concrete benefit is as follows:
(1) economic benefit: the present invention is Semen Euryales processing waste--Gorgon euryale kind shell is turned waste into wealth, and this not only adds the added value of Semen Euryales, and improves the economic benefit of Semen Euryales processing enterprise.
(2) environmental benefit: the present invention makes full use of Semen Euryales processing waste--Semen Euryales kind shell extracts to have alleviates allergy and inflammatory reaction material, and this makes Semen Euryales kind shell become dotey.Semen Euryales processing enterprise can be deposited in these Gorgon euryale kind shells to sell in warehouse, and can not arbitrarily they arbitrarily be stacked out of doors as rubbish, lets alone corruption, fermentation.Therefore, The present invention reduces because Semen Euryales kind shell arbitrarily stacks the waste of contaminated environment and the land resource caused.
(3) social benefit: Semen Euryales is a kind of is food that numerous people is liked over the past thousands of years.The present invention utilizes Semen Euryales processing waste-Gorgon euryale kind shell, works out a kind of green, safe production method with alleviation allergy and inflammatory reaction material newly.Alleviation allergy prepared by the present invention and the material of inflammatory reaction, from raw-food material, can be used for the crowd of the Different age group such as infant, have no side effect, and are expected to bring good social benefit.
Accompanying drawing explanation
Fig. 1 is the flow chart of preparation method of the present invention.
Detailed description of the invention
Below in conjunction with the drawings and specific embodiments, technical scheme of the present invention is described in further details.
embodiment 1
1.1 1 kinds of preparation methoies alleviating the material of allergy and inflammatory reaction
Have purchased 100 kilograms of Gorgon euryale seeds in the large market of Semen Euryales, long queue hilllock, sky, Anhui, first, Gorgon euryale seed is eluriated clean.Then, in pithos, put into " rich " type stirring rod, and put into the clean Gorgon euryale seed of elutriation.Subsequently, in pithos, add pure water make Gorgon euryale seed and pure water be 1:1, make pure water slightly not have Gorgon euryale seed.Open stirring rod power supply effect 30 minutes.Take out the mixture in earthen container, filter through the sieve basket of diameter at below 2mm mesh, collect 1 filtered solution.The ratio of the Gorgon euryale seed stayed in sieve basket and pure water 1:1 is in mass ratio put into earthen container, continues stirring 30 minutes with " rich " type driven stirring rod, collect 2 filtered solutions.Repeat 4 i.e. N=4 so altogether, collect 5 filtered solutions.By 5 filtered solutions obtained, under 12000 rpm conditions after centrifugal 10 minutes, namely the vitamin C adding 0.5% obtains a kind of material with alleviation allergy and inflammatory reaction effect prepared from Gorgon euryale kind shell.
a kind of research alleviating allergy and inflammatory reaction material alleviation allergy effect
(1) the volunteer needing injection tetanus antitoxin of regular hospital admission, inside its forearm, subcutaneous injection is containing tetanus antitoxin (TAT) the solution 0.1ml(TAT skin test of 15U).After 0.5 hour, find that there is area about 5.0 cm volunteer's forearm skin test injection site
2the irritated region of redness.
(2), when skin test about 1 hour, volunteer's skin test site has scratchiness, after scratching skin test site occur obviously hardening, swelling, irritated erythema area increases, about 7 cm
2.Now, with aseptic cotton carrier fully dip prepare from Gorgon euryale kind shell there is the material alleviating allergy and inflammatory reaction effect, skin test site is smeared, within every 2 hours, is coated with once, every day and every 24 hours 6-8 time.
(3) coating is after 36 hours, and the irritated erythema area of volunteer's skin test site diminishes gradually, red irritated region about 1.0 cm
2, and though patient's skin test site is without scratchiness, but still have slight swelling.
(4) coating is after 48 hours, volunteer's skin test site without obvious erythema, without scratchiness, without swelling symptom.
embodiment 2 one kinds alleviates the example of allergy and the reaction of inflammatory reaction material alleviation dermatitis
2.1 1 kinds of preparation methoies alleviating the material of allergy and inflammatory reaction
Have purchased 100 kilograms of Gorgon euryale seeds in the large market of Semen Euryales, long queue hilllock, sky, Anhui, first, Gorgon euryale seed is eluriated clean.Then, in pithos, put into " rich " type stirring rod, and put into the clean Gorgon euryale seed of elutriation.Subsequently, in pithos, add pure water make Gorgon euryale seed and pure water be 1:3, make pure water slightly not have Gorgon euryale seed.Open stirring rod power supply effect 45 minutes.Take out the mixture in earthen container, filter through the sieve basket of diameter at below 2mm mesh, collect 1 filtered solution.The ratio of the Gorgon euryale seed stayed in sieve basket and pure water 1:3 is in mass ratio put into earthen container, continues stirring 45 minutes with " rich " type driven stirring rod, collect 2 filtered solutions.Repeat 3 i.e. N=3 so altogether, collect 4 filtered solutions.By 4 filtered solutions obtained, under 12000 rpm conditions after centrifugal 10 minutes, namely the vitamin C adding 2.5% obtains a kind of material with alleviation allergy and inflammatory reaction effect prepared from Gorgon euryale kind shell.
a kind of research alleviating allergy and the reaction of inflammatory reaction material alleviation dermatitis
(1) stung the volunteer of forehead by hornet, stinging position has scratchiness, and the rear skin test site appearance of scratching is obviously hardened, swelling, dermatitis erythema area about 4 cm
2.
(2) fully dip the material with alleviation allergy and inflammatory reaction effect prepared from Gorgon euryale kind shell with aseptic cotton carrier, skin test site is smeared, within every 2 hours, be coated with once, every 24 hours 6-8 time.
(3) coating is after 48 hours, and the irritated erythema area of volunteer's skin test site diminishes gradually, red irritated region about 2.0 cm
2, and patient's skin test site is without scratchiness, but still have swelling symptom.
(4) coating is after 72 hours, and volunteer's skin test site only has slight erythema trace, without obvious scratchiness, only has slight swelling symptom.
embodiment 3 one kinds alleviates the example of allergy and inflammatory reaction material alleviation dermatitis symptom
3.1 1 kinds of preparation methoies alleviating the material of allergy and inflammatory reaction
Have purchased 100 kilograms of Gorgon euryale seeds in the large market of Semen Euryales, long queue hilllock, sky, Anhui, first, Gorgon euryale seed is eluriated clean.Then, in pithos, put into " rich " type stirring rod, and put into the clean Gorgon euryale seed of elutriation.Subsequently, in pithos, add pure water make Gorgon euryale seed and pure water be 1:5, make pure water slightly not have Gorgon euryale seed.Open stirring rod power supply effect 60 minutes.Take out the mixture in earthen container, filter through the sieve basket of diameter at below 2mm mesh, collect 1 filtered solution.The ratio of the Gorgon euryale seed stayed in sieve basket and pure water 1:5 is in mass ratio put into earthen container, continues stirring 60 minutes with " rich " type driven stirring rod, collect 2 filtered solutions.Repeat 3 i.e. N=3 so altogether, collect 4 filtered solutions.By 4 filtered solutions obtained, under 12000 rpm conditions after centrifugal 10 minutes, namely the vitamin C adding 5% obtains a kind of material with alleviation allergy and inflammatory reaction effect prepared from Gorgon euryale kind shell.
a kind of research alleviating allergy and inflammatory reaction material alleviation dermatitis response effect
(1) the Common Cold volunteer of two days, sneeze, stream clear water nasal mucus serious symptom, owing to wiping away one's snivel through common paper, causes area skin in nasal downside people and occurs red and swollen, coarse symptom, and with obvious pain, burning sensation and discomfort.
(2) fully dip the material with alleviation allergy and inflammatory reaction effect prepared from Gorgon euryale kind shell with aseptic cotton carrier, dermatitis position under nose is smeared, within every 2 hours, be coated with once, every 24 hours 6-8 time.
(3) coating is after 24 hours, and under volunteer's nose, dermatitis symptom alleviates, and shows as dermatitis position without obvious tumefaction symptom, and without burning sensation, volunteer's sense of discomfort obtains very large alleviation.
(4) coating is after 48 hours, and under volunteer's nose, dermatitis symptom is effectively improved, and patient is without sense of discomfort, and the pachylosis sense at dermatitis position is not obvious, without the significantly inflammatory symptom such as red, swollen, hot, swollen.
Claims (3)
1. alleviate a preparation method for the material of allergy and inflammatory reaction, it is characterized in that: repeatedly grind to grind when replacing a vice-minister when utilizing few, specifically comprise the following steps:
Step one, prepares the container of an opening, and stirring rod is longitudinally put into container, not bottom contacting container;
Step 2, puts into described container by Gorgon euryale seed and pure water in the ratio of 1:1 ~ 1:5;
Step 3, utilizes described stirring rod to stir 30 ~ 60 minutes to obtain mixture;
Step 4, takes out the described mixture in container, filters, collect 1 filtered solution with the sieve basket that sieve size is below 2mm;
Step 5, using the Gorgon euryale seed stayed in sieve basket as the Gorgon euryale seed in step 2, repeats step 2, till Gorgon euryale seed shows Gorgon euryale kernel and Semen Euryales to step 4 common N time; In repetitive process, correspondence is collected 2 times respectively, 3 times ... N+1 filtered solution;
Step 6, merges 1 time to N+1 filtered solution, and under centrifugal speed is 12000 rpm conditions after centrifugal 10 minutes, adds antioxidant and vitamin C, namely obtain the material of described alleviation allergy and inflammatory reaction effect.
2. a kind of preparation method alleviating the material of allergy and inflammatory reaction according to claim 1, it is characterized in that: described stirring rod is " rich " type driven stirring rod, to make Gorgon euryale seed under the abundant stirring of driven stirring rod, upper, middle and lower-ranking is ground fully in a reservoir.
3. a kind of preparation method alleviating the material of allergy and inflammatory reaction according to claim 1, it is characterized in that: described container is the earthen container of wide-mouth, to make Gorgon euryale seed achieve mutual grinding between Gorgon euryale seed under the stirring of " rich " type stirring rod, and make to achieve grinding between Gorgon euryale seed and earthen container inwall.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410831612.5A CN104586949B (en) | 2014-12-29 | 2014-12-29 | Preparation method of substance capable of relieving hypersensitive response and inflammatory response |
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| CN104586949B CN104586949B (en) | 2017-05-03 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130095171A1 (en) * | 2011-10-13 | 2013-04-18 | Taichung Veterans General Hospital | Herbal composition and method for treatment of airway inflammation using the same |
| CN104027397A (en) * | 2014-03-25 | 2014-09-10 | 江苏大学 | Preparation method and application of anti-allergic agent from both medicinal and edible plant extract |
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- 2014-12-29 CN CN201410831612.5A patent/CN104586949B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130095171A1 (en) * | 2011-10-13 | 2013-04-18 | Taichung Veterans General Hospital | Herbal composition and method for treatment of airway inflammation using the same |
| CN104027397A (en) * | 2014-03-25 | 2014-09-10 | 江苏大学 | Preparation method and application of anti-allergic agent from both medicinal and edible plant extract |
Non-Patent Citations (1)
| Title |
|---|
| 尹志娜: "植物多酚分离提取方法和生物功能研究进展", 《生命科学仪器》 * |
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